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  1. Book ; Online ; E-Book: Origin of life

    Deamer, David W.

    what everyone needs to know

    (What Everyone Needs to Know)

    2020  

    Abstract: ... What Everyone Needs to Know (R) is a comprehensive scientific guide on the origin of life. David W. Deamer sets out ... we can trust these answers is an important question, and Deamer provides answers to each big question ...

    Author's details David W. Deamer
    Series title What Everyone Needs to Know
    Abstract Our knowledge of our solar system has passed the point of no return. Increasingly, it seems possible that scientists will soon discover how life is created on habitable planets like Earth and Mars. Scientists have responded to a renewed public interest in the origin of life with research, but many questions still remain unanswered in the broader conversation. Other questions can be answered by the laws of chemistry and physics, but questions surrounding the origin of life are best answered by reasonable extrapolations of what scientists know from observing the Earth and its solar system. 0Origin of Life: What Everyone Needs to Know (R) is a comprehensive scientific guide on the origin of life. David W. Deamer sets out to answer the top forty questions about the origin of life, including: Where do the atoms of life come from? How old is Earth? What was the Earth like before life originated? Where does water come from? How did evolution begin? After he provides the informational answer for each question, there is a follow-up: How do we know? This question expands the horizon of the whole book, and provides scientific reasoning and explanations for hypotheses surrounding the origin of life. How scientists come to their conclusions and why we can trust these answers is an important question, and Deamer provides answers to each big question surrounding the origin of life, from what it is to why we should be curious.
    Keywords Life/Origin
    Subject code 577
    Language English
    Size 1 online resource.
    Publisher Oxford University Press
    Publishing place New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-19-009902-X ; 978-0-19-009902-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Origins of Life Research: The Conundrum between Laboratory and Field Simulations of Messy Environments.

    Deamer, David

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 9

    Abstract: Most experimental results that guide research related to the origin of life are from laboratory simulations of the early Earth conditions. In the laboratory, emphasis is placed on the purity of reagents and carefully controlled conditions, so there is a ... ...

    Abstract Most experimental results that guide research related to the origin of life are from laboratory simulations of the early Earth conditions. In the laboratory, emphasis is placed on the purity of reagents and carefully controlled conditions, so there is a natural tendency to reject impurities and lack of control. However, life did not originate in laboratory conditions; therefore, we should take into consideration multiple factors that are likely to have contributed to the environmental complexity of the early Earth. This essay describes eight physical and biophysical factors that spontaneously resolve aqueous dispersions of ionic and organic solutes mixed with mineral particles and thereby promote specific chemical reactions required for life to begin.
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12091429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Where Did Life Begin? Testing Ideas in Prebiotic Analogue Conditions.

    Deamer, David

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 2

    Abstract: Publications related to the origin of life are mostly products of laboratory research and have the tacit assumption that the same reactions would have been possible on the early Earth some 4 billion years ago. Can this assumption be tested? We cannot go ... ...

    Abstract Publications related to the origin of life are mostly products of laboratory research and have the tacit assumption that the same reactions would have been possible on the early Earth some 4 billion years ago. Can this assumption be tested? We cannot go back in time, but we are able to venture out of the laboratory and perform experiments in natural conditions that are presumably analogous to the prebiotic environment. This brief review describes initial attempts to undertake such studies and some of the lessons we have learned.
    Language English
    Publishing date 2021-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11020134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Template-Directed Replication and Chiral Resolution during Wet-Dry Cycling in Hydrothermal Pools.

    Ross, David / Deamer, David

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 8

    Abstract: The commonly supposed template-based format for RNA self-replication requires both duplex assembly and disassembly. This requisite binary provision presents a challenge to the development of a serviceable self-replication model since chemical reactions ... ...

    Abstract The commonly supposed template-based format for RNA self-replication requires both duplex assembly and disassembly. This requisite binary provision presents a challenge to the development of a serviceable self-replication model since chemical reactions are thermochemically unidirectional. We submit that a solution to this problem lies in volcanic landmasses that engage in continuous cycles of wetting and drying and thus uniquely provide the twofold state required for self-replication. Moreover, they offer conditions that initiate chain branching, and thus furnish a path to autocatalytic self-replication. The foundations of this dual thermochemical landscape arise from the broad differences in the properties of the bulk water phase on the one hand, and the air/water interfacial regions that emerge in the evaporative stages on the other. With this reaction system as a basis and employing recognized thermochemical and kinetic parameters, we present simulations displaying the spontaneous and autocatalyzed conversion of racemic and unactivated RNA monomers to necessarily homochiral duplex structures over characteristic periods of years.
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13081749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Addendum

    David Deamer

    Life, Vol 11, Iss 613, p

    Deamer, D. Where Did Life Begin? Testing Ideas in Prebiotic Analogue Conditions. Life 2021, 11 , 134

    2021  Volume 613

    Abstract: The author wishes to add the following information to the acknowledgements section of his paper published in Life [.] ...

    Abstract The author wishes to add the following information to the acknowledgements section of his paper published in Life [.]
    Keywords n/a ; Science ; Q
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Where Did Life Begin? Testing Ideas in Prebiotic Analogue Conditions

    David Deamer

    Life, Vol 11, Iss 2, p

    2021  Volume 134

    Abstract: Publications related to the origin of life are mostly products of laboratory research and have the tacit assumption that the same reactions would have been possible on the early Earth some 4 billion years ago. Can this assumption be tested? We cannot go ... ...

    Abstract Publications related to the origin of life are mostly products of laboratory research and have the tacit assumption that the same reactions would have been possible on the early Earth some 4 billion years ago. Can this assumption be tested? We cannot go back in time, but we are able to venture out of the laboratory and perform experiments in natural conditions that are presumably analogous to the prebiotic environment. This brief review describes initial attempts to undertake such studies and some of the lessons we have learned.
    Keywords prebiotic analogue conditions ; amphiphilic self-assembly ; non-enzymatic polymerization ; Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Duplex Formation and the Origins of Homochirality.

    Ross, David / Deamer, David

    Astrobiology

    2022  Volume 22, Issue 2, Page(s) 192–196

    Abstract: The roots of biological homochirality remain unknown despite decades of study. A commonly proposed path includes an initial small enantiomeric excess that was amplified over time, but a satisfactory source of the excess and a plausible amplification ... ...

    Abstract The roots of biological homochirality remain unknown despite decades of study. A commonly proposed path includes an initial small enantiomeric excess that was amplified over time, but a satisfactory source of the excess and a plausible amplification process have yet to be described. We propose here a route to oligonucleotide homochirality from unactivated racemic sources based upon the facts that duplex structures are inherently homochiral and their synthesis from strands of complementary string nucleotide subunits is both uncommonly rapid and exergonic. Simulations employing available kinetic and thermochemical data in an iterated sequence of three equilibria in dry/wet cycles running from unactivated and racemic RNA monomers through oligonucleotides to duplex structures have shown that the exceptional association rate distorts the otherwise simple equilibrium string and overcomes the severe kinetic and stoichiometric barriers to the pairing of the statistically scant homochiral fractions. The simulations reveal widespread deracemization and the full conversion of racemic monomers to populations of L- and D-duplexes in a succession of growth in which the initially formed duplexes are replaced over time with increasingly larger descendants. This claim is open to experimental testing.
    MeSH term(s) RNA/chemistry ; Stereoisomerism
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047736-3
    ISSN 1557-8070 ; 1531-1074
    ISSN (online) 1557-8070
    ISSN 1531-1074
    DOI 10.1089/ast.2021.0018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Visualizing RNA polymers produced by hot wet-dry cycling.

    Hassenkam, Tue / Deamer, David

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 10098

    Abstract: It is possible that the transition from abiotic systems to life relied on RNA polymers that served as ribozyme-like catalysts and for storing genetic information. The source of such polymers is uncertain, but previous investigations reported that wet-dry ...

    Abstract It is possible that the transition from abiotic systems to life relied on RNA polymers that served as ribozyme-like catalysts and for storing genetic information. The source of such polymers is uncertain, but previous investigations reported that wet-dry cycles simulating prebiotic hot springs provide sufficient energy to drive condensation reactions of mononucleotides to form oligomers and polymers. The aim of the study reported here was to verify this claim and visualize the products prepared from solutions composed of single mononucleotides and 1:1 mixture of two mononucleotides. Therefore, we designed experiments that allowed comparisons of all such mixtures representing six combinations of the four mononucleotides of RNA. We observed irregular stringy patches and crystal strands when wet-dry cycling was performed at room temperature (20 °C). However, when the same solutions were exposed to wet-dry cycles at 80 °C, we observed what appeared to be true polymers. Their thickness was consistent with RNA-like products composed of covalently bonded monomers, while irregular strings and crystal segments of mononucleotides dried or cycled at room temperature were consistent with structures assembled and stabilized by weak hydrogen bonds. In a few instances we observed rings with short polymer attachments. These observations are consistent with previous claims of polymerization during wet-dry cycling. We conclude that RNA-like polymers and rings could have been synthesized non-enzymatically in freshwater hot springs on the prebiotic Earth with sizes sufficient to fold into ribozymes and genetic molecules required for life to begin.
    MeSH term(s) Catalysis ; Polymerization ; Polymers/chemistry ; RNA/chemistry ; RNA, Catalytic
    Chemical Substances Polymers ; RNA, Catalytic ; RNA (63231-63-0)
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-14238-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Darwin's prescient guess.

    Deamer, David

    Proceedings of the National Academy of Sciences of the United States of America

    2017  Volume 114, Issue 43, Page(s) 11264–11265

    Language English
    Publishing date 2017-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1715433114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Conjecture and hypothesis: The importance of reality checks.

    Deamer, David

    Beilstein journal of organic chemistry

    2017  Volume 13, Page(s) 620–624

    Abstract: In origins of life research, it is important to understand the difference between conjecture and hypothesis. This commentary explores the difference and recommends alternative hypotheses as a way to advance our understanding of how life can begin on the ... ...

    Abstract In origins of life research, it is important to understand the difference between conjecture and hypothesis. This commentary explores the difference and recommends alternative hypotheses as a way to advance our understanding of how life can begin on the Earth and other habitable planets. As an example of how this approach can be used, two conditions have been proposed for sites conducive to the origin of life: hydrothermal vents in salty seawater, and fresh water hydrothermal fields associated with volcanic landmasses. These are considered as alternative hypotheses and the accumulating weight of evidence for each site is described and analyzed.
    Language English
    Publishing date 2017-03-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.13.60
    Database MEDical Literature Analysis and Retrieval System OnLINE

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