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Article ; Online: Yellow Fever Virus Maintained by

de Oliveira, Cirilo H / Andrade, Miguel S / Campos, Fabrício S / da C Cardoso, Jader / Gonçalves-Dos-Santos, Maria Eduarda / Oliveira, Ramon Silva / Aquino-Teixeira, Sandy Micaele / Campos, Aline As / Almeida, Marco Ab / Simonini-Teixeira, Danilo / da P Sevá, Anaiá / Temponi, Andrea Oliveira Dias / Magalhães, Fernando Maria / da Silva Menezes, Agna Soares / Lopes, Bartolomeu Teixeira / Almeida, Hermes P / Pedroso, Ana Lúcia / Gonçalves, Giovani Pontel / Chaves, Danielle Costa Capistrano /

de Menezes, Givaldo Gomes / Bernal-Valle, Sofía / Müller, Nicolas Fd / Janssen, Luis / Dos Santos, Edmilson / Mares-Guia, Maria A / Albuquerque, George R / Romano, Alessandro Pm / Franco, Ana C / Ribeiro, Bergmann M / Roehe, Paulo M / Lourenço-de-Oliveira, Ricardo / de Abreu, Filipe Vieira Santos

Viruses

2023 Volume 15, Issue 3

Abstract: In recent decades, waves of yellow fever virus (YFV) from the Amazon Rainforest have spread and caused outbreaks in other regions of Brazil, including the Cerrado, a savannah-like biome through which YFV usually moves before arriving at the Atlantic ... ...

Abstract	In recent decades, waves of yellow fever virus (YFV) from the Amazon Rainforest have spread and caused outbreaks in other regions of Brazil, including the Cerrado, a savannah-like biome through which YFV usually moves before arriving at the Atlantic Forest. To identify the vectors involved in the maintenance of the virus in semiarid environments, an entomological survey was conducted after confirmation of yellow fever (YF) epizootics at the peak of the dry season in the Cerrado areas of the state of Minas Gerais. In total, 917 mosquitoes from 13 taxa were collected and tested for the presence of YFV. Interestingly, mosquitoes of the
MeSH term(s)	Humans ; Animals ; Yellow fever virus/genetics ; Culicidae ; Seasons ; Brazil/epidemiology ; Mosquito Vectors
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15030757
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Serological Evidence of

Abreu, Filipe Vieira Santos de / Lorene Soares Rocha, Kamila / Silva-Oliveira, Ramon / Macedo, Mariana Viana / Silva, Thamires Gabriele Macedo / Gonçalves-Dos-Santos, Maria Eduarda / de Oliveira, Cirilo Henrique / Aquino-Teixeira, Sandy Micaele / Ottone, Vinícius de Oliveira / da Silva, Alex Junio Jardim / Dos Santos, Ronaldo Medeiros / Tátila-Ferreira, Aline / Almeida, Marco Antônio Barreto de / Dos Santos, Edmilson / da Cruz Cardoso, Jáder / Campos, Aline Alves Scarpellini / Albuquerque, George Rego / da Paixão Sevá, Anaiá / Ribeiro, Bergmann Morais /

Simonini Teixeira, Danilo / Campos, Fabrício Souza / Franco, Ana Cláudia / Roehe, Paulo Michel / de Souza Trindade, Giliane / Bretas de Oliveira, Danilo

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 10

Abstract: ... The ... ...

Abstract	The genus
Language	English
Publishing date	2022-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11101167
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Article: How can “my shoes” affect the amphibian health? A study of the toxicity of microplastics from shoe sole (Polyvinyl chloride acetate) on Physalaemus cuvieri tadpoles (Anura, Leptodactylidae)

Araújo, Amanda Pereira da Costa / Luz, Thiarlen Marinho da / Gonçalves, Sandy de Oliveira / Rajagopal, Rajakrishnan / Rahman, Md. Mostafizur / Silva, Daniela de Melo e / Malafaia, Guilherme

Journal of hazardous materials. 2022 Oct. 15, v. 440

2022

Abstract: More recently, many studies have reported the impacts of microplastics (MPs) on the health of organisms. However, our knowledge of its effects on some vertebrate groups, such as amphibians remains incipient. Thus, we evaluated whether the exposure of ... ...

Abstract	More recently, many studies have reported the impacts of microplastics (MPs) on the health of organisms. However, our knowledge of its effects on some vertebrate groups, such as amphibians remains incipient. Thus, we evaluated whether the exposure of Physalaemus cuvieri tadpoles to MPs from shoe soles can induce harmful effects on their health. After 30 days of exposure to different MP concentrations (2 ×10⁵ MP particles/m³ and 4 ×10⁶ MP particles/m³), we noticed that the tadpoles ingested particles with a mean diameter of 148.8 µm and irregular shapes, which accumulated in the intestinal tube. Such accumulation was associated with a lower-body condition index, non-uniformity in the keratinized structures of the jaw sheath, alterations in the intestine position in the abdominal cavity, bowel tube winding condition, and the emergence of dark regions in the intestine like pseudomelanosis. The reduction of superoxide dismutase and catalase activities suggests that MPs have affected the antioxidant system. The minor nitrite production provides evidence that the production of nitric oxide by cells of the intestinal immune system has been affected. In addition, we observed a significant reduction in the size (area, perimeter, and diameter) of MPs after ingestion, which suggests that tadpoles can act as vectors for their dispersal of MPs from shoe soles in the environment. The principal component analysis and integrated biomarker response assessment also confirm that higher MPs concentration induces a more stressful response. Therefore, our study demonstrates that “my sneakers,” while seemingly harmless, can pose a health risk to amphibians.
Keywords	Physalaemus ; abdominal cavity ; acetates ; amphibians ; antioxidants ; biomarkers ; catalase ; immune system ; ingestion ; intestines ; keratinization ; microplastics ; nitric oxide ; nitrites ; poly(vinyl chloride) ; principal component analysis ; risk ; superoxide dismutase ; toxicity
Language	English
Dates of publication	2022-1015
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.129847
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Article ; Online: Can spike fragments of SARS-CoV-2 induce genomic instability and DNA damage in the guppy, Poecilia reticulate? An unexpected effect of the COVID-19 pandemic.

Gonçalves, Sandy de Oliveira / Luz, Thiarlen Marinho da / Silva, Abner Marcelino / de Souza, Sindoval Silva / Montalvão, Mateus Flores / Guimarães, Abraão Tiago Batista / Ahmed, Mohamed Ahmed Ibrahim / Araújo, Amanda Pereira da Costa / Karthi, Sengodan / Malafaia, Guilherme

The Science of the total environment

2022 Volume 825, Page(s) 153988

Abstract: ... and Olive tail moment), suggesting that PSPD-2002 peptides were able to cause genomic instability and ...

Abstract	The identification of SARS-CoV-2 particles in wastewater and freshwater ecosystems has raised concerns about its possible impacts on non-target aquatic organisms. In this particular, our knowledge of such impacts is still limited, and little attention has been given to this issue. Hence, in our study, we aimed to evaluate the possible induction of mutagenic (via micronucleus test) and genotoxic (via single cell gel electrophoresis assay, comet assay) effects in Poecilia reticulata adults exposed to fragments of the Spike protein of the new coronavirus at the level of 40 μg/L, denominated PSPD-2002. As a result, after 10 days of exposure, we have found that animals exposed to the peptides demonstrated an increase in the frequency of erythrocytic nuclear alteration (ENA) and all parameters assessed in the comet assay (length tail, %DNA in tail and Olive tail moment), suggesting that PSPD-2002 peptides were able to cause genomic instability and erythrocyte DNA damage. Besides, these effects were significantly correlated with the increase in lipid peroxidation processes [inferred by the high levels of malondialdehyde (MDA)] reported in the brain and liver of P. reticulata and with the reduction of the superoxide dismutase (SOD) and catalase (CAT) activity. Thus, our study constitutes a new insight and promising investigation into the toxicity associated with the dispersal of SARS-CoV-2 peptide fragments in freshwater environments.
MeSH term(s)	Animals ; COVID-19 ; Comet Assay ; DNA Damage ; Ecosystem ; Genomic Instability ; Humans ; Pandemics ; Peptides ; Poecilia ; SARS-CoV-2 ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity
Chemical Substances	Peptides ; Water Pollutants, Chemical
Language	English
Publishing date	2022-02-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.153988
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Article ; Online: Steel wools microfibers causes iron overload and induces biochemical changes in Gallus gallus domesticus chicks (Galliformes: Phasianidae).

Nascimento, Ítalo Freitas / Souza, Sindoval Silva de / da Luz, Thiarlen Marinho / Gomes, Lux Attiê Santos / Gonçalves, Sandy de Oliveira / Ahmed, Mohamed Ahmed Ibrahim / Guimarães, Abraão Tiago Batista / Rodrigues, Aline Sueli de Lima / Malafaia, Guilherme

Chemosphere

2022 Volume 293, Page(s) 133632

Abstract: Steel wool (SW) has a broad-spectrum of applicability, particularly as abrasives, cleaning household utensils and surfaces in general. However, when present in the natural environment, they can be ingested by animals, such as birds, and may represent a ... ...

Abstract	Steel wool (SW) has a broad-spectrum of applicability, particularly as abrasives, cleaning household utensils and surfaces in general. However, when present in the natural environment, they can be ingested by animals, such as birds, and may represent a risk to the survival of individuals. Accordingly, in this study, we attempted the hypothesis that the ingestion of SW microfibers (SWMs) by Gallus gallus domesticus chicks (model system used) alters growth/development, induces redox imbalance and cholinesterasic effect, as well as promotes iron overload in different organs. For this, the animals received SWMs twice (within a 24-h interval) in an amount corresponding to 12% of their total stomach volume. At the end of the experiment, we observed less weight gain and less head growth, increased production of hydrogen peroxide (in the brain, liver, crop, and gizzard), nitrite (liver, crop, proventriculus and gizzard), malondialdehyde (brain, liver, muscle, proventriculus, and gizzard), along with increased superoxide dismutase activity in the liver, muscle and crop of animals exposed to SWMs. Such results were associated with iron overload observed in different organs, especially in liver, crop, and gizzard. Furthermore, we evidenced an anti-cholinesterasic effect in birds that ingested the SWMs, marked by a reduction in the acetylcholinesterase activity (in brain). Thus, our study sheds light on the (eco)toxicological potential of SWMs in avifauna, conceding us to associate their ingestion (despite ephemeral and occasional) with damage to the health of individuals, requiring a greater attention spotted to disposal of these materials in ecosystems.
MeSH term(s)	Acetylcholinesterase ; Animals ; Chickens/physiology ; Ecosystem ; Iron Overload ; Steel
Chemical Substances	Steel (12597-69-2) ; Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.133632
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Article ; Online: Toxicity induced via ingestion of naturally-aged polystyrene microplastics by a small-sized terrestrial bird and its potential role as vectors for the dispersion of these pollutants.

de Souza, Sindoval Silva / Freitas, Ítalo Nascimento / Gonçalves, Sandy de Oliveira / Luz, Thiarlen Marinho da / Araújo, Amanda Pereira da Costa / Rajagopal, Rajakrishnan / Balasubramani, Govindasamy / Rahman, Md Mostafizur / Malafaia, Guilherme

Journal of hazardous materials

2022 Volume 434, Page(s) 128814

Abstract: In recent years, there has been a growing number of studies on the impact of microplastics (MPs) on biota. However, its effects on birds' health are poorly understood. Thus, we aimed to evaluate the possible effects of ingestion of naturally-aged MPs by ... ...

Abstract	In recent years, there has been a growing number of studies on the impact of microplastics (MPs) on biota. However, its effects on birds' health are poorly understood. Thus, we aimed to evaluate the possible effects of ingestion of naturally-aged MPs by Coturnix Coturnix japonica (11 and 22 MP particles/day/bird, once a day, for 9 days), from different toxicity biomarkers. At the end of the experiment, it was found that the ingested MPs in birds showed a significant reduction in body biomass. Also, an increase in malondialdehyde production in the liver, brain, intestine, and gizzard of the birds, as well as a suppressive effect on hepatic nitric oxide production and superoxide dismutase activity in the liver and intestine were observed. Cerebral catalase activity was reduced in birds exposed to MPs and the cholinesterasic effect (marked by increased acetylcholinesterase activity) was observed in the muscle and brain of these animals. Despite these differences, through the main component analysis, hierarchical clustering analysis, and integrated biomarker response assessment, we observed similar toxicological effects in birds exposed to different amounts of MPs. In addition, the size of MPs was reduced, and their shape was altered as they transited through the gastrointestinal system, which probably explains their accumulation in the liver of birds. An expressive number of MPs are released through the feces of the birds throughout the experiment. As far as we know, this is the first report that associates MPs ingestion by small-sized terrestrial birds with biochemical alterations viz., predictive of oxidative stress, redox imbalance, and cholinesterasic effect, in addition to shedding light on the potential role of these birds as vectors for dispersal of MPs in natural environments.
MeSH term(s)	Acetylcholinesterase ; Animals ; Coturnix ; Eating ; Environmental Pollutants/analysis ; Microplastics/toxicity ; Plastics/toxicity ; Polystyrenes/analysis ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity
Chemical Substances	Environmental Pollutants ; Microplastics ; Plastics ; Polystyrenes ; Water Pollutants, Chemical ; Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2022-03-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.128814
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Article ; Online: Can spike fragments of SARS-CoV-2 induce genomic instability and DNA damage in the guppy, Poecilia reticulate? An unexpected effect of the COVID-19 pandemic

Science of the total environment. 2022 June 15, v. 825 p.153988-

2022

Abstract: ... and Olive tail moment), suggesting that PSPD-2002 peptides were able to cause genomic instability and ...

Abstract	The identification of SARS-CoV-2 particles in wastewater and freshwater ecosystems has raised concerns about its possible impacts on non-target aquatic organisms. In this particular, our knowledge of such impacts is still limited, and little attention has been given to this issue. Hence, in our study, we aimed to evaluate the possible induction of mutagenic (via micronucleus test) and genotoxic (via single cell gel electrophoresis assay, comet assay) effects in Poecilia reticulata adults exposed to fragments of the Spike protein of the new coronavirus at the level of 40 μg/L, denominated PSPD-2002. As a result, after 10 days of exposure, we have found that animals exposed to the peptides demonstrated an increase in the frequency of erythrocytic nuclear alteration (ENA) and all parameters assessed in the comet assay (length tail, %DNA in tail and Olive tail moment), suggesting that PSPD-2002 peptides were able to cause genomic instability and erythrocyte DNA damage. Besides, these effects were significantly correlated with the increase in lipid peroxidation processes [inferred by the high levels of malondialdehyde (MDA)] reported in the brain and liver of P. reticulata and with the reduction of the superoxide dismutase (SOD) and catalase (CAT) activity. Thus, our study constitutes a new insight and promising investigation into the toxicity associated with the dispersal of SARS-CoV-2 peptide fragments in freshwater environments.
Keywords	COVID-19 infection ; DNA damage ; Poecilia reticulata ; Severe acute respiratory syndrome coronavirus 2 ; brain ; catalase ; comet assay ; environment ; erythrocytes ; freshwater ; genetic instability ; lipid peroxidation ; liver ; malondialdehyde ; micronucleus tests ; mutagens ; peptides ; superoxide dismutase ; tail ; toxicity ; wastewater ; Mutagenicity ; Genotoxicity ; Freshwater fish ; Water pollution ; Viral particles ; COVID-19
Language	English
Dates of publication	2022-0615
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.153988
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Article: Steel wools microfibers causes iron overload and induces biochemical changes in Gallus gallus domesticus chicks (Galliformes: Phasianidae)

Chemosphere. 2022 Apr., v. 293

2022

Abstract	Steel wool (SW) has a broad-spectrum of applicability, particularly as abrasives, cleaning household utensils and surfaces in general. However, when present in the natural environment, they can be ingested by animals, such as birds, and may represent a risk to the survival of individuals. Accordingly, in this study, we attempted the hypothesis that the ingestion of SW microfibers (SWMs) by Gallus gallus domesticus chicks (model system used) alters growth/development, induces redox imbalance and cholinesterasic effect, as well as promotes iron overload in different organs. For this, the animals received SWMs twice (within a 24-h interval) in an amount corresponding to 12% of their total stomach volume. At the end of the experiment, we observed less weight gain and less head growth, increased production of hydrogen peroxide (in the brain, liver, crop, and gizzard), nitrite (liver, crop, proventriculus and gizzard), malondialdehyde (brain, liver, muscle, proventriculus, and gizzard), along with increased superoxide dismutase activity in the liver, muscle and crop of animals exposed to SWMs. Such results were associated with iron overload observed in different organs, especially in liver, crop, and gizzard. Furthermore, we evidenced an anti-cholinesterasic effect in birds that ingested the SWMs, marked by a reduction in the acetylcholinesterase activity (in brain). Thus, our study sheds light on the (eco)toxicological potential of SWMs in avifauna, conceding us to associate their ingestion (despite ephemeral and occasional) with damage to the health of individuals, requiring a greater attention spotted to disposal of these materials in ecosystems.
Keywords	acetylcholinesterase ; avifauna ; brain ; chickens ; gizzard ; head ; hydrogen peroxide ; ingestion ; iron overload ; liver ; malondialdehyde ; muscles ; nitrites ; proventriculus ; risk ; steel ; steel wool ; stomach ; superoxide dismutase ; toxicology ; weight gain
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.133632
Database	NAL-Catalogue (AGRICOLA)

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Article: Toxicity induced via ingestion of naturally-aged polystyrene microplastics by a small-sized terrestrial bird and its potential role as vectors for the dispersion of these pollutants

Journal of hazardous materials. 2022 July 15, v. 434

2022

Abstract: In recent years, there has been a growing number of studies on the impact of microplastics (MPs) on biota. However, its effects on birds’ health are poorly understood. Thus, we aimed to evaluate the possible effects of ingestion of naturally-aged MPs by ... ...

Abstract	In recent years, there has been a growing number of studies on the impact of microplastics (MPs) on biota. However, its effects on birds’ health are poorly understood. Thus, we aimed to evaluate the possible effects of ingestion of naturally-aged MPs by Coturnix Coturnix japonica (11 and 22 MP particles/day/bird, once a day, for 9 days), from different toxicity biomarkers. At the end of the experiment, it was found that the ingested MPs in birds showed a significant reduction in body biomass. Also, an increase in malondialdehyde production in the liver, brain, intestine, and gizzard of the birds, as well as a suppressive effect on hepatic nitric oxide production and superoxide dismutase activity in the liver and intestine were observed. Cerebral catalase activity was reduced in birds exposed to MPs and the cholinesterasic effect (marked by increased acetylcholinesterase activity) was observed in the muscle and brain of these animals. Despite these differences, through the main component analysis, hierarchical clustering analysis, and integrated biomarker response assessment, we observed similar toxicological effects in birds exposed to different amounts of MPs. In addition, the size of MPs was reduced, and their shape was altered as they transited through the gastrointestinal system, which probably explains their accumulation in the liver of birds. An expressive number of MPs are released through the feces of the birds throughout the experiment. As far as we know, this is the first report that associates MPs ingestion by small-sized terrestrial birds with biochemical alterations viz., predictive of oxidative stress, redox imbalance, and cholinesterasic effect, in addition to shedding light on the potential role of these birds as vectors for dispersal of MPs in natural environments
Keywords	Coturnix japonica ; acetylcholinesterase ; biomarkers ; biomass ; birds ; brain ; catalase ; feces ; gizzard ; ingestion ; intestines ; liver ; malondialdehyde ; microplastics ; muscles ; nitric oxide ; oxidative stress ; polystyrenes ; superoxide dismutase ; toxicity ; toxicology
Language	English
Dates of publication	2022-0715
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.128814
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Article ; Online: Fast surveillance response reveals the introduction of a new yellow fever virus sub-lineage in 2021, in Minas Gerais, Brazil.

Andrade, Miguel Souza / Campos, Fabrício Souza / Oliveira, Cirilo Henrique de / Oliveira, Ramon Silva / Campos, Aline Alves Scarpellini / Almeida, Marco Antônio Barreto de / Fonseca, Vagner de Souza / Simonini-Teixeira, Danilo / Sevá, Anaiá da Paixão / Temponi, Andrea Oliveira Dias / Magalhães, Fernando Maria / Chaves, Danielle Costa Capistrano / Pereira, Maira Alves / Lamounier, Ludmila Oliveira / Menezes, Givaldo Gomes de / Aquino-Teixeira, Sandy Micaele / Gonçalves-Dos-Santos, Maria Eduarda / Bernal-Valle, Sofía / Müller, Nicolas Felipe Drumm /

Cardoso, Jader da Cruz / Santos, Edmilson Dos / Mares-Guia, Maria Angélica / Albuquerque, George Rêgo / Romano, Alessandro Pecego Martins / Franco, Ana Cláudia / Ribeiro, Bergmann Morais / Roehe, Paulo Michel / Abreu, Filipe Vieira Santos de

Memorias do Instituto Oswaldo Cruz

2022 Volume 117, Page(s) e220127

Abstract: Background: In Brazil, the yellow fever virus (YFV) is maintained in a sylvatic cycle involving wild mosquitoes and non-human primates (NHPs). The virus is endemic to the Amazon region; however, waves of epidemic expansion reaching other Brazilian ... ...

Abstract	Background: In Brazil, the yellow fever virus (YFV) is maintained in a sylvatic cycle involving wild mosquitoes and non-human primates (NHPs). The virus is endemic to the Amazon region; however, waves of epidemic expansion reaching other Brazilian states sporadically occur, eventually causing spillovers to humans. Objectives: To report a surveillance effort that led to the first confirmation of YFV in NHPs in the state of Minas Gerais (MG), Southeast region, in 2021. Methods: A surveillance network was created, encompassing the technology of smartphone applications and coordinated actions of several research institutions and health services to monitor and investigate NHP epizootics. Findings: When alerts were spread through the network, samples from NHPs were collected and YFV infection confirmed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and genome sequencing at an interval of only 10 days. Near-complete genomes were generated using the Nanopore MinION sequencer. Phylogenetic analysis indicated that viral genomes were related to the South American genotype I, clustering with a genome detected in the Amazon region (state of Pará) in 2017, named YFVPA/MG sub-lineage. Fast YFV confirmation potentialised vaccination campaigns. Main conclusions: A new YFV introduction was detected in MG 6 years after the beginning of the major outbreak reported in the state (2015-2018). The YFV strain was not related to the sub-lineages previously reported in MG. No human cases have been reported, suggesting the importance of coordinated surveillance of NHPs using available technologies and supporting laboratories to ensure a quick response and implementation of contingency measures to avoid YFV spillover to humans.
MeSH term(s)	Yellow fever virus/genetics ; Phylogeny ; Brazil/epidemiology
Language	English
Publishing date	2022-12-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	953293-6
ISSN	1678-8060 ; 0074-0276
ISSN (online)	1678-8060
ISSN	0074-0276
DOI	10.1590/0074-02760220127
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