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  1. Article ; Online: Equity implications of patient-initiated recontact and follow-up in clinical genetics.

    Mackley, Michael P / Chad, Lauren

    European journal of human genetics : EJHG

    2023  Volume 31, Issue 5, Page(s) 495–496

    MeSH term(s) Humans ; Duty to Recontact ; Follow-Up Studies ; Genetic Testing ; Genetics, Medical ; Patients
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-023-01341-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Disordered eating in adolescents with type 1 diabetes: risk factors and screening recommendations.

    Chad-Friedman, Emma / Clary, Lauren / Jhe, Grace

    Current opinion in pediatrics

    2024  

    Abstract: Purpose of review: Adolescents with Type 1 diabetes (T1D) are at significantly greater risk for disordered eating behaviors compared to their peers without T1D. Given that this is a dangerous and potentially lethal combination, this review aims to ... ...

    Abstract Purpose of review: Adolescents with Type 1 diabetes (T1D) are at significantly greater risk for disordered eating behaviors compared to their peers without T1D. Given that this is a dangerous and potentially lethal combination, this review aims to support pediatric medical providers in increasing competence in identification, assessment, and prevention of disordered eating behaviors in adolescents with T1D.
    Recent findings: This review provides an up-to-date synthesis of unique risk factors for disordered eating behaviors in adolescents with T1D, including the daily diabetes management tasks, effects of insulin on weight and hunger, family conflict, and reinforcement from their environment for disordered behaviors. This review recommends two brief screening tools, the Diabetes Eating Problems Survey-Revised (DEPS-R) and Modified SCOFF (mSCOFF), to be used in busy practices; it also provides practical strategies for providersto use with patients in the form of effective, nonjudgmental language.
    Summary: A clear understanding of unique experiences impacting adolescents with T1D may increase use of evidence-based screening tools and identification of disordered eating behaviors among a high-risk population in clinic/practice. In addition, providers' intentional use of nonjudgmental and de-stigmatizing language may lead to more positive interactions for adolescents and willingness to engage in further treatment.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3049: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Please give me a copy of my child's raw genomic data.

    Chad, Lauren / Szego, Michael J

    NPJ genomic medicine

    2021  Volume 6, Issue 1, Page(s) 15

    Language English
    Publishing date 2021-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2813848-X
    ISSN 2056-7944 ; 2056-7944
    ISSN (online) 2056-7944
    ISSN 2056-7944
    DOI 10.1038/s41525-021-00175-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Author Correction: Please give me a copy of my child's raw genomic data.

    Chad, Lauren / Szego, Michael J

    NPJ genomic medicine

    2021  Volume 6, Issue 1, Page(s) 26

    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2813848-X
    ISSN 2056-7944 ; 2056-7944
    ISSN (online) 2056-7944
    ISSN 2056-7944
    DOI 10.1038/s41525-021-00191-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Bioethics at the bedside.

    Chad, Lauren / Helmers, Andrew / Kirsch, Roxanne

    Paediatrics & child health

    2022  Volume 27, Issue 4, Page(s) 203–205

    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2106767-3
    ISSN 1918-1485 ; 1205-7088
    ISSN (online) 1918-1485
    ISSN 1205-7088
    DOI 10.1093/pch/pxac021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Author Correction

    Lauren Chad / Michael J. Szego

    npj Genomic Medicine, Vol 6, Iss 1, Pp 1-

    Please give me a copy of my child’s raw genomic data

    2021  Volume 1

    Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41525-021-00191- ... ...

    Abstract A Correction to this paper has been published: https://doi.org/10.1038/s41525-021-00191-y
    Keywords Medicine ; R ; Genetics ; QH426-470
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: The Future of the U.S. Intercontinental Ballistic Missile Force

    Caston, Lauren / Leonard, Robert S / Mouton, Christopher A / Ohlandt, Chad J. R / Moore, S. Craig

    2014  

    Keywords Defence strategy, planning & research ; Weapons & equipment ; Arms negotiation & control ; Political Science ; History
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030610152
    ISBN 9780833076236 ; 083307623X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Please give me a copy of my child’s raw genomic data

    Lauren Chad / Michael J. Szego

    npj Genomic Medicine, Vol 6, Iss 1, Pp 1-

    2021  Volume 5

    Abstract: In this work, we explore whether raw genetic data generated during sequencing ought to be returned to a pediatric patient and/or their parents/guardians. We identify the principles used by various professional societies in their guidelines on the return ... ...

    Abstract In this work, we explore whether raw genetic data generated during sequencing ought to be returned to a pediatric patient and/or their parents/guardians. We identify the principles used by various professional societies in their guidelines on the return of secondary findings and apply them to this new context. We conclude that since each situation is unique, decisions should be made on a case-by-case basis according to the best interests of the child.
    Keywords Medicine ; R ; Genetics ; QH426-470
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Lipid-Specific Direct Translocation of the Cell-Penetrating Peptide NAF-1

    Drexler, Chad I / Cyran, Jenée D / Webb, Lauren J

    The journal of physical chemistry. B

    2023  Volume 127, Issue 9, Page(s) 2002–2010

    Abstract: The cell-penetrating peptide NAF-1 has recently emerged as a promising candidate for selective penetration and destruction of cancer cells. It displays numerous membrane-selective behaviors including cell-specific uptake and organelle-specific ... ...

    Abstract The cell-penetrating peptide NAF-1 has recently emerged as a promising candidate for selective penetration and destruction of cancer cells. It displays numerous membrane-selective behaviors including cell-specific uptake and organelle-specific degradation. In this work, we explore membrane penetration and translocation of NAF-1 in model lipid bilayer vesicles as a function of lipid identity in zwitterionic phosphatidylcholine lipids mixed with anionic phosphatidylserine, phosphatidylglycerol, and phosphatidic acid lipids. By monitoring the digestion of NAF-1 using the protease trypsin located inside but not outside the vesicles, we determined that the translocation of NAF-1 was significantly enhanced by the presence of phosphatidic acid in the membrane compared to the other three anionic or zwitterionic lipids. These findings were correlated to fluorescence measurements of dansyl-labeled NAF-1, which revealed whether noncovalent interactions between NAF-1 and the bilayer were most stable either at the membrane/solution interface or within the membrane interior. Phosphatidic acid promoted interactions with fatty acid tails, while phosphatidylcholine, phosphatidylserine, and phosphatidylglycerol stabilized interactions with polar lipid headgroups. Interfacial vibrational sum frequency spectroscopy experiments revealed that the phosphate moiety on phosphatidic acid headgroups was better hydrated than on the other three lipids, which helped to shuttle NAF-1 into the hydrophobic region. Our findings demonstrate that permeation does not depend on the net charge on phospholipid lipid headgroups in these model vesicles and suggest a model wherein NAF-1 crosses membranes selectively due to lipid-specific interactions at bilayer surfaces.
    MeSH term(s) Cell-Penetrating Peptides/metabolism ; Phosphatidylserines ; Phosphatidylcholines/chemistry ; Lipid Bilayers/chemistry ; Carrier Proteins ; Phosphatidylglycerols/chemistry
    Chemical Substances Cell-Penetrating Peptides ; Phosphatidylserines ; Phosphatidylcholines ; Lipid Bilayers ; Carrier Proteins ; Phosphatidylglycerols
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c08076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Screening for facial differences worldwide: equity and ethics.

    McCradden, Melissa D / Chad, Lauren

    The Lancet. Digital health

    2021  Volume 3, Issue 10, Page(s) e615–e616

    MeSH term(s) Health Equity ; Mass Screening ; Research
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2589-7500
    ISSN (online) 2589-7500
    DOI 10.1016/S2589-7500(21)00179-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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