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  1. Article ; Online: Is fenofibrate the missing piece in COVID-19 management?

    Mikhael, Ehab Mudher

    Alexandria Journal of Medicine

    2020  Volume 56, Issue 1, Page(s) 132–133

    Keywords covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2631785-0
    ISSN 2090-5068
    ISSN 2090-5068
    DOI 10.1080/20905068.2020.1785144
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Cost-Effectiveness Analysis of the Culturally Developed Diabetes Self-Management Education and Support Program among Type 2 Diabetes Mellitus Patients in Iraq.

    Mikhael, Ehab Mudher / Ong, Siew Chin / Hussain, Saad Abdulrahman

    Journal of pharmacy & bioallied sciences

    2023  Volume 15, Issue 1, Page(s) 49–56

    Abstract: Background: Diabetes mellitus (DM) is a chronic disease associated with a major economic burden on persons, health care systems, and countries. Diabetes self-management education and support (DSME(S)) programs are highly effective method in the ... ...

    Abstract Background: Diabetes mellitus (DM) is a chronic disease associated with a major economic burden on persons, health care systems, and countries. Diabetes self-management education and support (DSME(S)) programs are highly effective method in the management of T2DM patients. Therefore, this study aimed to determine the cost-effectiveness of the developed culturally-specific DSME(S) program regarding glycemic control, lipid profile, and body weight for Iraqi type 2 DM patients.
    Methods: A randomized controlled clinical trial design was used to assess the cost-effectiveness of the culturally-specific DSME(S) program from the perspective of health care providers. In the cost-effectiveness analysis (CEA), cost per patient and clinical outcomes over 6 months were compared between the intervention and control group. Incremental cost-effectiveness ratios (ICERs) were expressed as cost per unit improvement in glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high density lipoprotein- cholesterol (HDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), and body weight.
    Results: The effectiveness of most outcomes was better in the intervention group compared with the control group. The ICER per unit improvement in HbA1c, SBP, DBP, serum TC, and TG levels was <1 of the minimum CET compared with the control group, thus meeting the definition of being highly cost-effective.
    Conclusion: The currently developed DSME(S) was cost effective method to improve glycemic control, blood pressure, TC, and TG for T2DM patients in Iraq.
    Language English
    Publishing date 2023-04-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_767_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cost-Effectiveness analysis of the culturally developed diabetes self-management education and support program among type 2 diabetes mellitus patients in Iraq

    Ehab Mudher Mikhael / Siew Chin Ong / Saad Abdulrahman Hussain

    Journal of Pharmacy and Bioallied Sciences, Vol 15, Iss 1, Pp 49-

    2023  Volume 56

    Abstract: Background: Diabetes mellitus (DM) is a chronic disease associated with a major economic burden on persons, health care systems, and countries. Diabetes self-management education and support (DSME(S)) programs are highly effective method in the ... ...

    Abstract Background: Diabetes mellitus (DM) is a chronic disease associated with a major economic burden on persons, health care systems, and countries. Diabetes self-management education and support (DSME(S)) programs are highly effective method in the management of T2DM patients. Therefore, this study aimed to determine the cost-effectiveness of the developed culturally-specific DSME(S) program regarding glycemic control, lipid profile, and body weight for Iraqi type 2 DM patients. Methods: A randomized controlled clinical trial design was used to assess the cost-effectiveness of the culturally-specific DSME(S) program from the perspective of health care providers. In the cost-effectiveness analysis (CEA), cost per patient and clinical outcomes over 6 months were compared between the intervention and control group. Incremental cost-effectiveness ratios (ICERs) were expressed as cost per unit improvement in glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high density lipoprotein- cholesterol (HDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), and body weight. Results: The effectiveness of most outcomes was better in the intervention group compared with the control group. The ICER per unit improvement in HbA1c, SBP, DBP, serum TC, and TG levels was <1 of the minimum CET compared with the control group, thus meeting the definition of being highly cost-effective. Conclusion: The currently developed DSME(S) was cost effective method to improve glycemic control, blood pressure, TC, and TG for T2DM patients in Iraq.
    Keywords cost-effectiveness ; diabetes self-management education and support ; iraq ; type 2 diabetes mellitus ; Pharmacy and materia medica ; RS1-441 ; Analytical chemistry ; QD71-142
    Subject code 796
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Efficacy and Safety of Sitagliptin in the Treatment of COVID-19.

    Mikhael, Ehab Mudher / Ong, Siew Chin / Sheikh Ghadzi, Siti Maisharah

    Journal of pharmacy practice

    2022  Volume 36, Issue 4, Page(s) 980–987

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Sitagliptin Phosphate/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Diabetes Mellitus, Type 2/drug therapy ; COVID-19 ; Treatment Outcome
    Chemical Substances Sitagliptin Phosphate (TS63EW8X6F) ; Dipeptidyl-Peptidase IV Inhibitors
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/08971900221102119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effectiveness and Safety of Newer Antidiabetic Medications for Ramadan Fasting Diabetic Patients.

    Mudher Mikhael, Ehab

    Journal of diabetes research

    2016  Volume 2016, Page(s) 6962574

    Abstract: Hypoglycemia is the most common side effects for most glucose-lowering therapies. It constitutes a serious risk that faces diabetic patients who fast during Ramadan (the 9th month in the Islamic calendar). New glucose-lowering classes like dipeptidyl ... ...

    Abstract Hypoglycemia is the most common side effects for most glucose-lowering therapies. It constitutes a serious risk that faces diabetic patients who fast during Ramadan (the 9th month in the Islamic calendar). New glucose-lowering classes like dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 receptor agonist (GLP-1 RA), and sodium-glucose cotransporter-2 (SGLT-2) inhibitors are efficacious in controlling blood glucose level with less tendency to induce hypoglycemia and thus may constitute a good choice for diabetic patients during Ramadan. This study reviews the safety and efficacy of newer glucose-lowering therapies during Ramadan. This study was accomplished through a careful literature search about studies that assess the benefit and side effects of these new glucose-lowering therapies during Ramadan during September 2015. Vildagliptin, sitagliptin, liraglutide, exenatide, and dapagliflozin were the only studied glucose-lowering therapies. All of the studied newer glucose-lowering therapies except dapagliflozin were associated with reduced risk to induce hypoglycemia. Gastrointestinal upset was common with the usage of liraglutide while increased thirst sensation was common with dapagliflozin. In conclusion DPP-4 inhibitors such as vildagliptin and sitagliptin may form a suitable glucose-lowering therapy option for Ramadan fasting patients.
    MeSH term(s) Adamantane/adverse effects ; Adamantane/analogs & derivatives ; Adamantane/therapeutic use ; Benzhydryl Compounds/adverse effects ; Benzhydryl Compounds/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Exenatide ; Fasting ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucosides/adverse effects ; Glucosides/therapeutic use ; Holidays ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Islam ; Liraglutide/adverse effects ; Liraglutide/therapeutic use ; Nitriles/adverse effects ; Nitriles/therapeutic use ; Peptides/adverse effects ; Peptides/therapeutic use ; Pyrrolidines/adverse effects ; Pyrrolidines/therapeutic use ; Sitagliptin Phosphate/adverse effects ; Sitagliptin Phosphate/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors ; Venoms/adverse effects ; Venoms/therapeutic use ; Vildagliptin
    Chemical Substances Benzhydryl Compounds ; Dipeptidyl-Peptidase IV Inhibitors ; Glucagon-Like Peptide-1 Receptor ; Glucosides ; Hypoglycemic Agents ; Nitriles ; Peptides ; Pyrrolidines ; Sodium-Glucose Transporter 2 Inhibitors ; Venoms ; dapagliflozin (1ULL0QJ8UC) ; Liraglutide (839I73S42A) ; Exenatide (9P1872D4OL) ; Vildagliptin (I6B4B2U96P) ; Adamantane (PJY633525U) ; Sitagliptin Phosphate (TS63EW8X6F)
    Language English
    Publishing date 2016-08-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6745
    ISSN (online) 2314-6753
    ISSN 2314-6745
    DOI 10.1155/2016/6962574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Design and evaluation of a new mobile application to improve the management of minor ailments: a pilot study.

    Mikhael, Ehab Mudher / Al-Hamadani, Fadya Yaqoob / Hadi, Ali Mohammed

    BMC health services research

    2022  Volume 22, Issue 1, Page(s) 920

    Abstract: Background: Seeking pharmacist advice about minor ailments is a common practice among Iraqi patients because such advice is free and quick. Unfortunately, the assessment and management of minor ailments by Iraqi pharmacists were inappropriate. Therefore, ...

    Abstract Background: Seeking pharmacist advice about minor ailments is a common practice among Iraqi patients because such advice is free and quick. Unfortunately, the assessment and management of minor ailments by Iraqi pharmacists were inappropriate. Therefore, this study aimed to develop a model for a mobile application that can assist community pharmacists in the diagnosis and management of minor ailments.
    Methods: The scientific content of the application was based on the information in the symptoms in the pharmacy and British National Formulary books. The design and content of the application were approved by two experts. Thereafter, the application was built for Android mobiles using flutter technology and dart language. A pre-post pilot study was conducted to assess outcomes associated with use of the application, including user acceptance and appropriateness of clinical recommendations. Fifteen students from the College of Pharmacy/University of Baghdad who had an Android mobile participated in this study. Two different scenarios about diarrhea were used during the pilot study, in which the researcher acted as a patient (SP) and the participant student as a pharmacist.
    Results: After using the application, the number of questions asked by the participated student to the SP was significantly increased to about double. Additionally, providing the SP with appropriate non-pharmacological and pharmacological therapy along with optimum counseling and education were also significantly improved. All study participants agreed on the application's ease of use and ability to reduce diagnosis and medication errors.
    Conclusions: The implementation of the newly developed mobile application, diarrhea management step by step, was associated with improvements in assessment and recommended treatments for diarrhea cases with good acceptance by a pilot sample of pharmacy students at Baghdad University.
    MeSH term(s) Community Pharmacy Services ; Diarrhea ; Humans ; Mobile Applications ; Pharmacists/psychology ; Pilot Projects
    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-022-08292-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Validation of newly developed culturally specific diabetes self-management education and support program for Iraqi type 2 diabetes mellitus patients.

    Mikhael, Ehab Mudher / Hassali, Mohamed Azmi / Hussain, Saad Abdulrahman

    Journal of education and health promotion

    2021  Volume 10, Page(s) 357

    Abstract: Background: Diabetes self-management (DSM) is the cornerstone in diabetes mellitus (DM) management. Unfortunately, the practice of DSM by Iraqi type 2 DM (T2DM) patients is poor that mainly resulted from their poor knowledge about the required DSM ... ...

    Abstract Background: Diabetes self-management (DSM) is the cornerstone in diabetes mellitus (DM) management. Unfortunately, the practice of DSM by Iraqi type 2 DM (T2DM) patients is poor that mainly resulted from their poor knowledge about the required DSM behaviors. This lack of knowledge may be attributed to the lack of DSM education and support (DSMES) program in Iraq. Thus, this study was conducted with aim of developing and validating a culturally specific DSMES program for Iraqi T2DM patients.
    Materials and methods: The development and validation of the DSMES program was done according to the Hilda Taba model. Content validity of the program was done by a panel of 6 health-care experts in management of Iraqi DM patients. Face validity was confirmed by conducting a pilot study for six adults with uncontrolled T2DM at the National Diabetes Center, Baghdad, Iraq. Both the experts and patients were asked to evaluate the developed program in regard to its contents, design, and supporting material (booklet). The evaluation was done by filling in a questionnaire that based on a 5-point scale. Items with a score ≥4 by <70% of the experts and patients were subjected to revision and further assessment.
    Results: No total disagreement for any item was expressed by all participants (experts and patients). Content and face validity was ensured through obtaining a positive feedback from all participants at which all items about the program had scores of ≥4 by at least 75% of participants.
    Conclusion: The developed culturally based DSMES program is highly suitable for educating Iraqi T2DM patients.
    Language English
    Publishing date 2021-09-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_311_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Evaluating the reliability and accuracy of the promotional brochures for the generic pharmaceutical companies in Iraq using World Health Organization guidelines.

    Mikhael, Ehab Mudher

    Journal of pharmacy & bioallied sciences

    2015  Volume 7, Issue 1, Page(s) 65–68

    Abstract: Background: Pharmaceutical industries worldwide are heavily involved in aggressive drug promotions. Physician targeted promotion through medical representatives is one of the most common tactic for drug promotion by pharmaceutical drug companies. WHO ... ...

    Abstract Background: Pharmaceutical industries worldwide are heavily involved in aggressive drug promotions. Physician targeted promotion through medical representatives is one of the most common tactic for drug promotion by pharmaceutical drug companies. WHO states that medical representatives to work in an ethical way should make available to prescribers and dispensers complete and unbiased information for each product discussed; therefore this study aimed to evaluate the ethics in the medical brochures of generic pharmaceutical companies that are given through medical representatives to physicians in Iraq.
    Materials and methods: An observational, cross-sectional study was conducted in Iraq - Baghdad from February to April 2014. Promotional drug brochures were collected mainly from pharmaceutical exhibition during attendance of medical conferences that were sponsored by generic pharmaceutical companies. Evaluation of each brochure was based primarily on WHO criteria for ethical medicinal drug promotion. The availability of emotional pictures in each brochure was also examined. Furthermore, references were checked to find their retrievability, source, and authenticity of presentations.
    Results: Most medical brochures were for antibiotics, and drugs for cardiovascular diseases. All brochures mention drug name, with its active ingredient and indication, but there is a significant absence for drug interaction, while drug side effects and contraindications if present were written in a small font. Emotional picture presented in 70% of brochures. Reference citation was present in 72% of brochures, however only 75% of references in these brochures were correct.
    Conclusions: The information that is provided in medical brochures is biased and mainly persuasive since it is mainly focusing on the positive aspect of drug therapy.
    Language English
    Publishing date 2015-02-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/0975-7406.148781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Comparison Among Commonly Available Infant Formula Milks in the Iraqi Market.

    Mikhael, Ehab Mudher

    Global pediatric health

    2015  Volume 2, Page(s) 2333794X15608716

    Abstract: Breast-feeding is the best method of feeding infants. In some cases, formula milk can be a suitable alternative, so this study aimed to compare the safety and nutritional adequacy of commonly available formula milks in the Iraqi market. An observational ... ...

    Abstract Breast-feeding is the best method of feeding infants. In some cases, formula milk can be a suitable alternative, so this study aimed to compare the safety and nutritional adequacy of commonly available formula milks in the Iraqi market. An observational study for the commonly available formula milks was conducted in the largest supermarkets of Baghdad, Iraq, during January-March 2015. The macronutrient and micronutrient contents as presented in the label of each type of formula milk was compared with the standard requirement of formula milk according to the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines. Dielac formula milk is the commonest formula milk in the Iraqi market, with the lowest price when compared with other formula milks. All infant formula milks (Similac, Guigoz, and S-26 Gold) except Dielac have the mandatory contents within the specified ranges, according to the ESPGHAN guidelines. Dielac lacks more than 1 of the major mandatory contents besides lacking all optional contents in its formula. Guigoz formula milk lacks the optional ingredients arachidonic acid, docosahexaenoic acid, and nucleotides. Similac milk was supplemented with a higher-than-specified level of nucleotides, and its l-carnitine contents were not declared. Only S26 Gold formula milk contained all mandatory and optional ingredients within the specified range, according to the ESPGHAN guidelines. In conclusion, no formula milk can resemble breast milk; however, S26 Gold formula milk is the most acceptable formula, and Dielac formula milk is the worst. Therefore, it is recommended that Dielac be withdrawn from the Iraqi market.
    Language English
    Publishing date 2015-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785531-4
    ISSN 2333-794X ; 2333-794X
    ISSN (online) 2333-794X
    ISSN 2333-794X
    DOI 10.1177/2333794X15608716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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