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  1. Article ; Online: Rebuttal from Markus P. Schlaich, Yusuke Sata and Murray D. Esler.

    Schlaich, Markus P / Sata, Yusuke / Esler, Murray D

    The Journal of physiology

    2014  Volume 592, Issue 18, Page(s) 3947

    MeSH term(s) Animals ; Carotid Body/surgery ; Carotid Sinus/physiology ; Denervation/methods ; Electric Stimulation Therapy ; Humans ; Hypertension/surgery ; Hypertension/therapy
    Language English
    Publishing date 2014-09-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2014.279729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.65: Show issues Location:
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  2. Article ; Online: Coffee drinking then and now: research continues to better understand this ubiquitous beverage.

    Esler, Murray

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2023  Volume 33, Issue 6, Page(s) 613–615

    MeSH term(s) Humans ; Coffee/adverse effects ; Caffeine/adverse effects ; Central Nervous System Stimulants/pharmacology ; Beverages ; Blood Pressure
    Chemical Substances Coffee ; Caffeine (3G6A5W338E) ; Central Nervous System Stimulants
    Language English
    Publishing date 2023-09-14
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-023-00981-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3270: Show issues Location:
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  3. Article ; Online: Should an Alerting Response and Blood Pressure Measurement Never Be Mixed?

    Esler, Murray

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 78, Issue 4, Page(s) 1134–1137

    MeSH term(s) Blood Pressure ; Blood Pressure Determination ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.17874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  4. Article ; Online: Reflections on the past four decades of mental stress research in autonomic cardiology.

    Esler, Murray

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2021  Volume 31, Issue 1, Page(s) 11–14

    MeSH term(s) Autonomic Nervous System ; Cardiology ; Humans ; Hypertension ; Norepinephrine ; Sympathetic Nervous System
    Chemical Substances Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2021-01-12
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-020-00761-7
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  5. Article ; Online: Pivotal role of the sympathetic nerves of the human heart in mental stress responses and triggered cardiovascular catastrophes.

    Esler, Murray

    Autonomic neuroscience : basic & clinical

    2021  Volume 237, Page(s) 102925

    Abstract: Mental stress can trigger cardiac catastrophes, explicitly evident during national disasters such as earthquakes. Activation of the cardiac sympathetic outflow and inhibition of the cardiac vagus are important mediating mechanisms. This manuscript ... ...

    Abstract Mental stress can trigger cardiac catastrophes, explicitly evident during national disasters such as earthquakes. Activation of the cardiac sympathetic outflow and inhibition of the cardiac vagus are important mediating mechanisms. This manuscript describes efforts by the Human Neurotransmitters Research Laboratory of the Baker Institute in Melbourne to develop investigative methods to study the sympathetic nerves of the human heart, and to apply these in mental stress research. With laboratory mental stress, activation of the adrenal medulla was found to occur, accompanied by a regionalized sympathetic nervous response directed to the heart, but sparing the sympathetic outflow to the skeletal muscle vasculature. Patients with panic disorder are at increased cardiovascular risk. They exhibit high-level sympathetic activation during a panic attack, sometimes accompanied by coronary artery spasm. Patients with sudden ventricular arrhythmias causing collapse in the community were found to have as the predisposing substrate high baseline cardiac sympathetic activity, from previously unrecognized mild heart failure; it was surprising at the time that we did not find critical coronary artery stenosis as the substrate. In some the arrhythmia event had a behavioural trigger. In Takotsubo cardiomyopathy ("Broken Heart Syndrome") the myocardial stunning appears to represent a catecholamine cardiomyopathy, from astronomically high plasma adrenaline concentrations, rather than be caused by activation of the cardiac sympathetic nerves. Some diseases (essential hypertension, heart failure, panic disorder) have forms of sympathetic neural enhancement which contribute to cardiovascular risk: reuptake of noradrenaline by sympathetic nerves after release is faulty and single sympathetic fibres fire in multiple salvos within a single cardiac cycle. Paradoxically, obesity-hypertension does not share in this sympathetic neural augmentation, which is present only in normal-weight hypertensive patients, providing the possible basis for an observed "Obesity Paradox" (longer survival in obesity-hypertension than in normal weight hypertension). Community-wide specific prevention of cardiovascular triggering is not currently possible, due to there being no available simple screening tests which could be applied to the community at-large for the commonest substrates, silent coronary artery disease and mild heart failure. Standard medical preventive measures for coronary atherosclerosis will of course be helpful. Targeted prevention of triggering can be done in those with a detected predisposing substrate, such as genetic Long QT Syndrome, and in survivors of a serious triggered event, who need detailed, appropriate testing.
    MeSH term(s) Epinephrine ; Heart ; Humans ; Hypertension ; Norepinephrine ; Sympathetic Nervous System
    Chemical Substances Norepinephrine (X4W3ENH1CV) ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2021-12-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2021.102925
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    Zs.A 1533: Show issues Location:
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  6. Article ; Online: Ablating the renal nerves to treat heart failure with reduced ejection fraction: another treatment option in a crowded space?

    Esler, Murray

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2020  Volume 30, Issue 6, Page(s) 499–500

    MeSH term(s) Catheters ; Heart Failure/therapy ; Humans ; Kidney ; Sympathectomy
    Language English
    Publishing date 2020-11-11
    Publishing country Germany
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-020-00741-x
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  7. Article ; Online: Sympathetic Pathophysiology in Hypertension Origins: The Path to Renal Denervation.

    Esler, Murray D / Osborn, John W / Schlaich, Markus P

    Hypertension (Dallas, Tex. : 1979)

    2024  

    Abstract: The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the ... ...

    Abstract The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the 20
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21715
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  8. Article ; Online: Does increased 24-h ambulatory heart rate identify de facto neurogenic hypertension, and facilitate selection of hypertensive patients for renal denervation?

    Esler, Murray

    European heart journal

    2019  Volume 40, Issue 9, Page(s) 752–754

    MeSH term(s) Antihypertensive Agents ; Denervation ; Heart Rate ; Humans ; Hypertension ; Kidney
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz027
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  9. Article ; Online: Sympathetic Activation in Essential Hypertension: Understanding the Toxic Trifecta.

    Esler, Murray

    Heart, lung & circulation

    2018  Volume 27, Issue 3, Page(s) 271–273

    MeSH term(s) Blood Pressure/physiology ; Essential Hypertension/physiopathology ; Humans ; Sympathetic Nervous System/physiopathology
    Language English
    Publishing date 2018-02-07
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/S1443-9506(18)30002-7
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  10. Article ; Online: Renal nerve ablation for hypertension: Update from an insider.

    Esler, Murray

    European heart journal

    2018  Volume 39, Issue 46, Page(s) 4054–4055

    MeSH term(s) Blood Pressure/physiology ; Catheter Ablation/methods ; Humans ; Hypertension/physiopathology ; Hypertension/surgery ; Kidney/innervation ; Patient Selection ; Sympathectomy/methods
    Language English
    Publishing date 2018-09-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy717
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