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  1. Article: Editorial: Diagnostic, prognostic and predictive factors of response in the era of precision oncology in breast cancer.

    Favero, Diletta / Generali, Daniele / Schettini, Francesco

    Frontiers in oncology

    2023  Volume 13, Page(s) 1337315

    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1337315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Therapeutic resistance and optimal drug sequencing in HER2-positive metastatic breast cancer

    Francesco Schettini / Fabiola Giudici / Daniele Generali

    Heliyon, Vol 10, Iss 1, Pp e23367- (2024)

    unmet needs and future perspectives

    1481  

    Abstract: In the last couple of decades substantial therapeutic improvements deeply influenced the treatment of HER2-positive metastatic breast cancer. The most impactful advancements were obtained especially in the first-line setting, with the trastuzumab/ ... ...

    Abstract In the last couple of decades substantial therapeutic improvements deeply influenced the treatment of HER2-positive metastatic breast cancer. The most impactful advancements were obtained especially in the first-line setting, with the trastuzumab/pertuzumab anti-HER2 double blockade, and in the second line, with the advent of the potent antibody-drug conjugate trastuzumab deruxtecan. Nevertheless, a careful observation of the patterns of early-progression and long-term effects on overall survival of the most novel agents and combinations, highlights the challenges represented by the emergence of therapeutic resistance and optimal drug sequencing. The integration of sequence studies, tumor-related biomarker development/implementation and understanding of primary mechanisms of resistance to novel anti-HER2 agents, will be the way to move forward to effectively tackle these novel unmet needs.
    Keywords Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Therapeutic resistance and optimal drug sequencing in HER2-positive metastatic breast cancer: unmet needs and future perspectives.

    Schettini, Francesco / Giudici, Fabiola / Generali, Daniele

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23367

    Abstract: In the last couple of decades substantial therapeutic improvements deeply influenced the treatment of HER2-positive metastatic breast cancer. The most impactful advancements were obtained especially in the first-line setting, with the trastuzumab/ ... ...

    Abstract In the last couple of decades substantial therapeutic improvements deeply influenced the treatment of HER2-positive metastatic breast cancer. The most impactful advancements were obtained especially in the first-line setting, with the trastuzumab/pertuzumab anti-HER2 double blockade, and in the second line, with the advent of the potent antibody-drug conjugate trastuzumab deruxtecan. Nevertheless, a careful observation of the patterns of early-progression and long-term effects on overall survival of the most novel agents and combinations, highlights the challenges represented by the emergence of therapeutic resistance and optimal drug sequencing. The integration of sequence studies, tumor-related biomarker development/implementation and understanding of primary mechanisms of resistance to novel anti-HER2 agents, will be the way to move forward to effectively tackle these novel unmet needs.
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The combination of bevacizumab with chemotherapy is more beneficial in the metastatic setting rather than in the adjuvant setting for the treatment of HER2-negative breast cancer-a commentary on the E5103 randomized phase III clinical study.

    Roviello, Giandomenico / Generali, Daniele / Sobhani, Navid

    Translational cancer research

    2022  Volume 8, Issue Suppl 2, Page(s) S94–S96

    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2018.10.17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Corrigendum: Aromatase inhibitors: the journey from the state of the art to clinical open questions.

    Generali, Daniele / Berardi, Rossana / Caruso, Michele / Cazzaniga, Marina / Garrone, Ornella / Minchella, Ida / Paris, Ida / Pinto, Carmine / De Placido, Sabino

    Frontiers in oncology

    2024  Volume 14, Page(s) 1369562

    Abstract: This corrects the article DOI: 10.3389/fonc.2023.1249160.]. ...

    Abstract [This corrects the article DOI: 10.3389/fonc.2023.1249160.].
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1369562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Patients' Engagement in Early Detection of COVID-19 Symptoms: An Observational Study in the Very Early Peak of the Pandemic in Italy in 2020.

    Palamenghi, Lorenzo / Giudici, Fabiola / Graffigna, Guendalina / Generali, Daniele

    International journal of environmental research and public health

    2022  Volume 19, Issue 5

    Abstract: COVID-19 exerted a strong impact on the Italian healthcare systems, which in turn resulted in a reduction in the citizens’ trust towards healthcare authorities. Moreover, the focused attention on the typical COVID-19 symptoms (fever, cough) has also ... ...

    Abstract COVID-19 exerted a strong impact on the Italian healthcare systems, which in turn resulted in a reduction in the citizens’ trust towards healthcare authorities. Moreover, the focused attention on the typical COVID-19 symptoms (fever, cough) has also impacted the social representation of health priorities, potentially reducing the perceived importance and severity of other symptoms. This study aimed to determine the association of general-practitioner (GP) contact with various symptoms during the COVID-19 pandemic in Cremona, an Italian city at the very epicentre of the pandemic. Between April and June 2020, an anonymous survey was completed by 2161 respondents. Logistic-regression analyses were used to examine the associations of GP contact with sociodemographic characteristics and the presence of symptoms. Of the 2161 respondents (43.5% female, 75.0% aged less than 55 years), 959 (44.4%) reported experiencing various symptoms and 33.3% contacted a GP. GP contact was significantly associated with poor appetite (OR, 2.42; 95% CI 1.63 to 3.62; p < 0.001), taste dysfunctions (OR 1.67; 95% CI 1.20 to 2.34; p < 0.001) and sleepiness during the day (OR 4.15; 95% CI 2.13 to 8.09; p = 0.002). None of the gastrointestinal symptoms resulted in significantly increasing the likelihood of contacting a GP. This study offers a unique observation of citizens’ attitudes and behaviours in early symptom communication/detection during the initial peak of the Italian COVID-19 pandemic.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; Female ; General Practitioners ; Humans ; Male ; Middle Aged ; Pandemics ; Patient Participation ; SARS-CoV-2
    Language English
    Publishing date 2022-03-05
    Publishing country Switzerland
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19053058
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  7. Article ; Online: Corrigendum to "Breaking barriers in triple negative breast cancer (TNBC) - Unleashing the power of antibody-drug conjugates (ADCs)" [Cancer Treatment Reviews 123 (2024) 102672].

    Dri, Arianna / Arpino, Grazia / Bianchini, Giampaolo / Curigliano, Giuseppe / Danesi, Romano / De Laurentiis, Michelino / Del Mastro, Lucia / Fabi, Alessandra / Generali, Daniele / Gennari, Alessandra / Guarneri, Valentina / Santini, Daniele / Simoncini, Edda / Zamagni, Claudio / Puglisi, Fabio

    Cancer treatment reviews

    2024  Volume 125, Page(s) 102714

    Language English
    Publishing date 2024-03-16
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2024.102714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1022: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: DNA repair deficiency as circulating biomarker in prostate cancer.

    Catalano, Martina / Generali, Daniele / Gatti, Marta / Riboli, Barbara / Paganini, Leda / Nesi, Gabriella / Roviello, Giandomenico

    Frontiers in oncology

    2023  Volume 13, Page(s) 1115241

    Abstract: Deleterious aberrations in DNA repair genes are actionable in approximately 25% of metastatic castration-resistant prostate cancers (mCRPC) patients. Homology recombination repair (HRR) is the DNA damage repair (DDR) mechanism most frequently altered in ... ...

    Abstract Deleterious aberrations in DNA repair genes are actionable in approximately 25% of metastatic castration-resistant prostate cancers (mCRPC) patients. Homology recombination repair (HRR) is the DNA damage repair (DDR) mechanism most frequently altered in prostate cancer; of note
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1115241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Next-Generation Sequencing and Triple-Negative Breast Cancer: Insights and Applications.

    Tierno, Domenico / Grassi, Gabriele / Scomersi, Serena / Bortul, Marina / Generali, Daniele / Zanconati, Fabrizio / Scaggiante, Bruna

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: The poor survival of triple-negative breast cancer (TNBC) is due to its aggressive behavior, large heterogeneity, and high risk of recurrence. A comprehensive molecular investigation of this type of breast cancer using high-throughput next-generation ... ...

    Abstract The poor survival of triple-negative breast cancer (TNBC) is due to its aggressive behavior, large heterogeneity, and high risk of recurrence. A comprehensive molecular investigation of this type of breast cancer using high-throughput next-generation sequencing (NGS) methods may help to elucidate its potential progression and discover biomarkers related to patient survival. In this review, the NGS applications in TNBC research are described. Many NGS studies point to
    MeSH term(s) Humans ; Triple Negative Breast Neoplasms/pathology ; Mutation ; Biomarkers ; High-Throughput Nucleotide Sequencing
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119688
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  10. Article ; Online: New-Generation Hormone Therapies in Nonmetastatic Castration-Resistant Prostate Cancer: Why, Who, When.

    Roviello, Giandomenico / Generali, Daniele

    Clinical genitourinary cancer

    2019  Volume 17, Issue 3, Page(s) e534–e535

    MeSH term(s) Androgen Antagonists/therapeutic use ; Antineoplastic Agents, Hormonal/therapeutic use ; Clinical Trials as Topic ; Humans ; Male ; Patient Selection ; Prognosis ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Time Factors
    Chemical Substances Androgen Antagonists ; Antineoplastic Agents, Hormonal
    Language English
    Publishing date 2019-02-06
    Publishing country United States
    Document type Letter
    ZDB-ID 2225121-2
    ISSN 1938-0682 ; 1558-7673
    ISSN (online) 1938-0682
    ISSN 1558-7673
    DOI 10.1016/j.clgc.2019.01.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6168: Show issues Location:
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