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Article ; Online: Effect of a combination of gliptin and metformin on serum vitamin B12, folic acid, and ferritin levels.

Genc, Fevziye Turkoglu / Nalbant, Ahmet / Genc, Ahmed Cihad / Kaya, Tezcan

Revista da Associacao Medica Brasileira (1992)

2023 Volume 69, Issue 11, Page(s) e20230641

Abstract: Objective: The primary objective of this study was to explore the impact of metformin and metformin/gliptin combination therapy on the serum concentrations of vitamin B12, ferritin, and folic acid in individuals diagnosed with type 2 diabetes.: ... ...

Abstract	Objective: The primary objective of this study was to explore the impact of metformin and metformin/gliptin combination therapy on the serum concentrations of vitamin B12, ferritin, and folic acid in individuals diagnosed with type 2 diabetes. Methods: This study included 118 patients, classified into two groups: 59 patients using only metformin and 59 patients using a combination of metformin/gliptin. Among the latter group, 35 patients used vildagliptin/metformin, and 24 used sitagliptin/metformin. The study recorded the demographic data such as the age and gender of the patients, as well as their initial and 1-year follow-up blood parameters. Results: Folic acid decreased significantly in the metformin group but not in the metformin/gliptin group. Vitamin B12 and ferritin decreased significantly in both groups. The decrease in vitamin B12 and ferritin was not significantly different between the two groups. The decrease in fasting plasma glucose was more significant in the metformin/gliptin group than in the metformin group. Conclusion: After 1 year, both groups taking metformin and metformin/gliptin showed low serum ferritin and vitamin B12 levels. Therefore, vitamin B12 levels in patients using these drugs should be closely monitored. Ferritin levels can be used to indicate whether glycemic control has been achieved.
MeSH term(s)	Humans ; Metformin/therapeutic use ; Folic Acid/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/therapeutic use ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Vitamin B 12/therapeutic use ; Ferritins
Chemical Substances	Metformin (9100L32L2N) ; Folic Acid (935E97BOY8) ; Hypoglycemic Agents ; Dipeptidyl-Peptidase IV Inhibitors ; Vitamin B 12 (P6YC3EG204) ; Ferritins (9007-73-2)
Language	English
Publishing date	2023-10-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20230641
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Article: Effect of Transurethral Thermotherapy on Storage Symptoms Associated with Lower Urinary System Complaints in Elderly.

Yüce, Ahmet / Benli, Erdal / Çırakoğlu, Abdullah / Yazıcı, İbrahim / Nalbant, İsmail

Archivos espanoles de urologia

2022 Volume 75, Issue 9, Page(s) 764–770

Abstract: Background: Storage symptoms are pathology with increasing frequency and importance among elderly men. The efficacy and advantages of the new bipolar radiofrequency prostate thermotherapy method were investigated for storage symptoms in elderly.: ... ...

Abstract	Background: Storage symptoms are pathology with increasing frequency and importance among elderly men. The efficacy and advantages of the new bipolar radiofrequency prostate thermotherapy method were investigated for storage symptoms in elderly. Methods: The outcomes for 150 elderly patients with significant storage symptoms accompanying voiding symptoms were investigated. The patients' Qmax (maximum urinary flow rate), prostate volumes, OAB-V8 (overactivebladder-Validated 8) and quality of life scores were questioned before the procedure and 1st month and 6th month. Results: OAB-V8 total score had mean value of 26.3, with values identified as 16.2 ( Conclusions: The bipolar radiofrequency thermotherapy method provides significant improvement of storage symptoms in elderly men. It is thought that this method has advantages in terms of its effects on storage and voiding symptoms in the elderly.
Language	English
Publishing date	2022-12-05
Publishing country	Spain
Document type	Journal Article
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
DOI	10.56434/j.arch.esp.urol.20227509.112
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Article ; Online: Comparison of Serum Gamma Glutamyl Transferase Levels between Prostate Cancer Patients and Their Healthy Peers.

Yuce, Ahmet / Keles, Mevlut / Benli, Erdal / Cirakoglu, Abdullah / Yazici, Ibrahim / Nalbant, Ismail

Iranian journal of public health

2023 Volume 52, Issue 7, Page(s) 1487–1494

Abstract: Background: Prostate cancer (PCa) is the most common cancer affecting men, apart from cutaneous cancers. Serum prostate specific antigen (PSA) levels are frequently used to predict prostate cancer diagnosis. However, many causes (e.g., prostatitis, ... ...

Abstract	Background: Prostate cancer (PCa) is the most common cancer affecting men, apart from cutaneous cancers. Serum prostate specific antigen (PSA) levels are frequently used to predict prostate cancer diagnosis. However, many causes (e.g., prostatitis, benign prostate obstruction, urethral catheterization) may cause elevated PSA, in addition to PCa. We aimed to investigate the gamma glutamyl transferase (GGT) levels, a serum biomarker not affected by situations other than cancer causing elevated PSA. Methods: The study evaluated male patients with prostate biopsy due to high serum PSA levels and/or abnormal digital rectal examination (DRE) examined in Ordu University Education and Research Hospital, Ordu/Turkey urology clinic from April 2019 to April 2021. The patient group in the study included 261 men with PCa diagnosis and the control group included 245 healthy men with normal PSA levels, and no PCa and/or benign prostate obstruction (BPO). The two groups were compared in terms of serum GGT levels. Results: GGT was significantly low in the PCa group and might be a predictor in terms of PCa ( Conclusion: Serum GGT levels might assist in diagnosis of PCa. However, diagnostic power is weak due to low specificity. There is a need for studies investigating the efficacy of GGT levels for prediction of PCa diagnosis and assessing other parameters alongside GGT.
Language	English
Publishing date	2023-08-12
Publishing country	Iran
Document type	Journal Article
ISSN	2251-6093 ; 0304-4556
ISSN (online)	2251-6093
ISSN	0304-4556
DOI	10.18502/ijph.v52i7.13251
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Article: Bipolar radiofrequency thermotherapy vs. transurethral resection of the prostate: Effect on nocturia as a result of benign prostatic obstruction.

Yuce, Ahmet / Benli, Erdal / Cirakoglu, Abdullah / Yazici, Ibrahim / Nalbant, Ismail

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2022 Volume 16, Issue 11, Page(s) E545–E551

Abstract: Introduction: The purpose of this study was to investigate and compare the effects of radiofrequency thermotherapy (RF) thermotherapy and transurethral resection of the prostate (TURP) on nocturia and associated quality of life in patients diagnosed ... ...

Abstract	Introduction: The purpose of this study was to investigate and compare the effects of radiofrequency thermotherapy (RF) thermotherapy and transurethral resection of the prostate (TURP) on nocturia and associated quality of life in patients diagnosed with benign prostatic obstruction (BPO) under medical treatment who have complaints of persistent nocturia. Methods: The results of patients who underwent RF thermotherapy and TURP procedures between February 2019 and February 2022 were examined, and their three-month results were compared based on their uroflowmetry values, International Prostate Symptom Score (IPSS) values, nocturia frequency, and Nocturia Quality of Life Questionnaire scores. Results: While the frequency of nocturia in the RF thermotherapy group that was 4.5±1.6 before the procedure decreased to 2.3±1.4 after the procedure (p=0.002), this value in the TURP group decreased from 5.1±2.42 to 3.9±2.1 (p=0.044). RF thermotherapy was found to be more effective than TURP (p<0.005). Significantly, more noticeable improvements were observed in most nocturia-related next-day complaints and nocturia-related concerns in the RF thermotherapy group than the TURP group. Conclusions: It was observed that RF thermotherapy had a more acceptable effect on obstructive complaints in comparison to TURP, and it could be more effective on nocturia and associated quality of life. RF ablation treatment may be offered as an appropriate option to treat nocturia complaints in suitable patients.
Language	English
Publishing date	2022-04-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.7899
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Article ; Online: Comparison of Sexual Behavior and Inflammatory Parameters in Prostate Cancer Patients with Control Group: Prospective Controlled Study.

Benli, Erdal / Yuce, Ahmet / Cirakoglu, Abdullah / Yazici, Ibrahim / Nalbant, Ismail

Urology journal

2022 Volume 19, Issue 2, Page(s) 101–105

Abstract: Purpose: In spite of extraordinary developments in diagnostic and treatment methods for prostate cancer (PCa), the reason for this disease is not known. Our study aimed to compare men in the PCa group with a control group in terms of sexual behavior ... ...

Abstract	Purpose: In spite of extraordinary developments in diagnostic and treatment methods for prostate cancer (PCa), the reason for this disease is not known. Our study aimed to compare men in the PCa group with a control group in terms of sexual behavior like partner numbers and ejaculation frequency, and inflammatory parameters examined in serum. Material and methods: This study was performed prospectively between 2013 and April 2020 and the record system was kept by a single doctor. Patients were prospectively recorded by a single person. Patients with diagnosis of PCa were compared with a control group in terms of sexual behavior and in terms of inflammatory parameters like neutrophil lymphocyte ratio (NLR, neutrophil count/lymphocyte count), systemic inflammatory index (SII, neutrophil count x platelet count/lymphocyte count). Results: In this study, median marriage age was 18 ± 6 years in the control group and 20 ± 2.97 in the PCa group (P = .001). The median lifelong partner number was observed to be 1 ± 1 in the control group and 1 ± 9 in the PCa group (median ± IQR). Additionally, lifelong median ejaculation frequency was determined as 12 ± 5 for controls and 10 ± 4 for the PCa group. Inflammatory markers examined in serum and SII scores were observed to be statistically significantly increased in the cancer group. Conclusion: The sexual behavior and inflammatory parameters among patients with PCa diagnosis were identified to be significantly high compared to the control group and appear to be possible correctable risk factors. Informing men about sexual behavior from an early age and taking precautions for people at risk in the early period may be protective against this disease.
MeSH term(s)	Adolescent ; Adult ; Child ; Humans ; Leukocyte Count ; Lymphocytes ; Male ; Prospective Studies ; Prostatic Neoplasms ; Retrospective Studies ; Sexual Behavior ; Young Adult
Language	English
Publishing date	2022-05-15
Publishing country	Iran
Document type	Comparative Study ; Journal Article
ZDB-ID	2251940-3
ISSN	1735-546X ; 1735-1308
ISSN (online)	1735-546X
ISSN	1735-1308
DOI	10.22037/uj.v18i.6464
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Article ; Online: Effects of an Inclusive Physical Activity Program on the Motor Skills, Social Skills and Attitudes of Students with and without Autism Spectrum Disorder.

Sansi, Ahmet / Nalbant, Sibel / Ozer, Dilara

Journal of autism and developmental disorders

2020 Volume 51, Issue 7, Page(s) 2254–2270

Abstract: This study investigated the effects of an inclusive physical activity (IPA) program on the motor and social skills and attitudes of students with and without autism spectrum disorder (ASD). The study sample consisted of 45 ASD and typical development (TD) ...

Abstract	This study investigated the effects of an inclusive physical activity (IPA) program on the motor and social skills and attitudes of students with and without autism spectrum disorder (ASD). The study sample consisted of 45 ASD and typical development (TD) students aged between 6 and 11 years. The students were randomly divided into two groups: a training group consisting of 27 students (n = 13 with ASD and n = 14 with TD) and a control group consisting of 18 students (n = 9 with ASD and n = 9 with TD). In conclusion, the IPA program increased the motor and social skills of the ASD students and improved the motor skills of the TD students and positively affected their attitudes towards the ASD students.
MeSH term(s)	Attitude ; Autism Spectrum Disorder/psychology ; Child ; Exercise/psychology ; Female ; Humans ; Mainstreaming, Education/methods ; Male ; Motor Skills ; Physical Education and Training/methods ; Program Evaluation ; Random Allocation ; Social Skills ; Students/psychology
Language	English
Publishing date	2020-09-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-020-04693-z
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Article ; Online: Does isotretinoin affect spermatogenesis in the long term? A rat model.

Cirakoglu, Abdullah / Onder, Sevda / Hancı, Hatice / Benli, Erdal / Yüce, Ahmet / Kasko Arici, Yeliz / Bas, Orhan / Nalbant, Ismail

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2023 Volume 95, Issue 3, Page(s) 11502

Abstract: Objectives: Spermatogenesis, in which cell regeneration continues, can be affected by environmental, chemical, psychological factors or various diseases. There is conflicting information in the literature about the effect of isotretinoin, which is ... ...

Abstract	Objectives: Spermatogenesis, in which cell regeneration continues, can be affected by environmental, chemical, psychological factors or various diseases. There is conflicting information in the literature about the effect of isotretinoin, which is widely used in acne treatment, on testes and spermatogenesis. Therefore, we planned a rat study to evaluate the long-term efficacy of oral isotretinoin on testicular tissues and spermatogenesis. Materials and methods: The Group 1 (n = 6) 7.5 mg/kg/day and the Group 2 (n = 6) received isotretinoin at a dose of 30 mg/kg/day dissolved in sunflower oil, the Sham Group (n = 6) received only sunflower oil by gavage, and the control group (n = 6) received standard feed and water for four weeks. After the 4th week, all animals were fed with standard feed and water and followed for the next four weeks. At the end of the 8th week, all animals were sacrificed under deep anesthesia. Seminiferous tubule diameters, epithelial thickness, apoptotic index, sperm number and motility recorded Results: Sperm count, motility, vitality, diameter of seminiferous tubule and germinal epithelium thickness were decreased and apoptotic index increased in the groups received isotretinoin. There was no significant difference between the groups in terms of testosterone levels. Conclusions: We consider that further comprehensive studies, including human clinical trials, should be conducted to examine the negative effects of isotretinoin on spermatogenesis in the long term especially when there is a need using isotretinoin in men for various reasons and to eliminate the contradictions in the literature in this regard.
MeSH term(s)	Humans ; Male ; Rats ; Animals ; Isotretinoin/adverse effects ; Sunflower Oil/pharmacology ; Semen ; Spermatogenesis ; Testis ; Water/pharmacology
Chemical Substances	Isotretinoin (EH28UP18IF) ; Sunflower Oil ; Water (059QF0KO0R)
Language	English
Publishing date	2023-07-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2023.11502
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Article ; Online: Can transurethral thermotherapy save elderly patients with benign prostatic obstruction and high ASA score?

Benli, Erdal / Yuce, Ahmet / Nalbant, Ismail / Cirakoglu, Abdullah / Yazici, Ibrahim

The aging male : the official journal of the International Society for the Study of the Aging Male

2020 Volume 23, Issue 5, Page(s) 1316–1320

Abstract: Introduction: The Aim of this study was to investigate the efficacy of the new bipolar radiofrequency prostate thermotherapy method for those with high potential surgical risk and also for patients with a chronic catheter.: Material and methods: 103 ... ...

Abstract	Introduction: The Aim of this study was to investigate the efficacy of the new bipolar radiofrequency prostate thermotherapy method for those with high potential surgical risk and also for patients with a chronic catheter. Material and methods: 103 patients attending our clinic due to BPO and related complaints with high ASA score had outcomes after the procedure recorded prospectively and investigated retrospectively. Qmax, prostate volume, IPSS score, quality of life score, and presence of catheters were recorded before the procedure and analyzed with the outcomes after the procedure. Results: The ASA scores were calculated as 3.0 ± 1.0 (IQR). Before the procedure, Qmax values (mean (SD)) were 5.11 ± 5.37 ml/s, while in the 6th month after the procedure Qmax values were identified as 10.45 ± 3.8 ml/s ( Conclusion: Bipolar RF thermotherapy appears to be an effective method for patients with BPO who cannot be operated. Due to the surgical risks of patients dependent on the catheter in spite of receiving medical treatment, it is a good alternative to remove catheter dependence. It may be one of the methods that should be remembered, especially in this patient group.
MeSH term(s)	Aged ; Humans ; Male ; Prostatic Hyperplasia/surgery ; Quality of Life ; Retrospective Studies ; Transurethral Resection of Prostate ; Treatment Outcome
Language	English
Publishing date	2020-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2108146-3
ISSN	1473-0790 ; 1368-5538
ISSN (online)	1473-0790
ISSN	1368-5538
DOI	10.1080/13685538.2020.1765329
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Article ; Online: The prognostic significance of erythrocyte sedimentation rate in COVID-19.

Kaya, Tezcan / Nalbant, Ahmet / Kılıçcıoğlu, Gizem Karataş / Çayır, Kübra Tuğba / Yaylacı, Selçuk / Varım, Ceyhun

Revista da Associacao Medica Brasileira (1992)

2021 Volume 67, Issue 9, Page(s) 1305–1310

Abstract: Objective: There are limited data about the significance of erythrocyte sedimentation rate as a single prognostic parameter for the prognosis and mortality of COVID-19. This study aimed to investigate the diagnostic utility of erythrocyte sedimentation ... ...

Abstract	Objective: There are limited data about the significance of erythrocyte sedimentation rate as a single prognostic parameter for the prognosis and mortality of COVID-19. This study aimed to investigate the diagnostic utility of erythrocyte sedimentation rate as a prognostic factor for the disease severity and mortality in patients with COVID-19. Methods: A total of 148 consecutive patients with a confirmed diagnosis of COVID-19 and hospitalized at the intensive care unit or non-the intensive care unit were included in the study. The patients were allocated to groups as severe/critical disease versus nonsevere disease and survivors and nonsurvivors. The prognostic role and predictable values of erythrocyte sedimentation rate were analyzed. Results: Erythrocyte sedimentation rate was found to be higher among patients with severe/critical disease compared to those with nonsevere disease (p<0.001) and among nonsurvivors compared to survivors (p<0.001). The logistic regression analysis showed that erythrocyte sedimentation rate was an independent parameter for predicting disease severity and mortality. The role of erythrocyte sedimentation rate in the assessment of severity and mortality in patients with COVID-19 was analyzed using the receiver operating characteristic curve and was found to be significant in both. The analyses suggested that the optimum erythrocyte sedimentation rate cutoff point for disease severity and mortality were 52.5 mm/h with 65.5% sensitivity and 76.3% specificity and 56.5 mm/h with 66.7% sensitivity and 72.5% specificity. Conclusion: Our results suggest that erythrocyte sedimentation rate was an independent prognostic factor for severity and mortality in patients with COVID-19.
MeSH term(s)	Blood Sedimentation ; COVID-19 ; Humans ; Prognosis ; ROC Curve ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-11-19
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20210618
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Article ; Online: Association of ABO blood group and age with COVID-19 positive test.

Nalbant, Ahmet / Aydın, Ayhan / Yaylacı, Selçuk / Kaya, Tezcan / Wermeulen, Charlotte Lynn / Cinemre, Hakan

Revista da Associacao Medica Brasileira (1992)

2021 Volume 67Suppl 1, Issue Suppl 1, Page(s) 46–50

Abstract: Objective: The aim of this study is to evaluate the relation between the coronavirus (SARS-CoV-2) disease (COVID-19) and blood groups and the Rh factor.: Method: A total of 313 patients hospitalized in the Internal Medicine clinic, at the intensive ... ...

Abstract	Objective: The aim of this study is to evaluate the relation between the coronavirus (SARS-CoV-2) disease (COVID-19) and blood groups and the Rh factor. Method: A total of 313 patients hospitalized in the Internal Medicine clinic, at the intensive care unit (ICU) were included in the study. The cases were divided into two groups: those who were COVID-19 positive and those negative, detected with real-time reverse transcription polymerase chain reaction testing. The demographic, clinical, ABO blood groups, and Rh factor data of the cases were obtained from the hospital records retrospectively. Results: The mean age of COVID-19 positive (+) cases was 57.74±16 years and of COVID-19 negative (-) cases, 66.41±15 years. The difference was significant (p<0.001); there was no difference between the two groups in terms of sex (p=0.634). When age was categorically separated in COVID-19 (+) cases, χ2 was extremely significant. Among the ABO blood groups of COVID-19 (+) and (-) cases, χ2 was 4.975 (p=0.174). In the logistic regression, it was 4.1 (p=0.011) in the O blood group. COVID-19 positive test was determined as 13, 4, and 4 times higher in the 31-40, 41-50, and 51-60 age groups, respectively (p=0.001, p=0.010, p=0.003). Conclusion: The incidence of COVID-19 has increased in the younger population and in the O blood group. Our findings support that, in this population, the ABO blood groups can contribute to the early detection of COVID-19.
MeSH term(s)	ABO Blood-Group System ; Adult ; Aged ; COVID-19 ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	ABO Blood-Group System
Language	English
Publishing date	2021-07-09
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.67.Suppl1.20200703
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