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  1. Article ; Online: Antioxidant activities of thermally treated

    Kim, Seoyun / Lee, Hwa Jin / Ju, Jihyeung

    Food science and biotechnology

    2023  Volume 32, Issue 13, Page(s) 1935–1947

    Abstract: The study aimed to investigate antioxidant activities of two different thermally treated sesame ( ...

    Abstract The study aimed to investigate antioxidant activities of two different thermally treated sesame (
    Language English
    Publishing date 2023-09-23
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-023-01408-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: In Vitro Antioxidant and Anti-Colon Cancer Activities of

    Kim, Seoyun / Yang, Hyi Young / Lee, Hwa Jin / Ju, Jihyeung

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: Sesame ( ...

    Abstract Sesame (
    Language English
    Publishing date 2021-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10061216
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  3. Article: Antirrhinum majus

    Seo, Jina / Lee, Jungjae / Yang, Hyi Young / Ju, Jihyeung

    Food science & nutrition

    2020  Volume 8, Issue 11, Page(s) 6259–6268

    Abstract: ... ...

    Abstract Snapdragon
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.1924
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  4. Article ; Online: Glycine max

    Kwak, Youngeun / Ju, Jihyeung

    Food science and biotechnology

    2017  Volume 26, Issue 1, Page(s) 245–253

    Abstract: The present study aimed to investigate ... ...

    Abstract The present study aimed to investigate the
    Language English
    Publishing date 2017-02-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-017-0033-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Perilla frutescens

    Lee, Yuna / Lee, Jungjae / Ju, Jihyeung

    Food science and biotechnology

    2019  Volume 29, Issue 1, Page(s) 131–140

    Abstract: The aim of the current study was to investigate whether the leaves ... ...

    Abstract The aim of the current study was to investigate whether the leaves of
    Language English
    Publishing date 2019-11-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2000008-X
    ISSN 2092-6456 ; 1226-7708
    ISSN (online) 2092-6456
    ISSN 1226-7708
    DOI 10.1007/s10068-019-00711-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Anti-cancer activities of Brassica juncea leaves in vitro.

    Kwak, Youngeun / Lee, Jungjae / Ju, Jihyeung

    EXCLI journal

    2016  Volume 15, Page(s) 699–710

    Abstract: Mustard ( ...

    Abstract Mustard (
    Language English
    Publishing date 2016-11-15
    Publishing country Germany
    Document type Journal Article
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2016-586
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  7. Article: Perilla frutescens Britton var. frutescens leaves attenuate dextran sulfate sodium-induced acute colitis in mice and lipopolysaccharide-stimulated angiogenic processes in human umbilical vein endothelial cells

    Lee, Yuna / Lee, Jungjae / Ju, Jihyeung

    Food science and biotechnology. 2020 Jan., v. 29, no. 1

    2020  

    Abstract: The aim of the current study was to investigate whether the leaves of Perilla frutescens Britton var. frutescens (PL), a frequently consumed vegetable in Korea, attenuate dextran sulfate sodium (DSS)-induced acute colitis in mice and lipopolysaccharide ( ... ...

    Abstract The aim of the current study was to investigate whether the leaves of Perilla frutescens Britton var. frutescens (PL), a frequently consumed vegetable in Korea, attenuate dextran sulfate sodium (DSS)-induced acute colitis in mice and lipopolysaccharide (LPS)-stimulated angiogenic processes in human umbilical vein endothelial cells (HUVEC). In DSS-treated mice, dietary supplementation with PL mitigated DAI and colon shortening. The dietary PL also reduced colonic levels of inflammatory and angiogenic mediators, such as interleukin-1β, interleukin-6, monocyte chemoattractant protein-1, macrophage inflammatory protein-2, leukotriene B₄, inducible nitric oxide synthase, cyclooxygenase-2, basic fibroblast growth factor, and intercellular adhesion molecule-1 (ICAM-1). Treatment of HUVEC with ethanol extract of PL attenuated LPS-stimulated increases in ICAM-1 levels, monocyte adhesion, invasion, and tube formation. This study suggests that dietary PL effectively inhibited DSS-induced acute colitis in mice, and its anti-angiogenic activities may partially contribute to the inhibition.
    Keywords Perilla frutescens ; adhesion ; biotechnology ; chemokine CCL2 ; chemokine CXCL2 ; colitis ; colon ; dextran sulfate ; dietary supplements ; ethanol ; fibroblast growth factor 2 ; food science ; inducible nitric oxide synthase ; intercellular adhesion molecule-1 ; interleukin-6 ; lipopolysaccharides ; monocytes ; prostaglandin synthase ; vegetables ; Korean Peninsula
    Language English
    Dates of publication 2020-01
    Size p. 131-140.
    Publishing place Springer Singapore
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2000008-X
    ISSN 1226-7708
    ISSN 1226-7708
    DOI 10.1007/s10068-019-00711-8
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: In Vitro Antioxidant and Anti-Colon Cancer Activities of Sesamum indicum L. Leaf Extract and Its Major Component, Pedaliin

    Kim, Seoyun / Yang, Hyi Young / Lee, Hwa Jin / Ju, Jihyeung

    Foods. 2021 May 27, v. 10, no. 6

    2021  

    Abstract: Sesame (Sesamum indicum L.) leaves (SLs) are used as vegetables and traditional medicines in Asian and African countries. We investigated in vitro antioxidant and anti-colon cancer efficacy of ethanol extract of SL (SLE) and its major bioactive component. ...

    Abstract Sesame (Sesamum indicum L.) leaves (SLs) are used as vegetables and traditional medicines in Asian and African countries. We investigated in vitro antioxidant and anti-colon cancer efficacy of ethanol extract of SL (SLE) and its major bioactive component. SLE contained appreciable amount of major classes of antioxidant phytochemicals, such as total polyphenols, total flavonoids, and carotenoids, and correspondingly exhibited antioxidant activities, such as radical scavenging activity and ferric reducing antioxidant power (FRAP). A cell viability assay showed that SLE time- and dose-dependently attenuated the growth of human colon cancer cells, HT29 and HCT116. Flow cytometry analysis showed that SLE increased sub-G1 (in HT29 and HCT116) and G2/M (in HCT116) cell populations, suggesting that the growth inhibition by SLE was due to induction of apoptosis and G2/M cell cycle arrest. Trans-well and wound-healing assays showed that SLE alleviated invasion and migration of HT29 and HCT116 cells in non-cytotoxic conditions. High-performance liquid chromatography analysis revealed that pedaliin (6-hydroxylueolin 7-methyl ether 6-glucoside; pedalitin-6-O-glucoside) was a major constituent of SLE. Moreover, FRAP, growth-inhibitory, anti-invasive, and anti-migratory activities of pedaliin were found. These results demonstrated that SLE possesses in vitro antioxidant and anti-colon cancer activities and that pedaliin is a major component contributing to such activities.
    Keywords Sesamum indicum ; antioxidant activity ; antioxidants ; apoptosis ; bioactive compounds ; carotenoids ; cell cycle checkpoints ; cell viability ; colorectal neoplasms ; ethanol ; flavonoids ; flow cytometry ; growth retardation ; high performance liquid chromatography ; humans ; leaf extracts ; polyphenols ; viability assays
    Language English
    Dates of publication 2021-0527
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10061216
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Glycine max Merr. leaf extract possesses anti-oxidant properties, decreases inflammatory mediator production in murine macrophages, and inhibits growth, migration, and adhesion in human cancer cells

    Kwak, Youngeun / Jihyeung Ju

    Food science and biotechnology. 2017 Feb., v. 26, no. 1

    2017  

    Abstract: The present study aimed to investigate the in vitro anti-oxidant, anti-inflammatory, and anticancer properties of the ethanol extract of soybean (Glycine max Merr.) leaves (SLE). The total polyphenol and flavonoid levels were 142.0±14.0mg gallic acid ... ...

    Abstract The present study aimed to investigate the in vitro anti-oxidant, anti-inflammatory, and anticancer properties of the ethanol extract of soybean (Glycine max Merr.) leaves (SLE). The total polyphenol and flavonoid levels were 142.0±14.0mg gallic acid equivalent/g and 104.9±2.0 mg quercetin equivalent/g, respectively. The radical scavenging activity and ferric-reducing anti-oxidant power of SLE at the concentrations of 125–500 μg/mL were 5–61%. In lipopolysaccharide-treated RAW 264.7 macrophages, treatment with SLE at concentrations of 62.5–500 μg/mL dose-dependently decreased the production of nitric oxide and prostaglandin E2. In both HCT116 human colon cancer cells and H1299 human lung cancer cells, treatment with SLE inhibited the growth and anchorage-independent colony formation. SLE was also effective in inhibiting the migration of H1299 cells and the adhesion of both HCT116 and H1299 cells. These results suggest that SLE exerts anti-oxidant, antiinflammatory, and anti-cancer activities in vitro. It needs to be determined whether similar effects are reproduced in vivo.
    Keywords Glycine max ; adhesion ; antineoplastic activity ; antioxidant activity ; antioxidants ; colorectal neoplasms ; ethanol ; gallic acid ; humans ; leaf extracts ; leaves ; lung neoplasms ; macrophages ; mice ; neoplasm cells ; nitric oxide ; polyphenols ; prostaglandins ; quercetin ; soybeans
    Language English
    Dates of publication 2017-02
    Size p. 245-253.
    Publishing place The Korean Society of Food Science and Technology
    Document type Article
    ZDB-ID 2000008-X
    ISSN 1226-7708
    ISSN 1226-7708
    DOI 10.1007/s10068-017-0033-2
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Inhibitory activities of Perilla frutescens britton leaf extract against the growth, migration, and adhesion of human cancer cells.

    Kwak, Youngeun / Ju, Jihyeung

    Nutrition research and practice

    2015  Volume 9, Issue 1, Page(s) 11–16

    Abstract: Background/objectives: Perilla frutescens Britton leaves are a commonly consumed vegetable in different Asian countries including Korea. Cancer is a major cause of human death worldwide. The aim of the current study was to investigate the inhibitory ... ...

    Abstract Background/objectives: Perilla frutescens Britton leaves are a commonly consumed vegetable in different Asian countries including Korea. Cancer is a major cause of human death worldwide. The aim of the current study was to investigate the inhibitory effects of ethanol extract of perilla leaf (PLE) against important characteristics of cancer cells, including unrestricted growth, resisted apoptosis, and activated metastasis, using human cancer cells.
    Materials/methods: Two human cancer cell lines were used in this study, HCT116 colorectal carcinoma cells and H1299 non-small cell lung carcinoma cells. Assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide were performed for measurement of cell growth. Soft agar and wound healing assays were performed to determine colony formation and cell migration, respectively. Nuclear staining and cell cycle analysis were performed for assessment of apoptosis. Fibronectin-coated plates were used to determine cell adhesion.
    Results: Treatment of HCT116 and H1299 cells with PLE resulted in dose-dependent inhibition of growth by 52-92% (at the concentrations of 87.5, 175, and 350 µg/ml) and completely abolished the colony formation in soft agar (at the concentration of 350 µg/ml). Treatment with PLE at the 350 µg/ml concentration resulted in change of the nucleus morphology and significantly increased sub-G1 cell population in both cells, indicating its apoptosis-inducing activity. PLE at the concentration range of 87.5 to 350 µg/ml was also effective in inhibiting the migration of H1299 cells (by 52-58%) and adhesion of both HCT116 and H1299 cells (by 25-46%).
    Conclusions: These results indicate that PLE exerts anti-cancer activities against colon and lung cancers in vitro. Further studies are needed in order to determine whether similar effects are reproduced in vivo.
    Language English
    Publishing date 2015-01-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2387946-4
    ISSN 2005-6168 ; 1976-1457
    ISSN (online) 2005-6168
    ISSN 1976-1457
    DOI 10.4162/nrp.2015.9.1.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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