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Article: Préparation à la chirurgie bariatrique : lorsque prendre du temps n’est pas en perdre.

Corminboeuf, Yann / Rieben, Isabelle / Gebhard, Sandra / Pralong, François P / Stiefel, Friedrich

2017 Volume 13, Issue 555, Page(s) 650–654

Abstract: Obesity has become a worldwide public health concern. Bariatric surgery is nowadays the most effective treatment to lose weight and control somatic comorbidities of this disease. However, a careful preparation of the patients undergoing bariatric surgery ...

Title translation	Towards bariatric surgery : taking your time preserves you from loosing your time.
Abstract	Obesity has become a worldwide public health concern. Bariatric surgery is nowadays the most effective treatment to lose weight and control somatic comorbidities of this disease. However, a careful preparation of the patients undergoing bariatric surgery seems mandatory, despite the existence of a feeling of emergency that is often shared by the therapeutic team, and thus difficult to handle. In this context, the importance to address psychological issues such as patients' representation of their body while they will be confronted to a major physical transformation cannot be over-emphasized. Taking time is crucial to create a therapeutic context that raises the patients' awareness of their underlying psychological functioning.
Language	French
Publishing date	2017-03-22
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article ; Online: Oncology clinicians' feelings towards patients presented in supervision: A pre-post assessment using the feeling word checklist.

Stiefel, Friedrich / Bourquin, Céline / Wild, Beate / Schellberg, Dieter / Michaud, Laurent

Psycho-oncology

2024 Volume 33, Issue 3, Page(s) e6318

Abstract: ... towards patients presented in supervision.: Methods: Oncology clinicians' (n = 23) feelings towards patients ... in by supervisees prior and after their supervision sessions (n = 91), which were conducted by experienced ... supervisors (n = 6). Pre- post-modification of feelings was evaluated based on a selection of FWC items ...

Abstract	Objective: Clinical supervision of oncology clinicians by psycho-oncologists is an important means of psychosocial competence transfer and support. Research on this essential liaison activity remains scarce. The aim of this study was to assess the impact of supervision on oncology clinicians' feelings towards patients presented in supervision. Methods: Oncology clinicians' (n = 23) feelings towards patients presented in supervision were assessed with the Feeling Word Checklist (FWC). The FWC was filled in by supervisees prior and after their supervision sessions (n = 91), which were conducted by experienced supervisors (n = 6). Pre- post-modification of feelings was evaluated based on a selection of FWC items, which were beforehand considered as likely to change in a beneficial supervision. Items were evaluated on session level using t-tests for dependent groups. Composite scores were calculated for feelings expected to raise and feelings expected to decrease and analysed on the level of supervisees. Results: Feelings related to threats, loss of orientation or hostility such as "anxious", "overwhelmed", "impotent", "confused", "angry", "depreciated" and "guilty" decreased significantly after supervision, while feelings related to the resume of the relationship ("attentive", "happy"), a better understanding of the patient ("empathic"), a regain of control ("confident") and being "useful" significantly increased. Feeling "interested" and "calm" remained unchanged. Significant increase or decrease in the composite scores for supervisees confirmed these results. Conclusions: This study demonstrates modification of feelings towards patients presented in supervision. This modification corresponds to the normative, formative, and especially restorative function (support of the clinician) of supervision.
MeSH term(s)	Male ; Humans ; Checklist ; Emotions ; Anxiety ; Anger ; Guilt
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1118536-3
ISSN	1099-1611 ; 1057-9249
ISSN (online)	1099-1611
ISSN	1057-9249
DOI	10.1002/pon.6318
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Article ; Online: Calling situated: a survey among medical students supplemented by a qualitative study and a comparison with a surveyed sample of physicians.

Bonvin, S / Stiefel, F / Gholam, M / Bourquin, C

BMC medical education

2022 Volume 22, Issue 1, Page(s) 619

Abstract: ... among medical students (N = 1048; response rate above 60%) of the University of Lausanne in Switzerland. It was ... supplemented by a group discussion between bachelor medical students (N = 8) and senior physicians (N = 4 ...

Abstract	Background: Calling within the medical context receives growing academic attention and empirical research has started to demonstrate its beneficial effects. The purpose of this study is to investigate what motivates students to enter medical school and what role calling may play (i), to evaluate if calling influences the way in which they experience their studies (ii), and to compare medical students' experience of calling with those of physicians. Methods: A questionnaire survey was distributed among medical students (N = 1048; response rate above 60%) of the University of Lausanne in Switzerland. It was supplemented by a group discussion between bachelor medical students (N = 8) and senior physicians (N = 4), focusing on different facets of calling. An existing data set of a survey among physicians, addressing calling with the same questionnaire, was used to compare students' and physicians' attitudes towards calling. Survey data were analyzed with the habitual statistical procedures for categorical and continuous variables. The group discussion was analyzed with thematic analysis. Results: The survey showed that experiencing calling is a motivational factor for study choice and influences positively choice consistency. Students experiencing calling differed from those who did not: they attributed different definitions to calling, indicated more often prosocial motivational factors for entering medical school and perceived the learning context as less burdensome. The analysis of the group discussion revealed that the concept of calling has a fluid definition. It was conceived as having the characteristics of a double-edged sword and as originating from within or outside or from a dialectic interplay between the inner and outer world. Finally, calling is experienced less often by physicians than by medical students, with a decreasing prevalence as the immersion in the clinical years of the study of medicine progresses. Conclusions: Calling plays an important role in study choice and consistency of medical students. Given its relevance for medical students and its ramifications with the learning context, calling should become a topic of the reflexive parts of the medical curriculum. We critically discuss the role played by calling for medical students and provide some perspectives on how calling could be integrated in the reflection and teaching on physicianhood.
MeSH term(s)	Career Choice ; Curriculum ; Education, Medical, Undergraduate ; Humans ; Motivation ; Physicians/psychology ; Schools, Medical ; Students, Medical/psychology ; Surveys and Questionnaires ; Switzerland
Language	English
Publishing date	2022-08-15
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-022-03642-x
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Article: [PdS2C2(COOMe)2](6n) (n = 0, -1, -2, -3, -4): hexanuclear homoleptic palladium dithiolene complexes.

Beswick, Colin L / Terroba, Raquel / Greaney, Mark A / Stiefel, Edward I

Journal of the American Chemical Society

2002 Volume 124, Issue 33, Page(s) 9664–9665

Abstract: Reaction of a stoichiometric equivalent of the zinc-dithiolene complex, (tmeda)ZnS2C2(COOMe)2 (tmeda = tetramethylethylenediamine), with (MeCN)2PdCl2 results in a 1:1 homoleptic dithiolene that forms the hexanuclear cluster [PdS2C2(COOMe)2]6 (1). X-ray ... ...

Abstract	Reaction of a stoichiometric equivalent of the zinc-dithiolene complex, (tmeda)ZnS2C2(COOMe)2 (tmeda = tetramethylethylenediamine), with (MeCN)2PdCl2 results in a 1:1 homoleptic dithiolene that forms the hexanuclear cluster [PdS2C2(COOMe)2]6 (1). X-ray structure analysis of 1 indicates a Pd6S12 core comprised of six face-centered palladium atoms and 12 edge-centered sulfur atoms situated on an imaginary approximate cube. Complex 1 undergoes four distinct and reversible one-electron redox steps in dichloromethane at -186, -484, -1174, and -1524 mV versus a standard calomel electrode (ferrocenium+/ferrocene redox couple 409 mV). The two-electron reduction product of 1, [Bu4N]2[(PdS2C2(COOMe)2)6] (2), has been chemically isolated and characterized.
Language	English
Publishing date	2002-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja026079k
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Article ; Online: Observational study of suicide in Switzerland: comparison between psychiatric in- and outpatients.

Stauffacher, Maurice W D / Stiefel, Friedrich / Dorogi, Yves / Michaud, Laurent

Swiss medical weekly

2022 Volume 152, Page(s) w30140

Abstract: ... patients (64.7% males, n = 99). Three quarters (76.4%, n = 81) of the patients had at least one previous ... than in the general Swiss population. Seventy-two percent of the outpatients (n = 49) had a last personal contact ... n = 19).: Conclusions: Patients dying by suicide present most of the time a serious psychiatric ...

Abstract	Aims of the study: In Switzerland, suicide is a major cause of years of potential life lost. Among people who died by suicide, a significant number suffered from mental illness and were treated by psychiatric care institutions. Psychiatric patients are thus a specific target for suicide prevention. Based on data from a clinical committee reviewing every death by suicide of psychiatric patients in the Canton of Vaud (Switzerland), this observational study aimed to gain knowledge on sociodemographic and clinical characteristics of psychiatric patients who died by suicide by comparing in- and outpatients. Methods: Sociodemographic and clinical characteristics of patients who died by suicide in our department from January 2007 to December 2019 were analysed. In- and outpatients were compared. Results: The sample included 153 patients (64.7% males, n = 99). Three quarters (76.4%, n = 81) of the patients had at least one previous suicide attempt. In- and outpatients did not differ significantly in terms of sociodemographics data, psychiatric diagnosis or method of suicide. Almost all (97.2%) of the outpatients had at least one past psychiatric hospitalisation. We found gender disparities for several variables and a lower male/female suicide ratio than in the general Swiss population. Seventy-two percent of the outpatients (n = 49) had a last personal contact with clinicians less than a week before their suicide and 38.8 % of those less than 24 hours (28% of outpatients, n = 19). Conclusions: Patients dying by suicide present most of the time a serious psychiatric history. In- and outpatients seem to have a similar clinical and sociodemographic profile and suicide prevention should thus not be addressed differently in these two groups. The time between death of outpatients and last contact with a therapist was shorter than expected.
MeSH term(s)	Female ; Humans ; Male ; Mental Disorders/epidemiology ; Outpatients ; Risk Factors ; Suicide, Attempted/psychology ; Switzerland/epidemiology
Language	English
Publishing date	2022-02-28
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2022.w30140
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Article ; Online: Field and Thermal Emission Limited Charge Injection in Au-C60-Graphene van der Waals Vertical Heterostructures for Organic Electronics.

Oswald, Jacopo / Beretta, Davide / Stiefel, Michael / Furrer, Roman / Lohde, Sebastian / Vuillaume, Dominique / Calame, Michel

ACS applied nano materials

2023 Volume 6, Issue 11, Page(s) 9444–9452

Abstract: ... promising building blocks for future n-type vertical organic transistors exploiting graphene as tunneling ...

Abstract	Among the family of 2D materials, graphene is the ideal candidate as top or interlayer electrode for hybrid van der Waals heterostructures made of organic thin films and 2D materials due to its high conductivity and mobility and its inherent ability of forming neat interfaces without diffusing in the adjacent organic layer. Understanding the charge injection mechanism at graphene/organic semiconductor interfaces is therefore crucial to develop organic electronic devices. In particular, Gr/C60 interfaces are promising building blocks for future n-type vertical organic transistors exploiting graphene as tunneling base electrode in a two back-to-back Gr/C60 Schottky diode configuration. This work delves into the charge transport mechanism across Au/C60/Gr vertical heterostructures fabricated on Si/SiO
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ISSN	2574-0970
ISSN (online)	2574-0970
DOI	10.1021/acsanm.3c01090
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Article ; Online: Identifying complex patients in family medicine for potential benefit from a case manager: a short questionnaire derived from the INTERMED Self-Assessment (IMSA) questionnaire.

Cohidon, Christine / Gallay, Emilie / Wild, Pascal / Stiefel, Friedrich / Bourquin, Céline / Senn, Nicolas

BMC primary care

2022 Volume 23, Issue 1, Page(s) 276

Abstract: Purpose: To investigate how useful the Intermed-Self Assessment (IMSA) questionnaire and its components were for identifying which patient candidates would benefit most from case management (CM) in general practice.: Methods: The study was carried ... ...

Abstract	Purpose: To investigate how useful the Intermed-Self Assessment (IMSA) questionnaire and its components were for identifying which patient candidates would benefit most from case management (CM) in general practice. Methods: The study was carried out in a group family medicine practice in Lausanne comprising seven GPs and four medical assistants, from February to April 2019. All the patients attending the practice between February and April 2019 were invited to complete the IMSA questionnaire. Additionally, their GPs were asked for their opinions on the potential benefits of each patient being assigned a case manager. Each IMSA item's value has been assessed as a predictor of GPs' opinions by using multivariate logistic models. A score including items retained as predictor was built. Results: Three hundred and thirty one patients participated in the study (participation rate: 62%). Three items from the 20 item IMSA were sufficient to predict GPs' opinions about whether their patients could be expected to benefit if assigned a case manager. Those items addressed the patient's existing chronic diseases (item1), quality of life in relation to existing diseases (item 3), and their social situation (item 9). Using these three items as a score, a cut-off at 4 gave a sensitivity of 70% (ability to correctly identify patients who could benefit from a CM) and specificity of 73% (ability to correctly identify patients who should not benefit from a CM) and concerned about one patient in two. Conclusion: Identifying complex patients suitable for case management remains a challenge for primary care professionals. This paper describes a novel approach using a structured process of combining the results of standardized tools such as the one defined in this study, and the experience of the primary care team.
MeSH term(s)	Humans ; Self-Assessment ; Case Managers ; Quality of Life ; Family Practice ; Surveys and Questionnaires
Language	English
Publishing date	2022-11-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2731-4553
ISSN (online)	2731-4553
DOI	10.1186/s12875-022-01876-8
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Article: Evaluation des besoins bio-psycho-sociaux en médecine de famille: acceptabilité de l’INTERMED Self-Assessment.

Leckwyck, Lara van / Gallay, Emilie / Bourquin, Céline / Stiefel, Friedrich / Cohidon, Christine / Senn, Nicolas

Praxis

2022 Volume 111, Issue 3, Page(s) 135–140

Abstract: Bio-Psycho-Social Needs Assessment in Family Medicine: Acceptability of the Intermed Self- ... ...

Title translation	Bio-Psycho-Social Needs Assessment in Family Medicine: Acceptability of the Intermed Self-Assessment.
Abstract	Bio-Psycho-Social Needs Assessment in Family Medicine: Acceptability of the Intermed Self-Assessment
MeSH term(s)	Family Practice ; Humans ; Needs Assessment ; Self-Assessment ; Surveys and Questionnaires
Language	French
Publishing date	2022-03-01
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	209026-0
ISSN	1661-8165 ; 1661-8157 ; 0369-8394
ISSN (online)	1661-8165
ISSN	1661-8157 ; 0369-8394
DOI	10.1024/1661-8157/a003818
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Article: Adenosine modulates N-methyl-D-aspartate-stimulated hippocampal nitric oxide production in vivo.

Bhardwaj, A / Northington, F J / Koehler, R C / Stiefel, T / Hanley, D F / Traystman, R J

Stroke

1995 Volume 26, Issue 9, Page(s) 1627–1633

Abstract: ... between right- and left-sided probes perfused with various combinations of N-methyl-D-aspartate (NMDA ... adenosine agonists, adenosine antagonists, and the NO synthase inhibitor N omega-nitro-L-arginine methyl ...

Abstract	Background and purpose: Adenosine acts presynaptically to inhibit release of excitatory amino acids (EAAs) and is thus considered to be neuroprotective. Because EAA-stimulated synthesis of nitric oxide (NO) may play an important role in long-term potentiation and excitotoxic-mediated injury, we tested the hypotheses that adenosine agonists attenuate basal and EAA-induced NO production in the hippocampus in vivo and that adenosine A1 receptors mediate this response. Methods: Microdialysis probes were placed bilaterally into the CA3 region of the hippocampus of adult Sprague-Dawley rats under pentobarbital anesthesia. Probes were perfused for 5 hours with artificial cerebrospinal fluid containing 3 mumol/L [14C]L-arginine. Recovery of [14C]L-citrulline in the effluent was used as a marker of NO production. In 10 groups of rats, time-dependent increases in [14C]L-citrulline recovery were compared between right- and left-sided probes perfused with various combinations of N-methyl-D-aspartate (NMDA), adenosine agonists, adenosine antagonists, and the NO synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME). Results: Recovery of [14C]L-citrulline during perfusion with artificial cerebrospinal fluid progressively increased to 141 +/- 27 fmol/min (+/- SEM) over 5 hours. Contralateral perfusion with 1 mmol/L NMDA augmented [14C]L-citrulline recovery to 317 +/- 62 fmol/min. Perfusion of 1 mmol/L L-NAME with NMDA inhibited [14C]L-citrulline recovery compared with NMDA alone. Perfusion with 0.1 mmol/L 2-chloroadenosine attenuated basal as well as NMDA-enhanced [14C]L-citrulline recovery. This action of 2-chloroadenosine was reversed by infusion of 0.1 mmol/L 8-cyclopentyl-1,3-dipropylxanthine, a specific A1 receptor antagonist. Infusion of 0.1 mmol/L (2S)-N6-[2-endo-norboryl]adenosine, a specific A1 receptor agonist, also attenuated the 0.1 mmol/L and 1 mmol/L NMDA-enhanced [14C]L-citrulline recovery. Conclusions: Using an indirect method of assessing NO production in vivo, these data are consistent with in vitro results showing that NMDA receptor stimulation enhances NO production. Furthermore, we conclude that stimulation of A1 receptors can attenuate the basal as well as NMDA-induced production of NO. Because NMDA receptor stimulation amplifies glutamate release, our data are consistent with presynaptic A1 receptor-mediated inhibition of EAA release and consequent downregulation of NO production.
MeSH term(s)	2-Chloroadenosine/pharmacology ; Adenosine/agonists ; Adenosine/analogs & derivatives ; Adenosine/antagonists & inhibitors ; Adenosine/pharmacology ; Amino Acid Oxidoreductases/antagonists & inhibitors ; Animals ; Arginine/administration & dosage ; Arginine/analogs & derivatives ; Arginine/metabolism ; Arginine/pharmacology ; Carbon Radioisotopes ; Citrulline/analysis ; Citrulline/biosynthesis ; Excitatory Amino Acid Antagonists/pharmacology ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; N-Methylaspartate/pharmacology ; NG-Nitroarginine Methyl Ester ; Neuroprotective Agents/pharmacology ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase ; Norbornanes/pharmacology ; Purinergic P1 Receptor Antagonists ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P1/drug effects ; Xanthines/pharmacology
Chemical Substances	Carbon Radioisotopes ; Excitatory Amino Acid Antagonists ; N(6)-(2-endo-norbornyl)adenosine ; Neuroprotective Agents ; Norbornanes ; Purinergic P1 Receptor Antagonists ; Receptors, Purinergic P1 ; Xanthines ; 2-Chloroadenosine (146-77-0) ; Citrulline (29VT07BGDA) ; Nitric Oxide (31C4KY9ESH) ; N-Methylaspartate (6384-92-5) ; Arginine (94ZLA3W45F) ; 1,3-dipropyl-8-cyclopentylxanthine (9PTP4FOI9E) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Amino Acid Oxidoreductases (EC 1.4.-) ; Adenosine (K72T3FS567) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
Language	English
Publishing date	1995-09
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/01.str.26.9.1627
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Article: Transcription induction of the ferric citrate transport genes via the N-terminus of the FecA outer membrane protein, the Ton system and the electrochemical potential of the cytoplasmic membrane.

Kim, I / Stiefel, A / Plantör, S / Angerer, A / Braun, V

Molecular microbiology

1997 Volume 23, Issue 2, Page(s) 333–344

Abstract: ... in induction. Alignment of FecA with the other ferric siderophore receptors of E. coli reveals an N-terminal ... siderophores. In this study, we show that excision of the N-terminal region abolished the inducing activity ... of FecA, but retained its transport activity. Overproduction of the N-terminal FecA fragment inhibited ...

Abstract	Ferric citrate induces transcription of the ferric citrate transport genes fecABCDE without entering the cells of Escherichia coli K-12. Point mutants of the outer membrane-receptor protein FecA are affected in induction independent of the FecA transport activity, suggesting that FecA is directly involved in induction. Alignment of FecA with the other ferric siderophore receptors of E. coli reveals an N-terminal extension in FecA that is not found in the receptors whose synthesis is not induced by their cognate ferric siderophores. In this study, we show that excision of the N-terminal region abolished the inducing activity of FecA, but retained its transport activity. Overproduction of the N-terminal FecA fragment inhibited FecA-dependent induction, but not transport. Constitutive expression caused by C-terminally truncated FecR derivatives was not inhibited by the N-terminal FecA fragment. The N-terminal region of FecA was localized in the periplasm, which indicates that FecA probably interacts with FecR, which is involved in signal transduction across the cytoplasmic membrane. Transcription initiation of the fec transport genes required the Ton system, consisting of TonB, ExbB, and ExbD, and was inhibited by carbonylcyanide-m-chlorophenylhydrazone (CCCP) and 2,4-dinitrophenol (DNP), which dissipate the electrochemical potential of the cytoplasmic membrane. fec transcription of mutant fecA4, which displays constitutive fec transcription in the absence of TonB, was not affected by CCCP. The data support a model that proposes initiation of fec transport gene transcription by binding of ferric citrate to FecA. The transcription initiation signal is transferred across the outer membrane through the activity of the Ton system at the expense of the electrochemical potential of the cytoplasmic membrane. The N-terminus of FecA interacts in the periplasm with the C-terminus of FecR, through which the signal is transferred across the cytoplasmic membrane into the cytoplasm, where it increases the activity of the sigma factor Fecl, which then directs the RNA polymerase to the fec promoter upstream of fecA.
MeSH term(s)	Amino Acid Sequence ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Proteins ; Ferric Compounds/metabolism ; Membrane Proteins ; Receptors, Cell Surface ; Sequence Alignment ; Sequence Homology, Amino Acid ; Transcription, Genetic
Chemical Substances	Carrier Proteins ; Escherichia coli Proteins ; FecA protein, E coli ; Ferric Compounds ; Membrane Proteins ; Receptors, Cell Surface ; ferric citrate (63G354M39Z)
Language	English
Publishing date	1997-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	619315-8
ISSN	1365-2958 ; 0950-382X
ISSN (online)	1365-2958
ISSN	0950-382X
DOI	10.1046/j.1365-2958.1997.2401593.x
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