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  1. Article: Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against

    Zhu, Shixing / Yue, Jiali / Wang, Xintong / Zhang, Jiayuan / Yu, Mingming / Zhan, Yuanchao / Zhu, Yuanqi / Sy, Sherwin K B / Lv, Zhihua

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1217270

    Abstract: ... applied to investigate the synergistic effects of polymyxin-B, amikacin and sulbactam combination therapy ... amino acids and peptides as early as 15 min after administration. Amikacin and polymyxin-B alone perturbed ... of metabolites beyond 4 h. Compared to the double-combination, the addition of sulbactam to polymyxin-B/amikacin ...

    Abstract Introduction: The emergence of multidrug-resistant (MDR)
    Methods: Metabolomic analysis was applied to investigate the synergistic effects of polymyxin-B, amikacin and sulbactam combination therapy against MDR
    Results: The triple antibiotic combination significantly disrupted levels of metabolites involved in cell outer membrane structure including fatty acids, glycerophospholipids, nucleotides, amino acids and peptides as early as 15 min after administration. Amikacin and polymyxin-B alone perturbed a large number of metabolites at 15 min and 1 h, respectively, but the changes in metabolites were short-lived lasting for less than 4 h. In contrast, the combination treatment disrupted a large amount of metabolites beyond 4 h. Compared to the double-combination, the addition of sulbactam to polymyxin-B/amikacin combination produce a greater disorder in
    Conclusion: The metabolomic analysis identified mechanisms responsible for the synergistic activities of polymyxin-B/amikacin/sulbactam against MDR
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1217270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The combination effect of meropenem/sulbactam/polymyxin-B on the pharmacodynamic parameters for mutant selection windows against carbapenem-resistant

    Zhang, Jiayuan / Diao, Shuo / Liu, Yanfei / Wang, Hongxiang / Liu, Yuwei / Zhu, Shixing / Feng, Kun / Tang, Xiaoqian / Oo, Charles / Zhu, Peijuan / Lv, Zhihua / Yu, Mingming / Sy, Sherwin K B / Zhu, Yuanqi

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1024702

    Abstract: ... polymyxin-B could reduce or close the gap of mutant selection window (MSW) of individual antibiotics against ...

    Abstract The objective of this study was to evaluate whether combinations of sulbactam, meropenem, and polymyxin-B could reduce or close the gap of mutant selection window (MSW) of individual antibiotics against
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1024702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Metabolomic profiling of polymyxin-B in combination with meropenem and sulbactam against multi-drug resistant

    Zhu, Shixing / Zhang, Jiayuan / Song, Chu / Liu, Yuwei / Oo, Charles / Heinrichs, M Tobias / Lv, Zhihua / Zhu, Yuanqi / Sy, Sherwin K B / Deng, Pan / Yu, Mingming

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1013934

    Abstract: Empirical therapies using polymyxins combined with other antibiotics are recommended in the treatment ... ...

    Abstract Empirical therapies using polymyxins combined with other antibiotics are recommended in the treatment of
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1013934
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  4. Article: Effects of amikacin, polymyxin-B, and sulbactam combination on the pharmacodynamic indices of mutant selection against multi-drug resistant

    Zhu, Shixing / Song, Chu / Zhang, Jiayuan / Diao, Shuo / Heinrichs, Tobias M / Martins, Frederico S / Lv, Zhihua / Zhu, Yuanqi / Yu, Mingming / Sy, Sherwin K B

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1013939

    Abstract: Amikacin and polymyxins as monotherapies are ineffective against multidrug- ... ...

    Abstract Amikacin and polymyxins as monotherapies are ineffective against multidrug-resistant
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1013939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Internal Delensing of Cosmic Microwave Background Polarization B-Modes with the POLARBEAR Experiment.

    Adachi, S / Aguilar Faúndez, M A O / Akiba, Y / Ali, A / Arnold, K / Baccigalupi, C / Barron, D / Beck, D / Bianchini, F / Borrill, J / Carron, J / Cheung, K / Chinone, Y / Crowley, K / El Bouhargani, H / Elleflot, T / Errard, J / Fabbian, G / Feng, C /
    Fujino, T / Goeckner-Wald, N / Hasegawa, M / Hazumi, M / Hill, C A / Howe, L / Katayama, N / Keating, B / Kikuchi, S / Kusaka, A / Lee, A T / Leon, D / Linder, E / Lowry, L N / Matsuda, F / Matsumura, T / Minami, Y / Namikawa, T / Navaroli, M / Nishino, H / Peloton, J / Pham, A T P / Poletti, D / Puglisi, G / Reichardt, C L / Segawa, Y / Sherwin, B D / Silva-Feaver, M / Siritanasak, P / Stompor, R / Tajima, O / Takatori, S / Tanabe, D / Teply, G P / Vergès, C

    Physical review letters

    2020  Volume 124, Issue 13, Page(s) 131301

    Abstract: ... B-mode polarization delensing on subdegree scales at more than 5σ significance. We achieve a 14% B ... paving the way for the optimal analysis of next-generation primordial B-mode experiments. ...

    Abstract Using only cosmic microwave background polarization data from the polarbear experiment, we measure B-mode polarization delensing on subdegree scales at more than 5σ significance. We achieve a 14% B-mode power variance reduction, the highest to date for internal delensing, and improve this result to 22% by applying for the first time an iterative maximum a posteriori delensing method. Our analysis demonstrates the capability of internal delensing as a means of improving constraints on inflationary models, paving the way for the optimal analysis of next-generation primordial B-mode experiments.
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.124.131301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: New Probe of Inflationary Gravitational Waves: Cross-Correlations of Lensed Primary CMB B-Modes with Large-Scale Structure.

    Namikawa, Toshiya / Sherwin, Blake D

    Physical review letters

    2023  Volume 131, Issue 13, Page(s) 131001

    Abstract: ... of the lensing of inflationary B-mode polarization with a large-scale structure (LSS) tracer, which can also be ... of two CMB B-modes and an LSS tracer. We forecast expected 1σ constraints on the tensor-to-scalar ratio r ... B-mode lensing and LSST galaxies, σ_{r}≃5×10^{-3} from the correlation of CMB-S4-Deep B-mode lensing ...

    Abstract We propose a new probe of inflationary gravitational waves (IGWs): the cross-correlation of the lensing of inflationary B-mode polarization with a large-scale structure (LSS) tracer, which can also be a cosmic microwave background (CMB) lensing map. This is equivalent to measuring a three-point function of two CMB B-modes and an LSS tracer. We forecast expected 1σ constraints on the tensor-to-scalar ratio r, albeit with a simplistic foreground treatment, and find constraints of σ_{r}≃7×10^{-3} from the correlation of CMB-S4-Deep B-mode lensing and LSST galaxies, σ_{r}≃5×10^{-3} from the correlation of CMB-S4-Deep B-mode lensing and CMB-S4-Deep CMB lensing, and σ_{r}≃10^{-2} from the correlation of LiteBIRD B-mode lensing and CMB-S4-Wide lensing. Because this probe is inherently non-Gaussian, simple Gaussian foregrounds will not produce any biases to the measurement of r. While a detailed investigation of non-Gaussian foreground contamination for different cross-correlations will be essential, this observable has the potential to be a useful probe of IGWs, which, due to different sensitivity to many potential sources of systematic errors, can be complementary to standard methods for constraining r.
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.131001
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  7. Article ; Online: Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy.

    Fedrigo, Nayara Helisandra / Shinohara, Danielle Rosani / Mazucheli, Josmar / Nishiyama, Sheila Alexandra Belini / Carrara-Marroni, Floristher Elaine / Martins, Frederico Severino / Zhu, Peijuan / Yu, Mingming / Sy, Sherwin Kenneth B / Tognim, Maria Cristina Bronharo

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 11339

    Abstract: ... of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B alone and ... associated with resistance to polymyxin B administrated regimens as monotherapy and combination therapy ...

    Abstract The emergence of polymyxin resistance in Gram-negative bacteria infections has motivated the use of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B alone and in combination with meropenem and fosfomycin against A. baumannii strains belonging to clonal lineages I and III. To evaluate the inhibition of in vitro drug resistance, we investigate the MSW-derived pharmacodynamic indices associated with resistance to polymyxin B administrated regimens as monotherapy and combination therapy, such as the percentage of each dosage interval that free plasma concentration was within the MSW (%T
    MeSH term(s) Acinetobacter Infections/drug therapy ; Acinetobacter baumannii/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Humans ; Microbial Sensitivity Tests ; Polymyxin B/pharmacology ; Polymyxin B/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Polymyxin B (J2VZ07J96K)
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-90709-2
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  8. Article ; Online: Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy

    Nayara Helisandra Fedrigo / Danielle Rosani Shinohara / Josmar Mazucheli / Sheila Alexandra Belini Nishiyama / Floristher Elaine Carrara-Marroni / Frederico Severino Martins / Peijuan Zhu / Mingming Yu / Sherwin Kenneth B. Sy / Maria Cristina Bronharo Tognim

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 12

    Abstract: ... the use of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B ... pharmacodynamic indices associated with resistance to polymyxin B administrated regimens as monotherapy and ... the mutant prevention concentration (%T>MPC). The MSW of polymyxin B varied between 1 and 16 µg/mL ...

    Abstract Abstract The emergence of polymyxin resistance in Gram-negative bacteria infections has motivated the use of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B alone and in combination with meropenem and fosfomycin against A. baumannii strains belonging to clonal lineages I and III. To evaluate the inhibition of in vitro drug resistance, we investigate the MSW-derived pharmacodynamic indices associated with resistance to polymyxin B administrated regimens as monotherapy and combination therapy, such as the percentage of each dosage interval that free plasma concentration was within the MSW (%TMSW) and the percentage of each dosage interval that free plasma concentration exceeded the mutant prevention concentration (%T>MPC). The MSW of polymyxin B varied between 1 and 16 µg/mL for polymyxin B-susceptible strains. The triple combination of polymyxin B with meropenem and fosfomycin inhibited the polymyxin B-resistant subpopulation in meropenem-resistant isolates and polymyxin B plus meropenem as a double combination sufficiently inhibited meropenem-intermediate, and susceptible strains. T>MPC 90% was reached for polymyxin B in these combinations, while %TMSW was 0 against all strains. TMSW for meropenem and fosfomycin were also reduced. Effective antimicrobial combinations significantly reduced MSW. The MSW-derived pharmacodynamic indices can be used for the selection of effective combination regimen to combat the polymyxin B-resistant strain.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Pharmacodynamic Effects of Sulbactam/Meropenem/Polymyxin-B Combination Against Extremely Drug Resistant

    Menegucci, Thatiany Cevallos / Fedrigo, Nayara Helisandra / Lodi, Fernanda Gomes / Albiero, James / Nishiyama, Sheila Alexandra Belini / Mazucheli, Josmar / Carrara-Marroni, Floristher Elaine / Voelkner, Nivea Maria Falcão / Gong, Hui / Sy, Sherwin K B / Tognim, Maria Cristina Bronharo

    Microbial drug resistance (Larchmont, N.Y.)

    2019  Volume 25, Issue 9, Page(s) 1266–1274

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Acinetobacter Infections/drug therapy ; Acinetobacter Infections/microbiology ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/isolation & purification ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Area Under Curve ; Dose-Response Relationship, Drug ; Drug Combinations ; Drug Resistance, Multiple, Bacterial ; Drug Synergism ; Humans ; Meropenem/administration & dosage ; Meropenem/pharmacokinetics ; Meropenem/pharmacology ; Microbial Sensitivity Tests ; Polymyxin B/administration & dosage ; Polymyxin B/pharmacokinetics ; Polymyxin B/pharmacology ; Sulbactam/administration & dosage ; Sulbactam/pharmacokinetics ; Sulbactam/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Drug Combinations ; Meropenem (FV9J3JU8B1) ; Polymyxin B (J2VZ07J96K) ; Sulbactam (S4TF6I2330)
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1290490-9
    ISSN 1931-8448 ; 1076-6294
    ISSN (online) 1931-8448
    ISSN 1076-6294
    DOI 10.1089/mdr.2018.0283
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    Zs.A 4435: Show issues Location:
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  10. Article ; Online: Type B Aortic Arch Interruption in an Adult.

    Abdoli, Sherwin / Tatum, James M / Fratello, Ashley L / Bowdish, Michael E / Baker, Craig J

    The Annals of thoracic surgery

    2016  Volume 102, Issue 5, Page(s) e431–e432

    Abstract: The presentation and treatment of a patient with a type B interrupted aortic arch with an isolated ...

    Abstract The presentation and treatment of a patient with a type B interrupted aortic arch with an isolated left subclavian artery is described.
    MeSH term(s) Adult ; Aorta, Thoracic/abnormalities ; Aorta, Thoracic/diagnostic imaging ; Computed Tomography Angiography ; Humans ; Male ; Vascular Malformations/diagnosis ; Vascular Malformations/surgery ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2016-11
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2016.04.040
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