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  1. Book ; Online: Head and Neck Surgery: Clinical Updates and Perspectives

    Locatello, Luca Giovanni / Gallo, Oreste

    2023  

    Keywords Medicine ; Otorhinolaryngology ; head and neck surgery ;   ; salivary gland surgery ; laryngeal cancer ; oral cancer.
    Language English
    Size 1 electronic resource (164 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030649988
    ISBN 9783036592497 ; 3036592490
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Artificial intelligence's potential in tailoring prescription of biologic therapy for chronic rhinosinusitis.

    Minzoni, Alberto / Gallo, Oreste

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 10, Page(s) 3285–3286

    MeSH term(s) Humans ; Artificial Intelligence ; Biological Therapy ; Sinusitis/drug therapy ; Chronic Disease ; Rhinitis/drug therapy
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.07.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7086: Show issues Location:
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  3. Article ; Online: Comments on the article titled "Factors associated with unknown primary status in head and neck squamous cell carcinoma": Is the N status the overlooked elephant in the room?

    Fancello, Giuseppe / Jiang, Serena / Licci, Giuseppe / Gallo, Oreste

    Oral oncology

    2024  Volume 151, Page(s) 106727

    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck ; Neoplasms, Unknown Primary ; Carcinoma, Squamous Cell ; Head and Neck Neoplasms
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2024.106727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4869: Show issues Location:
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    Zs.A 456: Show issues Location:
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  4. Article ; Online: Risk for COVID-19 infection in patients with tobacco smoke-associated cancers of the upper and lower airway.

    Gallo, Oreste

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2020  Volume 278, Issue 8, Page(s) 2695–2702

    Abstract: Purpose: Cancer patients are regarded as a group at risk for both COVID-19 infection and severe clinical course because of advanced age, comorbidities and iatrogenic immune impairment. Among them, patients with cancer of the upper and lower airways ... ...

    Abstract Purpose: Cancer patients are regarded as a group at risk for both COVID-19 infection and severe clinical course because of advanced age, comorbidities and iatrogenic immune impairment. Among them, patients with cancer of the upper and lower airways share other risk factors, mostly related to tobacco-smoke exposure, including male gender, airway epithelial damages, chronic obstructive respiratory disease (COPD), cardiovascular and cerebrovascular diseases. Clinical and pathophysiological factors shared by these conditions are reviewed.
    Methods: Review of the published literature since the beginning of 2020.
    Results: COVID-19 is a respiratory infectious disease and SARS-CoV-2 replication and shedding occurs in nasal and bronchial epithelial respiratory cells through the interaction with ACE2 and TMPRSS2 receptors, both overexpressed in smokers and former smokers. Tobacco-smoke airway exposure is also characterized by a chronic inflammation with activation of inflammatory cells and cytokine release including interleukin-6 (IL-6). A high release of cytokine in response to viral infection is documented in COVID-19 patients with adverse clinical outcomes and IL-6 is a key element of the cytokine storm syndrome leading to multi-organ damage.
    Conclusions: Patients with cancers of the upper and lower airways might be at increased risk of infection, morbidity and mortality from COVID-19 also because of tobacco exposure, a key factor in triggering inflammation, immunity and cancer.
    MeSH term(s) COVID-19 ; Humans ; Male ; Neoplasms/epidemiology ; Neoplasms/etiology ; SARS-CoV-2 ; Nicotiana ; Tobacco Smoke Pollution
    Chemical Substances Tobacco Smoke Pollution
    Keywords covid19
    Language English
    Publishing date 2020-11-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06456-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul II Zs.50: Show issues Location:
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  5. Article: The Many Faces of Head and Neck Surgery in 2022 and Looking Ahead!

    Locatello, Luca Giovanni / Gallo, Oreste

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: Head and neck (HN) cancer, which mainly presents in the form of squamous cell carcinoma, was the seventh most common cancer worldwide in 2018, with approximately 890,000 new cases and 450,000 deaths [ ... ]. ...

    Abstract Head and neck (HN) cancer, which mainly presents in the form of squamous cell carcinoma, was the seventh most common cancer worldwide in 2018, with approximately 890,000 new cases and 450,000 deaths [...].
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11113174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Many Faces of Head and Neck Surgery in 2022 and Looking Ahead!

    Luca Giovanni Locatello / Oreste Gallo

    Journal of Clinical Medicine, Vol 11, Iss 3174, p

    2022  Volume 3174

    Abstract: Head and neck (HN) cancer, which mainly presents in the form of squamous cell carcinoma, was the seventh most common cancer worldwide in 2018, with approximately 890,000 new cases and 450,000 deaths [.] ...

    Abstract Head and neck (HN) cancer, which mainly presents in the form of squamous cell carcinoma, was the seventh most common cancer worldwide in 2018, with approximately 890,000 new cases and 450,000 deaths [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: All that glitters is not gold: Clinical implications from the genetic analysis of head and neck cancer recurrences.

    Gallo, Oreste / Locatello, Luca Giovanni

    Oral oncology

    2021  Volume 117, Page(s) 105187

    MeSH term(s) Head and Neck Neoplasms/genetics ; Humans ; Neoplasm Recurrence, Local/genetics
    Language English
    Publishing date 2021-02-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2021.105187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4869: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Long-term recovery from COVID-19 anosmia: Promising findings and unanswered questions.

    Locatello, Luca Giovanni / Gallo, Oreste

    Journal of internal medicine

    2021  Volume 290, Issue 2, Page(s) 462–463

    MeSH term(s) Anosmia ; COVID-19 ; Humans ; Olfaction Disorders ; SARS-CoV-2
    Language English
    Publishing date 2021-02-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Histological Background of Recurrence in Laryngeal Squamous Cell Carcinoma: An Insight into the Modifications of Tumor Microenvironment.

    Arcovito, Giorgia / Palomba, Annarita / Gallo, Oreste / Franchi, Alessandro

    Cancers

    2023  Volume 15, Issue 12

    Abstract: Recurrent laryngeal carcinoma presents differences from the primary tumor that largely depend on the treatment. In this article, we review the histologic and molecular treatment-induced changes that may affect the diagnosis of recurrent laryngeal ... ...

    Abstract Recurrent laryngeal carcinoma presents differences from the primary tumor that largely depend on the treatment. In this article, we review the histologic and molecular treatment-induced changes that may affect the diagnosis of recurrent laryngeal carcinoma, the assessment of predictive markers, and the response to treatment with immune checkpoint inhibitors. Radiotherapy induces profound modifications that are strictly related to necrosis of different tissue components, fibrosis, and damage of the tumor vessels. Postradiotherapy recurrent/persistent laryngeal squamous cell carcinoma typically presents a discohesive growth pattern within a fibrotic background associated with significant changes of the tumor immune microenvironment, with both important immunosuppressive and immunostimulatory effects. Overall, the increase of immunoregulatory cells and immune checkpoints such as CTLA-4, TIM-3, PD-1, and PD-L1 induced by radiotherapy and chemotherapy strongly supports the use of immune checkpoint inhibitors in recurrent/persistent laryngeal carcinoma. Future studies aiming to identify predictive factors of the response to immune checkpoint inhibitors should consider such treatment-induced modifications.
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15123259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: New Insight in Cardiorenal Syndrome: From Biomarkers to Therapy.

    Gallo, Giovanna / Lanza, Oreste / Savoia, Carmine

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Cardiorenal syndrome consists in the coexistence of acute or chronic dysfunction of heart and kidneys resulting in a cascade of feedback mechanisms and causing damage to both organs associated with high morbidity and mortality. In the last few years, ... ...

    Abstract Cardiorenal syndrome consists in the coexistence of acute or chronic dysfunction of heart and kidneys resulting in a cascade of feedback mechanisms and causing damage to both organs associated with high morbidity and mortality. In the last few years, different biomarkers have been investigated with the aim to achieve an early and accurate diagnosis of cardiorenal syndrome, to provide a prognostic role and to guide the development of targeted pharmacological and non-pharmacological therapies. In such a context, sodium-glucose cotransporter 2 (SGLT2) inhibitors, recommended as the first-line choice in the management of heart failure, might represent a promising strategy in the management of cardiorenal syndrome due to their efficacy in reducing both cardiac and renal outcomes. In this review, we will discuss the current knowledge on the pathophysiology of cardiorenal syndrome in adults, as well as the utility of biomarkers in cardiac and kidney dysfunction and potential insights into novel therapeutics.
    MeSH term(s) Humans ; Cardio-Renal Syndrome/diagnosis ; Cardio-Renal Syndrome/therapy ; Kidney ; Heart Failure/drug therapy ; Heart ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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