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Article ; Online: PD-1 and PD-L1 Blockade plus Chemotherapy in Endometrial Cancer.

Cetin, Bulent / Gumusay, Ozge

2023 Volume 389, Issue 9, Page(s) 866–867

MeSH term(s)	Humans ; Female ; Programmed Cell Death 1 Receptor ; B7-H1 Antigen ; Endometrial Neoplasms/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
Chemical Substances	pembrolizumab (DPT0O3T46P) ; Programmed Cell Death 1 Receptor ; B7-H1 Antigen ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2308037
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Should one use the combination of abiraterone and poly(ADP-ribose) polymerase inhibitors as first-line therapy for all patients with metastatic castration-resistant prostate cancer?

Cetin, Bulent / Wabl, Chiara A / Gumusay, Ozge

Future oncology (London, England)

2023 Volume 18, Issue 39, Page(s) 4235–4238

MeSH term(s)	Male ; Humans ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Androstenes/therapeutic use ; DNA Repair
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors ; abiraterone (G819A456D0) ; Androstenes
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2022-0668
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6478: Show issues

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Article ; Online: Transfer of Salmonella, Escherichia coli O157:H7 and Listeria monocytogenes from contaminated soilless substrate and seeds to microgreens.

Işık, Sefa / Çetin, Bülent / Topalcengiz, Zeynal

International journal of food microbiology

2024 Volume 414, Page(s) 110612

Abstract: Microgreens can be contaminated by various preharvest sources including soilless substrate, plant nutrition solution, water and seeds. The aim of this study was to determine the transfer level of Salmonella, Shiga toxin-producing Escherichia coli O157:H7, ...

Abstract	Microgreens can be contaminated by various preharvest sources including soilless substrate, plant nutrition solution, water and seeds. The aim of this study was to determine the transfer level of Salmonella, Shiga toxin-producing Escherichia coli O157:H7, and Listeria monocytogenes to the edible part of various type of microgreens from plant nutrient solution-soaked perlite as soilless substrate or seeds. Ampicillin resistant 3-strain cocktails of Salmonella and E. coli O157:H7 and non-resistant L. monocytogenes were independently inoculated into plant nutrient solution-soaked perlite and seeds in low (10
MeSH term(s)	Escherichia coli O157 ; Listeria monocytogenes ; Food Microbiology ; Colony Count, Microbial ; Salmonella ; Seeds ; Aluminum Oxide ; Silicon Dioxide
Chemical Substances	Perlite (0SG101ZGK9) ; Aluminum Oxide (LMI26O6933) ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2024.110612
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Article ; Online: Advancing immunotherapy in gastroesophageal cancer through rational combinations and biomarkers.

Cetin, Bulent / Wabl, Chiara A / Gumusay, Ozge

Immunotherapy

2023 Volume 15, Issue 12, Page(s) 945–962

Abstract: The impact of checkpoint inhibitors on gastroesophageal cancer treatment has been tremendous in the last 2 years. KEYNOTE-590, CHECKMATE 649 and CheckMate 648 are landmark trials that have introduced immunotherapy to the field as first-line therapy, ... ...

Abstract	The impact of checkpoint inhibitors on gastroesophageal cancer treatment has been tremendous in the last 2 years. KEYNOTE-590, CHECKMATE 649 and CheckMate 648 are landmark trials that have introduced immunotherapy to the field as first-line therapy, leading to a paradigm change for advanced esophageal and gastric cancer. Chemotherapy in combination with immunotherapy is now the standard of care for first-line treatment of locally advanced or metastatic adenocarcinoma of the esophagus, esophagogastric junction and stomach. Several new targets and treatments are available for gastroesophageal cancer that are based on the characterization of cancer cells and the tumor microenvironment. Biomarker-based therapy selection is critical to optimize outcomes and minimize toxicities, as well as give insight into the optimal timing and sequence of a patient's treatment course.
MeSH term(s)	Humans ; Stomach Neoplasms/drug therapy ; Esophageal Neoplasms/drug therapy ; Adenocarcinoma/drug therapy ; Immunotherapy ; Biomarkers, Tumor/therapeutic use ; Tumor Microenvironment
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2022-0287
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Usability of elemental analysis for antemortem and postmortem bone fracture differentiation.

Gulderen, Abuzer / Eren, Bulent / Cetin, Selcuk / Budak, Yakup

Journal of forensic and legal medicine

2023 Volume 99, Page(s) 102595

Abstract: The differentiation of antemortem and postmortem fractures is a challenging and important issue in forensic medicine. To investigate the usability of chemical element levels in blunt fracture ends for the differentiation of antemortem and postmortem ... ...

Abstract	The differentiation of antemortem and postmortem fractures is a challenging and important issue in forensic medicine. To investigate the usability of chemical element levels in blunt fracture ends for the differentiation of antemortem and postmortem fractures, antemortem and postmortem fractures were created in rats and left to decay in the natural environment. Forty-eight rats were used in this study. The rats divided into six groups, each group containing eight rats. We induced a left mandibular fracture in all rats under anesthesia and then waited for 2 d to become organized to fracture the hematoma. All rats were sacrificed under anesthesia, and a postmortem blunt fracture was created in the right mandible. Samples were taken from the fracture ending at 0, 7, 14, 30, 60, and 90 d after the blunt postmortem fracture. The Mg, S, K, Ca, and Fe contents were measured using inductively coupled plasma/optical emission spectrometry (ICP-OES). In our study, it was observed that antemortem Mg, K, S and Ca levels were generally higher than the post-mortem levels, although not statistically significant in all groups.
MeSH term(s)	Rats ; Animals ; Postmortem Changes ; Autopsy ; Fractures, Bone ; Forensic Medicine/methods ; Spectrum Analysis
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2268721-X
ISSN	1878-7487 ; 1752-928X
ISSN (online)	1878-7487
ISSN	1752-928X
DOI	10.1016/j.jflm.2023.102595
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Zs.A 4217: Show issues

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Article ; Online: Treatment of persistent large cystic lesions of the humerus with vascularized fibular grafts.

Çetin, Mehmet Ümit / Özçelik, İsmail Bülent

Joint diseases and related surgery

2022 Volume 33, Issue 2, Page(s) 426–434

Abstract: Objectives: In this study, we aimed to evaluate the short-to-midterm results of the resection and reconstruction of large cystic lesions of the humerus.: Patients and methods: Eight male patients (median age: 22.9±10.4 years; range, 12 to 42 years) ... ...

Abstract	Objectives: In this study, we aimed to evaluate the short-to-midterm results of the resection and reconstruction of large cystic lesions of the humerus. Patients and methods: Eight male patients (median age: 22.9±10.4 years; range, 12 to 42 years) with large cystic lesions of the humerus operated between January 2017 and December 2019 were retrospectively analyzed. The age of the patients, their previous treatments and follow-up periods, the size and location of the cysts, postoperative functional scores, presence of a union, recurrence of the cyst, and graft resorption were examined. Results: The mean follow-up was 42.8±7.5 (range, 34 to 54) months. Preoperatively, the mean length of the cystic lesions was 15.1±2.6 (range, 10 to 18) cm. At the final follow-up, the patients had a normal range of shoulder flexion-extension, internal rotation-external, abduction-adduction, and elbow flexion-extension, pronation-supination. The patients had a mean DASH score of 1.13±1.1 (range, 0 to 3.3) and MSTS score of 28.75±1.8 (range, 26 to 30) postoperatively. Complications such as pseudoarthrosis, graft resorption, or cyst recurrence were not observed in any of the patients. Conclusion: Although the risk of recurrence is low in small cystic lesions of the humerus, it increases as the size of the lesion increases. This reconstruction technique using vascularized fibular grafts, which we applied, seems to be extremely successful in ensuring biological healing and preventing recurrence and complications in patients with large cystic lesions of the humerus.
MeSH term(s)	Adolescent ; Adult ; Bone Neoplasms/pathology ; Bone Transplantation/methods ; Child ; Cysts/etiology ; Cysts/pathology ; Cysts/surgery ; Humans ; Humerus/surgery ; Male ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2022-07-06
Publishing country	Turkey
Document type	Journal Article
ISSN	2687-4792
ISSN (online)	2687-4792
DOI	10.52312/jdrs.2022.578
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Understanding relevant immune mechanisms in gastrointestinal oncology.

Cetin, Bulent / Gumusay, Ozge

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2021 Volume 27, Issue 5, Page(s) 1222–1234

Abstract: Rapid and successful drug development has resulted in multiple treatment options for gastrointestinal cancer, requiring careful decision making for individual patients. The general theme in modern immunology is that the field is moving beyond ... ...

Abstract	Rapid and successful drug development has resulted in multiple treatment options for gastrointestinal cancer, requiring careful decision making for individual patients. The general theme in modern immunology is that the field is moving beyond establishing the fundamental principles of immune response mechanisms to applying these propositions to understand human diseases and develop new therapies. Immunotherapy has contributed enormously to cancer treatments with a virtual explosion in novel therapeutics including checkpoint inhibitors and other recently developed immunomodulators and the development of novel therapeutic approaches. Although the majority of gastrointestinal (GI) cancers are generally considered poorly immunogenic, clinical trials have revealed that some of the patients with various gastrointestinal cancers are highly responsive to immune checkpoint inhibition-based therapies. We paid special attention to the clinical relevance of immunology and emphasized how newly developed therapies work, including what their strengths and pitfalls are. This review aims to enhance the interest of practitioners in the many specialties and subspecialties that the discipline influences and to assist them in understanding this increasing complexity.
MeSH term(s)	Gastrointestinal Neoplasms/therapy ; Humans ; Immunotherapy/methods
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/1078155221992862
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Zs.A 4488: Show issues

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Article ; Online: Pembrolizumab for Early Triple-Negative Breast Cancer.

Cetin, Bulent / Gumusay, Ozge

The New England journal of medicine

2020 Volume 382, Issue 26, Page(s) e108

MeSH term(s)	Antibodies, Monoclonal, Humanized ; Breast Neoplasms ; Humans ; Triple Negative Breast Neoplasms
Chemical Substances	Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
Language	English
Publishing date	2020-06-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2006684
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Combining ability and heterosis for fiber color and quality in cotton (Gossypium hirsutum L.)

ÇETİN, Bülent / ÇOPUR, Osman

Notulae botanicae Horti Agrobotanici Cluj-Napoca. 2022, v. 50, no. 2

2022

Abstract: The interest in organic cotton (colored) has been increased due to high contamination and environmental pollution during fabric dying process. However, detailed studies are needed to determine the genetic and yield related traits. Eight different cotton ... ...

Abstract	The interest in organic cotton (colored) has been increased due to high contamination and environmental pollution during fabric dying process. However, detailed studies are needed to determine the genetic and yield related traits. Eight different cotton genotypes (3 green, 3 brown and 2 white) with known fiber color values were used in the current study to record combining ability and heterosis for fiber colour and quality traits. An 8×8 half diallel hybrid population containing 28 F1 hybrids was analysed in the experimental area of GAP Agricultural Research Institute, Şanlıurfa, Turkey. The study including parents and hybrids was established in a randomized complete block design with three replications. The main aim was to examine the genetic structure for studied traits in the populations developed and detecting F1 hybrid vigour. Finding appropriate parent and hybrid combinations for breeding studies was the second major aim of the study. Sufficient variations were noted for the studied traits in hybrid population formed. Genetic parameters such as general and special compatibility abilities, heterosis and heterobeltiosis values were recorded in the formed population. Fiber length (mm), fiber fineness (micronaire), fiber strength (g tex-1), fiber uniformity (%), fiber color values L* (brightness), a* (red-greenness) and b* (yellow-blueness) values were recorded. It was noted that additive genetic effects were important for fiber length, fiber fineness, fiber strength, L, a and b* traits.
Keywords	Gossypium hirsutum ; agricultural research ; color ; cotton ; fabrics ; fineness ; genetic structure ; heterosis ; hybrids ; micronaire ; pollution ; research institutions
Language	English
Publishing place	AcademicPres
Document type	Article
ZDB-ID	2271404-2
ISSN	1842-4309 ; 0255-965X
ISSN (online)	1842-4309
ISSN	0255-965X
DOI	10.15835/nbha50212782
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Combining ability and heterosis for fiber color and quality in cotton (Gossypium hirsutum L.)

Bülent ÇETİN / Osman ÇOPUR

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, Vol 50, Iss

2022 Volume 2

Abstract	The interest in organic cotton (colored) has been increased due to high contamination and environmental pollution during fabric dying process. However, detailed studies are needed to determine the genetic and yield related traits. Eight different cotton genotypes (3 green, 3 brown and 2 white) with known fiber color values were used in the current study to record combining ability and heterosis for fiber colour and quality traits. An 8×8 half diallel hybrid population containing 28 F1 hybrids was analysed in the experimental area of GAP Agricultural Research Institute, Şanlıurfa, Turkey. The study including parents and hybrids was established in a randomized complete block design with three replications. The main aim was to examine the genetic structure for studied traits in the populations developed and detecting F1 hybrid vigour. Finding appropriate parent and hybrid combinations for breeding studies was the second major aim of the study. Sufficient variations were noted for the studied traits in hybrid population formed. Genetic parameters such as general and special compatibility abilities, heterosis and heterobeltiosis values were recorded in the formed population. Fiber length (mm), fiber fineness (micronaire), fiber strength (g tex-1), fiber uniformity (%), fiber color values L* (brightness), a* (red-greenness) and b* (yellow-blueness) values were recorded. It was noted that additive genetic effects were important for fiber length, fiber fineness, fiber strength, L, a and b* traits.
Keywords	Cotton ; Diallel analysis ; fiber color properties ; inheritance ; Forestry ; SD1-669.5 ; Agriculture (General) ; S1-972
Subject code	796
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	AcademicPres
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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