Article ; Online: Influence of forkhead box protein 3 gene polymorphisms in recurrent pregnancy loss: A meta-analysis.
2024 Volume 146, Page(s) 79–88
Abstract: Background: Treg cells play an important role in development of tolerance in maternal immune system against the semi-allogenic embryo. Human forkhead box protein 3 (FOXP3) gene, is the major transcription factor responsible for the regulation of Treg ... ...
| Abstract | Background: Treg cells play an important role in development of tolerance in maternal immune system against the semi-allogenic embryo. Human forkhead box protein 3 (FOXP3) gene, is the major transcription factor responsible for the regulation of Treg function during pregnancy. Single nucleotide polymorphisms (SNPs) of FOXP3 gene have been reported as a risk factor for Recurrent Pregnancy Loss (RPL), however, results from previous studies are inconsistent. Methodology: We have collected data from different studies to investigate the overall association of FOXP3 SNPs with risk of RPL. PubMed, Google Scholar, Elsevier, and Cochrane databases were searched to identify eligible studies. Odds Ratio (OR) and 95 % Confidence Interval (CI), calculated via fixed effect or random effect models, were used to evaluate strength of association. This meta-analysis included 11 studies (1383 RPL cases and 1413 controls) of 6 SNPs: rs3761548 A/C, rs2232365 A/G, rs2294021 T/C, 2280883 T/C, rs5902434del/ATT and rs141704699C/T, with ≥2 studies per SNPs and at least 1 significant result. Results: We observed that FOXP3 polymorphism was predominantly present in Asian women with history of RPL. rs2232365 A/G, rs3761548 A/C, rs2294021 T/C, rs2280883 T/C and rs5902434del/ATT polymorphisms were significantly associated with risk of RPL in Indian population. Further, among the most commonly seen polymorphism, rs3761548 A/C was significantly associated with risk of RPL in women from Kazakhstan, China and Gaza, Palestine; rs2232365 A/G in populations of Kazakhstan, Egypt, Iran and Gaza, Palestine. Results of this study indicates that FOXP3 polymorphism is significantly associated with risk of RPL, especially in Asians. |
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| MeSH term(s) | Female ; Humans ; Pregnancy ; Abortion, Habitual/ethnology ; Abortion, Habitual/genetics ; Asian People/ethnology ; Asian People/genetics ; Case-Control Studies ; Forkhead Transcription Factors/genetics ; Genetic Predisposition to Disease ; Genotype ; Polymorphism, Single Nucleotide/genetics ; Middle Eastern and North Africans/genetics |
| Chemical Substances | Forkhead Transcription Factors ; FOXP3 protein, human |
| Language | English |
| Publishing date | 2024-01-04 |
| Publishing country | Netherlands |
| Document type | Meta-Analysis ; Journal Article |
| ZDB-ID | 603951-0 |
| ISSN | 1532-3102 ; 0143-4004 |
| ISSN (online) | 1532-3102 |
| ISSN | 0143-4004 |
| DOI | 10.1016/j.placenta.2024.01.003 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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