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Article ; Online: Marie and Irène Curie, two brilliant women who pioneered the development of nuclear chemistry, radiotherapy, and radiobiology.

Janiak, Marek K / Mothersill, Carmel

International journal of radiation biology

2021 Volume 98, Issue 3, Page(s) 276–279

Abstract: Objective: To describe the contributions of Marie Sklodowska-Curie and her daughter Irene Curie to radiation science and how these studies in physics, chemistry and medicine led to the need to study radiobiological effects.: Conclusions: The seminal ... ...

Abstract	Objective: To describe the contributions of Marie Sklodowska-Curie and her daughter Irene Curie to radiation science and how these studies in physics, chemistry and medicine led to the need to study radiobiological effects. Conclusions: The seminal discoveries of Maria Sklodowska-Curie in radiation physics and chemistry provided the basis for later investigations of the effects of ionizing radiation on cells and tissues and the role of radioactivity in mutagenesis and carcinogenesis. Both Maria and Irene contributed to the development of radiotherapy and the use of x-rays and radioisotopes in medical diagnosis. Their legacy is not confined to their own generation but can be traced through grand- and great-grand-students of these pioneering women.
MeSH term(s)	Female ; Health Physics ; History, 20th Century ; Humans ; Radiation Oncology ; Radiobiology ; Radiography ; X-Rays
Language	English
Publishing date	2021-06-03
Publishing country	England
Document type	Historical Article ; Journal Article
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.1080/09553002.2021.1931528
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Article ; Online: Time to rejuvenate ultra-low dose whole-body radiotherapy of cancer.

Janiak, Marek K / Pocięgiel, Mateusz / Welsh, James S

Critical reviews in oncology/hematology

2021 Volume 160, Page(s) 103286

Abstract: The results of clinical trials performed from the 1930s until the end of the 20th century in which total-body ultra-low level ionizing radiation (TB-LLR) was used demonstrate that this form of treatment can be equal or superior to other systemic anti- ... ...

Abstract	The results of clinical trials performed from the 1930s until the end of the 20th century in which total-body ultra-low level ionizing radiation (TB-LLR) was used demonstrate that this form of treatment can be equal or superior to other systemic anti-neoplastic modalities in terms of the rates of remissions, toxicity, and side effects. In this review, we provide the rationale for TB-LLR and analyze the results of reliable clinical trials in patients with predominantly lymphoproliferative disorders but also advanced solid cancers. The doses used in these trials did not exceed 0.1-0.2 Gy per fraction and cumulative totals ranged from 1 to 4 Gy. Based on the reviewed results we conclude that it is appropriate to revive interest in and resume clinical investigations of TB-LLR in order to refine and improve the effectiveness of such treatment, whether employed alone or in combination with other anticancer strategies.
MeSH term(s)	Humans ; Neoplasms/radiotherapy ; Radiation, Ionizing ; Radiotherapy Dosage ; Whole-Body Irradiation
Language	English
Publishing date	2021-03-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2021.103286
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Article: Epidemiological evidence of childhood leukaemia around nuclear power plants.

Janiak, Marek K

Dose-response : a publication of International Hormesis Society

2014 Volume 12, Issue 3, Page(s) 349–364

Abstract: A few reports of increased numbers of leukaemia cases (clusters) in children living in the vicinity of nuclear power plants (NPP) and other nuclear installations have triggered a heated debate over the possible causes of the disease. In this review the ... ...

Abstract	A few reports of increased numbers of leukaemia cases (clusters) in children living in the vicinity of nuclear power plants (NPP) and other nuclear installations have triggered a heated debate over the possible causes of the disease. In this review the most important cases of childhood leukaemia clusters around NPPs are described and analyzed with special emphasis on the relationship between the environmental exposure to ionizing radiation and the risk of leukaemia. Since, as indicated, a lifetime residency in the proximity of an NPP does not pose any specific health risk to people and the emitted ionizing radiation is too small to cause cancer, a number of hypotheses have been proposed to explain the childhood leukaemia clusters. The most likely explanation for the clusters is 'population mixing', i.e., the influx of outside workers to rural regions where nuclear installations are being set up and where local people are not immune to pathogens brought along with the incomers.
Language	English
Publishing date	2014-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2440820-7
ISSN	1559-3258 ; 1559-3258
ISSN (online)	1559-3258
ISSN	1559-3258
DOI	10.2203/dose-response.14-005.Janiak
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Article ; Online: Cytokine profile and viral diversity in the early seronegative stage of community-acquired hepatitis C virus (HCV) infection.

Radkowski, Marek / Grabarczyk, Piotr / Kryczka, Tomasz / Caraballo Cortès, Kamila / Kubicka-Russel, Dorota / Janiak, Maciej / Osuch, Sylwia / Perlejewski, Karol / Laskus, Tomasz

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20045

Abstract: Most Hepatitis C virus (HCV)-infected subjects develop chronic infection, whereas a minority clear the virus in the early phase of infection. We analyzed factors associated with outcome (chronicity vs clearance) during the preclinical seronegative phase ... ...

Abstract	Most Hepatitis C virus (HCV)-infected subjects develop chronic infection, whereas a minority clear the virus in the early phase of infection. We analyzed factors associated with outcome (chronicity vs clearance) during the preclinical seronegative phase of community-acquired HCV infection. Among 17.5 million blood donations in the years 2000-2016, 124 blood donors were found to be HCV RNA-positive/anti-HCV-negative. All were contacted after 0.5-12.7 years and 40 responded and provided blood sample. Hypervariable region 1 was analyzed by ultradeep pyrosequencing and cytokines in serum were quantified by Luminex (R&D Systems) multiplex immunoassay. Twenty-one (52.5%) donors were found to be HCV-RNA-positive, while 19 (47.5%) were HCV RNA negative (none received antiviral treatment). All but one seroconverted to anti-HCV. Donors with resolving hepatitis did not differ significantly from donors with chronic infection with respect to age, genotypes, IL28B polymorphisms, number of viral variants, nucleotide diversity per site or the overall number of nucleotide substitutions. However, the former group had significantly higher levels of IL-1beta, IL-1RA, IL-6, IFN-gamma and FGF-2 in serum. In our study of community-acquired acute hepatitis C approximately half of all subjects eliminated the virus spontaneously, and this clearance was associated with marked cytokine response in the early seronegative stage of infection.
MeSH term(s)	Humans ; Hepacivirus/genetics ; Interferons/genetics ; Persistent Infection ; Interleukins/genetics ; Hepatitis C/genetics ; Cytokines/genetics ; Cytokines/therapeutic use ; Genotype ; Nucleotides/therapeutic use ; RNA ; Hepatitis C, Chronic/genetics ; Hepatitis C, Chronic/drug therapy
Chemical Substances	Interferons (9008-11-1) ; Interleukins ; Cytokines ; Nucleotides ; RNA (63231-63-0)
Language	English
Publishing date	2023-11-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47335-x
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Article ; Online: A derivative of vitamin B

Cheda, Aneta / Nowosielska, Ewa M / Gebicki, Jerzy / Marcinek, Andrzej / Chlopicki, Stefan / Janiak, Marek K

Scientific reports

2021 Volume 11, Issue 1, Page(s) 7922

Abstract: Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first time that ... ...

Abstract	Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first time that 1-methyl nicotinamide (MNA), a derivative of vitamin B
MeSH term(s)	6-Ketoprostaglandin F1 alpha/blood ; Animals ; Blood Cell Count ; Bone Marrow/drug effects ; Bone Marrow/radiation effects ; Cholecalciferol/pharmacology ; Gamma Rays ; Interleukin-1beta/blood ; Interleukin-6/blood ; Interleukin-8/blood ; Mice, Inbred BALB C ; Radiation Exposure ; Spleen/drug effects ; Spleen/radiation effects ; Tumor Necrosis Factor-alpha/blood ; Mice
Chemical Substances	Interleukin-1beta ; Interleukin-6 ; Interleukin-8 ; Tumor Necrosis Factor-alpha ; Cholecalciferol (1C6V77QF41) ; 6-Ketoprostaglandin F1 alpha (58962-34-8)
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-86870-3
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Article ; Online: Diagnostic and therapeutic management in gastroesophageal reflux disease: consensus of the Polish Society of Gastroenterology.

Świdnicka-Siergiejko, Agnieszka K / Marek, Tomasz / Waśko-Czopnik, Dorota / Gąsiorowska, Anita / Skrzydło-Radomańska, Barbara / Janiak, Maria / Reguła, Jarosław / Rydzewska, Grażyna / Wallner, Grzegorz / Dąbrowski, Andrzej

Polish archives of internal medicine

2022 Volume 132, Issue 2

Abstract: The paper was prepared by an expert group appointed by the Polish Society of Gastroenterology with an aim to update and systematize the knowledge about diagnosis and treatment of gastroesophageal reflux disease (GERD). Based on the previously published ... ...

Abstract	The paper was prepared by an expert group appointed by the Polish Society of Gastroenterology with an aim to update and systematize the knowledge about diagnosis and treatment of gastroesophageal reflux disease (GERD). Based on the previously published guidelines of international societies, expert consensuses, and recently published good quality data, we formulated 74 statements regarding the definition, diagnosis and treatment of GERD and assessed the level of acceptance of these statements and the reliability of the data. We discussed in details the possibilities and limitations of the available diagnostic methods and therapies, with particular emphasis on the diversity of gastroesophageal reflux symptoms and complications including Barrett's esophagus. Practical principles regarding interpretation of the diagnostic tests are presented. In addition, we discussed the indications for surgical treatment as well as the situations in which surgical treatment is not indicated with emphasis on the importance of preoperative diagnostics. The role of add-on therapy and indications for maintenance treatment are defined.
MeSH term(s)	Consensus ; Gastroenterology ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/therapy ; Humans ; Poland ; Reproducibility of Results
Language	English
Publishing date	2022-01-25
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16196
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Article ; Online: A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice

Aneta Cheda / Ewa M. Nowosielska / Jerzy Gebicki / Andrzej Marcinek / Stefan Chlopicki / Marek K. Janiak

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 15

Abstract: Abstract Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first ... ...

Abstract	Abstract Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first time that 1-methyl nicotinamide (MNA), a derivative of vitamin B3, significantly (1.6 to 1.9 times) prolonged survival of BALB/c mice irradiated at LD30/30 (6.5 Gy), LD50/30 (7.0 Gy) or LD80/30 (7.5 Gy) of γ-rays when the MNA administration started as late as 7 days post irradiation. A slightly less efficient and only after the highest dose (7.5 Gy) of γ-rays was another vitamin B3 derivative, 1-methyl-3-acetylpyridine (1,3-MAP) (1.4-fold prolonged survival). These pro-survival effects did not seem to be mediated by stimulation of haematopoiesis, but might be related to anti-inflammatory and/or anti-thrombotic properties of the vitamin B3 derivatives. Our results show that MNA may represent a prototype of a radioremedial agent capable of mitigating the severity and/or progression of radiation-induced injuries when applied several hours or days after exposure to high doses of ionizing radiation.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Micronized Powder of Raspberry Pomace as a Source of Bioactive Compounds.

Różyło, Renata / Amarowicz, Ryszard / Janiak, Michał Adam / Domin, Marek / Gawłowski, Sławomir / Kulig, Ryszard / Łysiak, Grzegorz / Rząd, Klaudia / Matwijczuk, Arkadiusz

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 12

Abstract: Red raspberries, which contain a variety of nutrients and phytochemicals that are beneficial for human health, can be utilized as a raw material in the creation of several supplements. This research suggests micronized powder of raspberry pomace ... ...

Abstract	Red raspberries, which contain a variety of nutrients and phytochemicals that are beneficial for human health, can be utilized as a raw material in the creation of several supplements. This research suggests micronized powder of raspberry pomace production. The molecular characteristics (FTIR), sugar, and biological potential (phenolic compounds and antioxidant activity) of micronized raspberry powders were investigated. FTIR spectroscopy results revealed spectral changes in the ranges with maxima at ~1720, 1635, and 1326, as well as intensity changes in practically the entire spectral range analyzed. The discrepancies clearly indicate that the micronization of the raspberry byproduct samples cleaved the intramolecular hydrogen bonds in the polysaccharides present in the samples, thus increasing the respective content of simple saccharides. In comparison to the control powders, more glucose and fructose were recovered from the micronized samples of the raspberry powders. The study's micronized powders were found to contain nine different types of phenolic compounds, including rutin, elagic acid derivatives, cyanidin-3-sophoroside, cyanidin-3-(2-glucosylrutinoside), cyanidin-3-rutinoside, pelargonidin-3-rutinoside, and elagic acid derivatives. Significantly higher concentrations of ellagic acid and ellagic acid derivatives and rutin were found in the micronized samples than in the control sample. The antioxidant potential assessed by ABTS and FRAP significantly increased following the micronization procedure.
MeSH term(s)	Humans ; Rubus/chemistry ; Powders/analysis ; Ellagic Acid/analysis ; Fruit/chemistry ; Antioxidants/pharmacology ; Antioxidants/analysis ; Phenols/analysis ; Rutin/analysis
Chemical Substances	Powders ; Ellagic Acid (19YRN3ZS9P) ; Antioxidants ; Phenols ; Rutin (5G06TVY3R7)
Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28124871
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Article ; Online: Effect of internal contamination with tritiated water on the neoplastic colonies in the lungs, innate anti-tumour reactions, cytokine profile, and haematopoietic system in radioresistant and radiosensitive mice.

Nowosielska, Ewa M / Cheda, Aneta / Zdanowski, Robert / Lewicki, Sławomir / Scott, Bobby R / Janiak, Marek K

Radiation and environmental biophysics

2018 Volume 57, Issue 3, Page(s) 251–264

Abstract: Tritium is a potentially significant source of internal radiation exposure which, at high levels, can be carcinogenic. We evaluated whether single intraperitoneal injection of BALB/c and C57BL/6 mice with tritiated water (HTO) leading to exposure to low ( ...

Abstract	Tritium is a potentially significant source of internal radiation exposure which, at high levels, can be carcinogenic. We evaluated whether single intraperitoneal injection of BALB/c and C57BL/6 mice with tritiated water (HTO) leading to exposure to low (0.01 or 0.1 Gy) and intermediate (1.0 Gy) cumulative whole-body doses of β radiation is immunosuppressive, as judged by enhancement of artificial tumour metastases, functioning of NK lymphocytes and macrophages, circulating cytokine's levels, and numbers of bone marrow, spleen, and peripheral blood cells. We demonstrate that internal contamination of radiosensitive BALB/c and radioresistant C57BL/6 mice with HTO at all the absorbed doses tested did not affect the development of neoplastic colonies in the lungs caused by intravenous injection of syngeneic cancer cells. However, internal exposure of BALB/c and C57BL/6 mice to 0.1 and 0.01 Gy of β radiation, respectively, up-regulated cytotoxic activity of and IFN-γ synthesis in NK lymphocytes and boosted macrophage secretion of nitric oxide. Internal contamination with HTO did not affect the serum levels of pro- (IL-1β, IL-2, IL-6, TNF-α,) and anti-inflammatory (IL-1Ra, IL-4, IL-10) cytokines. In addition, exposure of mice of both strains to low and intermediate doses from the tritium-emitted β-particles did not result in any significant changes in the numbers of bone marrow, spleen, and peripheral blood cells. Overall, our data indicate that internal tritium contamination of both radiosensitive and radioresistant mice leading to low and intermediate absorbed β-radiation doses is not immunosuppressive but may enhance some but not all components of anticancer immunity.
MeSH term(s)	Animals ; Cytokines/metabolism ; Dose-Response Relationship, Radiation ; Hematopoiesis/radiation effects ; Immunity, Innate/radiation effects ; Lung Neoplasms/blood ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Male ; Mice ; Radiation Tolerance ; Tritium/chemistry ; Water/chemistry ; Water/pharmacology
Chemical Substances	Cytokines ; Water (059QF0KO0R) ; Tritium (10028-17-8)
Language	English
Publishing date	2018-04-06
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	124987-3
ISSN	1432-2099 ; 0301-634X
ISSN (online)	1432-2099
ISSN	0301-634X
DOI	10.1007/s00411-018-0739-4
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Article ; Online: Whole Exome Sequencing-Based Identification of a Novel Gene Involved in Root Hair Development in Barley (

Gajek, Katarzyna / Janiak, Agnieszka / Korotko, Urszula / Chmielewska, Beata / Marzec, Marek / Szarejko, Iwona

International journal of molecular sciences

2021 Volume 22, Issue 24

Abstract: Root hairs play a crucial role in anchoring plants in soil, interaction with microorganisms and nutrient uptake from the rhizosphere. In contrast to Arabidopsis, there is a limited knowledge of root hair morphogenesis in monocots, including barley ( ...

Abstract	Root hairs play a crucial role in anchoring plants in soil, interaction with microorganisms and nutrient uptake from the rhizosphere. In contrast to Arabidopsis, there is a limited knowledge of root hair morphogenesis in monocots, including barley (
MeSH term(s)	Alleles ; Gene Expression Regulation, Plant/genetics ; Hordeum/genetics ; Mutation/genetics ; Phenotype ; Plant Proteins/genetics ; Plant Roots/genetics ; Rhizosphere ; Whole Exome Sequencing/methods
Chemical Substances	Plant Proteins
Language	English
Publishing date	2021-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222413411
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