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  1. Article ; Online: The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life.

    Haupt, Larisa M / Haywood, Alison / Sutherland, Heidi G / Yu, Chieh / Albury, Cassie L / Pharasi, Anushka / Zunk, Mathew / George, Rani / Griffiths, Lyn R / Good, Phillip / Hardy, Janet

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3411

    Abstract: Cancer pain is the most feared symptom at end of life. Methadone has advantages over other opioids but is associated with significant variability in clinical response, making dosing challenging in practice. OPRM1 is the most studied pharmacogene ... ...

    Abstract Cancer pain is the most feared symptom at end of life. Methadone has advantages over other opioids but is associated with significant variability in clinical response, making dosing challenging in practice. OPRM1 is the most studied pharmacogene associated with the pharmacodynamics of opioids, however reports on the association of the A118G polymorphism on opioid dose requirements are conflicting, with no reports including methadone as the primary intervention. This association study on OPRM1 A118G and response to methadone for pain management, includes a review of this genetic factor's role in inter-patient variability. Fifty-four adult patients with advanced cancer were recruited in a prospective, multi-centre, open label dose individualization study. Patient characteristics were not shown to influence methadone response, and no significant associations were observed for methadone dose or pain score. The findings of our review of association studies for OPRM1 A118G in advanced cancer pain demonstrate the importance of taking ancestry into account. While our sample size was small, our results were consistent with European populations, but in contrast to studies in Chinese patients, where carriers of the A118G polymorphism were associated with higher opioid dose requirements. Pharmacogenetic studies in palliative care are challenging, continued contribution will support future genotype-based drug dosing guidelines.
    MeSH term(s) Adult ; Humans ; Analgesics, Opioid/therapeutic use ; Cancer Pain/drug therapy ; Cancer Pain/genetics ; Genotype ; Methadone/therapeutic use ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/genetics ; Pain Management ; Polymorphism, Single Nucleotide ; Prospective Studies ; Receptors, Opioid, mu/genetics
    Chemical Substances Analgesics, Opioid ; Methadone (UC6VBE7V1Z) ; OPRM1 protein, human ; Receptors, Opioid, mu
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54009-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Call to Action for Improving Community Health While Reducing Health Disparities.

    Price-Haywood, Eboni G

    The Ochsner journal

    2023  Volume 23, Issue 2, Page(s) 104–105

    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.23.0040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Racial Differences in Strength of Associations Between Colorectal Cancer Screening, Area Deprivation, Demographics, and Clinical Characteristics.

    Price-Haywood, Eboni G / Burton, Jeffrey H

    The Ochsner journal

    2023  Volume 23, Issue 3, Page(s) 194–205

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.23.0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Alcohol and cannabinoid binges and daily exposure to nicotine in adolescent/young adult rats induce sex-dependent long-term appetitive instrumental learning impairment.

    Abela, Norbert / Haywood, Katie / Di Giovanni, Giuseppe

    Frontiers in behavioral neuroscience

    2023  Volume 17, Page(s) 1129866

    Abstract: Adolescence is a critical developmental period, concerning anatomical, neurochemical and behavioral changes. Moreover, adolescents are more sensitive to the long-term deleterious effects of drug abuse. Binge-like consumption of alcohol and marijuana, ... ...

    Abstract Adolescence is a critical developmental period, concerning anatomical, neurochemical and behavioral changes. Moreover, adolescents are more sensitive to the long-term deleterious effects of drug abuse. Binge-like consumption of alcohol and marijuana, along with tobacco smoking, is a dangerous pattern often observed in adolescents during weekends. Nevertheless, the long-term effect of their adolescent co-exposure has not been yet experimentally investigated. Long-Evans adolescent male (
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2023.1129866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Physician responses to insurance benefit restrictions: The case of ophthalmology.

    Abiona, Olukorede / Haywood, Phil / Yu, Serena / Hall, Jane / Fiebig, Denzil G / van Gool, Kees

    Health economics

    2024  Volume 33, Issue 5, Page(s) 911–928

    Abstract: This study examines the impact of social insurance benefit restrictions on physician behaviour, using ophthalmologists as a case study. We examine whether ophthalmologists use their market power to alter their fees and rebates across services to ... ...

    Abstract This study examines the impact of social insurance benefit restrictions on physician behaviour, using ophthalmologists as a case study. We examine whether ophthalmologists use their market power to alter their fees and rebates across services to compensate for potential policy-induced income losses. The results show that ophthalmologists substantially reduced their fees and rebates for services directly targeted by the benefit restriction compared to other medical specialists' fees and rebates. There is also some evidence that they increased their fees for services that were not targeted. High-fee charging ophthalmologists exhibited larger fee and rebate responses while the low-fee charging group raise their rebates to match the reference price provided by the policy environment.
    MeSH term(s) Humans ; United States ; Insurance Benefits ; Ophthalmology ; Fees, Medical ; Fees and Charges ; Physicians
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1135838-5
    ISSN 1099-1050 ; 1057-9230
    ISSN (online) 1099-1050
    ISSN 1057-9230
    DOI 10.1002/hec.4799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Stable isotope ratios on foraminifera from Site 138-846, supplementary data to: Scroxton, Nick; Bonham, Sarah G; Rickaby, Ros EM; Lawrence, Sophie H F; Hermoso, Michael; Haywood, Alan M (2011): Persistent El Ni?o-Southern Oscillation variation during the Pliocene Epoch. Paleoceanography, 26, PA2215, 13 pp

    Scroxton, Nick / Bonham, Sarah G / Haywood, Alan M / Hermoso, Michael / Lawrence, Sophie H F / Rickaby, Ros EM

    2011  

    Abstract: There is an urgent requirement to understand how large fluctuations in tropical heat distribution associated with the El Ni?o-Southern Oscillation (ENSO) will respond to anthropogenic emissions of greenhouse gases. Intervals of global warmth in Earth ... ...

    Abstract There is an urgent requirement to understand how large fluctuations in tropical heat distribution associated with the El Ni?o-Southern Oscillation (ENSO) will respond to anthropogenic emissions of greenhouse gases. Intervals of global warmth in Earth history provide a unique natural laboratory to explore the behaviour of the ENSO in a warmer world. To investigate interannual climatic variability, specifically ENSO, in the mid-Piacenzian Warm Period (mPWP: 3.26 - 3.03 Ma), we integrate observations from the stable isotopes of multiple individual planktonic foraminifera from three different species from the eastern equatorial Pacific (EEP) with ENSO simulations from HadCM3, a fully coupled ocean-atmosphere climate model. Our proxy data and model outputs show persistent inter-annual variability during the mPWP caused by a fluctuating thermocline, despite a deeper thermocline and reduced upwelling. We show that the likely cause of the deeper thermocline is due to warmer equatorial undercurrents rather than reduced physical upwelling. We conclude that the mPWP was characterized by ENSO related variability around a mean state akin to a modern El Ni?o event.? Furthermore, HadCM3 predicts that the warmer Pliocene world is characterized by a more periodic, regular amplitude ENSO fluctuation, suggestive that the larger and deeper west Pacific warm pool is more easily destabilized eastwards. These conclusions are comparable to the observed trend over the last forty years to more regular and intense ENSO events. Future research must resolve whether global warming alone, or in concert with tectonic factors, was sufficient to alter ENSO variability during warm intervals of the Pliocene.
    Language English
    Dates of publication 2011-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1029/2010PA002097
    DOI 10.1594/PANGAEA.744735
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: Roles and Responsibilities of Community Health Workers in Louisiana Medicaid Managed Care Organizations.

    Wennerstrom, Ashley / Sugarman, Meredith / Haywood, Catherine G / Jindal, Dakshu / True, Gala

    The Journal of ambulatory care management

    2023  Volume 47, Issue 1, Page(s) 22–32

    Abstract: We explored the roles of community health workers (CHWs) working in Medicaid Managed Care Organizations in Louisiana by conducting 10 interviews with CHWs, supervisors, and administrators. We identified 6 themes: CHWs' backgrounds and training; roles as ... ...

    Abstract We explored the roles of community health workers (CHWs) working in Medicaid Managed Care Organizations in Louisiana by conducting 10 interviews with CHWs, supervisors, and administrators. We identified 6 themes: CHWs' backgrounds and training; roles as they related to nationally recognized competencies; team integration; who CHWs serve and how members are identified; metrics for success; and the effects of COVID. CHWs are hired for their community connections. CHWs generally do not receive core competency training, and they focus primarily on improving individual-level health outcomes. Administrators and supervisors may need training and support on CHW competencies, supervision, and using common evaluation indicators.
    MeSH term(s) Humans ; Community Health Workers ; Medicaid ; Louisiana ; Managed Care Programs ; Qualitative Research
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 198845-1
    ISSN 1550-3267 ; 0148-9917
    ISSN (online) 1550-3267
    ISSN 0148-9917
    DOI 10.1097/JAC.0000000000000483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Stop the Divide: Facilitators and Barriers to Uptake of Digital Health Interventions Among Socially Disadvantaged Populations.

    Price-Haywood, Eboni G / Arnold, Connie / Harden-Barrios, Jewel / Davis, Terry

    The Ochsner journal

    2023  Volume 23, Issue 1, Page(s) 34–42

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.22.0101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Evaluating Racial Disparities in Implementation and Monitoring of a Remote Blood Pressure Program in a Pregnant Population-A Retrospective Cohort Study.

    Howard, Elizabeth / Gillispie-Bell, Veronica / Olet, Susan / Glenn, Beth / Ammar, Nariman / Price-Haywood, Eboni G

    Ochsner journal

    2024  Volume 24, Issue 1, Page(s) 22–30

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.23.0111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characterization of the robotic surgery experience in minimally invasive surgery fellowships from 2010 to 2021.

    Haywood, Nathan / Scott, Joshua / Zhang, Aimee / Hallowell, Peter / Schirmer, Bruce

    Surgical endoscopy

    2023  Volume 37, Issue 12, Page(s) 9393–9398

    Abstract: ... by operative category (e.g., bariatric, hernia, foregut), and robotic experience over time was evaluated ...

    Abstract Background: Robotic surgery has experienced exponential growth in the past decade. Few studies have evaluated the impact of robotics within minimally invasive surgery (MIS) fellowship training programs. The purpose of our study was to examine and characterize recent trends in robotic surgery within MIS fellowship training programs.
    Methods: De-identified case log data from the Fellowship Council from 2010 to 2021 were evaluated. Percentage of operations performed with robot assistance over time was assessed and compared to the laparoscopic and open experience. Case logs were further stratified by operative category (e.g., bariatric, hernia, foregut), and robotic experience over time was evaluated for each category. Programs were stratified by percent robot use and the experience over time within each quartile was evaluated.
    Results: MIS fellowship training programs with a robotic platform increased from 45.1% (51/113) to 90.4% (123/136) over the study period. The percentage of robotic cases increased from 2.0% (1127/56,033) to 23.2% (16,139/69,496) while laparoscopic cases decreased from 80.2% (44,954/56,033) to 65.3% (45,356/69,496). Hernia and colorectal case categories had the largest increase in robot usage [hernia: 0.7% (62/8614) to 38.4% (4661/12,135); colorectal 4.2% (116/2747) to 31.8% (666/2094)]. When stratified by percentage of robot utilization, current (2020-2021) programs in the > 95th percentile performed 21.8% (3523/16,139) of robotic operations and programs in the > 50th percentile performed 90.0% (14,533/16,139) of all robotic cases. The median number of robotic cases performed per MIS fellow significantly increased from 2010 to 2021 [0 (0-6) to 72.5 (17.8-171.5), p < 0.01].
    Conclusions: Robotic use in MIS fellowship training programs has grown substantially in the past decade, but the laparoscopic and open experience remains robust. There remains an imbalance with the top 50% of busiest robotic programs performing over 90% of robot trainee cases. The experience in MIS programs varies widely and trainees should examine program case logs closely to confirm parallel interests.
    MeSH term(s) Humans ; Robotic Surgical Procedures ; Fellowships and Scholarships ; Minimally Invasive Surgical Procedures/education ; Laparoscopy/education ; Hernia ; Colorectal Neoplasms ; Education, Medical, Graduate ; Internship and Residency ; Clinical Competence
    Language English
    Publishing date 2023-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10402-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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