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  1. Article ; Online: Corrigendum re "Hypofractionated Postoperative Radiotherapy for Prostate Cancer: Is the Field Ready Yet?" [Eur Urol Open Sci 2020;22:9-16].

    Mahase, Sean / Nagar, Himanshu

    European urology open science

    2022  Volume 44, Page(s) 52–53

    Abstract: This corrects the article DOI: 10.1016/j.euros.2020.10.001.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.euros.2020.10.001.].
    Language English
    Publishing date 2022-08-27
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2022.08.012
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  2. Article ; Online: Prostate SBRT Dose Escalation (9 Gy × 5, 13.3 Gy × 3, 24 Gy × 1): Are We Making Progress?

    Nagar, Himanshu / Spratt, Daniel E

    International journal of radiation oncology, biology, physics

    2021  Volume 111, Issue 1, Page(s) 110–112

    MeSH term(s) Clinical Trials as Topic ; Dose Fractionation, Radiation ; Humans ; Male ; Prostatic Neoplasms/radiotherapy ; Radiosurgery/adverse effects ; Radiosurgery/methods
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.05.013
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  3. Article ; Online: Challenging the Norm: What Level of Evidence Is Necessary to Adopt Postprostatectomy Hypofractionated Radiation Therapy?

    Nagar, Himanshu / Spratt, Daniel E

    International journal of radiation oncology, biology, physics

    2020  Volume 107, Issue 2, Page(s) 297–298

    MeSH term(s) Humans ; Male ; Nomograms ; Prostatectomy ; Radiation Dose Hypofractionation ; Salvage Therapy
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.02.465
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  4. Article ; Online: Cancer and COVID-19 - potentially deleterious effects of delaying radiotherapy.

    Nagar, Himanshu / Formenti, Silvia C

    Nature reviews. Clinical oncology

    2020  Volume 17, Issue 6, Page(s) 332–334

    MeSH term(s) Breast Neoplasms/complications ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/virology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/radiotherapy ; Coronavirus Infections/virology ; Disease-Free Survival ; Female ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/virology ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/radiotherapy ; Pneumonia, Viral/virology
    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-020-0375-1
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  5. Article ; Online: Hypofractionated Postoperative Radiotherapy for Prostate Cancer: Is the Field Ready Yet?

    Mahase, Sean / Nagar, Himanshu

    European urology open science

    2020  Volume 22, Page(s) 9–16

    Abstract: Context: Radiotherapy (RT) is a valid adjuvant treatment for men with high-risk pathological features after radical prostatectomy and a salvage treatment for biochemical recurrence. A major inconvenience is that RT takes course over 7-8 wk in these ... ...

    Abstract Context: Radiotherapy (RT) is a valid adjuvant treatment for men with high-risk pathological features after radical prostatectomy and a salvage treatment for biochemical recurrence. A major inconvenience is that RT takes course over 7-8 wk in these settings, which has been shown to limit its use. Retrospective and pilot prospective investigations suggest that hypofractionation may provide noninferior outcomes but report variable results regarding toxicities. Additionally, our evolving understanding of prostate cancer radiobiology suggests that hypofractionated regimens may not increase toxicity.
    Objective: We examine and review the rationale and clinical evidence of hypofractionated RT in the adjuvant and salvage settings for prostate cancer.
    Evidence acquisition: We reviewed relevant literature, with a particular focus on recent studies employing hypofractionated RT.
    Evidence synthesis: Hypofractionated RT in the adjuvant or salvage setting is not a standard option for prostate cancer RT outside of an investigational trial. While smaller studies show conflicting data regarding toxicity, initial evidence from larger clinical trials appears to demonstrate that hypofractionated postoperative RT is as effective and safe as conventionally fractionated courses.
    Conclusions: With the growing acceptance of hypofractionation across other cancer sites and the rise of extreme hypofractionation for definitive prostate cancer treatment, hypofractionated postoperative therapy for prostate cancer is poised to become an option, as it may reduce the burden on men and treatment centers while maintaining clinical efficacy and safety. Prospective trials are currently ongoing to address efficacy and safety concerns.
    Patient summary: Postoperative radiotherapy is a potentially curative treatment for patients with high-risk disease or recurrence after surgery. Shortening of the treatment regimen with the availability of modern treatment delivery techniques in conjunction with the integration of molecular imaging information to refine treatment volumes may improve therapeutic benefit without increasing toxicity.
    Language English
    Publishing date 2020-10-23
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3040546-4
    ISSN 2666-1683 ; 2058-4881
    ISSN (online) 2666-1683
    ISSN 2058-4881
    DOI 10.1016/j.euros.2020.10.001
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  7. Article ; Online: Pulse Sequence Dependence of a Simple and Interpretable Deep Learning Method for Detection of Clinically Significant Prostate Cancer Using Multiparametric MRI.

    Kim, Heejong / Margolis, Daniel J A / Nagar, Himanshu / Sabuncu, Mert R

    Academic radiology

    2022  Volume 30, Issue 5, Page(s) 966–970

    Abstract: Rationale and objectives: Multiparametric magnetic resonance imaging (mpMRI) is increasingly used for risk stratification and localization of prostate cancer (PCa). Thanks to the great success of deep learning models in computer vision, the potential ... ...

    Abstract Rationale and objectives: Multiparametric magnetic resonance imaging (mpMRI) is increasingly used for risk stratification and localization of prostate cancer (PCa). Thanks to the great success of deep learning models in computer vision, the potential application for early detection of PCa using mpMRI is imminent.
    Materials and methods: Deep learning analysis of the PROSTATEx dataset.
    Results: In this study, we show a simple convolutional neural network (CNN) with mpMRI can achieve high performance for detection of clinically significant PCa (csPCa), depending on the pulse sequences used. The mpMRI model with T2-ADC-DWI achieved 0.90 AUC score in the held-out test set, not significantly better than the model using K
    Conclusion: Convolutional neural networks incorporating multiple pulse sequences show high performance for detection of clinically-significant prostate cancer, and the model including dynamic contrast-enhanced information correlates best with grade.
    MeSH term(s) Male ; Humans ; Multiparametric Magnetic Resonance Imaging/methods ; Deep Learning ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Retrospective Studies
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2022.10.005
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    Zs.A 4594: Show issues Location:
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  8. Article ; Online: Cancer and COVID-19 — potentially deleterious effects of delaying radiotherapy

    Nagar, Himanshu / Formenti, Silvia C.

    Nature Reviews Clinical Oncology

    2020  Volume 17, Issue 6, Page(s) 332–334

    Keywords Oncology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-020-0375-1
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    Zs.A 6029: Show issues Location:
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  9. Article: MRI-LINAC: A transformative technology in radiation oncology.

    Ng, John / Gregucci, Fabiana / Pennell, Ryan T / Nagar, Himanshu / Golden, Encouse B / Knisely, Jonathan P S / Sanfilippo, Nicholas J / Formenti, Silvia C

    Frontiers in oncology

    2023  Volume 13, Page(s) 1117874

    Abstract: Advances in radiotherapy technologies have enabled more precise target guidance, improved treatment verification, and greater control and versatility in radiation delivery. Amongst the recent novel technologies, Magnetic Resonance Imaging (MRI) guided ... ...

    Abstract Advances in radiotherapy technologies have enabled more precise target guidance, improved treatment verification, and greater control and versatility in radiation delivery. Amongst the recent novel technologies, Magnetic Resonance Imaging (MRI) guided radiotherapy (MRgRT) may hold the greatest potential to improve the therapeutic gains of image-guided delivery of radiation dose. The ability of the MRI linear accelerator (LINAC) to image tumors and organs with on-table MRI, to manage organ motion and dose delivery in real-time, and to adapt the radiotherapy plan on the day of treatment while the patient is on the table are major advances relative to current conventional radiation treatments. These advanced techniques demand efficient coordination and communication between members of the treatment team. MRgRT could fundamentally transform the radiotherapy delivery process within radiation oncology centers through the reorganization of the patient and treatment team workflow process. However, the MRgRT technology currently is limited by accessibility due to the cost of capital investment and the time and personnel allocation needed for each fractional treatment and the unclear clinical benefit compared to conventional radiotherapy platforms. As the technology evolves and becomes more widely available, we present the case that MRgRT has the potential to become a widely utilized treatment platform and transform the radiation oncology treatment process just as earlier disruptive radiation therapy technologies have done.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1117874
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  10. Article ; Online: Prostate cancer grade migration and facility-level treatment trends for grade group 1 disease.

    Borregales, Leonardo D / Tzeng, Michael / Ramaswamy, Ashwin / Gu, Xiangmei / Davuluri, Meenakshi / Nagar, Himanshu / Hu, Jim C

    JNCI cancer spectrum

    2023  Volume 7, Issue 2

    Abstract: Overdiagnosis and overtreatment of low-grade prostate cancer (PCa) reflect poor quality of care and prompted changes to guidelines over the past decade. We used the National Cancer Database to characterize Gleason Grade Group (GG)1 PCa diagnosis trends ... ...

    Abstract Overdiagnosis and overtreatment of low-grade prostate cancer (PCa) reflect poor quality of care and prompted changes to guidelines over the past decade. We used the National Cancer Database to characterize Gleason Grade Group (GG)1 PCa diagnosis trends and assess facility-level treatment variability. Between 2010 and 2019, GG1 PCa incidence had a clinically and statistically significant decline, from 45% to 25% at biopsy and from 33% to 9.8% at radical prostatectomy (RP) pathology. Similarly, active surveillance (AS) uptake significantly increased to 49% and 62% among nonacademic and academic sites, respectively. Decreasing rates of definitive therapies were identified: among academic sites, RP decreased from 61.1% to 25.3% and radiation therapy (RT) from 25.2% to 12%, whereas among nonacademic sites, RP decreased from 53.6% to 28% and RT from 37.8% to 21.9% (Ptrend < .001). Declines in the diagnosis and treatment of low-grade disease demonstrate an encouraging shift in PCa epidemiology. However, heterogeneity in AS utilization remains and reflects opportunities for improvement.
    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/therapy ; Prostate/pathology ; Neoplasm Grading ; Prostatectomy ; Prostate-Specific Antigen
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2515-5091
    ISSN (online) 2515-5091
    DOI 10.1093/jncics/pkad018
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