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  1. Book ; Online: Report of the WHO collaborative study to establish a new international standard and three new international reference preparations for the MAPREC test of poliovirus type 1 (Sabin) / by Glynis Dunn, Jackie O'Brien, Alan Heath and Konstantin Chumakov

    Dunn, Glynis / O'Brien, Jackie / Heath, Alan / Chumakov, Konstantin / World Health Organization. Biologicals Unit / WHO Expert Committee on Biological Standardization (2009 : Geneva, Switzerland)

    2009  

    Abstract: WHO/BS/09.2103 ... 47 p. ... English ... ...

    Abstract WHO/BS/09.2103

    47 p.

    English only
    Keywords Pharmaceuticals and Biologicals
    Language English
    Publisher Geneva : World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Choosing the Right Path toward Polio Eradication. Reply.

    Chumakov, Konstantin / Plotkin, Stanley

    The New England journal of medicine

    2023  Volume 388, Issue 19, Page(s) 1824

    MeSH term(s) Humans ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control ; Vaccination
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2303169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Polio eradication efforts: Above all, do no harm.

    Plotkin, Stanley A / Chumakov, Konstantin

    Science (New York, N.Y.)

    2023  Volume 382, Issue 6672, Page(s) 778

    MeSH term(s) Humans ; Disease Eradication ; Global Health ; Immunization Programs ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adl2371
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  4. Article ; Online: Antigenic diversity of type 1 polioviruses and its implications for the efficacy of polio vaccines.

    Kouiavskaia, Diana / Mirochnitchenko, Olga / Troy, Stephanie / Chumakov, Konstantin

    Vaccine

    2023  Volume 41, Issue 13, Page(s) 2147–2154

    Abstract: Inactivated Polio Vaccines (IPV) and live Oral Polio Vaccine (OPV) were introduced in the mid-20th century, and their coordinated worldwide use led to almost complete elimination of the disease, with only one serotype of poliovirus remaining endemic in ... ...

    Abstract Inactivated Polio Vaccines (IPV) and live Oral Polio Vaccine (OPV) were introduced in the mid-20th century, and their coordinated worldwide use led to almost complete elimination of the disease, with only one serotype of poliovirus remaining endemic in just two countries. Polio eradication will lead to discontinuation of OPV use and its replacement with IPV or other vaccines that are currently under development that will need to be tested in clinical trials. Despite decades of research, questions remain about the serological correlates of polio vaccine efficacy, specifically whether the vaccines are equally protective against immunologically different strains of the same serotype. The absence of significant morbidity does not allow use of a protection endpoint in clinical trials, so the answer could be obtained only by using surrogate markers such as immunogenicity. In this study, a panel of wild and vaccine-derived polioviruses of serotype 1 were tested in neutralization assays with sera from vaccine-immunized individuals. The results demonstrated that there was a significant difference in titers of neutralizing antibodies in human sera when measured against different strains. When measured with a homologous strain used for vaccine manufacture all subjects had detectable levels of antibodies, while neutralization tests with some heterologous strains failed to detect neutralizing antibodies in a number of subjects. Administration of a booster dose of IPV led to a significant increase in neutralizing titers against all strains. Results of the experiments using animal sera, performed to obtain more information on protectivity of neutralizing antibodies against heterologous strains, were consistent with the results obtained in the assays using human sera. These results are discussed in the context of serological biomarkers of protection against poliomyelitis, suggesting that potency of vaccines made from serologically different strains should be determined against both homologous and heterologous challenge viruses.
    MeSH term(s) Animals ; Humans ; Poliovirus ; Poliovirus Vaccine, Oral ; Poliomyelitis ; Poliovirus Vaccine, Inactivated ; Antibodies, Neutralizing ; Antigenic Variation
    Chemical Substances Poliovirus Vaccine, Oral ; Poliovirus Vaccine, Inactivated ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-02-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.01.031
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  5. Article ; Online: Choosing the Right Path toward Polio Eradication.

    Chumakov, Konstantin / Brechot, Christian / Gallo, Robert C / Plotkin, Stanley

    The New England journal of medicine

    2023  Volume 388, Issue 7, Page(s) 577–579

    MeSH term(s) Humans ; Disease Eradication/methods ; Global Health ; Immunization Programs ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control ; Vaccination
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2215257
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  6. Article ; Online: Editorial: Fighting fire with fire: Using non-pathogenic viruses to control unrelated infections.

    Bakacs, Tibor / Chumakov, Konstantin / Safadi, Rifaat / Kovesdi, Imre

    Frontiers in immunology

    2022  Volume 13, Page(s) 1046851

    MeSH term(s) RNA, Double-Stranded ; RNA, Viral ; Viruses
    Chemical Substances RNA, Double-Stranded ; RNA, Viral
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1046851
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  7. Article ; Online: Sabin Strain Inactivated Polio Vaccine for the Polio Endgame.

    Modlin, John F / Chumakov, Konstantin

    The Journal of infectious diseases

    2019  Volume 221, Issue 4, Page(s) 504–505

    MeSH term(s) Humans ; Poliomyelitis ; Poliovirus/immunology ; Poliovirus Vaccine, Inactivated ; Vaccine Potency
    Chemical Substances Poliovirus Vaccine, Inactivated
    Language English
    Publishing date 2019-02-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiz077
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  8. Article ; Online: Methods to Monitor Molecular Consistency of Oral Polio Vaccine.

    Chumakov, Konstantin M

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1387, Page(s) 263–277

    Abstract: Replication of viruses leads to emergence of mutations and their content in viral populations can increase by selection depending on growth conditions. Some of these mutations have deleterious effect on vaccine safety, such as neurovirulent reversions in ...

    Abstract Replication of viruses leads to emergence of mutations and their content in viral populations can increase by selection depending on growth conditions. Some of these mutations have deleterious effect on vaccine safety, such as neurovirulent reversions in the 5'-UTR of attenuated Sabin strains of poliovirus. Their content in vaccine batches must be tightly controlled during vaccine manufacture to ensure safety of the product. This chapter describes a quantitative molecular procedure called mutant analysis by PCR and restriction enzyme cleavage (MAPREC) that is used to monitor content of neurovirulent revertants in Oral Polio Vaccine (OPV). The method can be used for quantitative analysis of any other mutation in a viral population.
    MeSH term(s) Base Sequence ; Genome, Viral ; Humans ; Mutation ; Poliomyelitis/prevention & control ; Poliomyelitis/virology ; Poliovirus/genetics ; Poliovirus/pathogenicity ; Poliovirus Vaccine, Oral/adverse effects ; Poliovirus Vaccine, Oral/genetics ; Polymerase Chain Reaction/methods ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; Restriction Mapping/methods
    Chemical Substances Poliovirus Vaccine, Oral ; RNA, Viral
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3292-4_14
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  9. Article: Improvement of the qmosRT-PCR Assay and Its Application for the Detection and Quantitation of the Three Serotypes of the Novel Oral Polio Vaccine in Stool Samples.

    Manukyan, Hasmik / Tritama, Erman / Wahid, Rahnuma / Anstadt, Jennifer / Konz, John / Chumakov, Konstantin / Laassri, Majid

    Vaccines

    2023  Volume 11, Issue 11

    Abstract: Recently, genetically stable novel OPVs (nOPV) were developed by modifying the genomes of Sabin viruses of conventional OPVs to reduce the risk of reversion to neurovirulence and therefore the risk of generating circulating vaccine-derived polioviruses. ... ...

    Abstract Recently, genetically stable novel OPVs (nOPV) were developed by modifying the genomes of Sabin viruses of conventional OPVs to reduce the risk of reversion to neurovirulence and therefore the risk of generating circulating vaccine-derived polioviruses. There is a need for specific and sensitive methods for the identification and quantification of nOPV viruses individually and in mixtures for clinical trials and potentially for manufacturing quality control and environmental surveillance. In this communication, we evaluated and improved the quantitative multiplex one-step reverse transcriptase polymerase chain reaction (qmosRT-PCR) assay for the identification and quantification of nOPV viruses in samples with different formulations and virus concentrations and in virus-spiked stool samples. The assay was able to specifically identify at least 1 log
    Language English
    Publishing date 2023-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11111729
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  10. Article ; Online: Tunable Sieving of Ions Using Graphene Oxide: Swelling Peculiarities in Free-Standing and Confined States.

    Eliseev, Andrei A / Gurianov, Konstantin E / Poyarkov, Andrei A / Komkova, Maria A / Sadilov, Ilia S / Chumakov, Andrei P / Petukhov, Dmitrii I

    Nano letters

    2023  Volume 23, Issue 21, Page(s) 9719–9725

    Abstract: The paper describes a comparative study of swelling processes in free-standing graphene oxide (GO) membranes and GO laminates encapsulated with epoxy glue. For free-standing graphene oxide membranes, a huge variation ... ...

    Abstract The paper describes a comparative study of swelling processes in free-standing graphene oxide (GO) membranes and GO laminates encapsulated with epoxy glue. For free-standing graphene oxide membranes, a huge variation in
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c02247
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