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  1. Book ; Online ; Thesis: Eignung der Niedrigdosis–Computertomographie mit modellbasierter iterativer Rekonstruktion für das Lungenkrebs–Screening

    König, Britta [Verfasser] / Kühl, Hilmar [Akademischer Betreuer]

    Eine quantitative Phantomstudie

    2022  

    Author's details Britta König ; Betreuer: Hilmar Kühl
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article: You Don't Bend It Like Beckham if You're Female and Reminded of It: Stereotype Threat Among Female Football Players.

    Grabow, Hilmar / Kühl, Melanie

    Frontiers in psychology

    2019  Volume 10, Page(s) 1963

    Abstract: Originally, the stereotype threat effect - poorer performance due to a fear of fulfilling a negative stereotype about one's group - was demonstrated for cognitive tasks (e.g. Steele and Aronson, 1995, or Steele, 1997). Drawing on the widespread ... ...

    Abstract Originally, the stereotype threat effect - poorer performance due to a fear of fulfilling a negative stereotype about one's group - was demonstrated for cognitive tasks (e.g. Steele and Aronson, 1995, or Steele, 1997). Drawing on the widespread stereotype of women being unable to play football we experimentally tested (
    Language English
    Publishing date 2019-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2019.01963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Morphological chest CT changes in cystic fibrosis and massive hemoptysis.

    Dohna, Martha / Kühl, Hilmar / Sutharsan, Sivagurunathan / Bruns, Nora / Vo Chieu, Van Dai / Hellms, Susanne / Kornemann, Norman / Montag, Michael J

    Radiologie (Heidelberg, Germany)

    2024  

    Abstract: Background: Massive hemoptysis (MH) is a rare but potentially life-threatening condition of patients with mainly advanced cystic fibrosis (CF). Morphological lung changes are aggravated with disease progression. The aim of this study was to determine ... ...

    Title translation Morphologische Veränderungen in der Thorax-CT bei zystischer Fibrose und massiven Hämoptysen.
    Abstract Background: Massive hemoptysis (MH) is a rare but potentially life-threatening condition of patients with mainly advanced cystic fibrosis (CF). Morphological lung changes are aggravated with disease progression. The aim of this study was to determine whether morphological lung changes differ between patients with CF (pwCF) who have MH and pwCF without MH.
    Methods: Chest computed tomography (CT) scans of pwCF and MH acquired at a maximum of 4 months prior to MH (1/2008 to 2/2015) were evaluated for morphological changes and bronchial artery (BA) diameters. Lung lobes with MH were compared with lobes without MH and with matched control patients with end-stage CF and no hemoptysis using the Helbich scoring system.
    Results: The study included 26 patients with MH (P
    Conclusion: Morphological changes are more severe in lobes with MH in the same patient, but there is no difference when compared with matched control patients. Besides abscess/sacculation, no specific changes for MH were identified. Other factors such as BA hypertrophy might play a pivotal role in the pathogenesis of MH in pwCF. Commonly used scores to evaluate chest CT in pwCF cannot be used to assess MH, and other factors, e.g., hypertrophied BA, not represented and not measured in these scores, might be more suitable for assessing the risk for MH.
    Language English
    Publishing date 2024-02-07
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-7056
    ISSN (online) 2731-7056
    DOI 10.1007/s00117-024-01266-4
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  4. Book ; Online ; Thesis: Stellenwert der Computertomographie in der Nachsorge von Patienten nach Lungentransplantation

    Ernst, Arne [Verfasser] / Kühl, Hilmar [Akademischer Betreuer]

    2021  

    Author's details Arne Ernst ; Betreuer: Hilmar Kühl
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Validation of iterative CT reconstruction by inter and intra observer performance assessment of artificial lung foci

    König Britta / Guberina Nika / Kühl Hilmar / Zylka Waldemar

    Current Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 534-

    2020  Volume 537

    Abstract: We investigate the suitability of statistical and model-based iterative reconstruction (IR) algorithm strengths and their influence on image quality and diagnostic performance in low-dose computer tomography (CT) protocols for lung-cancer screening ... ...

    Abstract We investigate the suitability of statistical and model-based iterative reconstruction (IR) algorithm strengths and their influence on image quality and diagnostic performance in low-dose computer tomography (CT) protocols for lung-cancer screening procedures. We evaluate the inter- and intra-observer performance for the assessment of iterative CT reconstruction. Artificial lung foci shaped as spheres and spicules made from material with calibrated Hounsfield units were pressed within layered granules in lung lobes of an anthropomorphic phantom. Adaptively, a soft-tissue- and fat- extension ring were attached. The phantom with foci was scanned using standard high contrast, low-dose and ultra lowdose protocols. For reconstruction the IR algorithm ADMIRE at four different strength levels were used. Two ranking tests and Friedman statistics were performed. Fleiss k and modified Cohen’s kneywere used to quantify inter- and intra-observer performance. In conjunction with the standard lung kernel BL75 radiologists evaluated medium to high IR strength, with preference to S4, as suitable for lung foci detection. When varying reconstruction kernels the ranking became more random than with varying phantom diameter. The inter-observer reliability shows poor to slight agreement expressed by k<0 and k=0-0.20 . For the intra-observer reliability non- agreement with kney=0-0.20and moderate agreement with kney=0.60-0.79 for the first ranking test, and almost perfect agreement with kney>0.90 for the second ranking test was observed. In conclusion, our validation suggests radiological preference of medium to high iteration strengths, especially S4, for lung foci detection. An investigation of the correlation between diagnostic experience and the subjective perception of IR reconstructed CT images still needs to be investigated.
    Keywords ct ; iterative reconstruction ; lung nodule detection ; inter- and intra-observer reliability ; low-dose ; image quality ; phantom ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Experimental Examination of Conventional, Semi-Automatic, and Automatic Volumetry Tools for Segmentation of Pulmonary Nodules in a Phantom Study.

    Hlouschek, Julian / König, Britta / Bos, Denise / Santiago, Alina / Zensen, Sebastian / Haubold, Johannes / Pöttgen, Christoph / Herz, Andreas / Opitz, Marcel / Wetter, Axel / Guberina, Maja / Stuschke, Martin / Zylka, Waldemar / Kühl, Hilmar / Guberina, Nika

    Diagnostics (Basel, Switzerland)

    2023  Volume 14, Issue 1

    Abstract: The aim of this study is to examine the precision of semi-automatic, conventional and automatic volumetry tools for pulmonary nodules in chest CT with phantom N1 LUNGMAN. The phantom is a life-size anatomical chest model with pulmonary nodules ... ...

    Abstract The aim of this study is to examine the precision of semi-automatic, conventional and automatic volumetry tools for pulmonary nodules in chest CT with phantom N1 LUNGMAN. The phantom is a life-size anatomical chest model with pulmonary nodules representing solid and subsolid metastases. Gross tumor volumes (GTV
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14010028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Design and first results of a phantom study on the suitability of iterative reconstruction for lung-cancer screening with low-dose computer tomography

    König Britta / Guberina Nika / Kühl Hilmar / Zylka Waldemar

    Current Directions in Biomedical Engineering, Vol 5, Iss 1, Pp 593-

    2019  Volume 596

    Abstract: In this research computer tomography (CT) iterative reconstruction (IR) algorithms are investigated, specifically the impact of their statistical and model-based strength on image quality in low-dose lung screening CT protocols in comparison to filtered ... ...

    Abstract In this research computer tomography (CT) iterative reconstruction (IR) algorithms are investigated, specifically the impact of their statistical and model-based strength on image quality in low-dose lung screening CT protocols in comparison to filtered back projection (FBP). It has been probed whether statistical, model-based IR in conjunction with low-dose, and ultra-low-dose protocols are suitable for lungcancer screening. To this end, artificial lung nodules shaped as spheres and spicules made from material with calibrated Hounsfield units (HU) were attached on marked positions in the lung structure of an anthropomorphic phantom. Nodule positions were selected by distinguished radiologists. The phantom with nodules was scanned on a CT Scanner using standard high contrast (SHC), low-dose (LD) and ultra low-dose (ULD) protocol. For reconstruction FBP and the IR algorithm ADMIRE at three different strength levels were used. Volume CT dose index (CTDIvol) and dose-length product were recorded. Radiologists assessed subjective image quality using a six-point Likert scale by reading all image series in terms detectability of lung nodules. As a measurable objective image quality parameter signal-to-noise ratios (SNR) were investigated. The CTDIvol decreases by more than 70% for all protocols and nodules compared to diagnostic reference value for chest CT (p<0.00001). The evaluation of image quality parameters, i.e. SNR, indicates that LD and ULD protocols in conjunction with IR assert high quality lung-nodule detection. The results reveal that IR algorithm with moderate to high strength is an indispensable alternative to FBP in low-dose scanning, thus, potentially suitable for lung-tumour screening.
    Keywords ct ; iterative reconstruction ; fbp ; low-dose ; image quality ; phantom study ; lung nodule detection ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Experimental Examination of Conventional, Semi-Automatic, and Automatic Volumetry Tools for Segmentation of Pulmonary Nodules in a Phantom Study

    Julian Hlouschek / Britta König / Denise Bos / Alina Santiago / Sebastian Zensen / Johannes Haubold / Christoph Pöttgen / Andreas Herz / Marcel Opitz / Axel Wetter / Maja Guberina / Martin Stuschke / Waldemar Zylka / Hilmar Kühl / Nika Guberina

    Diagnostics, Vol 14, Iss 1, p

    2023  Volume 28

    Abstract: The aim of this study is to examine the precision of semi-automatic, conventional and automatic volumetry tools for pulmonary nodules in chest CT with phantom N1 LUNGMAN. The phantom is a life-size anatomical chest model with pulmonary nodules ... ...

    Abstract The aim of this study is to examine the precision of semi-automatic, conventional and automatic volumetry tools for pulmonary nodules in chest CT with phantom N1 LUNGMAN. The phantom is a life-size anatomical chest model with pulmonary nodules representing solid and subsolid metastases. Gross tumor volumes (GTV i s) were contoured using various approaches: manually (0); as a means of semi-automated, conventional contouring with (I) adaptive-brush function; (II) flood-fill function; and (III) image-thresholding function. Furthermore, a deep-learning algorithm for automatic contouring was applied (IV). An intermodality comparison of the above-mentioned strategies for contouring GTV i s was performed. For the mean GTV ref (standard deviation (SD)), the interquartile range (IQR)) was 0.68 mL (0.33; 0.34–1.1). GTV segmentation was distributed as follows: (I) 0.61 mL (0.27; 0.36–0.92); (II) 0.41 mL (0.28; 0.23–0.63); (III) 0.65 mL (0.35; 0.32–0.90); and (IV) 0.61 mL (0.29; 0.33–0.95). GTV ref was found to be significantly correlated with GTV i s (I) p < 0.001, r = 0.989 (III) p = 0.001, r = 0.916, and (IV) p < 0.001, r = 0.986, but not with (II) p = 0.091, r = 0.595. The Sørensen–Dice indices for the semi-automatic tools were 0.74 (I), 0.57 (II) and 0.71 (III). For the semi-automatic, conventional segmentation tools evaluated, the adaptive-brush function (I) performed closest to the reference standard (0). The automatic deep learning tool (IV) showed high performance for auto-segmentation and was close to the reference standard. For high precision radiation therapy, visual control, and, where necessary, manual correction, are mandatory for all evaluated tools.
    Keywords radiation oncology ; radiotherapy ; target volume ; contouring ; semi-automation ; N1 LUNGMAN phantom ; Medicine (General) ; R5-920
    Subject code 006
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: In Reply.

    Stang, Andreas / Kowall, Bernd / Schuler, Martin / Darwiche, Kaid / Kühl, Hilmar / Jöckel, Karl-Heinz

    Deutsches Arzteblatt international

    2016  Volume 113, Issue 17, Page(s) 297–298

    Language English
    Publishing date 2016-04-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2016.0297b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bronchial artery diameter in massive hemoptysis in cystic fibrosis.

    Dohna, Martha / Kühl, Hilmar / Sutharsan, Sivagurunathan / Dohna-Schwake, Christian / Vo Chieu, Van Dai / Hellms, Susanne / Kornemann, Norman / Renz, Diane M / Montag, Michael J

    BMC pulmonary medicine

    2022  Volume 22, Issue 1, Page(s) 424

    Abstract: Background: Massive hemoptysis is a rare but potentially life-threatening condition of patients with cystic fibrosis (CF) and advanced pulmonary disease. Hypertrophied bronchial arteries are understood to cause massive hemoptysis when rupturing. Risk ... ...

    Abstract Background: Massive hemoptysis is a rare but potentially life-threatening condition of patients with cystic fibrosis (CF) and advanced pulmonary disease. Hypertrophied bronchial arteries are understood to cause massive hemoptysis when rupturing. Risk factors to predict massive hemoptysis are scarce and bronchial artery diameters are not part of any scoring system in follow-up of patients with CF. Aim of this study was to correlate bronchial artery diameter with massive hemoptysis in CF.
    Methods: Bronchial artery and non-bronchial systemic artery diameters were measured in contrast enhanced computed tomography (CT) scans in patients with massive hemoptysis and compared to patients with end-stage CF and no history of hemoptysis. Demographic and clinical data and side of bronchial artery/non-bronchial systemic artery hypertrophy and coil embolization were documented.
    Results: In this retrospective multicenter study 33 patients with massive hemoptysis were included for bronchial artery/non-bronchial systemic artery diameter measurements, (13 female, 20 male, median age 30 years (18-55)). Bronchial artery diameters were significantly larger in the case group than in the control group with median 4 mm (2.2-8.2 mm), and median 3 mm (1-7 mm), respectively (p = 0.002). Sensitivity of bronchial arteries ≥ 3.5 mm to be associated with hemoptysis was 0.76 and specificity 0.71 with ROC creating an area under the curve of 0.719. If non-bronchial systemic arteries were present, they were considered culprit and embolized in 92% of cases.
    Conclusion: Bronchial arteries ≥ 3.5 mm and presence of hypertrophied non-bronchial systemic arteries correlate with massive hemoptysis in patients with CF and might serve as risk predictor for massive hemoptysis. Therefore, in patients with advanced CF we propose CT scans to be carried out as CT angiography to search for bronchial arteries ≥ 3.5 mm and for hypertrophied non-bronchial systemic arteries as possible risk factors for massive hemoptysis.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Bronchial Arteries/diagnostic imaging ; Cystic Fibrosis/complications ; Embolization, Therapeutic/methods ; Hemoptysis/etiology ; Hemoptysis/therapy ; Angiography/adverse effects ; Angiography/methods
    Language English
    Publishing date 2022-11-17
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-022-02233-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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