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Book ; Conference proceedings: 15th European Meeting on Complement in Human Disease

Nilsson, Bo

2015, Uppsala, Sweden [June 27 - 30]

(Molecular immunology ; 67,1 = Spec. iss.)

2015

Event/congress	European Meeting on Complement in Human Disease (15., 2015, Uppsala)
Author's details	guest ed.: Bo Nilsson
Series title	Molecular immunology ; 67,1 = Spec. iss.
Collection
Language	English
Size	198 S. : Ill., graph. Darst.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book ; Conference proceedings
HBZ-ID	HT018691337
Database	Catalogue ZB MED Medicine, Health

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Article: Flow-flash study of the reaction between cytochrome bo and oxygen.

Svensson, M / Nilsson, T

Biochemistry

1993 Volume 32, Issue 20, Page(s) 5442–5447

Abstract: The reaction between reduced cytochrome bo from Escherichia coli and oxygen has been studied using ...

Abstract	The reaction between reduced cytochrome bo from Escherichia coli and oxygen has been studied using flash photolysis of the CO complex of the reduced protein after rapid mixing with oxygen. Absorbance changes were monitored in the alpha and Soret spectral regions. Two kinetic phases taking place at catalytically competent rates could be detected. The apparent rate constant obtained for both the first and second phase showed a hyperbolic dependence on the oxygen concentration. For the first phase, we obtained limiting first- and second-order rate constants at saturating and low oxygen concentrations of 4.5 x 10(4) s-1 and 1.6 x 10(8) M-1 s-1, respectively. The corresponding values for the second phase were 5 x 10(3) s-1 and 1.7 x 10(7) M-1 s-1. The first phase accounted for 30% of the total absorbance change in the Soret band (430 nm) and 15% of the total absorbance change in the alpha band (555 nm). These reactions are followed by a very slow phase with a lifetime of about 1 s. We have also studied the interaction between the fully oxidized enzyme and hydrogen peroxide, and we have found that peroxide binding induces an absorbance increase in the alpha band and a red shift of the Soret band. A consideration of the magnitude of the absorbance changes taking place during the first phase suggests that this reaction includes at least partial oxidation of the low-spin cytochrome b.
MeSH term(s)	Cytochrome b Group ; Cytochromes/chemistry ; Escherichia coli/chemistry ; Escherichia coli Proteins ; Kinetics ; Oxidation-Reduction ; Oxygen/chemistry ; Photolysis ; Protein Conformation ; Spectrophotometry
Chemical Substances	Cytochrome b Group ; Cytochromes ; Escherichia coli Proteins ; cytochrome bo, E coli (9035-48-7) ; Oxygen (S88TT14065)
Language	English
Publishing date	1993-05-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi00071a021
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Book ; Online: Exercises with Solutions in Radiation Physics

Nilsson, Bo N.

2015

Abstract: The textbook begins with exercises related to radioactive sources and decay schemes. The problems covered include series decay and how to determine the frequency and energy of emitted particles in disintegrations. The next chapter deals with the ... ...

Abstract	The textbook begins with exercises related to radioactive sources and decay schemes. The problems covered include series decay and how to determine the frequency and energy of emitted particles in disintegrations. The next chapter deals with the interaction of ionizing radiation, including the treatment of photons and charged particles. The main focus is on applications based on the knowledge of interaction, to be used in subsequent work and courses. The textbook then examines detectors and measurements, including both counting statistics and properties of pulse detectors. The chapter that follows is dedicated to dosimetry, which is a major subject in medical radiation physics. It covers theoretical applications, such as different equilibrium situations and cavity theories, as well as experimental dosimetry, including ionization chambers and solid state and liquid dosimeters. A shorter chapter deals with radiobiology, where different cell survival models are considered. The last chapter concerns radiation protection and health physics. Both radioecology and radiation shielding calculations are covered. The textbook includes tables to simplify the solutions of the exercises, but the reader is mainly referred to important websites for importing necessary data
Keywords	Physics
Size	1 electronic resource (278 p.)
Publisher	De Gruyter
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020089788
ISBN	9783110442069 ; 9783110433739 ; 311044206X ; 3110433737
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Cytochrome bo from E. coli does not exhibit the same proton transfer characteristics as the bovine cytochrome c oxidase during oxygen reduction.

Hallén, S / Svensson, M / Nilsson, T

FEBS letters

1993 Volume 325, Issue 3, Page(s) 299–302

Abstract: The reaction where fully reduced cytochrome bo from E. coli partially reduces dioxygen has been ... 10(3) s-1 and a stoichiometry of 0.8 H+/bo were recorded, using the indicator dye, Cresol red, at pH ...

Abstract	The reaction where fully reduced cytochrome bo from E. coli partially reduces dioxygen has been characterized with respect to the kinetics of the associated proton uptake, and with respect to the pH- and D2O-sensitivity of the electron transfer reactions. A monophasic proton uptake with a rate constant of about 8 x 10(3) s-1 and a stoichiometry of 0.8 H+/bo were recorded, using the indicator dye, Cresol red, at pH 8.2. The electron transfer reactions were independent of pH in the range 6.0-9.5 and were not affected by exchanging H2O to D2O as solvent. Comparison of these results with those obtained in an earlier investigation of the bovine cytochrome c oxidase [(1992) Biochemistry 31, 11853-11859], indicates differences between the two oxidases with respect to the role of protons in oxygen reduction and/or the mechanism of proton uptake from the medium.
MeSH term(s)	Animals ; Cattle ; Cytochrome b Group ; Cytochromes/metabolism ; Electron Transport Complex IV/metabolism ; Escherichia coli/enzymology ; Escherichia coli Proteins ; Hydrogen-Ion Concentration ; Oxidation-Reduction ; Oxygen/metabolism ; Protons ; Solvents
Chemical Substances	Cytochrome b Group ; Cytochromes ; Escherichia coli Proteins ; Protons ; Solvents ; cytochrome bo, E coli (9035-48-7) ; Electron Transport Complex IV (EC 1.9.3.1) ; Oxygen (S88TT14065)
Language	English
Publishing date	1993-07-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1016/0014-5793(93)81093-f
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Zs.B 282: Show issues

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Article ; Online: Early physiotherapy management of patients with Covid-19 admitted to a university hospital in Norway (March 2020 to July 2021).

Nilsson, Birgitta Blakstad / Bø, Elisabeth

Physiotherapy research international : the journal for researchers and clinicians in physical therapy

2023 , Page(s) e1998

Abstract: Aim: The aim of this retrospective observational study was to describe the scope of physiotherapy, the population and the physiotherapy management of Covid-19 patients referred to physiotherapy at a university hospital in the period from March 2020 to ... ...

Abstract	Aim: The aim of this retrospective observational study was to describe the scope of physiotherapy, the population and the physiotherapy management of Covid-19 patients referred to physiotherapy at a university hospital in the period from March 2020 to July 2021. Method: A descriptive observational study with access to data from a quality register, which contains clinical data of all patients admitted with Covid-19 to a university hospital in Norway. Data was obtained from electronic data sheets, where daily parameters for physiotherapy treatment were registered. Results: In total, 729 Covid-19 patients were admitted during this period. Of these, 507 (69.6%) received treatment by a physiotherapist (3510 sessions). The physiotherapy treatments were performed on intensive care units (ICU) (50%), intermediate care units (11%) and general medical units (39%), respectively. Patients were mainly treated during the day (98.5%) and 21% of the sessions were given on weekends or holidays. Within the 3510 sessions, 9459 interventions were performed in total (one to seven interventions per session). The most common intervention provided was positioning (35.4%). The most common interventions in medical units and intermediate care units were training with a positive expiratory pressure device (17.3% and 15.9% respectively), and techniques for reducing work of breathing (13% and 15% respectively). The most common intervention in the ICUs was passive mobilization (21.3%), mostly in combination with positioning, manual techniques and/or airway clearance. Conclusion: This study provides characteristics of, and experiences with early physiotherapy, in sequentially hospitalized patients at a university hospital in Norway.
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1432038-1
ISSN	1471-2865 ; 1358-2267
ISSN (online)	1471-2865
ISSN	1358-2267
DOI	10.1002/pri.1998
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Zs.A 5028: Show issues

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Article ; Online: Everyday navigation between adaptation and resistance: How young people negotiate their well-being in relation to assigned migrant positions in school.

Lögdberg, Ulrika / Öhlander, Magnus / Nilsson, Bo

PloS one

2023 Volume 18, Issue 2, Page(s) e0279762

Abstract: Concerning the so-called "refugee crisis" in 2015 and how it affected the position of young migrants in society, researchers have underscored the value of studies challenging one-sided images of migrant youth. This study examines how migrant positions ... ...

Abstract	Concerning the so-called "refugee crisis" in 2015 and how it affected the position of young migrants in society, researchers have underscored the value of studies challenging one-sided images of migrant youth. This study examines how migrant positions are constituted, negotiated, and related to young people's well-being. The study was undertaken using an ethnographic approach combined with the theoretical concept of translocational positionality to acknowledge how positions are created through historical and political processes and, at the same time, are context-dependent over time and space and thus contain incongruities. Our findings show how the newly arrived youth used multiple ways to navigate the school's everyday life and ascribed migrant positions to achieve well-being as illustrated through the distancing, adapting, defense, and the contradictory positions. Based on our findings, we understand the negotiations that occur in forming migrant positions within the school as asymmetric. At the same time, the youths' diverse and often contradictory positionality showed in various ways the striving for increased agency and well-being.
MeSH term(s)	Adolescent ; Humans ; Transients and Migrants ; Negotiating
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0279762
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Article ; Online: Everyday navigation between adaptation and resistance

Ulrika Lögdberg / Magnus Öhlander / Bo Nilsson

PLoS ONE, Vol 18, Iss 2, p e

How young people negotiate their well-being in relation to assigned migrant positions in school.

2023 Volume 0279762

Abstract	Concerning the so-called "refugee crisis" in 2015 and how it affected the position of young migrants in society, researchers have underscored the value of studies challenging one-sided images of migrant youth. This study examines how migrant positions are constituted, negotiated, and related to young people's well-being. The study was undertaken using an ethnographic approach combined with the theoretical concept of translocational positionality to acknowledge how positions are created through historical and political processes and, at the same time, are context-dependent over time and space and thus contain incongruities. Our findings show how the newly arrived youth used multiple ways to navigate the school's everyday life and ascribed migrant positions to achieve well-being as illustrated through the distancing, adapting, defense, and the contradictory positions. Based on our findings, we understand the negotiations that occur in forming migrant positions within the school as asymmetric. At the same time, the youths' diverse and often contradictory positionality showed in various ways the striving for increased agency and well-being.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Long-term sequelae following acute pulmonary embolism: A nationwide follow-up study regarding the incidence of CTEPH, dyspnea, echocardiographic and V/Q scan abnormalities.

Andersson, Therese / Nilsson, Lars / Larsen, Flemming / Carlberg, Bo / Söderberg, Stefan

Pulmonary circulation

2023 Volume 13, Issue 4, Page(s) e12306

Abstract: We aimed to follow a nationwide cohort of patients with pulmonary embolism (PE) without any exclusions to generate information regarding long-term symptoms, investigational findings and to determine the prevalence of chronic thromboembolic pulmonary ... ...

Abstract	We aimed to follow a nationwide cohort of patients with pulmonary embolism (PE) without any exclusions to generate information regarding long-term symptoms, investigational findings and to determine the prevalence of chronic thromboembolic pulmonary hypertension (CTEPH). We hypothesized that this approach would yield generalizable estimates of CTEPH prevalence and incidence. All individuals diagnosed with acute PE in Sweden in 2005 were identified using the National Patient Register. In 2007, survivors were asked to complete a questionnaire regarding current symptoms. Those with dyspnea were referred for further examinations with laboratory tests, electrocardiogram (ECG), and a ventilation/perfusion scan (V/Q scan). If CTEPH was suspected, a referral to the nearest pulmonary arterial hypertension-center was recommended. Of 5793 unique individuals with PE diagnosis in 2005, 3510 were alive at the beginning of 2007. Altogether 53% reported dyspnea at some degree whereof a large proportion had V/Q scans indicating mismatched defects. Further investigation revealed 6 cases of CTEPH and in parallel 18 cases were diagnosed outside this study. The overall prevalence of CTEPH was 0.4% (95% confidence interval [CI]: 0.2%-0.6%) and 0.7% (95% CI: 0.4%-1.0%) among the survivors. The cumulative incidence of CTEPH in the group of patients who underwent a V/Q scan was 1.1% (95% CI: 0.2%-2.0%). There was a high mortality following an acute PE, a high proportion of persistent dyspnea among survivors, whereof several had pathological findings on V/Q scans and echocardiography. Only a minority developed CTEPH, indicating that CTEPH is the tip of the iceberg of post-PE disturbances.
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2638089-4
ISSN	2045-8940 ; 2045-8932
ISSN (online)	2045-8940
ISSN	2045-8932
DOI	10.1002/pul2.12306
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Acamprosate reduces ethanol intake in the rat by a combined action of different drug components.

Ademar, Karin / Loftén, Anna / Nilsson, Mathilda / Domi, Ana / Adermark, Louise / Söderpalm, Bo / Ericson, Mia

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17863

Abstract: Alcohol misuse accounts for a sizeable proportion of the global burden of disease, and ... ...

Abstract	Alcohol misuse accounts for a sizeable proportion of the global burden of disease, and Campral
MeSH term(s)	Rats ; Male ; Animals ; Acamprosate ; Ethanol/pharmacology ; Rats, Wistar ; Calcium ; Calcium Chloride ; Dopamine ; Taurine ; Sodium
Chemical Substances	Acamprosate (N4K14YGM3J) ; Ethanol (3K9958V90M) ; Calcium (SY7Q814VUP) ; Calcium Chloride (M4I0D6VV5M) ; Dopamine (VTD58H1Z2X) ; Taurine (1EQV5MLY3D) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45167-3
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Article ; Online: What can we learn about functional importance of human antimicrobial peptide LL-37 in the oral environment from severe congenital neutropenia (Kostmann disease)?

Nilsson, Bengt-Olof

Peptides

2020 Volume 128, Page(s) 170311

Abstract: The human antimicrobial peptide LL-37 is produced by neutrophils and epithelial cells, and the peptide can be detected in plasma as well as saliva. LL-37 is active against both gram-positive and gram-negative bacteria including oral pathogens such as ... ...

Abstract	The human antimicrobial peptide LL-37 is produced by neutrophils and epithelial cells, and the peptide can be detected in plasma as well as saliva. LL-37 is active against both gram-positive and gram-negative bacteria including oral pathogens such as Porphyromonas gingivalis and Streptococcus mutans. Besides its antimicrobial properties, LL-37 modulates the innate immune system, and furthermore, it also affects host cell viability. Although, both structural and functional properties of LL-37 have been extensively investigated, its physiological/pathophysiological importance in-vivo is not completely understood. In this review, Kostmann disease (morbus Kostmann) is highlighted since it may represent a LL-37 knockdown model which can provide new important information and insights about the functional role of LL-37 in the human in-vivo setting. Patients with Kostmann disease suffer from neutropenia, and although they are treated with recombinant granulocyte colony-stimulating factor (G-CSF) to normalize their levels of neutrophils, they lack or have very low levels of LL-37 in plasma, saliva and neutrophils. Interestingly, these patients suffer from severe periodontal disease, linking LL-37-deficiency to oral infections. Thus, LL-37 seems to play an important pathophysiological role in the oral environment antagonizing oral pathogens and thereby prevents oral infections.
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/deficiency ; Antimicrobial Cationic Peptides/metabolism ; Congenital Bone Marrow Failure Syndromes/metabolism ; Congenital Bone Marrow Failure Syndromes/microbiology ; Congenital Bone Marrow Failure Syndromes/pathology ; Humans ; Mouth Diseases/blood ; Mouth Diseases/metabolism ; Mouth Diseases/microbiology ; Mouth Diseases/pathology ; Neutropenia/congenital ; Neutropenia/metabolism ; Neutropenia/microbiology ; Neutropenia/pathology ; Saliva/metabolism ; Saliva/microbiology
Chemical Substances	Antimicrobial Cationic Peptides ; ropocamptide (3DD771JO2H)
Language	English
Publishing date	2020-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	769028-9
ISSN	1873-5169 ; 0196-9781
ISSN (online)	1873-5169
ISSN	0196-9781
DOI	10.1016/j.peptides.2020.170311
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