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Article: [Mystery of Yiyin decoction theory: rule discovery and evaluation strategy of atypical pharmacological effects of Chinese medicinal prescription].

Dai, Ying / Zhang, Yi-Guan / Zeng, Jin / Hua, Hua / Zhao, Jun-Ning / Li, Li / Yan, Liang-Chun / Yin, Zhu-Jun / Wang, Jian-Bo / Tan, Peng / Tan, Rui-Rong / Zeng, An-Qi / Quan, Yun-Yun / Wei, Ping

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 16, Page(s) 4261–4268

Abstract: ... in the future. Yiyin decoction theory is the superior form of personalized combined medication with advanced ... the connotation of modern multi-target drugs. The core of Yiyin decoction theory can be summarized as compound ... the mystery of Yiyin decoction theory, we should not only simply study the known active substances(components ...

Abstract	Yi Yin, a famous medical scientist and culinary master in the late Xia Dynasty and early Shang Dynasty, developed the Chinese medicinal liquids and Chinese medicinal prescriptions emerged after that. Chinese medicinal prescriptions have attracted much attention because of their unique advantages in the treatment of chronic multifactorial diseases, representing an important direction of drug discovery in the future. Yiyin decoction theory is the superior form of personalized combined medication with advanced consciousness. It is different from not only the magic bullet theory of single component action but also the connotation of modern multi-target drugs. The core of Yiyin decoction theory can be summarized as compound compatibility, multiple effects, and moderate regulation. Compound compatibility refers to that the formulation of Chinese medicinal prescriptions involves the complex synergy and interactions between sovereign, minister, assistant, and guide medicinal materials. Multiple effects mean that the prescriptions employ a variety of mechanisms to exert comprehensive pharmacological effects of nonlinear feedback. Moderate regulation reflects that the prescriptions can accurately regulate the multiple points of the disease biological network as a whole. To solve the mystery of Yiyin decoction theory, we should not only simply study the known active substances(components) and their independent target effects in the mixture, but also mine the "dark matter" and "dark effect" of Chinese medicinal prescriptions. That is, we should learn the neglected atypical pharmacological effects of Chinese medicinal prescriptions and the multi-point nesting mechanism that plays a precise regulatory function in the body. Yiyin decoction theory focuses on the overall pharmacological effect to reflect the comprehensive clinical value of Chinese medicinal prescriptions, which is of great significance for the development of a new model for the evaluation and application of new Chinese medicinal prescriptions in line with the theory of traditional Chinese medicine.
MeSH term(s)	China ; Drugs, Chinese Herbal/pharmacology ; Medicine, Chinese Traditional ; Prescriptions
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2022-08-25
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220713.601
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Zs.A 3056: Show issues

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Article: Genome-wide identification, expression profiling, and functional analysis of ammonium transporter 2 (AMT2) gene family in cassava (

Xia, Jinze / Wang, Yu / Zhang, Tingting / Pan, Chengcai / Ji, Yiyin / Zhou, Yang / Jiang, Xingyu

Frontiers in genetics

2023 Volume 14, Page(s) 1145735

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1145735
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Article ; Online: 'Fear, uncertain, tired…...' psychological distress among pulmonary hypertension patients: a qualitative interview study.

Zhang, Juxia / Zhang, Yiyin / Yin, Yuhuan / Feng, Yuping / Zhang, Rong / Meng, Hongyan / Wang, Jing

BMC psychiatry

2024 Volume 24, Issue 1, Page(s) 100

Abstract: Background: Patient-centered health care for patients with pulmonary hypertension (PH) is important and requires an understanding of patient experiences. However, there is a lack of approaches to examine what's the effects and how the disease impact ... ...

Abstract	Background: Patient-centered health care for patients with pulmonary hypertension (PH) is important and requires an understanding of patient experiences. However, there is a lack of approaches to examine what's the effects and how the disease impact patients' psychological well-beings. Methods: We conducted qualitative interviews with PH patient representatives to understand patient psychological experiences and inform patient-centered research and care. Participants were chosen from a tertiary hospital located in northwest China. 20 patients with PH who be treated at the hospital (13 participants were women, aged 18-74 years) were strategically selected and individually interviewed. We used qualitative analysis to identify themes relating to existential psychological distress that would clarify the nature of such concerns. Results: We found that patients experience tremendous psychological distress throughout the treatment process. Four categories that describe patients' psychological experiences emerged: burden of PH treatment, fear and uncertainty about the disease, frustration in social and family role, and lack of recognition of the condition. Conclusions: Existential concerns are salient in PH and involve the experience of loss and disruptions to the sense of self and relationships. Healthcare practitioners must work more in collaboration to detect patients' need for support and to develop the patient's own skills to manage daily life. The PH teams should tailor interventions to provide emotional, informational and instrumental support and guidance to patients.
MeSH term(s)	Humans ; Female ; Male ; Uncertainty ; Hypertension, Pulmonary ; Fear ; Psychological Distress ; Qualitative Research
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-024-05539-z
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Article ; Online: A 3-hour time interval may not be sufficient for delayed enhancement magnetic resonance imaging with intravenous gadoteridol injection based on 3d-real IR sequence of the inner ear in Meniere's disease patient.

Chen, Wei / Xiao, Hanyu / Zhang, Yiyin / Wang, Luxi / Li, Bingrong / Sha, Yan

Acta oto-laryngologica

2024 Volume 144, Issue 1, Page(s) 1–6

Abstract: Background: Magnetic resonance imaging (MRI) can be applied to visualize endolymphatic hydrops (EH).: Aims/objectives: To explore whether a 3-h time interval was feasible for clinical practice.: Materials and methods: We prospectively enrolled 15 ... ...

Abstract	Background: Magnetic resonance imaging (MRI) can be applied to visualize endolymphatic hydrops (EH). Aims/objectives: To explore whether a 3-h time interval was feasible for clinical practice. Materials and methods: We prospectively enrolled 15 patients with unilateral Meniere's disease, each of whom underwent delayed enhancement MRI scan of the inner ear after intravenous gadoteridol injection at a 3-h interval. The ears of these patients were divided into two groups (group A: the affected ears; group B: the unaffected ears). Among the two groups, the signal intensity in perilymphatic area of the basal turn of cochlea, the results of visual evaluations in the vestibule, cochlea and semicircular canal and the detection results of EH were compared. Results: Regarding the signal intensity, a difference was found between group A and group B ( Conclusions and significance: In the clinical application of gadoteridol for the inner ear, 3-h delayed MR imaging may not be sufficient.
MeSH term(s)	Humans ; Meniere Disease/diagnosis ; Endolymphatic Hydrops/diagnosis ; Vestibule, Labyrinth/pathology ; Magnetic Resonance Imaging/methods ; Contrast Media ; Gadolinium ; Heterocyclic Compounds ; Organometallic Compounds
Chemical Substances	gadoteridol (0199MV609F) ; Contrast Media ; Gadolinium (AU0V1LM3JT) ; Heterocyclic Compounds ; Organometallic Compounds
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2024.2311796
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Article ; Online: The Treatment Outcomes of Radiotherapy and Surgical Treatment for Patients with Cavernous Sinus Hemangioma: A Meta-Analysis.

Helmy, Mohamed / Liao, Yujun / Zhang, YiYin / He, Kangmin

World neurosurgery

2023 Volume 178, Page(s) e345–e354

Abstract: Objective: Cavernous sinus hemangiomas (CSHs) are infrequent benign neoplasms. This meta-analysis was conducted with the objective of examining the prognostic outcomes of surgical interventions and radiotherapy (RT) in patients diagnosed with CSHs.: ... ...

Abstract	Objective: Cavernous sinus hemangiomas (CSHs) are infrequent benign neoplasms. This meta-analysis was conducted with the objective of examining the prognostic outcomes of surgical interventions and radiotherapy (RT) in patients diagnosed with CSHs. Methods: A comprehensive literature search was performed across PubMed, Embase, and Web of Science databases, with traceability up to June 22, 2021. The evaluation of continuous variables was conducted by applying the weighted mean difference (WMD) and 95% confidence interval. A one-arm meta-analysis was used to scrutinize the tumor control rate, clinical improvement rate, recovery rates of abducens nerve palsy and visual disturbance, total resection rate, and the incidence rate of permanent nerve palsy post-treatment. Results: In total, 29 articles were incorporated into the meta-analysis. Post-RT for CSHs, a significant reduction in tumor volume was observed (WMD [95% confidence interval] = -17.16 [-21.52, -12.80] cm Conclusions: The results of this meta-analysis underscore that RT is an effective and safe treatment modality for CSHs. Furthermore, the prognostic outcomes of RT demonstrated superiority over surgical intervention.
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.07.068
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Zs.A 1159: Show issues

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Article ; Online: Prediction of overwintering crane population in Poyang Lake wetland based on RS and regression Model, China

Yiyin Liang / Bin Dong / Pengfei Li / Ke Zhang / Xiang Gao

Ecological Indicators, Vol 149, Iss , Pp 110183- (2023)

2023

Abstract: Reasonable prediction of the crane population that arrives at Poyang Lake Reserve for overwintering every year is of great significance to protect cranes and to provide data about reserve planning. In this paper, considering the time-lag effect of ... ...

Abstract	Reasonable prediction of the crane population that arrives at Poyang Lake Reserve for overwintering every year is of great significance to protect cranes and to provide data about reserve planning. In this paper, considering the time-lag effect of landscape index on crane population, the Landsat satellite images of Poyang Lake wetland in 19 winter periods from 2001 to 2019 were selected. The land-use types of the images were classified by support vector machine to acquire the landscape pattern index. In addition, the Pearson test was adopted to examine the correlation between crane population dynamics and landscape pattern index during overwintering. Finally, the regression model of the crane population was obtained by multivariate linear regression analysis. The results showed that the landscape index had a delayed impact on the crane population, which was significantly correlated with the crane population in the following five years. This effect on different crane population was disparate. The number of siberian cranes and white-naped crane populations showed a downward trend, while that of hooded cranes and common crane populations showed an upward trend. Furthermore, the landscape index affects the crane population to a certain extent, but the landscape pattern has diverse effects on different crane populations. It is suggested that corresponding protection measures be taken for different crane populations to provide a better habitat for cranes in Poyang Lake.
Keywords	Remote sensing ; Overwintering cranes ; Landscape pattern ; Poyang Lake wetland ; China ; Ecology ; QH540-549.5
Subject code	710
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fe-Doped polydopamine nanoparticles with peroxidase-mimicking activity for the detection of hypoxanthine related to meat freshness.

Zhang, Yiyin / Gao, Xiang / Ye, Yingwang / Shen, Yizhong

The Analyst

2022 Volume 147, Issue 5, Page(s) 956–964

Abstract: Rapid and accurate monitoring of food freshness to provide consumers with high-quality meat continues to be of tremendous importance to the food industry. In this report, an efficient Fe-doped polydopamine (Fe-PDA) nanozyme with peroxidase-mimicking ... ...

Abstract	Rapid and accurate monitoring of food freshness to provide consumers with high-quality meat continues to be of tremendous importance to the food industry. In this report, an efficient Fe-doped polydopamine (Fe-PDA) nanozyme with peroxidase-mimicking activity was synthesized by a high-temperature hydrothermal method, and was applied to a spectrophotometric sensing system, which successfully reports the concentration of hypoxanthine (Hx) related to meat freshness. The Fe-PDA nanozyme showed excellent peroxidase simulation activity, which was primarily verified by steady-state kinetics experiments. In the presence of xanthine oxidase (XOD), Hx can react quantitatively with dissolved O
MeSH term(s)	Colorimetry ; Hydrogen Peroxide ; Hypoxanthine ; Indoles ; Meat ; Nanoparticles ; Peroxidases ; Polymers
Chemical Substances	Indoles ; Polymers ; polydopamine ; Hypoxanthine (2TN51YD919) ; Hydrogen Peroxide (BBX060AN9V) ; Peroxidases (EC 1.11.1.-)
Language	English
Publishing date	2022-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d1an02325j
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Article ; Online: Differentiation of Sinonasal NKT From Diffuse Large B-Cell Lymphoma Using Machine Learning and MRI-Based Radiomics.

Zhang, Yiyin / Lin, Naier / Xiao, Hanyu / Xin, Enhui / Sha, Yan

Journal of computer assisted tomography

2023 Volume 47, Issue 6, Page(s) 973–981

Abstract: Purpose: The aim of this study was to construct and validate a noninvasive radiomics method based on magnetic resonance imaging to differentiate sinonasal extranodal natural killer/T-cell lymphoma from diffuse large B-cell lymphoma.: Methods: We ... ...

Abstract	Purpose: The aim of this study was to construct and validate a noninvasive radiomics method based on magnetic resonance imaging to differentiate sinonasal extranodal natural killer/T-cell lymphoma from diffuse large B-cell lymphoma. Methods: We collected magnetic resonance imaging scans, including contrast-enhanced T1-weighted imaging and T2-weighted imaging, from 133 patients with non-Hodgkin lymphoma (103 sinonasal extranodal natural killer/T-cell lymphoma and 30 diffuse large B-cell lymphoma) and randomly split them into training and testing cohorts at a ratio of 7:3. Clinical characteristics and image performance were analyzed to build a logistic regression clinical-image model. The radiomics features were extracted on contrast-enhanced T1-weighted imaging and T2-weighted imaging images. Maximum relevance minimum redundancy, selectKbest, and the least absolute shrinkage and selection operator algorithms (LASSO) were applied for feature selection after balancing the training set. Five machine learning classifiers were used to construct the single and combined sequences radiomics models. Sensitivity, specificity, accuracy, precision, F1score, the area under receiver operating characteristic curve, and the area under precision-recall curve were compared between the 15 models and the clinical-image model. The diagnostic results of the best model were compared with those of 2 radiologists. Results: The combined sequence model using support vector machine proves to be the best, incorporating 7 features and providing the highest values of specificity (0.903), accuracy (0.900), precision (0.727), F1score (0.800), and area under precision-recall curve (0.919) with relatively high sensitivity (0.889) in the testing set, along with a minimum Brier score. The diagnostic results differed significantly ( P < 0.05) from those of radiology residents, but not significantly ( P > 0.05) from those of experienced radiologists. Conclusions: Magnetic resonance imaging based on machine learning and radiomics to identify the type of sinonasal non-Hodgkin lymphoma is effective and has the potential to help radiology residents for diagnosis and be a supplement for biopsy.
MeSH term(s)	Humans ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Lymphoma, Non-Hodgkin ; Machine Learning ; Cell Differentiation ; Lymphoma, T-Cell
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80392-3
ISSN	1532-3145 ; 0363-8715
ISSN (online)	1532-3145
ISSN	0363-8715
DOI	10.1097/RCT.0000000000001497
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Article ; Online: Respiratory pathogenic microbial infections: a narrative review.

Long, Yiyin / Zheng, Yan / Li, Changlin / Guo, Zhanjun / Li, Peng / Zhang, Fuqing / Liu, Wei / Wang, Yuliang

International journal of medical sciences

2024 Volume 21, Issue 5, Page(s) 826–836

Abstract: Respiratory infectious diseases have long been recognised as a substantial global healthcare burden and are one of the leading causes of death worldwide, particularly in vulnerable individuals. In the post COVID-19 era, there has been a surge in the ... ...

Abstract	Respiratory infectious diseases have long been recognised as a substantial global healthcare burden and are one of the leading causes of death worldwide, particularly in vulnerable individuals. In the post COVID-19 era, there has been a surge in the prevalence of influenza virus A and other multiple known viruses causing cold compared with during the same period in the previous three years, which coincided with countries easing COVID-19 restrictions worldwide. This article aims to review community-acquired respiratory illnesses covering a broad spectrum of viruses, bacteria, and atypical microorganisms and focuses on the cluster prevalence of multiple known respiratory pathogens in China, thereby providing effective prevention and control measures.
MeSH term(s)	Humans ; Respiratory Tract Infections/epidemiology ; COVID-19/epidemiology ; China
Language	English
Publishing date	2024-03-17
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.93628
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Article ; Online: Corrigendum: Knowledge, Attitude, and Practice Survey of COVID-19 Among Healthcare Students During the COVID-19 Outbreak in China: An Online Cross-Sectional Survey.

Zhang, Juxia / Yin, Yuhuan / Dean, Judith / Zhang, Xiaoli / Zhang, Yiyin / Wang, Jiancheng / Zhang, Yinping

Frontiers in public health

2022 Volume 9, Page(s) 829550

Abstract: This corrects the article DOI: 10.3389/fpubh.2021.742314.]. ...

Abstract	[This corrects the article DOI: 10.3389/fpubh.2021.742314.].
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2021.829550
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