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  1. Book ; Online: Frailty and Herbal Medicines- From Molecular Mechanisms to Clinical Efficacy

    Inui, Akio / Bo Li, Jiang / Ataka, Koji / Takahashi, Ryuji / Iizuka, Noiro

    2020  

    Keywords Medicine ; Dietetics & nutrition ; herbal medicine ; Kampo medicine ; Ninjin'yoeito ; frailty ; aging
    Size 1 electronic resource (325 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230849
    ISBN 9782889637614 ; 2889637611
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Conference proceedings: 9th International NPY Symposium

    Inui, Akio

    Okinawa, Japan (March 16 - 19, 2008)

    (Nutrition ; 24,9)

    2008  

    Event/congress International NPY Symposium (9, 2008)
    Author's details [Akio Inui ...]
    Series title Nutrition ; 24,9
    Collection
    Language English
    Size S. 785 - 923 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015705315
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    Z 4802 (24,9) available for loan (reading room) Freihandmagazin (U1)

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  3. Article ; Online: Neuropeptide regulation by herbal medicine.

    Ohsawa, Masahiro / Takimoto, Yoshiyuki / Herzog, Herbert / Inui, Akio

    Neuropeptides

    2022  Volume 93, Page(s) 102240

    MeSH term(s) Drugs, Chinese Herbal ; Herbal Medicine ; Neuropeptides ; Phytotherapy ; Plants, Medicinal
    Chemical Substances Drugs, Chinese Herbal ; Neuropeptides
    Language English
    Publishing date 2022-03-11
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 9048-7
    ISSN 1532-2785 ; 0143-4179
    ISSN (online) 1532-2785
    ISSN 0143-4179
    DOI 10.1016/j.npep.2022.102240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1592: Show issues Location:
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  4. Article ; Online: Anamorelin in Japanese patients with cancer cachexia: an update.

    Wakabayashi, Hidetaka / Arai, Hidenori / Inui, Akio

    Current opinion in supportive and palliative care

    2023  Volume 17, Issue 3, Page(s) 162–167

    Abstract: Purpose of review: Anamorelin was approved for production and marketing in Japan on 22 January 2021 for cancer cachexia in non-small-cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer. The authors describe the updates of ... ...

    Abstract Purpose of review: Anamorelin was approved for production and marketing in Japan on 22 January 2021 for cancer cachexia in non-small-cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer. The authors describe the updates of anamorelin for cancer cachexia in Japan.
    Recent findings: Recent evidence showed that anamorelin improved lean body mass, body weight, and appetite in patients with cancer cachexia in clinical practice. Anamorelin does not increase body weight in the severe-weight-loss group in cachectic patients with pancreatic cancer. Several case reports showed that anamorelin can cause cardiac adverse drug reactions. Among the cardiac adverse reactions, fatal arrhythmias should be monitored carefully even if it is the first dose. Anamorelin combined with nutrition, physical activity, and exercise may be more useful than anamorelin alone for treating cancer cachexia. An interim analysis from post-marketing all-case surveillance was performed; however, details have not yet been published. When anamorelin cannot be used for cancer cachexia, Kampo medicines can be considered as an option.
    Summary: Anamorelin has changed the clinical practice of cancer cachexia in Japan. The authors hope that anamorelin is available for other disease-related cachexia along with appropriate multidisciplinary interventions.
    MeSH term(s) Humans ; Body Weight/drug effects ; Cachexia/drug therapy ; Cachexia/etiology ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/drug therapy ; East Asian People ; Lung Neoplasms/complications ; Neoplasms/complications ; Neoplasms/drug therapy ; Pancreatic Neoplasms
    Chemical Substances anamorelin (DD5RBA1NKF)
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6946: Show issues Location:
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  5. Article: [Programs for Continuing Medical Education: A session; 8. Stress and internal disease].

    Inui, Akio

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2016  Volume 105, Issue 3, Page(s) 464–470

    MeSH term(s) Aged ; Cachexia/complications ; Cachexia/therapy ; Education, Medical, Continuing ; Frail Elderly ; Humans ; Internal Medicine/education ; Psychophysiologic Disorders ; Stress, Psychological/complications ; Stress, Psychological/therapy
    Language Japanese
    Publishing date 2016-05-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.105.464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 594: Show issues Location:
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  6. Article: Editorial: Ageing-Related Symptoms, Kampo Medicine, and Treatment.

    Ohsawa, Masahiro / Uezono, Yasuhito / Inui, Akio

    Frontiers in nutrition

    2021  Volume 8, Page(s) 749320

    Language English
    Publishing date 2021-11-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2021.749320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Degalactosylated Whey Protein Suppresses Inflammatory Responses Induced by Lipopolysaccharide in Mice.

    Inui, Toshio / Kawamura, Namiko / Nakama, Riho / Inui, Akio / Katsuura, Goro

    Frontiers in nutrition

    2022  Volume 9, Page(s) 852355

    Abstract: The effects of degalactosylated whey protein on lipopolysaccharide (LPS)-induced inflammatory responses in mice were observed in comparison with intact whey protein. Intraperitoneal administration of both intact and degalactosylated whey proteins for 5 ... ...

    Abstract The effects of degalactosylated whey protein on lipopolysaccharide (LPS)-induced inflammatory responses in mice were observed in comparison with intact whey protein. Intraperitoneal administration of both intact and degalactosylated whey proteins for 5 days did not affect body weight and food intake in mice. On day 6, intraperitoneal administration of LPS induced a marked decrease in body weight 4 h later. The LPS-induced decrease in body weight was significantly suppressed by the administration of degalactosylated whey protein, but not intact whey protein. Administration of LPS also significantly increase plasma tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels, which were significantly suppressed by the administration of degalactosylated whey protein, but not intact whey protein. Moreover, the application of degalactosylated whey protein to RAW264.7 cells significantly reduced mRNA expression of toll-like receptor 4 (TLR4) and significantly increased mRNA expression of mitogen-activated protein kinase phosphatase-1 (MKP-1). The marked increased expression of TNF-α and IL-1β in response to LPS in RAW264.7 cells was significantly suppressed by the application of degalactosylated whey protein. These results suggest that degalactosylated whey protein suppresses the effects of LPS in part by decreasing in TLR4 and increasing in MKP-1.
    Language English
    Publishing date 2022-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.852355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish.

    Kawabe, Momoko / Nishida, Takumi / Takahashi, Ryuji / Inui, Akio / Shiozaki, Kazuhiro

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1168229

    Abstract: Ninjinyoeito, Hochuekkito, and Juzentaihoto are the three types of Kampo-hozai used to support the treatment of various diseases by energizing patients through improved mental health. While Kampo-hozais are clinically used to improve mental energy ... ...

    Abstract Ninjinyoeito, Hochuekkito, and Juzentaihoto are the three types of Kampo-hozai used to support the treatment of various diseases by energizing patients through improved mental health. While Kampo-hozais are clinically used to improve mental energy decline, a comparison between their effects on neuropsychiatric symptoms like anxiety and sociability and the strength of their effects has not been conducted. Therefore, this study compared the effects of Ninjinyoeito, Hochuekkito, and Juzentaihoto on psychiatric symptoms using neuropeptide Y knockout (NPY-KO) zebrafish, a suitable animal model for anxiety and low sociability. Neuropeptide Y knockout zebrafish were fed a Ninjinyoeito, Hochuekkito, or Juzentaihoto-supplemented diet for 4 days. Then, sociability was analyzed using a three-Chambers test and anxiety-like behavior was evaluated using the cold stress and novel tank tests. The results showed that Ninjinyoeito treatment improved the low sociability of neuropeptide Y knockout, while Hochuekkito and Juzentaihoto did not. Neuropeptide Y knockout exhibited anxiety-like behaviors, such as freezing and swimming in the wall area under cold stress, but Ninjinyoeito treatment improved these behaviors. However, these anxiety-like behaviors were not improved by Hochuekkito and Juzentaihoto. Ninjinyoeito treatment also improved anxiety-like behaviors of neuropeptide Y knockout in the novel tank test. However, no improvement was shown in the Hochuekkito and Juzentaihoto groups. This trend was also confirmed in the low water stress test using wild-type zebrafish. This study exhibits that among the three types of Kampo-hozai, Ninjinyoeito is the most effective in psychiatric disorders associated with anxiety and low sociability.
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1168229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Obesity and upper gastrointestinal system with special emphasis on ghrelin].

    Inui, Akio / Sakaki, Mika / Sameshima-Uto, Nanami

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2021  Volume 118, Issue 6, Page(s) 517–524

    MeSH term(s) Gastrointestinal Tract ; Ghrelin ; Humans ; Obesity ; Upper Gastrointestinal Tract
    Chemical Substances Ghrelin
    Language Japanese
    Publishing date 2021-06-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.118.517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.34: Show issues Location:
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  10. Article ; Online: Comparative study of the effects of the three kinds of Kampo-hozai

    Momoko Kawabe / Takumi Nishida / Ryuji Takahashi / Akio Inui / Kazuhiro Shiozaki

    Frontiers in Pharmacology, Vol

    Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish

    2023  Volume 14

    Abstract: Ninjinyoeito, Hochuekkito, and Juzentaihoto are the three types of Kampo-hozai used to support the treatment of various diseases by energizing patients through improved mental health. While Kampo-hozais are clinically used to improve mental energy ... ...

    Abstract Ninjinyoeito, Hochuekkito, and Juzentaihoto are the three types of Kampo-hozai used to support the treatment of various diseases by energizing patients through improved mental health. While Kampo-hozais are clinically used to improve mental energy decline, a comparison between their effects on neuropsychiatric symptoms like anxiety and sociability and the strength of their effects has not been conducted. Therefore, this study compared the effects of Ninjinyoeito, Hochuekkito, and Juzentaihoto on psychiatric symptoms using neuropeptide Y knockout (NPY-KO) zebrafish, a suitable animal model for anxiety and low sociability. Neuropeptide Y knockout zebrafish were fed a Ninjinyoeito, Hochuekkito, or Juzentaihoto-supplemented diet for 4 days. Then, sociability was analyzed using a three-Chambers test and anxiety-like behavior was evaluated using the cold stress and novel tank tests. The results showed that Ninjinyoeito treatment improved the low sociability of neuropeptide Y knockout, while Hochuekkito and Juzentaihoto did not. Neuropeptide Y knockout exhibited anxiety-like behaviors, such as freezing and swimming in the wall area under cold stress, but Ninjinyoeito treatment improved these behaviors. However, these anxiety-like behaviors were not improved by Hochuekkito and Juzentaihoto. Ninjinyoeito treatment also improved anxiety-like behaviors of neuropeptide Y knockout in the novel tank test. However, no improvement was shown in the Hochuekkito and Juzentaihoto groups. This trend was also confirmed in the low water stress test using wild-type zebrafish. This study exhibits that among the three types of Kampo-hozai, Ninjinyoeito is the most effective in psychiatric disorders associated with anxiety and low sociability.
    Keywords Kampo (traditional Japanese herbal medicine) ; zebrafish ; anxious behavior ; sociability ; Ninjinyoeito ; Hochuekkito ; Therapeutics. Pharmacology ; RM1-950
    Subject code 150
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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