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  1. Book ; Conference proceedings: Targeted therapies in cancer

    Colotta, Francesco

    myth or reality? : [International Meeting on Targeted Therapies in Cancer: Myth or Reality ... held in Milan in September 2005]

    (Advances in experimental medicine and biology ; 610)

    2008  

    Event/congress International Meeting on Targeted Therapies in Cancer: Myth or Reality (2005, Mailand)
    Author's details Francesco Colotta ..., ed
    Series title Advances in experimental medicine and biology ; 610
    Collection
    Language English
    Size VIII, 191 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York, NY
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT015411962
    ISBN 978-0-387-73897-0 ; 0-387-73897-5 ; 9780387738987 ; 0387738983
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -610- not available for loan Zeitschriften-Lesesaal

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  2. Article: Soluble interleukin-1 receptor type 2 plasma levels in Parkinson's disease: relationship with cardiac autonomic profile before and after peripheral mechanical somatosensory stimulation.

    Shiffer, Dana / Zamunér, Antonio Roberto / Minonzio, Maura / Bulgheroni, Mara / Porta, Alberto / Leone, Roberto / Bottazzi, Barbara / Garlanda, Cecilia / Colotta, Francesco / Barbic, Franca / Mantovani, Alberto / Furlan, Raffaello

    Frontiers in physiology

    2023  Volume 14, Page(s) 1168652

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1168652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Targeting genetic instability in cancer cells.

    Colotta, Francesco

    Current drug targets

    2010  Volume 11, Issue 10, Page(s) 1293–1295

    MeSH term(s) Base Sequence ; DNA, Neoplasm ; Genetic Predisposition to Disease ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/pathology ; Risk Factors
    Chemical Substances DNA, Neoplasm
    Language English
    Publishing date 2010-09-11
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450111007011293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
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  4. Article: Anticancer drug discovery and development.

    Colotta, Francesco

    Advances in experimental medicine and biology

    2008  Volume 610, Page(s) 19–42

    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor ; Chemistry, Pharmaceutical/methods ; Chemistry, Pharmaceutical/trends ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Medical Oncology/methods ; Medical Oncology/trends ; Molecular Conformation ; Neoplasms/therapy ; Oligonucleotide Array Sequence Analysis ; Technology, Pharmaceutical/methods ; Technology, Pharmaceutical/trends
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-0-387-73898-7_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Modulation of inflammatory and immune responses by vitamin D.

    Colotta, Francesco / Jansson, Birger / Bonelli, Fabrizio

    Journal of autoimmunity

    2017  

    Abstract: Vitamin D (VitD) is a prohormone most noted for the regulation of calcium and phosphate levels in circulation, and thus of bone metabolism. Inflammatory and immune cells not only convert inactive VitD metabolites into calcitriol, the active form of VitD, ...

    Abstract Vitamin D (VitD) is a prohormone most noted for the regulation of calcium and phosphate levels in circulation, and thus of bone metabolism. Inflammatory and immune cells not only convert inactive VitD metabolites into calcitriol, the active form of VitD, but also express the nuclear receptor of VitD that modulates differentiation, activation and proliferation of these cells. In vitro, calcitriol upregulates different anti-inflammatory pathways and downregulates molecules that activate immune and inflammatory cells. Administration of VitD has beneficial effects in a number of experimental models of autoimmune disease. Epidemiologic studies have indicated that VitD insufficiency is frequently associated with immune disorders and infectious diseases, exacerbated by increasing evidence of suboptimal VitD status in populations worldwide. To date, however, most interventional studies in human inflammatory and immune diseases with VitD supplementation have proven to be inconclusive. One of the reasons could be that the main VitD metabolite measured in these studies was the 25-hydroxyVitD (25OHD) rather than its active form calcitriol. Although our knowledge of calcitriol as modulator of immune and inflammatory reactions has dramatically increased in the past decades, further in vivo and clinical studies are needed to confirm the potential benefits of VitD in the control of immune and inflammatory conditions.
    Language English
    Publishing date 2017-07-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2017.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2368: Show issues Location:
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  6. Article: Targeted therapies in cancer: myth or reality? Introduction.

    Colotta, Francesco / Mantovani, Alberto

    Advances in experimental medicine and biology

    2008  Volume 610, Page(s) v–vi

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Chemistry, Pharmaceutical/trends ; Congresses as Topic ; Humans ; Medical Oncology/methods ; Medical Oncology/trends ; Neoplasms/pathology ; Neoplasms/therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Introductory Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Targeted therapies in cancer

    Colotta, Francesco / Mantovani, Alberto

    myth or reality?

    (Advances in experimental medicine and biology, ; v. 610)

    2008  

    Author's details Francesco Colotta, Alberto Mantovani, editors
    Series title Advances in experimental medicine and biology, ; v. 610
    MeSH term(s) Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Gene Targeting
    Language English
    Size viii, 191 p. :, ill.
    Publisher Springer
    Publishing place New York
    Document type Book
    Note Collection of contributions to a meeting held September 2005 in Milan.
    ISBN 9780387738970 ; 0387738975 ; 9780387738987 ; 0387738983
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article: Targeting cell division cycle 7 kinase: a new approach for cancer therapy.

    Montagnoli, Alessia / Moll, Jürgen / Colotta, Francesco

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2010  Volume 16, Issue 18, Page(s) 4503–4508

    Abstract: The cell division cycle 7 (Cdc7) is a serine-threonine kinase, originally discovered in budding yeast, required to initiate DNA replication. Human Cdc7 phosphorylates the minichromosome maintenance protein 2 (Mcm2), a component of the DNA replicative ... ...

    Abstract The cell division cycle 7 (Cdc7) is a serine-threonine kinase, originally discovered in budding yeast, required to initiate DNA replication. Human Cdc7 phosphorylates the minichromosome maintenance protein 2 (Mcm2), a component of the DNA replicative helicase needed for genome duplication. Inhibition of Cdc7 in cancer cells impairs progression through S phase, inducing a p53-independent apoptotic cell death, whereas in normal cells, it does not affect cell viability. Small molecule compounds able to interfere with Cdc7 activity have been identified and shown to be effective in controlling tumor growth in animal models. Two Cdc7 inhibitors are currently in phase I clinical development. Inhibition of Cdc7 kinase activity in cancer cells restricts DNA replication and induces apoptotic cell death by an unprecedented molecular mechanism of action.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Apoptosis/physiology ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/physiology ; Clinical Trials, Phase I as Topic ; DNA Replication/drug effects ; DNA Replication/genetics ; Humans ; Models, Biological ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/trends ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/physiology ; Therapies, Investigational/methods ; Therapies, Investigational/trends
    Chemical Substances Antineoplastic Agents ; Cell Cycle Proteins ; Protein Kinase Inhibitors ; CDC7 protein, human (EC 2.7.1.-) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2010-09-15
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Review
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-10-0185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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  9. Article ; Online: A low plasma 1,25(OH)

    Masson, Serge / Barlera, Simona / Colotta, Francesco / Magnoli, Michela / Bonelli, Fabrizio / Moro, Milena / Marchioli, Roberto / Tavazzi, Luigi / Tognoni, Gianni / Latini, Roberto

    International journal of cardiology

    2016  Volume 224, Page(s) 220–225

    Abstract: Background: Dysregulation of the vitamin D system promotes renal dysfunction and has direct detrimental effects on the heart. Progressive deterioration of renal function is common in patients with chronic heart failure (HF) and is invariably associated ... ...

    Abstract Background: Dysregulation of the vitamin D system promotes renal dysfunction and has direct detrimental effects on the heart. Progressive deterioration of renal function is common in patients with chronic heart failure (HF) and is invariably associated with unfavorable outcomes which can be improved by early identification and timely interventions. We examined the relation between two plasma markers of vitamin D metabolism and worsening of renal function (WRF) in a large cohort of patients with chronic HF.
    Methods: Plasma levels of 1,25-dihydroxyvitamin D (1,25(OH)
    Results: Lower 1,25(OH)
    Conclusions: The plasma 1,25(OH)
    MeSH term(s) Aged ; Biomarkers/blood ; Chronic Disease ; Cohort Studies ; Double-Blind Method ; Female ; Follow-Up Studies ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/mortality ; Humans ; Kidney Diseases/blood ; Kidney Diseases/diagnosis ; Kidney Diseases/mortality ; Kidney Function Tests/trends ; Male ; Middle Aged ; Mortality/trends ; Parathyroid Hormone/blood ; Predictive Value of Tests ; Vitamin D/analogs & derivatives ; Vitamin D/blood
    Chemical Substances Biomarkers ; Parathyroid Hormone ; Vitamin D (1406-16-2) ; 1,25-dihydroxyvitamin D (66772-14-3)
    Language English
    Publishing date 2016-12-01
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2016.09.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1673: Show issues Location:
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  10. Article ; Online: Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability.

    Colotta, Francesco / Allavena, Paola / Sica, Antonio / Garlanda, Cecilia / Mantovani, Alberto

    Carcinogenesis

    2009  Volume 30, Issue 7, Page(s) 1073–1081

    Abstract: Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular ... ...

    Abstract Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.
    MeSH term(s) Cell Proliferation ; Cytokines/metabolism ; Genomic Instability/immunology ; Humans ; Inflammation/genetics ; Inflammation Mediators/metabolism ; Neoplasms/genetics ; Neoplasms/immunology ; Signal Transduction ; Transcription Factors/metabolism
    Chemical Substances Cytokines ; Inflammation Mediators ; Transcription Factors
    Language English
    Publishing date 2009-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgp127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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