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  1. Book ; Online: DAN

    Xu, Chang / Paris, Cecile / Nepal, Surya / Sparks, Ross / Long, Chong / Wang, Yafang

    Dual-View Representation Learning for Adapting Stance Classifiers to New Domains

    2020  

    Abstract: ... dual-view adaptation network (DAN) to adapt these expressions across domains. The proposed model first ...

    Abstract We address the issue of having a limited number of annotations for stance classification in a new domain, by adapting out-of-domain classifiers with domain adaptation. Existing approaches often align different domains in a single, global feature space (or view), which may fail to fully capture the richness of the languages used for expressing stances, leading to reduced adaptability on stance data. In this paper, we identify two major types of stance expressions that are linguistically distinct, and we propose a tailored dual-view adaptation network (DAN) to adapt these expressions across domains. The proposed model first learns a separate view for domain transfer in each expression channel and then selects the best adapted parts of both views for optimal transfer. We find that the learned view features can be more easily aligned and more stance-discriminative in either or both views, leading to more transferable overall features after combining the views. Results from extensive experiments show that our method can enhance the state-of-the-art single-view methods in matching stance data across different domains, and that it consistently improves those methods on various adaptation tasks.

    Comment: Accepted at ECAI2020
    Keywords Computer Science - Computation and Language ; Computer Science - Machine Learning
    Subject code 004
    Publishing date 2020-03-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: DAN-Net

    Wang, Tao / Xia, Wenjun / Huang, Yongqiang / Sun, Huaiqiang / Liu, Yan / Chen, Hu / Zhou, Jiliu / Zhang, Yi

    Dual-Domain Adaptive-Scaling Non-local Network for CT Metal Artifact Reduction

    2021  

    Abstract: ... performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR ... module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates ...

    Abstract Metal implants can heavily attenuate X-rays in computed tomography (CT) scans, leading to severe artifacts in reconstructed images, which significantly jeopardize image quality and negatively impact subsequent diagnoses and treatment planning. With the rapid development of deep learning in the field of medical imaging, several network models have been proposed for metal artifact reduction (MAR) in CT. Despite the encouraging results achieved by these methods, there is still much room to further improve performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR. We correct the corrupted sinogram using adaptive scaling first to preserve more tissue and bone details as a more informative input. Then, an end-to-end dual-domain network is adopted to successively process the sinogram and its corresponding reconstructed image generated by the analytical reconstruction layer. In addition, to better suppress the existing artifacts and restrain the potential secondary artifacts caused by inaccurate results of the sinogram-domain network, a novel residual sinogram learning strategy and nonlocal module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates performance competitive with several state-of-the-art MAR methods in both qualitative and quantitative aspects.

    Comment: 29 pages, 11 figures
    Keywords Physics - Medical Physics ; Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2021-02-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Toxicological safety evaluation of Qin-Zhi-Zhu-Dan formula in rats during the treatment and recovery periods.

    Xu, Wenxiu / Chen, Dan / Zhang, Zehan / Liu, Shuling / Chen, Congai / Sun, Chunyan / Ni, Wenchao / Kang, Xiangdong / Shang, Guojiao / Wang, Xueqian / Cheng, Fafeng / Wang, Qingguo

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 987997

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.987997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Qi-dan-dihuang decoction ameliorates renal fibrosis in diabetic rats via p38MAPK/AKT/mTOR signaling pathway.

    Kuang, Liuyan / You, Yanting / Qi, Jieying / Chen, Jieyu / Zhou, Xinghong / Ji, Shuai / Cheng, Jingru / Kwan, Hiu Yee / Jiang, Pingping / Sun, Xiaomin / Su, Mengting / Wang, Ming / Chen, Wenxiao / Luo, Ren / Zhao, Xiaoshan / Zhou, Lin

    Environmental toxicology

    2024  

    Abstract: Context: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD ...

    Abstract Context: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood.
    Objective: This study reveals the mechanism by which QDD ameliorates DKD.
    Materials and methods: The compounds in QDD were identified by high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS). Key targets and signaling pathways were screened through bioinformatics. Nondiabetic Lepr db/m mice were used as control group, while Lepr db/db mice were divided into model group, dapagliflozin group, 1% QDD-low (QDD-L), and 2% QDD-high (QDD-H) group. After 12 weeks of administration, 24 h urinary protein, serum creatinine, and blood urea nitrogen levels were detected. Kidney tissues damage and fibrosis were evaluated by pathological staining. In addition, 30 mmol/L glucose-treated HK-2 and NRK-52E cells to induce DKD model. Cell activity and migration capacity as well as protein expression levels were evaluated.
    Results: A total of 46 key target genes were identified. Functional enrichment analyses showed that key target genes were significantly enriched in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) signaling pathways. In addition, in vivo and in vitro experiments confirmed that QDD ameliorated renal fibrosis in diabetic mice by resolving inflammation and inhibiting the epithelial-mesenchymal transition (EMT) via the p38MAPK and AKT-mammalian target of rapamycin (mTOR) pathways.
    Discussion and conclusion: QDD inhibits EMT and the inflammatory response through the p38MAPK and AKT/mTOR signaling pathways, thereby playing a protective role in renal fibrosis in DKD.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: RecSys-DAN

    Wang, Cheng / Niepert, Mathias / Li, Hui

    Discriminative Adversarial Networks for Cross-Domain Recommender Systems

    2019  

    Abstract: ... RecSys-DAN focuses on alleviating the cross-domain and within-domain data sparsity and data imbalance and ... for a discriminator. Four neural architectural instances of ResSys-DAN are proposed and explored. Empirical results ... RecSys-DAN achieves competitive performance as compared to the state-of-the-art supervised methods. More ...

    Abstract Data sparsity and data imbalance are practical and challenging issues in cross-domain recommender systems. This paper addresses those problems by leveraging the concepts which derive from representation learning, adversarial learning and transfer learning (particularly, domain adaptation). Although various transfer learning methods have shown promising performance in this context, our proposed novel method RecSys-DAN focuses on alleviating the cross-domain and within-domain data sparsity and data imbalance and learns transferable latent representations for users, items and their interactions. Different from existing approaches, the proposed method transfers the latent representations from a source domain to a target domain in an adversarial way. The mapping functions in the target domain are learned by playing a min-max game with an adversarial loss, aiming to generate domain indistinguishable representations for a discriminator. Four neural architectural instances of ResSys-DAN are proposed and explored. Empirical results on real-world Amazon data show that, even without using labeled data (i.e., ratings) in the target domain, RecSys-DAN achieves competitive performance as compared to the state-of-the-art supervised methods. More importantly, RecSys-DAN is highly flexible to both unimodal and multimodal scenarios, and thus it is more robust to the cold-start recommendation which is difficult for previous methods.

    Comment: 10 pages, IEEE-TNNLS
    Keywords Computer Science - Information Retrieval ; Computer Science - Machine Learning
    Subject code 006
    Publishing date 2019-03-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Dan-Deng-Tong-Nao softgel capsule promotes angiogenesis of cerebral microvasculature to protect cerebral ischemia reperfusion injury via activating HIF-1α-VEGFA-Notch1 signaling pathway.

    Wang, Lei / Li, Jiacheng / Wang, Yang / Ge, Chaowen / Huang, Qi / Li, Lili / Wang, Ning / Chen, Yuang / Zhou, Xian / Chang, Dennis / Li, Dan / Hou, Jincai

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2023  Volume 118, Page(s) 154966

    Abstract: Background: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC ...

    Abstract Background: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC) is used to treat ischemic stroke. However, the preventive mechanisms of DDTNC against cerebral ischemia reperfusion injury (CIRI) haven not been characterized.
    Objective: To explore the mechanisms of protective effects of DDTNC against CIRI from both internal and external levels.
    Methods: Chemical characterization was performed using UPLC. The potential protective mechanisms of DDTNC against CIRI were predicted using network pharmacology. Model of middle cerebral artery occlusion/reperfusion (MCAO/R) was established in rats. An model of brain microvascular endothelial cells (BMECs) induced by oxygen-glucose deprivation/reoxygenation (OGD/R) was also established. We evaluated neurological deficits, cerebral infarct volume, cortical neuron damage, and mitochondrial swelling in vivo. We evaluated the expression of VEGFR2, VEGFA, HIF-1α, CD31, and CD34 in ischemic cortex, and VEGF, bFGF, BDNF, angiostatin, and endostatin in serum of rats and in BMEC supernatants. We also evaluated cell viability, cytotoxicity, intracellular ROS, apoptosis, and migration ability in vitro.
    Results: Seven components were detected in DDTNC. KEGG enrichment analysis showed that DDTNC may modulate angiogenesis via the HIF-1 signaling pathway. DDTNC treatment reduced neurological score and infarct volume, and improved cell morphology of damaged neurons. Transmission electron microscopy showed that DDTNC reduced mitochondria swelling in cortical neurons. Furthermore, DDTNC reduced intracellular ROS and inhibited apoptosis. DDTNC boosted the expression of CD31, CD34, VEGFR2, VEGFA and HIF-1α, highlighting its involvement in angiogenesis, according to immunofluorescence studies. Furthermore, DDTNC enhanced tube formation and migration of BMECs in vitro. ELISA and western blotting indicated that DDTNCCSF induced the expression of VEGF, BDNF and bFGF, reduced the level of angiostatin and endostatin, increased the protein expression of VEGFA, Notch1 and HIF-1α in vitro and in vivo.
    Conclusions: DDTNC promoted angiogenesis to protect brain tissue against MCAO/R, and exerted protective effects against OGD/R in BMECs via activating HIF-1α-VEGFA-NOTCH1 signal transduction pathway.
    MeSH term(s) Rats ; Animals ; Endothelial Cells ; Vascular Endothelial Growth Factor A/metabolism ; Angiostatins/metabolism ; Angiostatins/pharmacology ; Angiostatins/therapeutic use ; Brain-Derived Neurotrophic Factor/metabolism ; Endostatins/metabolism ; Endostatins/pharmacology ; Endostatins/therapeutic use ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Microvessels/metabolism ; Receptor, Notch1/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A ; Angiostatins (86090-08-6) ; Brain-Derived Neurotrophic Factor ; Endostatins ; Reactive Oxygen Species ; Notch1 protein, rat ; Receptor, Notch1
    Language English
    Publishing date 2023-07-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2023.154966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Dan-Shen-Yin Granules Prevent Hypoxia-Induced Pulmonary Hypertension

    Wang, Ran-Ran / Yuan, Tian-Yi / Chen, Di / Chen, Yu-Cai / Sun, Shu-Chan / Wang, Shou-Bao / Kong, Ling-Lei / Fang, Lian-Hua / Du, Guan-Hua

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 844400

    Abstract: ... of their multiple components. The present study aims to evaluate the effects of Dan-Shen-Yin (DSY) granules ...

    Abstract Traditional Chinese medicine (TCM) plays an important role in the treatment of complex diseases, especially cardiovascular diseases. However, it is hard to identify their modes of action on account of their multiple components. The present study aims to evaluate the effects of Dan-Shen-Yin (DSY) granules on hypoxia-induced pulmonary hypertension (HPH), and then to decipher the molecular mechanisms of DSY. Systematic pharmacology was employed to identify the targets of DSY on HPH. Furthermore, core genes were identified by constructing a protein-protein interaction (PPI) network and analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) analysis. Related genes and pathways were verified using a hypoxia-induced mouse model and hypoxia-treated pulmonary artery cells. Based on network pharmacology, 147 potential targets of DSY on HPH were found, constructing a PPI network, and 13 hub genes were predicted. The results showed that the effect of DSY may be closely associated with AKT serine/threonine kinase 1 (AKT1), signal transducer and activator of transcription 3 (STAT3), and HIF-1 signaling pathways, as well as biological processes such as cell proliferation. Consistent with network pharmacology analysis, experiments
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.844400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dan-shen Yin promotes bile acid metabolism and excretion to prevent atherosclerosis via activating FXR/BSEP signaling pathway.

    Sheng, Yingkun / Meng, Guibing / Zhang, Min / Chen, Xiaopeng / Chai, Xin / Yu, Haiyang / Han, Lifeng / Wang, Qilong / Wang, Yuefei / Jiang, Miaomiao

    Journal of ethnopharmacology

    2024  Volume 330, Page(s) 118209

    Abstract: Ethnopharmacological relevance: Dan-shen Yin (DSY), a traditional prescription, has been ...

    Abstract Ethnopharmacological relevance: Dan-shen Yin (DSY), a traditional prescription, has been demonstrated to be effective in decreasing hyperlipidemia and preventing atherosclerosis (AS), but its mechanism remains unknown. We hypothesized that DSY activates farnesoid X receptor (FXR) to promote bile acid metabolism and excretion, thereby alleviating AS.
    Aim of the study: This study was designed to explore whether DSY reduces liver lipid accumulation and prevents AS by activating FXR and increasing cholesterol metabolism and bile acid excretion.
    Materials and methods: The comprehensive chemical characterization of DSY was analyzed by UHPLC-MS/MS. The AS models of ApoE
    Results: A total of 36 ingredients in DSY were identified by UPLC-MS/MS analysis. In vivo, high-dose DSY significantly inhibited aortic intimal thickening, improved arrangement disorder, tortuosity, and rupture of elastic fibers, decreased lipid levels, and reduced the number of fat vacuoles and lipid droplets in liver tissue in SD rats and ApoE
    Conclusion: This study demonstrated that DSY promotes bile acid metabolism and excretion to prevent AS by activating FXR. For the prevent of AS and drug discovery provided experimental basis.
    Language English
    Publishing date 2024-04-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The effect of Ding-kun-dan comparing with Marvelon on primary dysmenorrhea: A prospective, double-blind, multicenter, randomized controlled trial.

    Gan, Jingwen / Zhu, Shi-Yang / Ma, Xiao / Ding, Xue-Song / Deng, Yan / Wang, Yanfang / Sun, Ai-Jun

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt B, Page(s) 116975

    Abstract: Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known ... Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and ... 4: Conclusion: Ding-kun-dan is another available, effective and safe method for patients ...

    Abstract Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered as an effective prescription to regulate menstruation, benefit Qi and nourish the blood. Previous studies had showed that DKD could improve sex hormone levels, insulin resistance, metabolism abnormalities and regulate immunity in animal models with polycystic ovary syndrome or endometriosis, however, little study conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD).
    Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients with primary dysmenorrhea.
    Materials and method: 136 patients with primary dysmenorrhea were randomly assigned to the DKD group (n = 73, take one tablet per day from 5th day of the menstrual cycle for 10 days every 28 days) and the Marvelon group (n = 63, take one tablet per day from 5th day of the menstrual cycle for 21 days every 28 days), the therapeutic effects were analyzed through evaluating the change of VAS scores, CMSS scores and the level of PGF
    Results: Both DKD and Marvelon could effectively relief pain and other associated symptoms at each visit (Baseline, 4
    Conclusion: Ding-kun-dan is another available, effective and safe method for patients with primary dysmenorrhea to choose, especially for those who are suffered from mild pain and/or contraindicated to hormonal agents.
    MeSH term(s) Female ; Humans ; Desogestrel/therapeutic use ; Dinoprostone ; Double-Blind Method ; Dysmenorrhea/drug therapy ; Dysmenorrhea/diagnosis ; Endometriosis ; Medicine, Chinese Traditional ; Prospective Studies
    Chemical Substances Desogestrel (81K9V7M3A3) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2023-07-29
    Publishing country Ireland
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effect of Dan-Lou tablets on coronary heart disease revealed by microarray analysis integrated with molecular mechanism studies.

    Li, Zhu / Cheng, Qi / He, Yuanyuan / Wang, Shuo / Xie, Jing / Zheng, Yanchao / Liu, Yijia / Li, Lin / Gao, Shan / Yu, Chunquan

    Heliyon

    2023  Volume 9, Issue 5, Page(s) e15777

    Abstract: Dan-Lou tablets (DLT) effectively treat coronary heart disease (CHD). However, its pharmacological ...

    Abstract Dan-Lou tablets (DLT) effectively treat coronary heart disease (CHD). However, its pharmacological mechanism in CHD treatment requires further investigation. This study aimed to elucidate the underlying pharmacological mechanisms of DLT in the treatment of CHD through clinical trials, microarray research, bioinformatics analysis, and molecular mechanism research. In this study, DLT improved coagulation function, endothelial injury, and levels of lipids, metalloproteases, adhesion molecules, inflammatory mediators, and homocysteine. The results of molecular biology research demonstrated that DLT can increase the gene and protein expressions of meningioma expressed antigen 5 (MGEA5) and mouse doubleminute 2 (MDM2) and inhibited the gene and protein expressions of signal transcription and transcription activator 5 B (STAT5B), tropomyosin-1 (TPM1), and aromatic hydrocarbon receptor nuclear transpose (ARNT). The results indicate that DLT reduced the extent of vascular endothelial damage in CHD rats by reducing the expressions of STAT5B, TPM1, and MDM2; inhibiting the inflammatory reaction; and increasing the expressions of ARNT and MGEA5.
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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