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Article: [Observation of effect of Wu Yun Liu Qi on reproductive hormones in varicocele patients].

Shi, Qing-Jing / Pan, Lian-Jun / Pan, Feng / Zhao, Dan / Zhang, Xing-Yuan / Li, Hai-Bo / Liao, Kai / Zhang, Feng-Lei

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 12, Page(s) 1018–1021

Abstract: ... of Wu Yun Liu Qi, and explore whether the cycle had effect on the roproductive hormone levels. Methods ... in 2016 than other years except 2018 and 2020( All P< 0.05). Conclusions: Shi Xiang factors of Wu Yun Liu ...

Abstract	Objective： To observe roproductive hormone levels in varicocele patients during a cycle (6 years) of Wu Yun Liu Qi, and explore whether the cycle had effect on the roproductive hormone levels. Methods： Data of roproductive hormone levels in varicocele patients from 2015 to 2020 were analyzed retrospectively. FSH、LH、T、PRL、E2 levels and T/E2 ratio were compared among the six years. According to Chinese sexagenary cycle heavenly stems and earthly branches of each year from 2015 to 2020 its yunqi characteristics were determined. Results: Totally data of 848 cases of varicocele patients were collected from 2015 to 2020. Among which, in 2015 (Yiwei year) there were 57 cases, in 2016 (Bingshen year) 83 cases, in 2017 (Dingyou year ) 133 cases, in 2018(Wuxu year) 156 cases, in 2019(Sihai year) 274 cases, and in 2020(Gengzi year) 145 cases. The levels of FSH、LH、PRL、T were not diferrent statistically from the six years except individual year. However, the level of E2 in 2016 when the Yunqi was Shao Yang Xiang Huo Si Tian and Jue Yin Feng Mu Zai Quan obviously higher than other years excpet 2018( All P< 0.05). And T/E2 ratio was lower in 2016 than other years except 2018 and 2020( All P< 0.05). Conclusions: Shi Xiang factors of Wu Yun Liu Qi had effect on roproductive hormone levels in varicocele patients, showing by higher E2 level in Yinshen year when the Shi Xiang factors may have bad effect on human fertility.
MeSH term(s)	Male ; Humans ; Qi ; Varicocele ; Retrospective Studies ; Follicle Stimulating Hormone
Chemical Substances	Follicle Stimulating Hormone (9002-68-0)
Language	Chinese
Publishing date	2024-04-19
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Zs.A 6577: Show issues

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Article ; Online: The Yun/Prohibitin complex regulates adult

Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ren, Xuejing / Ma, Rui / Jia, Lemei / Ma, Meifang / Lu, Shan / Xu, Ran / Binari, Richard / Wang, Jian-Hua / Dong, Meng-Qiu / Perrimon, Norbert / Li, Zhouhua

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 6

Abstract: Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, ... ...

Abstract	Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, from an RNA interference (RNAi) screen in adult
MeSH term(s)	Adult Stem Cells/metabolism ; Animals ; Animals, Genetically Modified ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; E2F1 Transcription Factor/metabolism ; Homeostasis/physiology ; Intestines/metabolism ; Prohibitins/metabolism ; RNA Interference/physiology ; Signal Transduction/physiology
Chemical Substances	Drosophila Proteins ; E2F1 Transcription Factor ; Prohibitins
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2111711119
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Zs.A 1148: Show issues

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Article ; Online: Phosphorylation of Yun is required for stem cell proliferation and tumorigenesis.

Ren, Xuejing / Zhao, Hang / Shi, Lin / Li, Zhengran / Kong, Ruiyan / Ma, Rui / Jia, Lemei / Lu, Shan / Wang, Jian-Hua / Dong, Meng-Qiu / Wang, Yingchun / Li, Zhouhua

Cell proliferation

2022 Volume 55, Issue 5, Page(s) e13230

Abstract: ... understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation ... of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun ... among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important ...

Abstract	Stem cells maintain adult tissue homeostasis under physiological conditions. Uncontrolled stem cell proliferation will lead to tumorigenesis. How stem cell proliferation is precisely controlled is still not fully understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun can be phosphorylated at multiple residues in vivo. Interestingly, we show that the phosphorylation among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important for its function in ISC proliferation regulation. Thus, our study unveils the important role of post-translational modification of Yun in stem cell proliferation.
MeSH term(s)	Adult ; Cell Proliferation ; Cell Transformation, Neoplastic ; Drosophila Proteins/metabolism ; Humans ; Intestines ; Phosphorylation
Chemical Substances	Drosophila Proteins
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/cpr.13230
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Zs.A 532: Show issues

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Article: Jian Yun Qing Hua Decoction inhibits malignant behaviors of gastric carcinoma cells via COL12A1 mediated ferroptosis signal pathway.

Liu, Baoxinzi / Li, Yu / Xu, Yuanyuan / Xue, Weiwei / Jin, Zhichao

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 118

Abstract: Background: Jian Yun Qing Hua Decoction (JYQHD), a traditional Chinese medicine decoction ...

Abstract	Background: Jian Yun Qing Hua Decoction (JYQHD), a traditional Chinese medicine decoction, which has been applied in the treatment of gastric cancer (GC). We attempt to confirm the anti-gastric cancer effect of JYQHD and explore the mechanism of JYQHD. Methods: Acute toxicity test was used to understand the toxicity of JYQHD. We studied the expression and prognostic outcome of COL12A1 within GC tissues through the network databases. Using several web-based databases, we analyzed the major components and targets of JYQHD, as well as known therapeutic targets in gastric cancer. The Venn diagram was utilized to obtain the overlapped genes. Lentiviral vector, shRNAs and plasmids, were used to transfect GC cells. Cell counting kit-8 (CCK8), sphere formation, malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS), Fe Results: The results showed that JYQHD was non-toxic and safe. JYQHD inhibited growth and sphere formation ability through inducing the ferroptosis of GC cells, and suppressed the GC cells induced subcutaneous xenograft tumor growth. COL12A1 was highly expressed in gastric cancer tissues, indicating poor prognosis. COL12A1 specifically enhanced GC cell progression and stemness via suppressing ferroptosis. JYQHD down-regulated COL12A1 in order to suppress the stemness of GC cells via inducing ferroptosis. Conclusion: COL12A1 inhibited ferroptosis and enhanced stemness in GC cells. JYQHD inhibited the development of GC cells by inhibiting cancer cell stemness via the ferroptosis pathway mediated by COL12A1.
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00799-5
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Article ; Online: Novel intrinsic factor Yun maintains female germline stem cell fate through Thickveins.

Zhao, Hang / Li, Zhengran / Kong, Ruiyan / Shi, Lin / Ma, Rui / Ren, Xuejing / Li, Zhouhua

Stem cell reports

2022 Volume 17, Issue 9, Page(s) 1914–1923

Abstract: ... is not fully understood. Here, we find that the novel intrinsic factor Yun is required for female GSC ... factor Bam by defective BMP/Dpp signaling in the absence of yun. Mechanistically, Yun associates with and ...

Abstract	Germline stem cells (GSCs) are critical for the reproduction of an organism. The self-renewal and differentiation of GSCs must be tightly controlled to avoid uncontrolled stem cell proliferation or premature stem cell differentiation. However, how the self-renewal and differentiation of GSCs are properly controlled is not fully understood. Here, we find that the novel intrinsic factor Yun is required for female GSC maintenance in Drosophila. GSCs undergo precocious differentiation due to de-repression of differentiation factor Bam by defective BMP/Dpp signaling in the absence of yun. Mechanistically, Yun associates with and stabilizes Thickveins (Tkv), the type I receptor of Dpp/BMP signaling. Finally, ectopic expression of a constitutively active Tkv (Tkv
MeSH term(s)	Animals ; Cell Differentiation/physiology ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Female ; Germ Cells ; Intrinsic Factor/metabolism ; Oogonial Stem Cells/metabolism ; Ovary/metabolism ; Protein Serine-Threonine Kinases ; Receptors, Cell Surface/metabolism
Chemical Substances	Drosophila Proteins ; Receptors, Cell Surface ; dpp protein, Drosophila ; Intrinsic Factor (9008-12-2) ; tkv protein, Drosophila (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2022.07.014
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Article: The therapeutic effect and mechanism of Chinese medicine Xuan-Yun-Ding on posterior circulation ischemia with vertigo in a rabbit model.

Chunhua, Liu / Zhixiong, Li / Dahua, Wu / Chunyun, Yuan / Haoqin, Deng / Sisi, Yuan / Fang, Liu / Yao, Xiao

Pakistan journal of pharmaceutical sciences

2021 Volume 34, Issue 3, Page(s) 843–854

Abstract: The aim of research is to unveil the mechanisms of the beneficial effects of XYD on PCIV in a rabbit model. 40 New Zealand white rabbits were randomly divided into 5 groups,including normal control group (NC), model control group (MC), low-dose of XYD ... ...

Abstract	The aim of research is to unveil the mechanisms of the beneficial effects of XYD on PCIV in a rabbit model. 40 New Zealand white rabbits were randomly divided into 5 groups,including normal control group (NC), model control group (MC), low-dose of XYD group (LXYD), high-dose of XYD group (HXYD) and Yang-Xue-Qin-Nao group (YXQN). PCIV rabbit model was established by feeding high-fat diet companied with paravertebral sclerotherapy and rotation exercise. The general observation, step-down test, rheoencephalogram, blood tests, histopathological detection and the plasma concentration of the effective component of XYD were investigated. After pharmacological intervening, the step-down time, REG, PL, IPL, blood viscosity, the levels of blood lipids, CRGP were significantly improved. Moreover, the vertebral artery showed the reduced stenosis of arterial lumen and less proliferation of fibrous tissue in the arterial wall in the LXYD, HXYD and YXQN group. Based on the LC-MS detection, the blood concentrations of puerarin in the LXYD and HXYD group were significantly increased after pharmacological intervening. XYD could ameliorate the symptoms of vertigo, Qi-deficiency and blood stasis in PCIV rabbits via effectively regulating the levels of blood lipids and vasoactive substances, decreasing blood viscosity, increasing CBF and protecting vestibular function.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Evoked Potentials, Auditory, Brain Stem/drug effects ; Hemorheology ; Lipid Metabolism/drug effects ; Medicine, Chinese Traditional ; Rabbits ; Vertebral Artery/drug effects ; Vertebral Artery/pathology ; Vertebral Artery/ultrastructure ; Vertebrobasilar Insufficiency/physiopathology ; Vertigo/physiopathology ; Vestibular Nuclei/drug effects ; Vestibular Nuclei/pathology ; Vestibular Nuclei/ultrastructure
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-09-08
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Zs.A 6588: Show issues

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Article ; Online: Erratum: SHUO QI, ZHI-TONG LYU, JIAN WANG, YUN-MING MO, ZHAO-CHI ZENG, YANG-JIN ZENG, KE-YUAN DAI, YUAN-QIU LI, L. LEE GRISMER amp; YING-YONG WANG (2022) Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China. Zootaxa, 5072: 401438.

Qi, Shuo / Lyu, Zhi-Tong / Wang, Jian / Mo, Yun-Ming / Zeng, Zhao-Chi / Zeng, Yang-Jin / Dai, Ke-Yuan / Li, Yuan-Qiu / Grismer, L Lee / Wang, Ying-Yong

Zootaxa

2022 Volume 5115, Issue 4, Page(s) 600

Language	English
Publishing date	2022-03-16
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5115.4.10
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Article ; Online: Application of the Deep Neural Network in Retrieving the Atmospheric Temperature and Humidity Profiles from the Microwave Humidity and Temperature Sounder Onboard the Feng-Yun-3 Satellite.

He, Qiurui / Wang, Zhenzhan / Li, Jiaoyang

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 14

Abstract: The shallow neural network (SNN) is a popular algorithm in atmospheric parameters retrieval from microwave remote sensing. However, the deep neural network (DNN) has a stronger nonlinear mapping capability compared to SNN and has great potential for ... ...

Abstract	The shallow neural network (SNN) is a popular algorithm in atmospheric parameters retrieval from microwave remote sensing. However, the deep neural network (DNN) has a stronger nonlinear mapping capability compared to SNN and has great potential for applications in microwave remote sensing. The Microwave Humidity and Temperature Sounder (Beijing, China, MWHTS) onboard the Fengyun-3 (FY-3) satellite has the ability to independently retrieve atmospheric temperature and humidity profiles. A study on the application of DNN in retrieving atmospheric temperature and humidity profiles from MWHTS was carried out. Three retrieval schemes of atmospheric parameters in microwave remote sensing based on DNN were performed in the study of bias correction of MWHTS observation and the retrieval of the atmospheric temperature and humidity profiles using MWHTS observations. The experimental results show that, compared with SNN, DNN can obtain better bias-correction results when applied to MWHTS observation, and can obtain higher retrieval accuracy of temperature and humidity profiles in all three retrieval schemes. Meanwhile, DNN shows higher stability than SNN when applied to the retrieval of temperature and humidity profiles. The comparative study of DNN and SNN applied in different atmospheric parameter retrieval schemes shows that DNN has a more superior performance.
MeSH term(s)	China ; Humidity ; Microwaves ; Neural Networks, Computer ; Temperature
Language	English
Publishing date	2021-07-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21144673
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Article: Prof. Yun Fan: persistence guarantees expertise, patience conquers difficulties.

Zhang, Kai-Ping / Ma, Li

Journal of thoracic disease

2017 Volume 9, Issue Suppl 11, Page(s) S1162–S1167

Language	English
Publishing date	2017-03-27
Publishing country	China
Document type	News
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd.2017.09.144
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Article: Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis.

Li, Li / Jiang, Huabo / Wei, Xuecong / Geng, Dandan / He, Ming / Du, Huilan

Evidence-based complementary and alternative medicine : eCAM

2019 Volume 2019, Page(s) 3949824

Abstract: ... the mitogen-activated protein kinase (MAPK) signaling pathway and plays an important role in angiogenesis. Bu Shen Zhu Yun decoction ...

Abstract	Vascular endothelial growth factor receptor-2 (VEGFR-2) regulates the mitogen-activated protein kinase (MAPK) signaling pathway and plays an important role in angiogenesis. Bu Shen Zhu Yun decoction (BSZYD) can improve endometrial receptivity and embryo implantation rates in patients undergoing in vitro fertilization. However, whether BSZYD improves endometrial receptivity via angiogenesis remains unclear. Here, we investigated the effects of BSZYD on the proliferation, migration, and angiogenesis of human endometrial microvascular endothelial cells (HEMECs) and found that BSZYD upregulated the expression of cyclin D1, matrix metalloproteinase 9 (MMP9), and proliferating cell nuclear antigen (PCNA) in HEMECs. Cell Counting Kit 8 assay, scratch-wound assay, and Tube Formation Assay results showed that BSZYD promoted the proliferation, migration, and angiogenesis of HEMECs. Western blot analysis results revealed the activation of the MAPK signaling pathway by BSZYD through the upregulation of VEGF and VEGFR-2 expression. Together, these findings highlight the novel mechanism underlying BSZYD-mediated improvement in endometrial receptivity through the MAPK signaling pathway.
Language	English
Publishing date	2019-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2019/3949824
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