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Article ; Online: Improved recovery of nontuberculous mycobacteria in culture with adjunctive use of a selective agar.

Caldwell, Mikayla / Tisdale, Jena / Khare, Reeti

2024 Volume 62, Issue 3, Page(s) e0167823

MeSH term(s)	Humans ; Nontuberculous Mycobacteria ; Agar ; Mycobacterium Infections, Nontuberculous/microbiology ; Cystic Fibrosis/microbiology
Chemical Substances	Agar (9002-18-0)
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Letter
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.01678-23
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Article ; Online: Thyroid and Adrenal Dysfunction in Hemoglobinopathies Before and After Allogeneic Hematopoietic Cell Transplant.

Mandava, Mamatha / Lew, Jeffrey / Tisdale, John F / Limerick, Emily / Fitzhugh, Courtney D / Hsieh, Matthew M

Journal of the Endocrine Society

2023 Volume 7, Issue 12, Page(s) bvad134

Abstract: Purpose: To determine the rate and clinical characteristics associated with abnormal thyroid and adrenal function in recipients of nonmyeloablative hematopoietic cell transplantation (HCT) for sickle cell disease (SCD) and beta-thalassemia.: Methods: ...

Abstract	Purpose: To determine the rate and clinical characteristics associated with abnormal thyroid and adrenal function in recipients of nonmyeloablative hematopoietic cell transplantation (HCT) for sickle cell disease (SCD) and beta-thalassemia. Methods: We retrospectively reviewed patients who enrolled in 4 nonmyeloablative HCT regimens with alemtuzumab and total body irradiation (TBI). Baseline and annual post-HCT data were compared, which included age, sex, sickle phenotype, thyroid panel (total T3, free T4, thyroid stimulating hormone, antithyroid antibodies), cortisol level, ACTH stimulation testing, ferritin, medications, and other relevant medical history. Results: Among 43 patients in haploidentical transplant and 84 patients in the matched related donor protocols with mostly SCD, the rate of any thyroid disorder pre-HCT was 3.1% (all subclinical hypothyroidism) and post-HCT was 29% (10 hypothyroidism, 4 Grave's disease, and 22 subclinical hypothyroidism). Ninety-two (72%) patients had ferritin >1000 ng/dL, of which 33 patients (35.8%) had thyroid dysfunction. Iron overload was noted in 6 of 10 patients with hypothyroidism and 12 of 22 patients with subclinical hypothyroidism.Sixty-one percent were on narcotics for pain control. With respect to adrenal insufficiency (AI) pre-HCT, 2 patients were maintained on corticosteroids for underlying rheumatologic disorder and 8 had AI diagnosed during pre-HCT ACTH stimulation testing (total 10, 7.9%). Post-HCT, an additional 4 (3%) developed AI from corticosteroid use for acute graft vs host disease, Evans syndrome, or hemolytic anemia. Conclusion: Although iron overload was common in SCD, thyroid dysfunction pre-HCT related to excess iron was less common. Exposure to alemtuzumab or TBI increased the rates of thyroid dysfunction post-HCT. In contrast, AI was more common pre-HCT, but no risk factor was identified. AI post-HCT was infrequent and associated with corticosteroid use for HCT-related complications.
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvad134
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Article: Halogenated PETN derivatives: interplay between physical and chemical factors in explosive sensitivity.

Lease, Nicholas / Spielvogel, Kyle D / Davis, Jack V / Tisdale, Jeremy T / Klamborowski, Lisa M / Cawkwell, M J / Manner, Virginia W

Chemical science

2023 Volume 14, Issue 25, Page(s) 7044–7056

Abstract: Determining the factors that influence and can help predict energetic material sensitivity has long been a challenge in the explosives community. Decades of literature reports identify a multitude of factors both chemical and physical that influence ... ...

Abstract	Determining the factors that influence and can help predict energetic material sensitivity has long been a challenge in the explosives community. Decades of literature reports identify a multitude of factors both chemical and physical that influence explosive sensitivity; however no unifying theory has been observed. Recent work by our team has demonstrated that the kinetics of "trigger linkages" (
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc01627g
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Article ; Online: Increased Rates of Rhabdomyolysis in Male Hematopoietic Cell Transplantation Recipients Taking Sirolimus and Trimethoprim/Sulfamethoxazole.

Lew, Jeffrey / Fitzhugh, Courtney D / Tisdale, John F / Hsieh, Matthew M

Transplantation and cellular therapy

2021 Volume 27, Issue 12, Page(s) 1019.e1–1019.e4

Abstract: Hematopoietic cell transplantation (HCT) offers long-term cure against early morbidity and mortality of hemoglobinopathies, such as sickle cell disease (SCD) and beta-thalassemia. Following HCT, sirolimus is an immunosuppressant used to prevent graft- ... ...

Abstract	Hematopoietic cell transplantation (HCT) offers long-term cure against early morbidity and mortality of hemoglobinopathies, such as sickle cell disease (SCD) and beta-thalassemia. Following HCT, sirolimus is an immunosuppressant used to prevent graft-versus-host disease (GVHD) while receiving trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis jirovecii prophylaxis and other antimicrobial agents (including acyclovir). One rare adverse event associated with both drugs is rhabdomyolysis, defined as creatine kinase (CK) elevation at least 5 to 10 times the upper limit of normal. This study was conducted to evaluate the rate of and risk factors for developing rhabdomyolysis in the post-HCT setting. Across 4 haploidentical and matched related donor (MRD) nonmyeloablative protocols, CK levels were prospectively monitored and patients were retrospectively identified for rhabdomyolysis. The rhabdomyolysis was graded based on the severity of CK elevation and other organ injury. At diagnosis, patients were queried for concurrent medication use (ie, sirolimus, TMP-SMX, acyclovir, or statins), sex, age, donor genotype, and time from transplantation. Among 127 patients with mostly SCD, rhabdomyolysis occurred in 22 (17%), including 2 recipients of haploidentical donor HCT and 20 recipients of MRD HCT. The time to the development of rhabdomyolysis was 61 and 73 days for the 2 recipients of haploidentical HCT and a median of 73 days for the MRD HCT recipients. Among the 22 patients who developed rhabdomyolysis, 20 (91%) were receiving sirolimus (2 haploidentical HCT recipients and 18 MRD HCT recipients), and 14 (64%) were also receiving TMP-SMX (all in the MRD HCT group). Seventy-five percent of the haploidentical donors and 69% of the MRDs had sickle cell trait. All but 2 patients with rhabdomyolysis were male. No patients who developed rhabdomyolysis were receiving statins at any point. Higher-than-expected rates of rhabdomyolysis were found post-transplantation for patients with SCD and beta-thalassemia. Contributing risk factors included immunosuppression with sirolimus, TMP-SMX, male sex, and sickle trait donor. These factors differ from the excessive muscle strain or injury, seizures, infections, or HMG-CoA inhibitors typically identified in non-HCT recipients.
MeSH term(s)	Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Pneumonia, Pneumocystis ; Retrospective Studies ; Rhabdomyolysis/chemically induced ; Sirolimus/adverse effects ; Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects
Chemical Substances	Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2021.08.011
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Zs.A 5082: Show issues

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Article ; Online: Longitudinal neurocognitive effects of nonmyeloablative hematopoietic stem cell transplant among older adolescents and adults with sickle cell disease: A description and comparison with sibling donors.

Carlson, Emily J / Al Ghriwati, Nour / Wolters, Pam / Anne Tamula, Mary / Tisdale, John / Fitzhugh, Courtney / Hsieh, Matt / Martin, Staci

Neuropsychological rehabilitation

2023 , Page(s) 1–20

Abstract: Sickle cell disease (SCD) is associated with increased risk of neurocognitive deficits. However, whether functioning changes following nonmyeloablative hematopoietic stem cell transplant (HSCT) remains unclear. This study aimed to examine changes in ... ...

Abstract	Sickle cell disease (SCD) is associated with increased risk of neurocognitive deficits. However, whether functioning changes following nonmyeloablative hematopoietic stem cell transplant (HSCT) remains unclear. This study aimed to examine changes in neuropsychological functioning pre- to post-transplant among patients with SCD and compare patients and siblings. Adults with SCD (
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1080508-4
ISSN	1464-0694 ; 0960-2011
ISSN (online)	1464-0694
ISSN	0960-2011
DOI	10.1080/09602011.2023.2238948
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Zs.A 3276: Show issues

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Article ; Online: Hematopoietic-Stem-Cell-Targeted Gene-Addition and Gene-Editing Strategies for β-hemoglobinopathies.

Drysdale, Claire M / Nassehi, Tina / Gamer, Jackson / Yapundich, Morgan / Tisdale, John F / Uchida, Naoya

Cell stem cell

2021 Volume 28, Issue 2, Page(s) 191–208

Abstract: Sickle cell disease (SCD) is caused by a well-defined point mutation in the β-globin gene and therefore is an optimal target for hematopoietic stem cell (HSC) gene-addition/editing therapy. In HSC gene-addition therapy, a therapeutic β-globin gene is ... ...

Abstract	Sickle cell disease (SCD) is caused by a well-defined point mutation in the β-globin gene and therefore is an optimal target for hematopoietic stem cell (HSC) gene-addition/editing therapy. In HSC gene-addition therapy, a therapeutic β-globin gene is integrated into patient HSCs via lentiviral transduction, resulting in long-term phenotypic correction. State-of-the-art gene-editing technology has made it possible to repair the β-globin mutation in patient HSCs or target genetic loci associated with reactivation of endogenous γ-globin expression. With both approaches showing signs of therapeutic efficacy in patients, we discuss current genetic treatments, challenges, and technical advances in this field.
MeSH term(s)	CRISPR-Cas Systems/genetics ; Gene Editing ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells ; Hemoglobinopathies/genetics ; Hemoglobinopathies/therapy ; Humans
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2021.01.001
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Zs.A 6589: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 75: Show issues

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Article ; Online: Patient-Centered, Sustainable Hypertension Care: The Case for Adopting a Differentiated Service Delivery Model for Hypertension Services in Low- and Middle-Income Countries.

Tisdale, Rebecca L / Cazabon, Danielle / Moran, Andrew E / Rabkin, Miriam / Bygrave, Helen / Cohn, Jennifer

Global heart

2021 Volume 16, Issue 1, Page(s) 59

Abstract: Expanding hypertension services in low- and middle-income countries requires efficient and effective service delivery approaches that meet the needs and expectations of people living with hypertension within the resource constraints of existing national ... ...

Abstract	Expanding hypertension services in low- and middle-income countries requires efficient and effective service delivery approaches that meet the needs and expectations of people living with hypertension within the resource constraints of existing national health systems. Ideally, a hypertension program will extend treatment coverage while maintaining service quality, maximizing efficient resource utilization and improving clinical outcomes. In this article, we discuss lessons learned from HIV differentiated service delivery initiatives, and make the case that the same approach should be adopted for hypertension programs.
MeSH term(s)	Developing Countries ; HIV Infections ; Humans ; Hypertension/epidemiology ; Hypertension/therapy ; Income ; Patient-Centered Care
Language	English
Publishing date	2021-09-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2629633-0
ISSN	2211-8179 ; 2211-8160
ISSN (online)	2211-8179
ISSN	2211-8160
DOI	10.5334/gh.978
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Article: Colloidal nano-MOFs nucleate and stabilize ultra-small quantum dots of lead bromide perovskites.

Protesescu, Loredana / Calbo, Joaquín / Williams, Kristopher / Tisdale, William / Walsh, Aron / Dincă, Mircea

Chemical science

2021 Volume 12, Issue 17, Page(s) 6129–6135

Abstract: The development of synthetic routes to access stable, ultra-small ( ...

Abstract	The development of synthetic routes to access stable, ultra-small (
Language	English
Publishing date	2021-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d1sc00282a
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Article ; Online: Effect of menopausal symptom treatment options on palpitations: a systematic review.

Sheng, Y / Carpenter, J S / Elomba, C D / Alwine, J S / Yue, M / Chen, C X / Tisdale, J E

Climacteric : the journal of the International Menopause Society

2021 Volume 25, Issue 2, Page(s) 128–140

Abstract: This systematic review provides an overview of the effects of menopausal symptom treatment options on palpitations, defined as feelings of missed or exaggerated heart beats, reported by perimenopausal and postmenopausal women. Guided by the Preferred ... ...

Abstract	This systematic review provides an overview of the effects of menopausal symptom treatment options on palpitations, defined as feelings of missed or exaggerated heart beats, reported by perimenopausal and postmenopausal women. Guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searches were conducted in PubMed, CINAHL and PsycINFO to identify articles meeting pre-specified inclusion criteria. Of 670 unique articles identified, 37 were included in the review. Treatments included drug therapies and non-drug therapies. Palpitations were studied as an outcome in 89% of articles and as an adverse effect in 11%. Articles provided mostly level II/III evidence due to their design and/or small sample sizes. Based on available evidence, no therapies can be fully recommended for clinical practice. Only some hormonal agents (e.g. estradiol) can be recommended with caution based on some positive evidence for reducing palpitation prevalence or severity. However, other drug therapies (e.g. moxonidine, atenolol), dietary supplementary treatments (e.g. isoflavones,
MeSH term(s)	Cognitive Behavioral Therapy ; Female ; Humans ; Isoflavones ; Menopause
Chemical Substances	Isoflavones
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	1469153-x
ISSN	1473-0804 ; 1369-7137
ISSN (online)	1473-0804
ISSN	1369-7137
DOI	10.1080/13697137.2021.1948006
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Zs.A 5245: Show issues

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Article ; Online: Retrospective Self-Reports of How Adolescent Substance Use Changed with the COVID-19 Pandemic.

Leung, Janni / Quinn, Catherine / Carlyle, Molly / Ellem, Rhiannon / Tisdale, Calvert / Davidson, Lily / White, Melanie J / Kavanagh, David J / Hides, Leanne

International journal of environmental research and public health

2022 Volume 19, Issue 20

Abstract: The final year of high school is a challenging phase of adolescents' lives and substance use can play an important role. We examined changes in the frequency and quantity of alcohol and cannabis use, and demographic correlates among Grade 12 students of ... ...

Abstract	The final year of high school is a challenging phase of adolescents' lives and substance use can play an important role. We examined changes in the frequency and quantity of alcohol and cannabis use, and demographic correlates among Grade 12 students of 2020. Students (N = 844) from nine schools retrospectively self-reported changes in substance use after the easing of COVID-19 lockdowns (back to school), compared to before the pandemic. Changes in use were examined with age, gender, Aboriginal or Torres Islander, parental and family characteristics, and truancy. Thirty-one percent of students reported that they used alcohol less frequently, and 24% reported that they used it more frequently compared to pre-COVID-19. Most students (46%) reported that they used cannabis less, while a subset reported using more frequently (22%). A history of truancy was associated with an increased frequency (OR = 2.13 [1.18-3.83]) of cannabis use. A substantial minority of adolescents used more alcohol and cannabis after the initial COVID-19 lockdown period. Students in their final year who reported increased use may benefit from increased support to manage their substance use.
MeSH term(s)	Humans ; Adolescent ; Self Report ; COVID-19/epidemiology ; Pandemics ; Retrospective Studies ; Adolescent Behavior ; Communicable Disease Control ; Substance-Related Disorders/epidemiology ; Alcohol Drinking
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192013680
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