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  1. Article ; Online: Postmastectomy radiation therapy in women with T1-T2 tumors and 1 to 3 positive lymph nodes: analysis of the breast international group 02-98 trial.

    Gregucci, Fabiana / De Santis, Maria Carmen / Lozza, Laura / Fiorentino, Alba

    Translational cancer research

    2022  Volume 8, Issue Suppl 2, Page(s) S84–S86

    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2018.08.22
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  2. Article ; Online: Letter: Congress of Neurological Surgeons Systematic Review and Evidence-Based Practice Guidelines on the Role of Surgery in the Management of Adults With Metastatic Brain Tumors.

    Gregucci, Fabiana / Fiorentino, Alba

    Neurosurgery

    2019  Volume 85, Issue 3, Page(s) E616–E617

    MeSH term(s) Brain Neoplasms ; Evidence-Based Practice ; Humans ; Neurosurgeons
    Language English
    Publishing date 2019-08-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyz233
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    Zs.A 1424: Show issues Location:
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  3. Article ; Online: Re: Lisa Moris, Marcus G. Cumberbatch, Thomas Van den Broeck, et al. Benefits and Risks of Primary Treatments for High-risk Localized and Locally Advanced Prostate Cancer: An International Multidisciplinary Systematic Review. Eur Urol 2020;77:614-27.

    Gregucci, Fabiana / Carbonara, Roberta / Fiorentino, Alba

    European urology

    2020  Volume 78, Issue 3, Page(s) e114–e115

    MeSH term(s) Humans ; Lymphoscintigraphy ; Male ; Prostatic Neoplasms/therapy ; Risk Assessment
    Language English
    Publishing date 2020-06-10
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.05.034
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  4. Article ; Online: Re: Liselotte M.S. Boevé, Maarten C.C.M. Hulshof, André N. Vis, et al. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomized Clinical Trial: Data from the HORRAD Trial. Eur Urol 2019;75:410-8.

    Gregucci, Fabiana / Fiorentino, Alba

    European urology

    2018  Volume 75, Issue 5, Page(s) e129–e130

    MeSH term(s) Androgen Antagonists ; Bone Neoplasms ; Humans ; Male ; Prospective Studies ; Prostatic Neoplasms
    Chemical Substances Androgen Antagonists
    Language English
    Publishing date 2018-12-24
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.12.025
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  5. Article: MRI-LINAC: A transformative technology in radiation oncology.

    Ng, John / Gregucci, Fabiana / Pennell, Ryan T / Nagar, Himanshu / Golden, Encouse B / Knisely, Jonathan P S / Sanfilippo, Nicholas J / Formenti, Silvia C

    Frontiers in oncology

    2023  Volume 13, Page(s) 1117874

    Abstract: Advances in radiotherapy technologies have enabled more precise target guidance, improved treatment verification, and greater control and versatility in radiation delivery. Amongst the recent novel technologies, Magnetic Resonance Imaging (MRI) guided ... ...

    Abstract Advances in radiotherapy technologies have enabled more precise target guidance, improved treatment verification, and greater control and versatility in radiation delivery. Amongst the recent novel technologies, Magnetic Resonance Imaging (MRI) guided radiotherapy (MRgRT) may hold the greatest potential to improve the therapeutic gains of image-guided delivery of radiation dose. The ability of the MRI linear accelerator (LINAC) to image tumors and organs with on-table MRI, to manage organ motion and dose delivery in real-time, and to adapt the radiotherapy plan on the day of treatment while the patient is on the table are major advances relative to current conventional radiation treatments. These advanced techniques demand efficient coordination and communication between members of the treatment team. MRgRT could fundamentally transform the radiotherapy delivery process within radiation oncology centers through the reorganization of the patient and treatment team workflow process. However, the MRgRT technology currently is limited by accessibility due to the cost of capital investment and the time and personnel allocation needed for each fractional treatment and the unclear clinical benefit compared to conventional radiotherapy platforms. As the technology evolves and becomes more widely available, we present the case that MRgRT has the potential to become a widely utilized treatment platform and transform the radiation oncology treatment process just as earlier disruptive radiation therapy technologies have done.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1117874
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  6. Article ; Online: The Next Chapter in Immunotherapy and Radiation Combination Therapy: Cancer-Specific Perspectives.

    Wisdom, Amy J / Barker, Christopher A / Chang, Joe Y / Demaria, Sandra / Formenti, Silvia / Grassberger, Clemens / Gregucci, Fabiana / Hoppe, Bradford S / Kirsch, David G / Marciscano, Ariel E / Mayadev, Jyoti / Mouw, Kent W / Palta, Manisha / Wu, Cheng-Chia / Jabbour, Salma K / Schoenfeld, Jonathan D

    International journal of radiation oncology, biology, physics

    2024  Volume 118, Issue 5, Page(s) 1404–1421

    Abstract: Immunotherapeutic agents have revolutionized cancer treatment over the past decade. However, most patients fail to respond to immunotherapy alone. A growing body of preclinical studies highlights the potential for synergy between radiation therapy and ... ...

    Abstract Immunotherapeutic agents have revolutionized cancer treatment over the past decade. However, most patients fail to respond to immunotherapy alone. A growing body of preclinical studies highlights the potential for synergy between radiation therapy and immunotherapy, but the outcomes of clinical studies have been mixed. This review summarizes the current state of immunotherapy and radiation combination therapy across cancers, highlighting existing challenges and promising areas for future investigation.
    MeSH term(s) Humans ; Neoplasms/radiotherapy ; Neoplasms/drug therapy ; Immunotherapy ; Combined Modality Therapy
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2023.12.046
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    Zs.A 1218: Show issues Location:
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  7. Article ; Online: Omission of adjuvant radiotherapy for older adults with early-stage breast cancer particularly in the COVID era: A literature review (on the behalf of Italian Association of Radiotherapy and Clinical Oncology).

    Palumbo, Isabella / Borghesi, Simona / Gregucci, Fabiana / Falivene, Sara / Fontana, Antonella / Aristei, Cynthia / Ciabattoni, Antonella

    Journal of geriatric oncology

    2021  Volume 12, Issue 7, Page(s) 1130–1135

    Abstract: This review is aimed at evaluating whether radiation therapy (RT) can be omitted in older adult early-stage low-risk breast cancer (BC) patients. The published data are particularly relevant at present, during the COVID-19 pandemic emergency, to define a ...

    Abstract This review is aimed at evaluating whether radiation therapy (RT) can be omitted in older adult early-stage low-risk breast cancer (BC) patients. The published data are particularly relevant at present, during the COVID-19 pandemic emergency, to define a treatment strategy and to prioritize essential therapy. Cochrane Database of Systematic Reviews and PubMED were systematically researched from outset through April 2020 using Mesh terms. Only randomized controlled trials (RCT), with one arm without adjuvant whole-breast irradiation (WBI), were included in the analysis. Recent literature regarding the COVID pandemic and BC RT was assessed. The reported RCTs identified a group of BC patients (pT1-2N0M0 R0, grade 1-2, estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative tumours) in which the absolute risk of local recurrence (LR) was considered low enough to omit RT. The most common risk factors were tumor diameter, nodal and receptor status. Adjuvant RT had a significant impact on LR but not on distant metastasis (DM) or death. During the COVID 19 pandemic, results from RTCs were re-considered to define treatment recommendations for BC patients. International scientific societies and radiation oncology experts suggested RT omission, whenever possible, in older adult early-stage BC patients. Adjuvant RT might be omitted in a highly selected group of older adult early-stage BC patients with favourable prognostic factors. Hypofractionated regimens should be the standard. RT omission, partial breast irradiation (PBI), and ultra- hypofractionated regimens could be considered in selected cases due to the pandemic.
    MeSH term(s) Aged ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; COVID-19 ; Female ; Humans ; Italy ; Mastectomy, Segmental ; Neoplasm Recurrence, Local ; Radiation Oncology ; Radiotherapy, Adjuvant ; SARS-CoV-2 ; Systematic Reviews as Topic
    Language English
    Publishing date 2021-05-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2021.05.008
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  8. Article ; Online: Linear accelerator-based stereotactic arrhythmia radioablation for paroxysmal atrial fibrillation in elderly: a prospective phase II trial.

    Di Monaco, Antonio / Gregucci, Fabiana / Bonaparte, Ilaria / Romanazzi, Imma / Troisi, Federica / Surgo, Alessia / Vitulano, Nicola / Quadrini, Federico / Valenti, Noemi / Carbonara, Roberta / Di Guglielmo, Fiorella Cristina / Ludovico, Elena / Calbi, Roberto / Guida, Pietro / Ciliberti, Maria Paola / Fiorentino, Alba / Grimaldi, Massimo

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2024  Volume 25, Issue 12

    Abstract: Aims: Stereotactic arrhythmia radioablation (STAR) is a novel therapeutic approach for cardiac arrhythmias. The aim of this trial is to investigate the feasibility of STAR for the treatment of paroxysmal atrial fibrillation (AF) in elderly patients.: ... ...

    Abstract Aims: Stereotactic arrhythmia radioablation (STAR) is a novel therapeutic approach for cardiac arrhythmias. The aim of this trial is to investigate the feasibility of STAR for the treatment of paroxysmal atrial fibrillation (AF) in elderly patients.
    Methods and results: Inclusion criteria were age >70 years, symptomatic AF, antiarrhythmic drugs failure, or intolerance. All patients underwent to 4D cardiac computed tomography simulation. The clinical target volume was identified in the area around pulmonary veins (PV). Stereotactic arrhythmia radioablation was performed with a total dose of 25 Gy (single fraction) delivered in 3 min. Twenty patients were enrolled and 18 underwent STAR. One patient withdrew informed consent before treatment and one patient was excluded due to unfavourable oesophagus position. With a median follow-up (FU) of 16 months (range 12-23), no acute toxicity more than Grade 3 was reported. Five patients had a Grade 1 oesophagitis 24 h after STAR; eight patients had an asymptomatic Grade 1 pericardial effusion, and one patient had a torsade de pointes treated effectively by electrical cardioversion and subsequent cardiac implantable cardioverter-defibrillator implantation. Most patients had a significant reduction in AF episodes. Five patients, due to arrhythmias recurrences after STAR, performed electrophysiological study documenting successful PV isolation. Finally, a significant improvement of quality of life was documented (48 ± 15 at enrolment vs. 75 ± 15 at 12 months FU; P < 0.001).
    Conclusion: The present phase II trial demonstrated the feasibility of STAR in paroxysmal AF elderly patients and its potential role in increasing the quality of life. Surely, more robust data are needed about safety and efficacy.
    Trial registration: ClinicalTrials.gov: NCT04575662.
    MeSH term(s) Humans ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Atrial Fibrillation/drug therapy ; Prospective Studies ; Quality of Life ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Treatment Outcome ; Pulmonary Veins/surgery ; Particle Accelerators ; Recurrence
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euad344
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    Zs.A 5434: Show issues Location:
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  9. Article ; Online: Cancer patients in Covid-19 era: Swimming against the tide.

    Gregucci, Fabiana / Caliandro, Morena / Surgo, Alessia / Carbonara, Roberta / Bonaparte, Ilaria / Fiorentino, Alba

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2020  Volume 149, Page(s) 109–110

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Italy ; Neoplasms ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Swimming
    Keywords covid19
    Language English
    Publishing date 2020-04-04
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2020.04.002
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    Zs.A 1926: Show issues Location:
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  10. Article ; Online: Impact on mental health of the COVID-19 pandemic in a radiation oncology department.

    Caliandro, Morena / Fabiana, Gregucci / Surgo, Alessia / Carbonara, Roberta / Ciliberti, Maria Paola / Bonaparte, Ilaria / Caputo, Sergio / Fiorentino, Alba

    La Radiologia medica

    2022  Volume 127, Issue 2, Page(s) 220–224

    Abstract: Aim: To evaluate the emotional state and organizational well-being of healthcare workers in radiation oncology departments, during the COVID pandemic.: Methods: A survey was carried out with three questionnaires: Impact of Event Scale-Revised (IES-R); ...

    Abstract Aim: To evaluate the emotional state and organizational well-being of healthcare workers in radiation oncology departments, during the COVID pandemic.
    Methods: A survey was carried out with three questionnaires: Impact of Event Scale-Revised (IES-R); Italian ANAC questionnaire; and Maslach Burnout Inventory (MBI). Comparisons between groups were done by Student's t test.
    Results: Seventy-eight questionnaires for 26 workers were analyzed. Thirty-three percent of the sample obtained an IES-R high score, such as post-traumatic syndrome. In terms of organizational well-being, younger age and lower working seniority were statistically significant for higher score of ANAC items (p < 0.5). Regarding MBI, 0, 27 and 50% high scores of emotional exhaustion, depersonalization and personal accomplishment were reported, respectively. Low working seniority and male sex were correlated with high score of personal accomplishment (p:0.05; p:0.03).
    Conclusion: Intervention to promote mental health well-being should be implemented in radiation oncology department.
    MeSH term(s) Adult ; Burnout, Professional/psychology ; COVID-19/psychology ; Female ; Humans ; Male ; Mental Health/statistics & numerical data ; Pandemics ; Radiation Oncologists/psychology ; Radiation Oncology ; SARS-CoV-2 ; Surveys and Questionnaires
    Language English
    Publishing date 2022-01-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-021-01440-x
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