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Book: Neue Antidepressiva, atypische Neuroleptika

Lehmann, Peter / Aderhold, Volkmar / Rufer, Marc / Zehentbauer, Josef / Heinz, Andreas / Ansari, Peter / Ansari, Sabine

Risiken, Placebo-Effekte, Niedrigdosierung und Alternativen : mit einem Exkurs zur Wiederkehr des Elektroschocks

2017

Author's details	Peter Lehmann, Volkmar Aderhold, Marc Rufer, Josef Zehentbauer ; Geleitworte von Andreas Heinz und Peter & Sabine Ansari ; medizinjuristisches Nachwort von Marina Langfeldt
Keywords	Antidepressivum ; Neuroleptikum
Subject	Depotneuroleptikum ; Langzeitneuroleptikum ; Neuroplegikum ; Psycholeptikum ; Antipsychotikum ; Neuroleptika
Language	German
Size	241 Seiten, Illustrationen, 21 cm x 14.8 cm
Publisher	Peter Lehmann Publishing
Publishing place	Berlin
Publishing country	Germany
Document type	Book
HBZ-ID	HT019486849
ISBN	978-3-925931-68-0 ; 3-925931-68-6 ; 9783925931694 ; 9783925931708 ; 9783925931716 ; 3925931694 ; 3925931708 ; 3925931716
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2017 A 1882	available for loan (reading room)	Lesesaal EG

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Article: 17q Gain in Neuroblastoma: A Review of Clinical and Biological Implications.

Mlakar, Vid / Dupanloup, Isabelle / Gonzales, Fanny / Papangelopoulou, Danai / Ansari, Marc / Gumy-Pause, Fabienne

Cancers

2024 Volume 16, Issue 2

Abstract: Neuroblastoma (NB) is the most frequent extracranial solid childhood tumor. Despite advances in the understanding and treatment of this disease, the prognosis in cases of high-risk NB is still poor. 17q gain has been shown to be the most frequent genomic ...

Abstract	Neuroblastoma (NB) is the most frequent extracranial solid childhood tumor. Despite advances in the understanding and treatment of this disease, the prognosis in cases of high-risk NB is still poor. 17q gain has been shown to be the most frequent genomic alteration in NB. However, the significance of this remains unclear because of its high frequency and association with other genetic modifications, particularly segmental chromosomal aberrations, 1p and 11q deletions, and
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020338
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Machine learning based multipurpose medical image watermarking.

Sinhal, Rishi / Ansari, Irshad Ahmad

Neural computing & applications

2023 , Page(s) 1–22

Abstract: ... watermarking framework using deep neural network to provide effective security solutions for medical images ... During watermarking, the region of interest (ROI) data of the original image is preserved by employing ... the LZW (Lampel-Ziv-Welch) compression algorithm. Subsequently the robust watermark is inserted ...

Abstract	Digital data security has become an exigent area of research due to a huge amount of data availability at present time. Some of the fields like medical imaging and medical data sharing over communication platforms require high security against counterfeit access, manipulation and other processing operations. It is essential because the changed/manipulated data may lead to erroneous judgment by medical experts and can negatively influence the human's heath. This work offers a blind and robust medical image watermarking framework using deep neural network to provide effective security solutions for medical images. During watermarking, the region of interest (ROI) data of the original image is preserved by employing the LZW (Lampel-Ziv-Welch) compression algorithm. Subsequently the robust watermark is inserted into the original image using IWT (integer wavelet transform) based embedding approach. Next, the SHA-256 algorithm-based hash keys are generated for ROI and RONI (region of non-interest) regions. The fragile watermark is then prepared by ROI recovery data and the hash keys. Further, the LSB replacement-based insertion mechanism is utilized to embed the fragile watermark into RONI embedding region of robust watermarked image. A deep neural network-based framework is used to perform robust watermark extraction for efficient results with less computational time. Simulation results verify that the scheme has significant imperceptibility, efficient robust watermark extraction, correct authentication and completely reversible nature for ROI recovery. The relative investigation with existing schemes confirms the dominance of the proposed work over already existing work.
Language	English
Publishing date	2023-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1480526-1
ISSN	1433-3058 ; 0941-0643
ISSN (online)	1433-3058
ISSN	0941-0643
DOI	10.1007/s00521-023-08457-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; E-Book: Atlas of cone beam computed tomography

Safi, Yaser / Ahsaie, Mitra Ghazizadeh / Różyło-Kalinowska, Ingrid / Ansari, Ghassem / Tayefi Nasrabadi, Mahsima / Fazlalipour, Maryam

2022

Abstract: ... in Dentistry -- 1.3 Indications in Medicine -- Chapter 2 CBCT and Artifacts -- Chapter 3 Anatomic Landmarks ... 3.1 Normal Landmarks -- 3.2 Variations -- Chapter 4 CBCT of Dental Structures -- 4.1 Normal Anatomy ...

Author's details	Yaser Safi, Mitra Ghazizadeh, Ingrid Różyło-Kalinowska, Ghassem Ansari, Mahsima Tayefi Nasrabadi, Maryam Fazlalipour
Abstract	Cover -- Title Page -- Copyright Page -- Table of Contents -- Preface -- About the Companion Website -- Chapter 1 CBCT Introduction -- 1.1 Science, Preparation, and Evaluation -- 1.2 Indications in Dentistry -- 1.3 Indications in Medicine -- Chapter 2 CBCT and Artifacts -- Chapter 3 Anatomic Landmarks -- 3.1 Normal Landmarks -- 3.2 Variations -- Chapter 4 CBCT of Dental Structures -- 4.1 Normal Anatomy and Anomalies -- 4.2 Difficulties of Eruption -- Chapter 5 CBCT of Congenital and Developmental Maxillofacial Anomalies -- Chapter 6 CBCT of Maxillofacial Trauma -- 6.1 Dental Fracture -- 6.2 Dento-Alveolar Fracture -- 6.3 Bone Fractures -- Chapter 7 CBCT and Soft Tissue Calcifications and Ossifications -- Chapter 8 CBCT of Foreign Bodies -- Chapter 9 CBCT in Endodontics, Periodontics, and Orthodontics -- 9.1 Endodontics -- 9.2 Periodontics -- 9.3 Orthodontics -- Chapter 10 CBCT and Maxillofacial Pathology Assessment -- 10.1 Odontogenic Lesions -- 10.2 Non-odontogenic Lesions -- Chapter 11 CBCT and ENT Assessment -- Chapter 12 CBCT and the IAN Canal -- Chapter 13 CBCT of Dental Implants -- 13.1 Pre-surgical Implant Assessments -- 13.2 Postoperative Complications -- Chapter 14 CBCT and TMJ Evaluations -- Chapter 15 Interventional CBCT -- Conclusion -- Bibliography and Further Reading -- Index -- EULA.
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (viii, 456 Seiten), Illustrationen
Publisher	Wiley Blackwell
Publishing place	Hoboken, NJ
Publishing country	United States
Document type	Book ; Online ; E-Book
Note	Description based on publisher supplied metadata and other sources
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021221552
ISBN	978-1-119-66776-6 ; 9781119667773 ; 1-119-66776-3 ; 1119667771
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Integrated frequency-modulated optical parametric oscillator.

Stokowski, Hubert S / Dean, Devin J / Hwang, Alexander Y / Park, Taewon / Celik, Oguz Tolga / McKenna, Timothy P / Jankowski, Marc / Langrock, Carsten / Ansari, Vahid / Fejer, Martin M / Safavi-Naeini, Amir H

Nature

2024 Volume 627, Issue 8002, Page(s) 95–100

Abstract: Optical frequency combs have revolutionized precision measurement, time-keeping and molecular ... ...

Abstract	Optical frequency combs have revolutionized precision measurement, time-keeping and molecular spectroscopy
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07071-2
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Zs.MO 244: Show issues

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Article: Médecine de précision dans le traitement des cancers pédiatriques.

Ben Hassine, Khalil / Ceppi, Francesco / Baleydier, Frederic / Von Bueren, André O / Beck Popovic, Maja / Ansari, Marc

Revue medicale suisse

2023 Volume 19, Issue 815, Page(s) 380–387

Abstract: Despite the progress in cure rates for pediatric cancers, several challenges remain, such as the management of diseases with poor prognosis. The efficacy of intensified chemotherapies is also accompanied by increased risks of severe acute and chronic ... ...

Title translation	Precision medicine in the treatment of pediatric cancers.
Abstract	Despite the progress in cure rates for pediatric cancers, several challenges remain, such as the management of diseases with poor prognosis. The efficacy of intensified chemotherapies is also accompanied by increased risks of severe acute and chronic toxicities. Thus, therapies specifically targeting tumor cells, or inhibiting oncogenic molecular aberrations, could provide more effective and less toxic treatments for pediatric cancers. Personalization of chemotherapies through pharmacogenetics and precision dosing could also improve the efficacy and toxicity of chemotherapies. In this review, we describe precision medicine strategies implemented or undergoing clinical evaluation in the treatment of pediatric cancers.
MeSH term(s)	Child ; Humans ; Precision Medicine ; Neoplasms/drug therapy ; Pharmacogenetics ; Molecular Targeted Therapy
Language	French
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2023.19.815.380
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The Possibilities of Immunotherapy for Children with Primary Immunodeficiencies Associated with Cancers.

Baleydier, Frederic / Bernard, Fanette / Ansari, Marc

Biomolecules

2020 Volume 10, Issue 8

Abstract: Many primary immunodeficiencies (PIDs) are recognised as being associated with malignancies, particularly lymphoid malignancies, which represent the highest proportion of cancers occurring in conjunction with this underlying condition. When patients ... ...

Abstract	Many primary immunodeficiencies (PIDs) are recognised as being associated with malignancies, particularly lymphoid malignancies, which represent the highest proportion of cancers occurring in conjunction with this underlying condition. When patients present with genetic errors of immunity, clinicians must often reflect on whether to manage antitumoral treatment conventionally or to take a more personalised approach, considering possible existing comorbidities and the underlying status of immunodeficiency. Recent advances in antitumoral immunotherapies, such as monoclonal antibodies, antigen-specific adoptive cell therapies or compounds with targeted effects, potentially offer significant opportunities for optimising treatment for those patients, especially with lymphoid malignancies. In cases involving PIDs, variable oncogenic mechanisms exist, and opportunities for antitumoral immunotherapies can be considered accordingly. In cases involving a DNA repair defect or genetic instability, monoclonal antibodies can be proposed instead of chemotherapy to avoid severe toxicity. Malignancies secondary to uncontrolled virus-driven proliferation or the loss of antitumoral immunosurveillance may benefit from antivirus cell therapies or allogeneic stem cell transplantation in order to restore the immune antitumoral caretaker function. A subset of PIDs is caused by gene defects affecting targetable signalling pathways directly involved in the oncogenic process, such as the constitutive activation of phosphoinositol 3-kinase/protein kinase B (PI3K/AKT) in activated phosphoinositide 3-kinase delta syndrome (APDS), which can be settled with PI3K/AKT inhibitors. Therefore, immunotherapy provides clinicians with interesting antitumoral therapeutic weapons to treat malignancies when there is an underlying PID.
MeSH term(s)	Animals ; Antibodies, Monoclonal, Humanized/therapeutic use ; Child ; DNA Repair ; Genomic Instability ; Humans ; Immunologic Factors/therapeutic use ; Immunotherapy/methods ; Neoplasms/complications ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; Primary Immunodeficiency Diseases/complications ; Primary Immunodeficiency Diseases/genetics ; Primary Immunodeficiency Diseases/immunology ; Primary Immunodeficiency Diseases/therapy
Chemical Substances	Antibodies, Monoclonal, Humanized ; Immunologic Factors
Language	English
Publishing date	2020-07-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10081112
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Article: Case report: Hepatotoxicity and nephrotoxicity induced by methotrexate in a paediatric patient, what is the role of precision medicine in 2023?

El Masri, Ali El Rida / Tobler, Caroline / Willemijn, Breunis / Von Bueren, Andre O / Ansari, Marc / Samer, Caroline Flora

Frontiers in pharmacology

2023 Volume 14, Page(s) 1130548

Abstract: Methotrexate is an immunosuppressant and chemotherapeutic agent used in the treatment of a range of autoimmune disorders and cancers. Its main serious adverse effects, bone marrow suppression and gastrointestinal complications, arise from its ... ...

Abstract	Methotrexate is an immunosuppressant and chemotherapeutic agent used in the treatment of a range of autoimmune disorders and cancers. Its main serious adverse effects, bone marrow suppression and gastrointestinal complications, arise from its antimetabolite effect. Nevertheless, hepatotoxicity and nephrotoxicity are two widely described adverse effects of methotrexate. Its hepatotoxicity has been studied mainly in the low-dose, chronic setting, where patients are at risk of fibrosis/cirrhosis. Studies of acute hepatoxicity of high dose methotrexate, such as during chemotherapy, are scarce. We present the case of a 14-year-old patient who received high-dose methotrexate and subsequently developed acute fulminant liver failure and acute kidney injury. Genotyping of
Language	English
Publishing date	2023-05-02
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1130548
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Article ; Online: Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases.

Robin, Shannon K D / Ansari, Marc / Uppugunduri, Chakradhara Rao S

Journal of visualized experiments : JoVE

2020 , Issue 164

Abstract: Glutathione S-transferases (GSTs) are metabolic enzymes responsible for the elimination of endogenous or exogenous electrophilic compounds by glutathione (GSH) conjugation. In addition, GSTs are regulators of mitogen-activated protein kinases (MAPKs) ... ...

Abstract	Glutathione S-transferases (GSTs) are metabolic enzymes responsible for the elimination of endogenous or exogenous electrophilic compounds by glutathione (GSH) conjugation. In addition, GSTs are regulators of mitogen-activated protein kinases (MAPKs) involved in apoptotic pathways. Overexpression of GSTs is correlated with decreased therapeutic efficacy among patients undergoing chemotherapy with electrophilic alkylating agents. Using GST inhibitors may be a potential solution to reverse this tendency and augment treatment potency. Achieving this goal requires the discovery of such compounds, with an accurate, quick, and easy enzyme assay. A spectrophotometric protocol using 1-chloro-2,4-dinitrobenzene (CDNB) as the substrate is the most employed method in the literature. However, already described GST inhibition experiments do not provide a protocol detailing each stage of an optimal inhibition assay, such as the measurement of the Michaelis-Menten constant (Km) for CDNB or indication of the employed enzyme concentration, crucial parameters to assess the inhibition potency of a tested compound. Hence, with this protocol, we describe each step of an optimized spectrophotometric GST enzyme assay, to screen libraries of potential inhibitors. We explain the calculation of both the half-maximal inhibitory concentration (IC50) and the constant of inhibition (Ki)-two characteristics used to measure the potency of an enzyme inhibitor. The method described can be implemented using a pool of GSTs extracted from cells or pure recombinant human GSTs, namely GST alpha 1 (GSTA1), GST mu 1 (GSTM1) or GST pi 1 (GSTP1). However, this protocol cannot be applied to GST theta 1 (GSTT1), as CDNB is not a substrate for this isoform. This method was used to test the inhibition potency of curcumin using GSTs from equine liver. Curcumin is a molecule exhibiting anti-cancer properties and showed affinity towards GST isoforms after in silico docking predictions. We demonstrated that curcumin is a potent competitive GST inhibitor, with an IC50 of 31.6 ± 3.6 µM and a Ki of 23.2 ± 3.2 µM. Curcumin has potential to be combined with electrophilic chemotherapy medication to improve its efficacy.
MeSH term(s)	Animals ; Curcumin/pharmacology ; Cytosol/enzymology ; Dinitrobenzenes/metabolism ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/analysis ; Enzyme Inhibitors/pharmacology ; Ethacrynic Acid/pharmacology ; Glutathione/metabolism ; Glutathione Transferase/antagonists & inhibitors ; Glutathione Transferase/metabolism ; Horses ; Inhibitory Concentration 50 ; Isoenzymes/metabolism ; Kinetics ; Liver/enzymology ; Spectrophotometry/methods ; Substrate Specificity/drug effects
Chemical Substances	2,4-dinitrobenzene ; Dinitrobenzenes ; Enzyme Inhibitors ; Isoenzymes ; Glutathione Transferase (EC 2.5.1.18) ; Glutathione (GAN16C9B8O) ; Curcumin (IT942ZTH98) ; Ethacrynic Acid (M5DP350VZV)
Language	English
Publishing date	2020-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/61347
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dual-energy computed tomography to detect early pulmonary vascular changes in children with sickle cell disease: a pilot study.

Joye, Raphael / Wacker, Julie / Nguyen, Duy-Anh / Hachulla, Anne-Lise / Maggio, Albane B R / Cimasoni, Laurent / Lador, Frederic / Ansari, Marc / Beghetti, Maurice

Frontiers in pediatrics

2023 Volume 11, Page(s) 1221977

Abstract: Introduction: Pulmonary hypertension (PH) is a rare but fatal complication of sickle cell disease (SCD) that is possibly reversible if treated early. Dual-energy computed tomography (DECT) is a valuable tool for diagnosing PH. We attempted to determine ... ...

Abstract	Introduction: Pulmonary hypertension (PH) is a rare but fatal complication of sickle cell disease (SCD) that is possibly reversible if treated early. Dual-energy computed tomography (DECT) is a valuable tool for diagnosing PH. We attempted to determine if DECT can detect early signs of PH in children with SCD. Methods: This prospective observational pilot study was conducted at the Geneva University Hospitals and was approved by the local human ethics committee (CCER 2019-01975). A written informed consent was obtained from the patients and/or their legal guardian. Eight children (consisting of five girls and three boys) with homozygous SCD were included in the study. They underwent full cardiological workup using transthoracic echocardiography (TTE) and cardiopulmonary exercise test (CPET), as well as DECT. Results: The median age of the children was 11 years old (range 8-12). All patients exhibited a normal biventricular systo-diastolic function using the TTE. The median tricuspid regurgitant jet velocity value was 2.24 m/s (range 1.96-2.98). Four children were found to have signs of vasculopathy detected on DECT. Of them, two had abnormal screening test results. They both had an increased VE/VCO Conclusion: DECT is capable of identifying early signs of pulmonary vascular disease in children with SCD. Further studies are needed to understand the correlation between DECT abnormalities and hemodynamic pulmonary circulation better.
Language	English
Publishing date	2023-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1221977
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