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  1. Article ; Online: COVID-19 and childhood acute lymphoblastic leukemia.

    Greaves, Mel

    Pediatric blood & cancer

    2020  Volume 67, Issue 12, Page(s) e28481

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28481
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    Zs.A 1131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Convergent TP53 loss and evolvability in cancer.

    Mansur, Marcela Braga / Greaves, Mel

    BMC ecology and evolution

    2023  Volume 23, Issue 1, Page(s) 54

    Abstract: Cancer cell populations evolve by a stepwise process involving natural selection of the fittest variants within a tissue ecosystem context and as modified by therapy. Genomic scrutiny of patient samples reveals an extraordinary diversity of mutational ... ...

    Abstract Cancer cell populations evolve by a stepwise process involving natural selection of the fittest variants within a tissue ecosystem context and as modified by therapy. Genomic scrutiny of patient samples reveals an extraordinary diversity of mutational profiles both between patients with similar cancers and within the cancer cell population of individual patients. Does this signify highly divergent evolutionary trajectories or are there repetitive and predictable patterns?Major evolutionary innovations or adaptations in different species are frequently repeated, or convergent, reflecting both common selective pressures and constraints on optimal solutions. We argue this is true of evolving cancer cells, especially with respect to the TP53 gene. Functional loss variants in TP53 are the most common genetic change in cancer. We discuss the likely microenvironmental selective pressures involved and the profound impact this has on cell fitness, evolvability and probability of subsequent drug resistance.
    MeSH term(s) Humans ; Ecosystem ; Biological Evolution ; Mutation ; Selection, Genetic ; Genome ; Neoplasms/genetics ; Tumor Suppressor Protein p53/genetics
    Chemical Substances TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2730-7182
    ISSN (online) 2730-7182
    DOI 10.1186/s12862-023-02146-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID‐19 and childhood acute lymphoblastic leukemia

    Greaves, Mel

    Pediatric Blood & Cancer

    2020  Volume 67, Issue 12

    Keywords Pediatrics, Perinatology, and Child Health ; Oncology ; Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28481
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Nothing in cancer makes sense except….

    Greaves, Mel

    BMC biology

    2018  Volume 16, Issue 1, Page(s) 22

    Abstract: Paraphrasing Dobzhansky's famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging picture of cancer captures its extensive ... ...

    Abstract Paraphrasing Dobzhansky's famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging picture of cancer captures its extensive diversity and therapeutic resilience, highlighting the need for more innovative approaches to control.
    MeSH term(s) Animals ; Biological Evolution ; Drug Resistance/physiology ; Humans ; Mutation/physiology ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/therapy ; Selection, Genetic/physiology
    Language English
    Publishing date 2018-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-018-0493-8
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  6. Article ; Online: Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia.

    Greaves, Mel

    Nature reviews. Cancer

    2018  Volume 18, Issue 8, Page(s) 526

    Abstract: The article as originally published cited the incorrect paper as reference 123. The correct reference is Kroll, M. E., Draper, G. J., Stiller, C. A. & Murphy, M. F. G. Childhood leukemia incidence in Britain, 1974-2000: time trends and possible relation ... ...

    Abstract The article as originally published cited the incorrect paper as reference 123. The correct reference is Kroll, M. E., Draper, G. J., Stiller, C. A. & Murphy, M. F. G. Childhood leukemia incidence in Britain, 1974-2000: time trends and possible relation to influenza epidemics. J. Natl Cancer Inst. 98, 417-420 (2006). This has been corrected in the online and print versions of the article.
    Language English
    Publishing date 2018-05-26
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-018-0029-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5563: Show issues Location:
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    Zs.MG 24: Show issues

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  7. Article ; Online: A causal mechanism for childhood acute lymphoblastic leukaemia.

    Greaves, Mel

    Nature reviews. Cancer

    2018  Volume 18, Issue 8, Page(s) 471–484

    Abstract: In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation by fusion gene formation or ... ...

    Abstract In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation by fusion gene formation or hyperdiploidy generates a covert, pre-leukaemic clone. Second, in a small fraction of these cases, the postnatal acquisition of secondary genetic changes (primarily V(D)J recombination-activating protein (RAG) and activation-induced cytidine deaminase (AID)-driven copy number alterations in the case of ETS translocation variant 6 (ETV6)-runt-related transcription factor 1 (RUNX1)
    MeSH term(s) Causality ; Child ; Core Binding Factor Alpha 2 Subunit/genetics ; Fusion Proteins, bcr-abl/genetics ; Genes, RAG-1/genetics ; Humans ; Infections/epidemiology ; Mutation ; Myeloid-Lymphoid Leukemia Protein/genetics ; Oncogene Proteins, Fusion/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; V(D)J Recombination/genetics
    Chemical Substances BCR-ABL1 fusion protein, human ; Core Binding Factor Alpha 2 Subunit ; MLL-AF4 fusion protein, human ; Oncogene Proteins, Fusion ; TEL-AML1 fusion protein ; Myeloid-Lymphoid Leukemia Protein (149025-06-9) ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2018-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-018-0015-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 24: Show issues

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  8. Article ; Online: Nothing in cancer makes sense except…

    Mel Greaves

    BMC Biology, Vol 16, Iss 1, Pp 1-

    2018  Volume 8

    Abstract: Abstract Paraphrasing Dobzhansky’s famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging picture of cancer captures its ... ...

    Abstract Abstract Paraphrasing Dobzhansky’s famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging picture of cancer captures its extensive diversity and therapeutic resilience, highlighting the need for more innovative approaches to control.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2018-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Covert pre-leukaemic clones in healthy co-twins of patients with childhood acute lymphoblastic leukaemia.

    Ford, Anthony M / Colman, Susan / Greaves, Mel

    Leukemia

    2022  Volume 37, Issue 1, Page(s) 47–52

    MeSH term(s) Humans ; Child ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Clone Cells
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-022-01756-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2295: Show issues Location:
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  10. Book: Krebs - der blinde Passagier der Evolution

    Greaves, Melvyn F.

    2003  

    Title translation Cancer - the evolutionary legacy
    Author's details Mel Greaves
    Keywords Krebs ; Evolutionstheorie
    Subject Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung ; Abstammungslehre ; Deszendenztheorie ; Entwicklungstheorie ; Evolution
    Language German
    Size 284 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    Note Aus dem Engl. übers.
    HBZ-ID HT013444732
    ISBN 3-540-43669-3 ; 978-3-540-43669-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 A 4709 order for loan Magazin

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