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  1. Article ; Online: Can molecular mimicry explain the cytokine storm of SARS-CoV-2?: An in silico approach.

    Obando-Pereda, Gustavo

    Journal of medical virology

    2021  Volume 93, Issue 9, Page(s) 5350–5357

    Abstract: PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena ... ...

    Abstract PARP14 and PARP9 play a key role in macrophage immune regulation. SARS-CoV-2 is an emerging viral disease that triggers hyper-inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS-CoV-2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS-CoV-2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper-inflammatory state in SARS-CoV-2 patients.
    MeSH term(s) Amino Acid Sequence ; Binding Sites ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Computer Simulation ; Consensus Sequence ; Coronavirus Papain-Like Proteases/chemistry ; Coronavirus Papain-Like Proteases/genetics ; Coronavirus Papain-Like Proteases/immunology ; Cytokine Release Syndrome/genetics ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/pathology ; Cytokine Release Syndrome/virology ; Epitopes/chemistry ; Epitopes/genetics ; Epitopes/immunology ; Gene Expression ; Histocompatibility Antigens Class I/chemistry ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/chemistry ; Histocompatibility Antigens Class II/genetics ; Histocompatibility Antigens Class II/immunology ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Macrophages/immunology ; Macrophages/virology ; Molecular Docking Simulation ; Molecular Mimicry ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Neoplasm Proteins/immunology ; Poly(ADP-ribose) Polymerases/chemistry ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/immunology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Sequence Alignment ; Sequence Homology, Amino Acid ; Thermodynamics
    Chemical Substances Epitopes ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; Neoplasm Proteins ; PARP9 protein, human ; PARP14 protein, human (EC 2.4.2.30) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Coronavirus Papain-Like Proteases (EC 3.4.22.2) ; papain-like protease, SARS-CoV-2 (EC 3.4.22.2)
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between

    Obando-Pereda, Gustavo Alberto

    Autoimmune diseases

    2016  Volume 2016, Page(s) 5472320

    Abstract: Periodontal disease afflicts 20% of world population. This process usually occurs in the form of being lethargic and chronic, and consequently this disease is known as chronic process. All chronic diseases constantly cause activation of the immune system, ...

    Abstract Periodontal disease afflicts 20% of world population. This process usually occurs in the form of being lethargic and chronic, and consequently this disease is known as chronic process. All chronic diseases constantly cause activation of the immune system, and therefore the presentation of microbial peptides which are presented to lymphocytes by professional antigen presenting cells can present microbial peptides very similar to important structures of human economy causing autoimmune diseases, process known as molecular mimicry. Thus, the aim of this study was to verify the presence of molecular mimicry phenomenon between periodontopathogens and human proteins. Blasting microbes of Socransky periodontal complexes against human collagen were performed and then the proteins with similarities were modelled and were screened in the MHI binding virtual methods. The epitopes selected were produced and plasma of chronic periodontal volunteers was obtained and a dot immunobinding assay was performed. Hypothetical protein of
    Language English
    Publishing date 2016-12-25
    Publishing country United States
    Document type Journal Article
    ISSN 2090-0422
    ISSN 2090-0422
    DOI 10.1155/2016/5472320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen

    Gustavo Alberto Obando-Pereda

    Autoimmune Diseases, Vol

    Evidence of Molecular Mimicry in Chronic Periodontitis

    2016  Volume 2016

    Abstract: Periodontal disease afflicts 20% of world population. This process usually occurs in the form of being lethargic and chronic, and consequently this disease is known as chronic process. All chronic diseases constantly cause activation of the immune system, ...

    Abstract Periodontal disease afflicts 20% of world population. This process usually occurs in the form of being lethargic and chronic, and consequently this disease is known as chronic process. All chronic diseases constantly cause activation of the immune system, and therefore the presentation of microbial peptides which are presented to lymphocytes by professional antigen presenting cells can present microbial peptides very similar to important structures of human economy causing autoimmune diseases, process known as molecular mimicry. Thus, the aim of this study was to verify the presence of molecular mimicry phenomenon between periodontopathogens and human proteins. Blasting microbes of Socransky periodontal complexes against human collagen were performed and then the proteins with similarities were modelled and were screened in the MHI binding virtual methods. The epitopes selected were produced and plasma of chronic periodontal volunteers was obtained and a dot immunobinding assay was performed. Hypothetical protein of Prevotella sp. and human collagen epitopes with high similarities were positive for dot immunobinding assay. With this result it can be suggested that the mimicry phenomena can occur on periodontal disease.
    Keywords Internal medicine ; RC31-1245 ; Immunologic diseases. Allergy ; RC581-607
    Subject code 610
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Comparison between Obando´s anthropometric formula and Mondelli´s formula to estimate central incisor width.

    Sara Rodríguez-Alayza / Gustavo Obando-Pereda

    Journal of Oral Research, Vol 5, Iss 3, Pp 114-

    2016  Volume 118

    Abstract: Objective: to compare Mondelli’s formula with Obando’s anthropometric formula in order to determine ... Inter-alar distance and longitudinal axis of the ear were used for Obando’s formula. Correlations and ... estimated. Results: Obando’s formula presented a strong correlation (r=0.8846) with the mesiodistal width ...

    Abstract Objective: to compare Mondelli’s formula with Obando’s anthropometric formula in order to determine the mesiodistal width of maxillary central incisor. Materials and Methods: 100 adults (50 women) were selected. The mesiodistal width of maxillary central incisor was measured. Maximum smile was used for Mondelli’s formula. Inter-alar distance and longitudinal axis of the ear were used for Obando’s formula. Correlations and differences between estimates of both formulas and the actual mesiodistal width of the central incisor were estimated. Results: Obando’s formula presented a strong correlation (r=0.8846) with the mesiodistal width, with no statistically significant differences between the two measures (p>0.05). Mondelli’s formula presented a moderate negative correlation with the mesiodistal width (r=-0.3401) and a statistically significant difference with respect to the mesiodistal width (p<0.0001), in both men and women. Conclusion: Obando’s formula estimated more accurately the mesiodistal width of the central incisor in comparison to Mondelli’s formula in the Peruvian population.
    Keywords Dental aesthetics ; Incisor ; Anthropometry ; Medicine ; R ; Dentistry ; RK1-715
    Subject code 511
    Language English
    Publishing date 2016-05-01T00:00:00Z
    Publisher Universidad de Concepción.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Estudio de las propiedades antimicrobianas de la Camellia sinensis en un modelo microbiano oral

    Alberto Figueroa Banda / Marco Figueroa Banda / Fernando Torres Vela / Gustavo Obando-Pereda

    Odontología, Vol 19, Iss

    2018  Volume 1

    Abstract: Objetivo: Determinar el efecto antibacteriano in vitro del extracto de Camellia Sinensis (té verde) sobre un modelo de microflora oral. Materiales y métodos: Fueron utilizados dos extractos etanólicos de té verde de diferente procedencia (Perú y China), ... ...

    Abstract Objetivo: Determinar el efecto antibacteriano in vitro del extracto de Camellia Sinensis (té verde) sobre un modelo de microflora oral. Materiales y métodos: Fueron utilizados dos extractos etanólicos de té verde de diferente procedencia (Perú y China), en concentraciones de 16, 8, 4, 2, 1, 0.5 y 0.25mg/ml. Se evaluaron la concentración mínima y máxima inhibitoria sobre cepas de S. mutans, S. mitis, C. albicans, C. tropicalis, S. aureus, F. nucleatum, L. rhamnosus, L. casei, C. glabrata y E. faecalis. Los datos obtenidos fueron analizados estadísticamente utilizando la prueba estadística Kruskal Wallis con un nivel de significancia de 5%. Resultados: La C. sinensis mostró un efecto bacteriostático para las cepas de S. mutans, y fungiestático para C. albicans, C. tropicalis y C. glabrata. (p<0.05). Conclusión: El extracto etanólico de 16mg/ml de Camellia Sinensis presenta efecto inhibitorio sobre cepas de S. mutans, C. albicans, C. tropicalis y C. glabrata.
    Keywords Phytotherapy ; Streptococcus mutans ; Candida Albicans ; Medicine ; R ; Dentistry ; RK1-715
    Language Spanish
    Publishing date 2018-10-01T00:00:00Z
    Publisher Universidad Central del Ecuador
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Sexual dimorphism on cytokines expression in the temporomandibular joint: the role of gonadal steroid hormones.

    Torres-Chávez, Karla E / Fischer, Luana / Teixeira, Juliana Maia / Fávaro-Moreira, Nadia Cristina / Obando-Pereda, Gustavo Alberto / Parada, Carlos Amílcar / Tambeli, Claudia Herrera

    Inflammation

    2010  Volume 34, Issue 5, Page(s) 487–498

    Abstract: Temporomandibular joint pain-related conditions are generally characterized by local inflammation; however, little studies have focused on the role of gonadal hormones in the expression of inflammatory mediators, such as cytokines. Therefore, we asked ... ...

    Abstract Temporomandibular joint pain-related conditions are generally characterized by local inflammation; however, little studies have focused on the role of gonadal hormones in the expression of inflammatory mediators, such as cytokines. Therefore, we asked whether gonadal steroid hormones affect formalin-induced cytokines expression in the rat temporomcandibular joint. The expression of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, and cytokine-induced neutrophil chemoattractant (CINC)-1 was significantly higher in males than in diestrus and proestrus females and was decreased by orchiectomy and restored by testosterone replacement. The expression of IL-6 was significantly higher in diestrus and proestrus females than in males, and was decreased by ovariectomy and restored by estradiol or progesterone administration. We conclude that testosterone increases the expression of TNF-α, IL-1β and CINC-1, and estradiol and progesterone increase the expression of IL-6. New clinical approaches based on inhibition of pro-inflammatory mediators are starting to supplant traditional immunosuppressive therapies and gonadal hormones may influence their effectiveness or clinical dosage.
    MeSH term(s) Animals ; Chemokine CXCL1/metabolism ; Cytokines/metabolism ; Estradiol/pharmacology ; Female ; Gonadal Steroid Hormones/metabolism ; Inflammation Mediators/metabolism ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Male ; Orchiectomy ; Ovariectomy ; Pain Measurement ; Progesterone/pharmacology ; Rats ; Sex Characteristics ; Temporomandibular Joint/drug effects ; Temporomandibular Joint/metabolism ; Temporomandibular Joint Disorders/chemically induced ; Temporomandibular Joint Disorders/metabolism ; Testosterone/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Chemokine CXCL1 ; Cxcl1 protein, rat ; Cytokines ; Gonadal Steroid Hormones ; Inflammation Mediators ; Interleukin-1beta ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Testosterone (3XMK78S47O) ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2010-09-24
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-010-9256-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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