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  1. Book ; Online: Le tournant social de l'international

    Lagrange, Delphine / Louis, Marieke / Nay, Olivier

    Les organisations internationales face aux sociétés civiles

    (Res publica)

    2021  

    Series title Res publica
    Keywords International relations ; politique ; sociologie ; international
    Language 0|f
    Size 1 electronic resource (202 pages)
    Publisher Presses universitaires de Rennes
    Publishing place Rennes
    Document type Book ; Online
    Note French ; Open Access
    HBZ-ID HT021617723
    ISBN 9782753579224 ; 2753579229
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Can a virus undermine human rights?

    Nay, Olivier

    The Lancet. Public health

    2020  Volume 5, Issue 5, Page(s) e238–e239

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Human Rights ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country England
    Document type Journal Article
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(20)30092-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bridging the gap between science and policy in global health governance.

    Nay, Olivier / Barré-Sinoussi, Françoise

    The Lancet. Global health

    2022  Volume 10, Issue 3, Page(s) e322–e323

    MeSH term(s) Climate Change ; Global Health/legislation & jurisprudence ; Government ; Health Policy/legislation & jurisprudence ; Humans ; Policy Making ; World Health Organization
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(21)00567-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The WHO we want.

    Nay, Olivier / Kieny, Marie-Paule / Marmora, Lelio / Kazatchkine, Michel

    Lancet (London, England)

    2020  Volume 395, Issue 10240, Page(s) 1818–1820

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections/epidemiology ; Global Health ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Politics ; SARS-CoV-2 ; United States ; World Health Organization
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31298-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

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  7. Article ; Online: Oxidative and glycolytic skeletal muscles deploy protective mechanisms to avoid atrophy under pathophysiological iron overload.

    Martin, David / Nay, Kévin / Robin, François / Rebillard, Amélie / Orfila, Luz / Martin, Brice / Leroyer, Patricia / Guggenbuhl, Pascal / Dufresne, Suzanne / Noirez, Philippe / Ropert, Martine / Loréal, Olivier / Derbré, Frédéric

    Journal of cachexia, sarcopenia and muscle

    2022  Volume 13, Issue 2, Page(s) 1250–1261

    Abstract: Background: Iron excess has been proposed as an essential factor in skeletal muscle wasting. Studies have reported correlations between muscle iron accumulation and atrophy, either through ageing or by using experimental models of secondary iron ... ...

    Abstract Background: Iron excess has been proposed as an essential factor in skeletal muscle wasting. Studies have reported correlations between muscle iron accumulation and atrophy, either through ageing or by using experimental models of secondary iron overload. However, iron treatments performed in most of these studies induced an extra-pathophysiological iron overload, more representative of intoxication or poisoning. The main objective of this study was to determine the impact of iron excess closer to pathophysiological conditions on structural and metabolic adaptations (i) in differentiated myotubes and (ii) in skeletal muscle exhibiting oxidative (i.e. the soleus) or glycolytic (i.e. the gastrocnemius) metabolic phenotypes.
    Methods: The impact of iron excess was assessed in both in vitro and in vivo models. Murine differentiated myotubes were exposed to ferric ammonium citrate (FAC) (i.e. 10 and 50 μM) for the in vitro component. The in vivo model was achieved by a single iron dextran subcutaneous injection (1 g/kg) in mice. Four months after the injection, soleus and gastrocnemius muscles were harvested for analysis.
    Results: In vitro, iron exposure caused dose-dependent increases of iron storage protein ferritin (P < 0.01) and dose-dependent decreases of mRNA TfR1 levels (P < 0.001), which support cellular adaptations to iron excess. Extra-physiological iron treatment (50 μM FAC) promoted myotube atrophy (P = 0.018), whereas myotube size remained unchanged under pathophysiological treatment (10 μM FAC). FAC treatments, whatever the doses tested, did not affect the expression of proteolytic markers (i.e. NF-κB, MurF1, and ubiquitinated proteins). In vivo, basal iron content and mRNA TfR1 levels were significantly higher in the soleus compared with the gastrocnemius (+130% and +127%; P < 0.001, respectively), supporting higher iron needs in oxidative skeletal muscle. Iron supplementation induced muscle iron accumulation in the soleus and gastrocnemius muscles (+79%, P < 0.001 and +34%, P = 0.002, respectively), but ferritin protein expression only increased in the gastrocnemius (+36%, P = 0.06). Despite iron accumulation, muscle weight, fibre diameter, and myosin heavy chain distribution remained unchanged in either skeletal muscle.
    Conclusions: Together, these data support that under pathophysiological conditions, skeletal muscle can protect itself from the related deleterious effects of excess iron.
    MeSH term(s) Animals ; Iron Overload/metabolism ; Iron Overload/pathology ; Mice ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Atrophy/metabolism ; Oxidative Stress
    Language English
    Publishing date 2022-02-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.12897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: High-flow nasal oxygenation versus standard oxygenation for gastrointestinal endoscopy with sedation. The prospective multicentre randomised controlled ODEPHI study protocol.

    Eugene, Axelle / Fromont, Lucie / Auvet, Adrien / Baert, Olivier / Mfam, Willy-Serge / Remerand, Francis / Boulain, Thierry / Nay, Mai-Anh

    BMJ open

    2020  Volume 10, Issue 2, Page(s) e034701

    Abstract: Introduction: Hypoxaemia is a major complication during gastrointestinal endoscopy (GIE) procedures (upper/lower) when performed under deep sedation in the procedure room. Standard oxygen therapy (SOT) is used to prevent hypoxaemia. Data suggest that ... ...

    Abstract Introduction: Hypoxaemia is a major complication during gastrointestinal endoscopy (GIE) procedures (upper/lower) when performed under deep sedation in the procedure room. Standard oxygen therapy (SOT) is used to prevent hypoxaemia. Data suggest that risk factors for hypoxaemia under deep sedation during GIE are obstructive sleep apnoea syndrome, a body mass index above 30 kg/m², high blood pressure, diabetes, heart disease, age over 60 years old, high American Society of Anesthesiologists physical status class and the association of upper and lower GIE. High-flow nasal oxygenation (HFNO) may potentially improve oxygenation during GIE under deep sedation. We hypothesised that HFNO could decrease the incidence of hypoxaemia in comparison with SOT.
    Methods and analysis: The ODEPHI (High-flow nasal
    Ethics and dissemination: This study has been approved by the ethics committee (CPP Sud Est Paris V, France), and patients are included after informed consent. The results will be submitted for publication in peer-reviewed journals. As provided for by French law, patients participating in the study are informed that they have the possibility to ask the investigators, once the study is completed, to be informed of the overall results of the study. Thus, a summary of the results will be sent by post to the participants on request.
    Trial registration number: ClinicalTrials.gov Registry (NCT03829293).
    MeSH term(s) Administration, Intranasal ; Anesthesia/adverse effects ; Endoscopy, Gastrointestinal/adverse effects ; France ; Humans ; Hypoxia/etiology ; Hypoxia/prevention & control ; Multicenter Studies as Topic ; Oxygen/administration & dosage ; Prospective Studies ; Randomized Controlled Trials as Topic ; Reference Standards
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2020-02-18
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2019-034701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model.

    Jollet, Maxence / Nay, Kevin / Chopard, Angèle / Bareille, Marie-Pierre / Beck, Arnaud / Ollendorff, Vincent / Vernus, Barbara / Bonnieu, Anne / Mariadassou, Mahendra / Rué, Olivier / Derbré, Frédéric / Goustard, Bénédicte / Koechlin-Ramonatxo, Christelle

    Nutrients

    2021  Volume 13, Issue 11

    Abstract: Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles ... ...

    Abstract Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles are widespread and associated with negative health and socio-economic impacts. The study aim was to determine the effect of Dry Immersion (DI), a severe hypoactivity model, on the human gut microbiota composition. Stool samples were collected from 14 healthy men before and after 5 days of DI to determine the gut microbiota taxonomic profiles by 16S metagenomic sequencing in strictly controlled dietary conditions. The α and β diversities indices were unchanged. However, the operational taxonomic units associated with the Clostridiales order and the
    MeSH term(s) Adult ; Feces/chemistry ; Feces/microbiology ; Gastrointestinal Microbiome/physiology ; Healthy Volunteers ; Humans ; Immersion/physiopathology ; Male ; Propionates/metabolism ; Rest/physiology ; Sedentary Behavior ; Weightlessness Simulation
    Chemical Substances Propionates
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13113865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: High-flow nasal oxygenation or standard oxygenation for gastrointestinal endoscopy with sedation in patients at risk of hypoxaemia: a multicentre randomised controlled trial (ODEPHI trial).

    Nay, Mai-Anh / Fromont, Lucie / Eugene, Axelle / Marcueyz, Jean-Louis / Mfam, Willy-Serge / Baert, Olivier / Remerand, Francis / Ravry, Céline / Auvet, Adrien / Boulain, Thierry

    British journal of anaesthesia

    2021  Volume 127, Issue 1, Page(s) 133–142

    Abstract: Background: We aimed to determine whether high-flow nasal oxygen could reduce the incidence of decreased peripheral oxygen saturation (SpO: Methods: This was a multicentre, randomised controlled trial with blinded assessment of the primary outcome ... ...

    Abstract Background: We aimed to determine whether high-flow nasal oxygen could reduce the incidence of decreased peripheral oxygen saturation (SpO
    Methods: This was a multicentre, randomised controlled trial with blinded assessment of the primary outcome evaluating high-flow nasal oxygen (gas flow 70 L min
    Results: In 379 patients, a decrease in SpO
    Conclusions: In patients at risk of hypoxaemia undergoing gastrointestinal endoscopy under deep sedation, use of high-flow nasal oxygen significantly reduced the incidence of peripheral oxygen desaturation.
    Clinical trial registration: NCT03829293.
    MeSH term(s) Aged ; Cannula ; Endoscopy, Gastrointestinal/adverse effects ; Endoscopy, Gastrointestinal/methods ; Female ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/adverse effects ; Hypoxia/diagnosis ; Hypoxia/etiology ; Hypoxia/prevention & control ; Male ; Middle Aged ; Oxygen Inhalation Therapy/instrumentation ; Oxygen Inhalation Therapy/methods ; Risk Factors ; Single-Blind Method
    Chemical Substances Hypnotics and Sedatives
    Language English
    Publishing date 2021-04-28
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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