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  1. Book ; Online ; E-Book: Immunology for dentistry

    Rahman, Mohammad Tariqur / Teughels, Wim / Lamont, Richard J.

    2023  

    Author's details edited by Mohammas Tariqur Rahman, Wim Teughels, Richard J. Lamont
    Keywords Electronic books ; Stomatognathic Diseases / microbiology ; Stomatognathic Diseases / immunology ; Dentistry / methods
    Language English
    Size 1 Online-Ressource (x, 262 Seiten), Illustrationen, Diagramme
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030058568
    ISBN 978-1-119-89302-8 ; 978-1-119-89301-1 ; 9781119893004 ; 1-119-89302-X ; 1-119-89301-1 ; 1119893003
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Potential benefits of combination of

    Rahman, Mohammad Tariqur

    Journal of herbal medicine

    2020  Volume 23, Page(s) 100382

    Abstract: An effective vaccine to prevent the SARS-CoV-2 causing COVID-19 is yet to be approved. Further there is no drug that is specific to treat COVID-19. A number of antiviral drugs such as Ribavirin, Remdesivir, Lopinavir/ritonavir, Azithromycin and ... ...

    Abstract An effective vaccine to prevent the SARS-CoV-2 causing COVID-19 is yet to be approved. Further there is no drug that is specific to treat COVID-19. A number of antiviral drugs such as Ribavirin, Remdesivir, Lopinavir/ritonavir, Azithromycin and Doxycycline have been recommended or are being used to treat COVID-19 patients. In addition to these drugs, rationale and evidence have been presented to use chloroquine to treat COVID-19, arguably with certain precautions and criticism. In line with the proposed use of chloroquine, Nigella sativa (black seed) could be considered as a natural substitute that contains a number of bioactive components such as thymoquinone, dithymoquinone, thymohydroquinone, and nigellimine. Further benefits to use
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2210-8033
    ISSN 2210-8033
    DOI 10.1016/j.hermed.2020.100382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Potential benefits of combination of Nigella sativa and Zn supplements to treat COVID-19

    Rahman, Mohammad Tariqur

    Journal of Herbal Medicine

    2020  Volume 23, Page(s) 100382

    Keywords Complementary and alternative medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2210-8033
    DOI 10.1016/j.hermed.2020.100382
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Potential benefits of combination of Nigella sativa and Zn supplements to treat COVID-19

    Rahman, Mohammad Tariqur

    J. Herbal Med.

    Abstract: An effective vaccine to prevent the SARS-CoV-2 causing COVID-19 is yet to be approved. Further there is no drug that is specific to treat COVID-19. A number of antiviral drugs such as Ribavirin, Remdesivir, Lopinavir/ritonavir, Azithromycin and ... ...

    Abstract An effective vaccine to prevent the SARS-CoV-2 causing COVID-19 is yet to be approved. Further there is no drug that is specific to treat COVID-19. A number of antiviral drugs such as Ribavirin, Remdesivir, Lopinavir/ritonavir, Azithromycin and Doxycycline have been recommended or are being used to treat COVID-19 patients. In addition to these drugs, rationale and evidence have been presented to use chloroquine to treat COVID-19, arguably with certain precautions and criticism. In line with the proposed use of chloroquine, Nigella sativa (black seed) could be considered as a natural substitute that contains a number of bioactive components such as thymoquinone, dithymoquinone, thymohydroquinone, and nigellimine. Further benefits to use N. sativa could be augmented by Zn supplement. Notably, Zn has been proven to improve innate and adaptive immunity in the course of any infection, be it by pathogenic virus or bacteria. The effectiveness of the Zn salt supplement could also be enhanced with N. sativa as its major bioactive component might work as ionophore to allow Zn2+ to enter pneumocytes – the target cell for SARSCoV-2. Given those benefits, this review paper describes how N. sativa in combination with Zn could be useful as a complement to COVID-19 treatment.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #612561
    Database COVID19

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  5. Article: Potential benefits of combination of Nigella sativa and Zn supplements to treat COVID-19

    Rahman, Mohammad Tariqur

    Journal of herbal medicine. 2020 Oct., v. 23

    2020  

    Abstract: An effective vaccine to prevent the SARS-CoV-2 causing COVID-19 is yet to be approved. Further there is no drug that is specific to treat COVID-19. A number of antiviral drugs such as Ribavirin, Remdesivir, Lopinavir/ritonavir, Azithromycin and ... ...

    Abstract An effective vaccine to prevent the SARS-CoV-2 causing COVID-19 is yet to be approved. Further there is no drug that is specific to treat COVID-19. A number of antiviral drugs such as Ribavirin, Remdesivir, Lopinavir/ritonavir, Azithromycin and Doxycycline have been recommended or are being used to treat COVID-19 patients. In addition to these drugs, rationale and evidence have been presented to use chloroquine to treat COVID-19, arguably with certain precautions and criticism. In line with the proposed use of chloroquine, Nigella sativa (black seed) could be considered as a natural substitute that contains a number of bioactive components such as thymoquinone, dithymoquinone, thymohydroquinone, and nigellimine. Further benefits to use N. sativa could be augmented by Zn supplement. Notably, Zn has been proven to improve innate and adaptive immunity in the course of any infection, be it by pathogenic virus or bacteria. The effectiveness of the Zn salt supplement could also be enhanced with N. sativa as its major bioactive component might work as ionophore to allow Zn2+ to enter pneumocytes – the target cell for SARSCoV-2. Given those benefits, this review paper describes how N. sativa in combination with Zn could be useful as a complement to COVID-19 treatment.
    Keywords COVID-19 infection ; Nigella sativa ; Severe acute respiratory syndrome coronavirus 2 ; adaptive immunity ; azithromycin ; bioactive compounds ; chloroquine ; doxycycline ; herbal medicines ; pneumocytes ; thymoquinone ; vaccines ; virulent strains
    Language English
    Dates of publication 2020-10
    Publishing place Elsevier GmbH
    Document type Article
    Note NAL-light
    ISSN 2210-8033
    DOI 10.1016/j.hermed.2020.100382
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Can Zn Be a Critical Element in COVID-19 Treatment?

    Rahman, Mohammad Tariqur / Idid, Syed Zahir

    Biological trace element research

    2020  Volume 199, Issue 2, Page(s) 550–558

    Abstract: The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an effective anti-viral treatment. A number of anti-viral drugs such as ribavirin, remdesivir, lopinavir/ritonavir, antibiotics such as azithromycin and ...

    Abstract The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an effective anti-viral treatment. A number of anti-viral drugs such as ribavirin, remdesivir, lopinavir/ritonavir, antibiotics such as azithromycin and doxycycline, and anti-parasite such as ivermectin have been recommended for COVID-19 treatment. In addition, sufficient pre-clinical rationale and evidence have been presented to use chloroquine for the treatment of COVID-19. Furthermore, Zn has the ability to enhance innate and adaptive immunity in the course of a viral infection. Besides, Zn supplement can favour COVID-19 treatment using those suggested and/or recommended drugs. Again, the effectiveness of Zn can be enhanced by using chloroquine as an ionophore while Zn inside the infected cell can stop SARS-CoV-2 replication. Given those benefits, this perspective paper describes how and why Zn could be given due consideration as a complement to the prescribed treatment of COVID-19.
    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Chloroquine/therapeutic use ; Humans ; Lopinavir/therapeutic use ; Ritonavir/therapeutic use ; Zinc/therapeutic use
    Chemical Substances Antiviral Agents ; Lopinavir (2494G1JF75) ; Chloroquine (886U3H6UFF) ; Zinc (J41CSQ7QDS) ; Ritonavir (O3J8G9O825)
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-020-02194-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Inflammatory Responses in Periodontitis with or Without Rheumatoid Arthritis Alter Salivary Metallothionein and Zinc.

    Aziz, Jazli / Vaithilingam, Rathna Devi / Radzi, Zamri / Rahman, Mohammad Tariqur

    Biological trace element research

    2022  Volume 201, Issue 7, Page(s) 3162–3174

    Abstract: Periodontitis (PD) and rheumatoid arthritis (RA) are causally linked by their common inflammatory responses, yet it is largely unknown if these inflammatory responses might have an impact on salivary metallothionein (MT), zinc (Zn), and calcium (Ca) ... ...

    Abstract Periodontitis (PD) and rheumatoid arthritis (RA) are causally linked by their common inflammatory responses, yet it is largely unknown if these inflammatory responses might have an impact on salivary metallothionein (MT), zinc (Zn), and calcium (Ca) content. In this study, we analysed salivary concentrations of pro-inflammatory (IFN-γ, IL-6, and IL-17) and anti-inflammatory (IL-4 and IL-10) cytokines, as well as MT, Zn, and Ca in four groups of participants, namely control (without PD or RA, n = 21), PD (n = 21), RA (n = 21), or RAPD (n = 19). As expected, an increased amount of salivary pro-inflammatory cytokines were observed in the PD, RA, and RAPD groups. While Ca concentration was not significantly different between the groups, Zn concentration was lower in the PD, RA, and RAPD groups compared to the control group (p < 0.05). These groups also expressed higher MT/Zn ratios compared to the control group (p < 0.05). Unlike the control group, concentrations of inflammatory cytokines, MT, Zn, and Ca correlated with each other in the PD, RA, and RAPD groups (p < 0.05). Additionally, comorbidity of PD and RA appears to have a cumulative immuno-pathological impact that warrants further investigation. This study suggests that, in addition to inflammatory cytokines, salivary MT and Zn could reflect the severity of PD with or without RA, hence providing an important biomarker for diagnosis.
    MeSH term(s) Humans ; Zinc ; Metallothionein ; Random Amplified Polymorphic DNA Technique ; Arthritis, Rheumatoid ; Periodontitis ; Cytokines
    Chemical Substances Zinc (J41CSQ7QDS) ; Metallothionein (9038-94-2) ; Cytokines
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-022-03416-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2323: Show issues Location:
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  8. Article ; Online: Dysregulation of metallothionein and zinc aggravates periodontal diseases.

    Aziz, Jazli / Rahman, Mohammad Tariqur / Vaithilingam, Rathna Devi

    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

    2021  Volume 66, Page(s) 126754

    Abstract: Background: Periodontitis (PD) is a multifaceted inflammatory disease connected to bacterial infection that results in the destruction of tooth supporting structures and eventually tooth loss. Given their involvement in infection and inflammation, both ... ...

    Abstract Background: Periodontitis (PD) is a multifaceted inflammatory disease connected to bacterial infection that results in the destruction of tooth supporting structures and eventually tooth loss. Given their involvement in infection and inflammation, both metallothionein (MT) and zinc (Zn) might play vital roles in the development and progression of PD. More specifically, both MT and Zn are heavily involved in regulating immune functions, controlling bacterial infection, balancing inflammatory responses, and reducing oxidative stress, all of which are associated with the pathogenesis of PD.
    Objective: This review paper will explore the physiological functions of MT and Zn and hypothesise how dysregulation could negatively affect periodontal health, leading to PD.
    Findings: Bacterial lipopolysaccharide (LPS) derived from periodontal pathogens, namely P. gingivalis initiates the acute phase response, thus upregulating the expression of MT which leads to the subsequent deficiency of Zn, a hallmark of periodontal disease. This deficiency leads to ineffective NETosis, increases the permeability of the gingival epithelium, and disrupts the humoral immune response, collectively contributing to PD. In addition, the presence of LPS in Zn deficient conditions favours M1 macrophage polarisation and maturation of dendritic cells, and also inhibits the anti-inflammatory activity of regulatory T cells. Collectively, these observations could theoretically give rise to the chronic inflammation seen in PD.
    Conclusion: A disrupted MT and Zn homeostasis is expected to exert an adverse impact on periodontal health and contribute to the development and progression of PD.
    MeSH term(s) Animals ; Humans ; Metallothionein/metabolism ; Periodontal Diseases/metabolism ; Zinc/metabolism
    Chemical Substances Metallothionein (9038-94-2) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2021-04-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1236267-0
    ISSN 1878-3252 ; 1611-602X ; 0946-672X
    ISSN (online) 1878-3252 ; 1611-602X
    ISSN 0946-672X
    DOI 10.1016/j.jtemb.2021.126754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2279: Show issues Location:
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  9. Article ; Online: Can Zn Be a Critical Element in COVID-19 Treatment?

    Rahman, Mohammad Tariqur / Idid, Syed Zahir

    Biological Trace Element Research ; ISSN 0163-4984 1559-0720

    2020  

    Keywords Inorganic Chemistry ; Clinical Biochemistry ; Biochemistry ; Endocrinology, Diabetes and Metabolism ; Biochemistry, medical ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s12011-020-02194-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Possible Benefits of Zinc supplement in CVD and COVID-19 Comorbidity

    Muhammad Manjurul Karim / Shahnaz Sultana / Rokaia Sultana / Mohammad Tariqur Rahman

    Journal of Infection and Public Health, Vol 14, Iss 11, Pp 1686-

    2021  Volume 1692

    Abstract: As far as comorbidity is concerned, cardiovascular diseases (CVD) appear to be accounted for the highest prevalence, severity, and fatality among COVID 19 patients. A wide array of causal links connecting CVD and COVID-19 baffle the overall prognosis as ... ...

    Abstract As far as comorbidity is concerned, cardiovascular diseases (CVD) appear to be accounted for the highest prevalence, severity, and fatality among COVID 19 patients. A wide array of causal links connecting CVD and COVID-19 baffle the overall prognosis as well as the efficacy of the given therapeutic interventions. At the centre of this puzzle lies ACE2 that works as a receptor for the SARS-CoV-2, and functional expression of which is also needed to minimize vasoconstriction otherwise would lead to high blood pressure. Furthermore, SARS-CoV-2 infection seems to reduce the functional expression of ACE2. Given these circumstances, it might be advisable to consider a treatment plan for COVID-19 patients with CVD in an approach that would neither aggravate the vasodeleterious arm of the renin-angiotensinogen-aldosterone system (RAAS) nor compromise the vasoprotective arm of RAAS but is effective to minimize or if possible, inhibit the viral replication. Given the immune modulatory role of Zn in both CVD and COVID-19 pathogenesis, zinc supplement to the selective treatment plan for CVD and COVID-19 comorbid conditions, to be decided by the clinicians depending on the cardiovascular conditions of the patients, might greatly improve the therapeutic outcome. Notably, ACE2 is a zinc metalloenzyme and zinc is also known to inhibit viral replication.
    Keywords Angiotensinogen converting enzyme ; CVD and COVID 19 Comorbidity ; High blood pressure ; Vasoconstriction ; SARS-CoV-2 ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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