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  1. Book ; Online ; Thesis: Mechanistic and structural insights into the quality control of the MHC I antigen processing pathway

    Winter, Christian [Verfasser] / Tampé, Robert [Akademischer Betreuer] / Tampé, Robert [Gutachter] / Pos, Klaas Martinus [Gutachter]

    2023  

    Author's details Christian Winter ; Gutachter: Robert Tampé, Klaas Martinus Pos ; Betreuer: Robert Tampé
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Nerve transfer from the median to musculocutaneous nerve to induce active elbow flexion in selected cases of arthrogryposis multiplex congenita.

    Hagemann, Christian / Stücker, Ralf / Breyer, Sandra / Kunkel, Philip O S

    Microsurgery

    2019  Volume 39, Issue 8, Page(s) 710–714

    Abstract: Background: Arthrogryposis multiplex congenita (AMC) is a rare disease which affects mainly upper and lower extremities. Affected patients are not able to eat unassisted due to elbow contracture and nonexistent active elbow flexion. In traumatic ... ...

    Abstract Background: Arthrogryposis multiplex congenita (AMC) is a rare disease which affects mainly upper and lower extremities. Affected patients are not able to eat unassisted due to elbow contracture and nonexistent active elbow flexion. In traumatic brachial plexus palsies, a nerve transfer from either median or ulnar nerve to the musculocutaneous nerve has proved to induce active elbow flexion, and we report our results of such a procedure in a nontraumatic condition, that is, arthrogryposis.
    Methods: We selected four patients with AMC type 1 (6 extremities, 2 males, 2 females) diagnosed with AMC presenting to our institution shortly after birth from 2014 to 2016 to perform a nerve transfer from the median nerve to the musculocutaneous nerve in order to induce active elbow flexion. The indication of application of this surgical procedure was based on active finger and wrist flexion, limited contracture of elbow joints and evidence of flexing muscle fibers detected by sonography.
    Results: Five nerve transfers were conducted with a follow up of 2-5 years. Two extremities reached active elbow flexion motorgrade M4, two M3, and one M1 at latest follow up. One patient developed a postoperative suture granuloma. One nerve transfer was abandoned due to neuroanatomic variation. One extremity was treated with botulinum toxin in triceps muscle in addition to the nerve transfer.
    Conclusions: In this series of selected cases of AMC Type 1 we were able to induce active elbow flexion using a nerve transfer technique developed for traumatic and obstetric brachial plexus palsies. In four extremities the procedure achieved independent hand-to-mouth active elbow flexion. Level of evidence four.
    MeSH term(s) Arthrogryposis/surgery ; Elbow/physiology ; Elbow Joint ; Female ; Humans ; Infant ; Male ; Median Nerve/surgery ; Musculocutaneous Nerve/surgery ; Nerve Transfer/methods ; Range of Motion, Articular ; Recovery of Function ; Retrospective Studies
    Language English
    Publishing date 2019-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605524-2
    ISSN 1098-2752 ; 0738-1085
    ISSN (online) 1098-2752
    ISSN 0738-1085
    DOI 10.1002/micr.30451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Daily Intravoxel Incoherent Motion (IVIM) In Prostate Cancer Patients During MR-Guided Radiotherapy-A Multicenter Study.

    Kooreman, Ernst S / van Houdt, Petra J / Keesman, Rick / van Pelt, Vivian W J / Nowee, Marlies E / Pos, Floris / Sikorska, Karolina / Wetscherek, Andreas / Müller, Arndt-Christian / Thorwarth, Daniela / Tree, Alison C / van der Heide, Uulke A

    Frontiers in oncology

    2021  Volume 11, Page(s) 705964

    Abstract: Purpose: Daily quantitative MR imaging during radiotherapy of cancer patients has become feasible with MRI systems integrated with linear accelerators (MR-linacs). Quantitative images could be used for treatment response monitoring. With intravoxel ... ...

    Abstract Purpose: Daily quantitative MR imaging during radiotherapy of cancer patients has become feasible with MRI systems integrated with linear accelerators (MR-linacs). Quantitative images could be used for treatment response monitoring. With intravoxel incoherent motion (IVIM) MRI, it is possible to acquire perfusion information without the use of contrast agents. In this multicenter study, daily IVIM measurements were performed in prostate cancer patients to identify changes that potentially reflect response to treatment.
    Materials and methods: Forty-three patients were included, treated with 20 fractions of 3 Gy on a 1.5 T MR-linac. IVIM measurements were performed on each treatment day. The diffusion coefficient (D), perfusion fraction (f), and pseudo-diffusion coefficient (D*) were calculated based on the median signal intensities in the non-cancerous prostate and the tumor. Repeatability coefficients (RCs) were determined based on the first two treatment fractions. Separate linear mixed-effects models were constructed for the three IVIM parameters.
    Results: In total, 726 fractions were analyzed. Pre-treatment average values, measured on the first fraction before irradiation, were 1.46 × 10
    Conclusions: It is feasible to perform daily IVIM measurements on an MR-linac system. Although the repeatability coefficients were high, changes in IVIM perfusion parameters were measured on a group level, indicating that IVIM has potential for measuring treatment response.
    Language English
    Publishing date 2021-08-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.705964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The framing of innovation among European research funding actors

    Khan, Shumaisa S / Benighaus, Ludger / Boer, Alie de / Coutinho, Daniela / Da Pos, Lara / Hadwiger, Klaus / Hofmaier, Christian / Llerena Morán, José Luis / Neresini, Federico / Newton, Rachel / Ortega, Santiago / Raats, Monique M / Strähle, Michael / Timotijevic, Lada / Urban, Christine / Xhaferri, Zamira

    Food policy : economics planning and politics of food and agriculture Vol. 62 , p. 78-87

    assessing the potential for "responsible research and innovation" in the food and health domain

    2016  Volume 62, Page(s) 78–87

    Author's details Shumaisa S. Khan, Lada Timotijevic, Rachel Newton, Daniela Coutinho, José Luis Llerena, Santiago Ortega, Ludger Benighaus, Christian Hofmaier, Zamira Xhaferri, Alie de Boer, Christine Urban, Michael Strähle, Lara Da Pos, Federico Neresini, Monique M. Raats, Klaus Hadwiger
    Keywords Food and health ; Research funding ; Innovation ; Europe ; Responsible research and innovation ; RRI
    Language English
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 194840-4
    ISSN 0306-9192
    ISSN 0306-9192
    Database ECONomics Information System

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  5. Article: The framing of innovation among European research funding actors: Assessing the potential for ‘responsible research and innovation’ in the food and health domain

    Khan, Shumaisa S / Alie de Boer / Christian Hofmaier / Christine Urban / Daniela Coutinho / Federico Neresini / José Luis Llerena / Klaus Hadwiger / Lada Timotijevic / Lara Da Pos / Ludger Benighaus / Michael Strähle / Monique M. Raats / Rachel Newton / Santiago Ortega / Zamira Xhaferri

    Food policy. 2016 July, v. 62

    2016  

    Abstract: Responsible Research and Innovation (RRI) has recently emerged as a new framework for science and technology governance. The concept articulates the need for mutual exchange by which societal actors become responsive to each other early on in the process ...

    Abstract Responsible Research and Innovation (RRI) has recently emerged as a new framework for science and technology governance. The concept articulates the need for mutual exchange by which societal actors become responsive to each other early on in the process of innovation, with a view to facilitate ethically acceptable and sustainable innovation. There is relatively limited evidence to explore the extent to which the process of research and innovation under the terms of RRI is realised in practice, particularly in the context of food and health research. Although research to date has been examining innovation from the point of view of inputs and outputs—R&D funding and patents—we propose to examine the cognitive framing of innovation that shapes decisions of those who constitute a part of the innovation chain. This paper explores how the concept of innovation is understood and used in policy implementation, with a particular focus upon ‘food and health’ science and research policy and funding. Our analysis is based on 55 interviews of various actors engaged in research funding decision-making across eight European countries. Three themes emerged from the analysis: concept of innovation; conditions for innovation; and drivers of innovation; through these themes, the cognitive framing was drawn out. The cognitive framing suggests that innovation in the food and health domain is perceived to be focused on biosciences and marketable applications to the neglect of social sciences and broader public interest; that the “innovation network” is primarily viewed as centred around scientific/technical and industrial actors; and that the demand-pull dynamic is relevant to innovation in the area of food and health, despite having been relegated in contemporary thinking and policies around innovation. These findings point to the inadequate consideration of the normative issues—how problems are to be defined and addressed—among national research funders in the food and health domain, and indicate a gap between the ideas of innovation under the terms of RRI and innovation as conceptualised by those involved in its governance.
    Keywords cognition ; decision making ; governance ; interviews ; research policy ; research support ; social sciences ; Europe
    Language English
    Dates of publication 2016-07
    Size p. 78-87.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 194840-4
    ISSN 0306-9192
    ISSN 0306-9192
    DOI 10.1016/j.foodpol.2016.04.004
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Dynamic of a papuã pasture under two grazing intensities and two nitrogen levels

    Adami, Paulo Fernando(UTFPR Programa de pós-graduação Agronomia) / Soares, André Brugnara(UTFPR Curso de Agronomia) / Assmann, Tangriani Simione(UTFPR Curso de Agronomia) / Assmann, Alceu Luiz(Instituto Agronômico do Paraná - IAPAR) / Sartor, Laércio Ricardo(UTFPR Programa de pós-graduação Agronomia) / Pitta, Christiano Santos Rocha(UTFPR Programa de pós-graduação Agronomia) / Franchin, Marcia Fernanda(UTFPR Programa de pós-graduação Agronomia) / Migliorini, Francisco(UTFPR Curso de Agronomia)

    Revista Brasileira de Zootecnia

    2010/12  

    Abstract: This work aimed to evaluate the effects of grazing intensities and nitrogen fertilization levels on the dynamics of a Brachiaria plantaginea pasture. The experiment was laid out as a random block design, in a 3 × 2 factorial scheme, composed of three ... ...

    Abstract This work aimed to evaluate the effects of grazing intensities and nitrogen fertilization levels on the dynamics of a Brachiaria plantaginea pasture. The experiment was laid out as a random block design, in a 3 × 2 factorial scheme, composed of three nitrogen levels (0, 200 and 400 kg/ha nitrogen in urea form) and two grazing intensities termed low mass (LM; forage mass of 1500 kg of DM/ha) and high mass (HM; forage mass of 3000 kg of DM/ha) in a continuously stocked swards with two replications. Animals used were half-blood Boer goats averaging five months old and 21 kg body weight (BW) for adjustment of the target forage mass. Real forage mass, average height of the plants and animal stocking rates were of 2,567 and 3,862 kg DM/ha; 23.6 and 31.2 cm and 2,804 and 2,089 kg BW/ha respectively for low and high mass. Accumulation rate was of 100, 147 and 132 kg DM/ha/day and total production 13,659; 19,834 and 17,820 kg DM/ha, respectively to the 0, 200 and 400 kg N/ha. There were no differences on pasture yield among grazing intensities suggesting that higher stocking rates can be used. The level of 200 kg N/ha promotes the best response on papuã grass pastures. Papuã grass shows high yield, good production distribution during the plant cycle and excellent nutritional value.
    Language English
    Document type Article
    ISSN 1516-3598
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  7. Article ; Online: Nothing lasts forever: Dominant species decline under rapid environmental change in global grasslands

    Wilfahrt, Peter A. / Seabloom, Eric W. / Bakker, Jonathan D. / Biederman, Lori / Bugalho, Miguel N. / Cadotte, Marc W. / Caldeira, Maria C. / Catford, Jane A. / Qingqing / Donohue, Ian / Ebeling, Anne / Eisenhauer, Nico / Haider, Sylvia / Heckman, Robert W. / Jentsch, Anke / Koerner, Sally E. / Komatsu, Kimberly J. / Laungani, Ramesh / MacDougall, Andrew /
    Martina, Jason P. / Martinson, Holly / Moore, Joslin L. / Niu, Yujie / Ohlert, Timothy / Venterink, Harry Olde / Orr, Devyn / Peri, Pablo / Pos, Edwin / Price, Jodi / Raynaud, Xavier / Ren, Zhengwei / Roscher, Christiane / Smith, Nicholas G. / Stevens, Carly J. / Sullivan, Lauren L. / Tedder, Michelle / Tognetti, Pedro M. / Veen, Ciska / Wheeler, George / Young, Alyssa L. / Young, Hillary / Borer, Elizabeth T.

    Journal of Ecology. 2023 Nov., v. 111, no. 11 p.2472-2482

    2023  

    Abstract: Dominance often indicates one or a few species being best suited for resource capture and retention in a given environment. Press perturbations that change availability of limiting resources can restructure competitive hierarchies, allowing new species ... ...

    Abstract Dominance often indicates one or a few species being best suited for resource capture and retention in a given environment. Press perturbations that change availability of limiting resources can restructure competitive hierarchies, allowing new species to capture or retain resources and leaving once dominant species fated to decline. However, dominant species may maintain high abundances even when their new environments no longer favour them due to stochastic processes associated with their high abundance, impeding deterministic processes that would otherwise diminish them. Here, we quantify the persistence of dominance by tracking the rate of decline in dominant species at 90 globally distributed grassland sites under experimentally elevated soil nutrient supply and reduced vertebrate consumer pressure. We found that chronic experimental nutrient addition and vertebrate exclusion caused certain subsets of species to lose dominance more quickly than in control plots. In control plots, perennial species and species with high initial cover maintained dominance for longer than annual species and those with low initial cover respectively. In fertilized plots, species with high initial cover maintained dominance at similar rates to control plots, while those with lower initial cover lost dominance even faster than similar species in controls. High initial cover increased the estimated time to dominance loss more strongly in plots with vertebrate exclosures than in controls. Vertebrate exclosures caused a slight decrease in the persistence of dominance for perennials, while fertilization brought perennials' rate of dominance loss in line with those of annuals. Annual species lost dominance at similar rates regardless of treatments. Synthesis. Collectively, these results point to a strong role of a species' historical abundance in maintaining dominance following environmental perturbations. Because dominant species play an outsized role in driving ecosystem processes, their ability to remain dominant—regardless of environmental conditions—is critical to anticipating expected rates of change in the structure and function of grasslands. Species that maintain dominance while no longer competitively favoured following press perturbations due to their historical abundances may result in community compositions that do not maximize resource capture, a key process of system responses to global change.
    Keywords dominant species ; ecosystems ; global change ; grasslands ; new species ; population dynamics ; soil nutrients ; vertebrates
    Language English
    Dates of publication 2023-11
    Size p. 2472-2482.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 3023-5
    ISSN 0022-0477
    ISSN 0022-0477
    DOI 10.1111/1365-2745.14198
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Author Correction: General destabilizing effects of eutrophication on grassland productivity at multiple spatial scales.

    Hautier, Yann / Zhang, Pengfei / Loreau, Michel / Wilcox, Kevin R / Seabloom, Eric W / Borer, Elizabeth T / Byrnes, Jarrett E K / Koerner, Sally E / Komatsu, Kimberly J / Lefcheck, Jonathan S / Hector, Andy / Adler, Peter B / Alberti, Juan / Arnillas, Carlos A / Bakker, Jonathan D / Brudvig, Lars A / Bugalho, Miguel N / Cadotte, Marc / Caldeira, Maria C /
    Carroll, Oliver / Crawley, Mick / Collins, Scott L / Daleo, Pedro / Dee, Laura E / Eisenhauer, Nico / Eskelinen, Anu / Fay, Philip A / Gilbert, Benjamin / Hansar, Amandine / Isbell, Forest / Knops, Johannes M H / MacDougall, Andrew S / McCulley, Rebecca L / Moore, Joslin L / Morgan, John W / Mori, Akira S / Peri, Pablo L / Pos, Edwin T / Power, Sally A / Price, Jodi N / Reich, Peter B / Risch, Anita C / Roscher, Christiane / Sankaran, Mahesh / Schütz, Martin / Smith, Melinda / Stevens, Carly / Tognetti, Pedro M / Virtanen, Risto / Wardle, Glenda M / Wilfahrt, Peter A / Wang, Shaopeng

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 630

    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-20997-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Níveis de probiótico em rações de origem animal e vegetal para frangos de corte

    Appelt, Matias Djalma(UFPR Programa de Pós-graduação em Ciências Veterinárias) / Nunes, Ricardo Vianna(UNIOESTE Departamento de Zootecnia) / Pozza, Paulo Cesar(UNIOESTE Departamento de Zootecnia) / Silva, Wagner Thiago Mozer da(UNIOESTE Programa de Pós-graduação em Zootecnia) / Venturi, Iderson(PUC Programa de Pós-graduação em Vigilância Sanitária e Controle de Qualidade de Alimentos) / Nunes, Christiane Garcia Vilela(UTFPR)

    Revista Brasileira de Zootecnia

    2010/04  

    Abstract: Avaliou-se o efeito de diferentes níveis de probiótico na dieta sobre o desempenho, os rendimentos de carcaça, cortes nobres e gordura abdominal, o pH intestinal e os parâmetros sanguíneos de frangos de corte de 1 a 40 dias de idade alimentados com ... ...

    Abstract Avaliou-se o efeito de diferentes níveis de probiótico na dieta sobre o desempenho, os rendimentos de carcaça, cortes nobres e gordura abdominal, o pH intestinal e os parâmetros sanguíneos de frangos de corte de 1 a 40 dias de idade alimentados com rações com ingredientes de origens vegetal e animal. Foram utilizados 1.000 pintos machos da linhagem Cobb 500, distribuídos em delineamento inteiramente casualizado, com 10 tratamentos, cada um com 5 repetições de 20 aves por unidade experimental, alojados em cama reutilizada. O probiótico utilizado era à base de Bacillus cereus e Bacillus subtilis e foi incluído nos níveis 0,00; 0,05; 0,10; 0,15 e 0,20% em cada ração. As características de desempenho avaliadas foram peso final, ganho de peso, consumo de ração, conversão alimentar e mortalidade, avaliados aos 7, 21 e 40 dias de idade. Avaliaram-se também o pH intestinal (duodeno e jejuno) e os parâmetros sanguíneos (cálcio, fósforo, ácido úrico, colesterol, triglicérides e proteínas totais) aos 21 e 39 dias de idade, respectivamente. Aos 40 dias de idade, foram avaliados os rendimentos de carcaça inteira e de cortes nobres e a porcentagem de gordura abdominal. Não houve interação entre os níveis de probiótico e o tipo de ração (origem animal ou vegetal), mas houve efeito dos níveis de probiótico e do tipo de ração sobre o peso, o ganho de peso, a conversão alimentar e a mortalidade na fase de 1 a 21 dias de idade, uma vez que a ração de origem vegetal promoveu melhores valores sanguíneos de cálcio, colesterol e triglicérides, determinados aos 39 dias de idade, em comparação à ração de origem animal.
    Language Portuguese
    Document type Article
    ISSN 1516-3598
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  10. Article: Desempenho e morfometria intestinal de juvenis de tilápia-do-nilo alimentados com dietas suplementadas com L-glutamina e L-glutamato

    Silva, Lilian Carolina Rosa da(Universidade Estadual de Maringá Programa de Pós-graduação em Zootecnia) / Furuya, Wilson Massamitu(UEM Departamento de Zootecnia) / Natali, Maria Raquel Marçal(UEM Departamento de Ciências Morfofisiológicas) / Schamber, Christiano Rodrigues(Universidade Estadual de Maringá Programa de Pós-graduação em Zootecnia) / Santos, Lilian Dena dos(Universidade Estadual de Maringá Programa de Pós-graduação em Zootecnia) / Vidal, Luiz Vitor Oliveira(Universidade Estadual de Maringá Programa de Pós-graduação em Zootecnia)

    Revista Brasileira de Zootecnia

    2010/06  

    Abstract: Este estudo foi realizado para avaliar níveis de L-glutamina e L-glutamato em dietas para juvenis de tilápia-do-nilo (0,60 ± 0,1 g). Foi utilizado delineamento inteiramente casualizado com quatro dietas e três repetições e 90 peixes por unidade ... ...

    Abstract Este estudo foi realizado para avaliar níveis de L-glutamina e L-glutamato em dietas para juvenis de tilápia-do-nilo (0,60 ± 0,1 g). Foi utilizado delineamento inteiramente casualizado com quatro dietas e três repetições e 90 peixes por unidade experimental. Foi utilizada dieta controle, com 29% de proteína digestível e 2.940 kcal/kg de energia digestível, suplementada mistura de L-glutamina e L-glutamato na proporção de 0, 1, 2 e 3% da dieta, durante 85 dias. Não foi observado efeito da L-glutamina e L-glutamato sobre o consumo, a conversão alimentar, a taxa de eficiência protéica, a eficiência de retenção de nitrogênio, o índice hepatossomático, a composição química corporal, a amônia e ureia sanguíneas. O aumento nos níveis de L-glutamina e L-glutamato nas dietas teve aumento linear sobre o ganho de peso e efeito quadrático na altura dos vilos. A adição de L-glutamina e L-glutamato melhora o ganho de peso e a altura das vilosidades intestinais de tilápia-do-nilo.
    Language Portuguese
    Document type Article
    ISSN 1516-3598
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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