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Article ; Online: Construction of Hierarchical Films via Layer-by-Layer Assembly of Exfoliated Unilamellar Zeolite Nanosheets.

Wang, Chenhui / Sakai, Nobuyuki / Ebina, Yasuo / Kikuchi, Takayuki / Grzybek, Justyna / Roth, Wieslaw J / Gil, Barbara / Ma, Renzhi / Sasaki, Takayoshi

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2308293

Abstract: Zeolites have been widely applied as versatile catalysts, sorbents, and ion exchangers with unique porous structures showing molecular sieving capability. In these years, it is reported that some layered zeolites can be delaminated into molecularly thin ... ...

Abstract	Zeolites have been widely applied as versatile catalysts, sorbents, and ion exchangers with unique porous structures showing molecular sieving capability. In these years, it is reported that some layered zeolites can be delaminated into molecularly thin 2-dimensional (2D) nanosheets characterized by inherent porous structures and highly exposed active sites. In the present study, two types of zeolite nanosheets with distinct porous structures with MWW topology (denoted mww) and ferrierite-related structure (denoted bifer) are deposited on a substrate through the solution process via electrostatic self-assembly. Alternate deposition of zeolite nanosheets with polycation under optimized conditions allows the layer-by-layer growth of their multilayer films with a stacking distance of 2-3 nm. Furthermore, various hierarchical structures defined at the unit-cell dimensions can be constructed simply by conducting the deposition of mww and bifer nanosheets in a designed sequence. Adsorption of a dye, Rhodamine B, in these films, is examined to show that adsorption is dependent on constituent zeolite nanosheets and their assembled nanostructures. This work has provided fundamental advancements in the fabrication of artificial zeolite-related hierarchical structures, which may be extended to other zeolite nanosheets, broadening their functionalities, applications, and benefits.
Language	English
Publishing date	2024-01-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202308293
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Article ; Online: Transcriptomic Profiling for the Autophagy Pathway in Colorectal Cancer.

Gil, Justyna / Karpiński, Paweł / Sąsiadek, Maria M

International journal of molecular sciences

2020 Volume 21, Issue 19

Abstract: The role of autophagy in colorectal cancer (CRC) pathogenesis appears to be crucial. Autophagy acts both as a tumor suppressor, by removing redundant cellular material, and a tumor-promoting factor, by providing access to components necessary for growth, ...

Abstract	The role of autophagy in colorectal cancer (CRC) pathogenesis appears to be crucial. Autophagy acts both as a tumor suppressor, by removing redundant cellular material, and a tumor-promoting factor, by providing access to components necessary for growth, metabolism, and proliferation. To date, little is known about the expression of genes that play a basal role in the autophagy in CRC. In this study, we aimed to compare the expression levels of 46 genes involved in the autophagy pathway between tumor-adjacent and tumor tissue, employing large RNA sequencing (RNA-seq) and microarray datasets. Additionally, we verified our results using data on 38 CRC cell lines. Gene set enrichment analysis revealed a significant deregulation of autophagy-related gene sets in CRC. The unsupervised clustering of tumors using the mRNA levels of autophagy-related genes revealed the existence of two major clusters: microsatellite instability (MSI)-enriched and -depleted. In cluster 1 (MSI-depleted),
MeSH term(s)	Autophagy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Databases, Nucleic Acid ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Transcriptome
Chemical Substances	Neoplasm Proteins
Language	English
Publishing date	2020-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21197101
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Article ; Online: Transcriptomic Profiling for the Autophagy Pathway in Colorectal Cancer

Justyna Gil / Paweł Karpiński / Maria M. Sąsiadek

International Journal of Molecular Sciences, Vol 21, Iss 7101, p

2020 Volume 7101

Abstract	The role of autophagy in colorectal cancer (CRC) pathogenesis appears to be crucial. Autophagy acts both as a tumor suppressor, by removing redundant cellular material, and a tumor-promoting factor, by providing access to components necessary for growth, metabolism, and proliferation. To date, little is known about the expression of genes that play a basal role in the autophagy in CRC. In this study, we aimed to compare the expression levels of 46 genes involved in the autophagy pathway between tumor-adjacent and tumor tissue, employing large RNA sequencing (RNA-seq) and microarray datasets. Additionally, we verified our results using data on 38 CRC cell lines. Gene set enrichment analysis revealed a significant deregulation of autophagy-related gene sets in CRC. The unsupervised clustering of tumors using the mRNA levels of autophagy-related genes revealed the existence of two major clusters: microsatellite instability (MSI)-enriched and -depleted. In cluster 1 (MSI-depleted), ATG9B and LAMP1 genes were the most prominently expressed, whereas cluster 2 (MSI-enriched) was characterized by DRAM1 upregulation. CRC cell lines were also clustered according to MSI-enriched/-depleted subgroups. The moderate deregulation of autophagy-related genes in cancer tissue, as compared to adjacent tissue, suggests a prominent field cancerization or early disruption of autophagy. Genes differentiating these clusters are promising candidates for CRC targeting therapy worthy of further investigation.
Keywords	autophagy ; gene expression ; colorectal cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Clinical Observation of a Child with Prenatally Diagnosed De Novo Partial Trisomy of Chromosome 20.

Stembalska, Agnieszka / Gil, Justyna / Laczmanska, Izabela / Sasiadek, Maria

Fetal and pediatric pathology

2019 Volume 38, Issue 3, Page(s) 245–256

Abstract: Background: Small supernumerary marker chromosomes (sSMCs) represent a group of structural chromosome rearrangements that cannot be characterized by conventional cytogenetic analysis, but can be identified by microarray studies. sSMCs are observed in ... ...

Abstract	Background: Small supernumerary marker chromosomes (sSMCs) represent a group of structural chromosome rearrangements that cannot be characterized by conventional cytogenetic analysis, but can be identified by microarray studies. sSMCs are observed in approximately 0.075% of prenatal cytogenetic tests with clinical pathology in no more than 30% of sSMCS carriers. Case: We present a boy who was diagnosed prenatally with a partial trisomy of chromosome 20. An increased nuchal translucency NT >99%tile, fetal neck cysts and abnormalities of the lumbosacral spine were observed in prenatal screening. After birth, facial dysmorphism, small male genitalia and defects of the vertebrae were observed. In the fourth year of life, dysmorphic features, brachydactyly, small male genitalia, short stature, psychomotor delay, hyperactivity as well as conductive hearing loss became apparent. Conclusion: Partial trisomy of chromosome 20, covering the region 20q21→20q23, results in serious clinical complications, including dysmorphic features and delay in psychomotor development.
MeSH term(s)	Adult ; Child ; Child Development/physiology ; Chromosomes, Human, Pair 20/genetics ; Comparative Genomic Hybridization/methods ; Female ; Humans ; In Situ Hybridization, Fluorescence/methods ; Karyotyping/methods ; Male ; Prenatal Diagnosis/methods ; Trisomy/genetics
Language	English
Publishing date	2019-03-20
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2165508-X
ISSN	1551-3823 ; 1551-3815 ; 1522-7952
ISSN (online)	1551-3823
ISSN	1551-3815 ; 1522-7952
DOI	10.1080/15513815.2019.1576818
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Article: VEGF Expression in Umbilical Cord MSC Depends on the Patient's Health, the Week of Pregnancy in Which the Delivery Took Place, and the Body Weight of the Newborn - Preliminary Report.

Bieńko, Karolina / Leszcz, Monika / Więckowska, Marta / Białek, Justyna / Petniak, Alicja / Szymanowski, Rafał / Wilińska, Agnieszka / Piszcz, Bartosz / Krzyżanowski, Arkadiusz / Kwaśniewska, Anna / Płachno, Bartosz J / Gil-Kulik, Paulina / Kocki, Janusz

Stem cells and cloning : advances and applications

2023 Volume 16, Page(s) 5–18

Abstract: Introduction: Cells collected from Wharton's jelly are a rich source of mesenchymal stem cells. They can be easily obtained and grown using the adhesive method. They produce many types of proteins, including VEGF. Their role is to participate in ... ...

Abstract	Introduction: Cells collected from Wharton's jelly are a rich source of mesenchymal stem cells. They can be easily obtained and grown using the adhesive method. They produce many types of proteins, including VEGF. Their role is to participate in angiogenesis, vasodilation, stimulation of cells to migrate, and chemotactic activity. The aim of this study was to evaluate expression of genes from the vascular endothelial growth factor family: Material and methods: The research material was an umbilical cord obtained from 40 patients hospitalized in the Department of Obstetrics and Pathology of Pregnancy of the Independent Public Clinical Hospital No.1 in Lublin. The age of the women was 21-46, all gave birth by cesarean section. Some of the patients suffered from hypertension and hypothyroidism. Material collected from patients immediately after delivery was subjected to enzymatic digestion with type I collagenase. The isolated cells were then cultured in adherent conditions, and then gene expression was assessed using qPCR and the immunophenotype of the cells was assessed cytometrically. Results: Conducted studies have shown significant differences in expression of VEGF family genes depending on clinical condition of mother and child. Significant differences in VEGF-family gene expression level in umbilical cord MSC collected from women with hypothyroidism, hypertension, time of labor and birth weight of the baby were shown. Conclusion: Probably due to hypoxia (caused, for example, by hypothyroidism or hypertension), the MSCs found in the umbilical cord may react with an increased expression of VEGF and a compensatory increase in the amount of secreted factor, the aim of which is, i.a., vasodilation and increase of blood supply to the fetus through the umbilical vessels.
Language	English
Publishing date	2023-04-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2511404-9
ISSN	1178-6957
ISSN	1178-6957
DOI	10.2147/SCCAA.S399303
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Article: Personalized medicine in oncology. New perspectives in management of gliomas.

Gil, Justyna / Laczmanska, Izabela / Pesz, Karolina A / Sasiadek, Maria M

Contemporary oncology (Poznan, Poland)

2018 Volume 22, Issue 1A, Page(s) 1–2

Abstract: Studies on genetic and epigenetic mechanisms of carcinogenesis have led to the discovery of crucial genetic events for many of particular malignancies. This was followed by invention of new therapeutic approaches based on molecular mechanisms underlying ... ...

Abstract	Studies on genetic and epigenetic mechanisms of carcinogenesis have led to the discovery of crucial genetic events for many of particular malignancies. This was followed by invention of new therapeutic approaches based on molecular mechanisms underlying cancer development and progression that bears the name of personalised medicine. In the case of gliomas, ascertainment of genetic/epigenetic markers was the basis for re-classification of tumours that until now depended on histopathological analysis. This article reviews recent advances in personalised medicine and the new World Health Organisation classification of gliomas.
Language	English
Publishing date	2018-03-05
Publishing country	Poland
Document type	Journal Article ; Review
ISSN	1428-2526
ISSN	1428-2526
DOI	10.5114/wo.2018.73872
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Article: Technical aspects of inter-recti distance measurement with ultrasonographic imaging for physiotherapy purposes: the scoping review.

Opala-Berdzik, Agnieszka / Rudek-Zeprzałka, Magdalena / Niesporek, Justyna / Cebula, Maciej / Baron, Jan / Gruszczyńska, Katarzyna / Pascoal, Augusto Gil / Mota, Patrícia / Chmielewska, Daria

Insights into imaging

2023 Volume 14, Issue 1, Page(s) 92

Abstract: Background: Inter-recti distance (IRD) measurement using musculoskeletal USI has been used in physiotherapy research, in particular, to investigate pregnancy-related diastasis recti abdominis (DRA) and to seek its effective treatment methods. Severe and ...

Abstract	Background: Inter-recti distance (IRD) measurement using musculoskeletal USI has been used in physiotherapy research, in particular, to investigate pregnancy-related diastasis recti abdominis (DRA) and to seek its effective treatment methods. Severe and untreated diastasis may result in the formation of umbilical or epigastric hernias. Objective: This study aimed to systematically map physiotherapy-related research articles that included descriptions of IRD measurement procedures using USI to present their similarities and differences, and formulate recommendations on the procedure. Design: A scoping review was conducted according to PRISMA-ScR guidelines, including 49 of 511 publications from three major databases. Publications were selected and screened by two independent reviewers whose decisions were consulted with a third reviewer. The main synthesized data items were: the examinees' body position, breathing phase, measurement sites, and DRA screening methods. The final conclusions and recommendations were the result of a consensus between seven reviewers from four research centers. Results: Studies used 1-5 measurement sites that were differently determined. IRD was measured at the umbilicus (n = 3), at its superior (n = 16) and/or inferior border (n = 9), and at different levels: between 2 and 12 cm above the umbilicus, or a third of the distance and halfway between the umbilicus and xiphoid (n = 37); between 2 and 4.5 cm below the umbilicus or halfway between the umbilicus and pubis (n = 27). Different approaches were used to screen subjects for DRA. Conclusions: The discrepancies between the measurement procedures prevent between-study comparisons. The DRA screening method should be standardized. IRD measurement protocol standardization has been proposed. Critical relevance statement: This scoping review indicates that the inter-recti distance measurement procedures using ultrasound imaging differ between studies, preventing between-study comparisons. Based on the results synthesis, the measurement protocol standardization has been proposed. Key points: The inter-recti distance measurement procedures using USI differ between studies. Proposed standardization concerns body position, breathing phase, measurements number per location. Determination of measurement locations considering individual linea alba length is suggested. Recommended locations: umbilical top, ½ of umbilical top-xiphoid, ¼ of umbilical top-xiphoid/pubis distances. Diastasis recti abdominis diagnostic criteria are needed for proposed measurement locations.
Language	English
Publishing date	2023-05-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-023-01443-4
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Article: Effect of 5-fluorouracil on branched-chain α-keto acid dehydrogenase (BCKDH) complex in rat's heart.

Knapik-Czajka, Małgorzata / Jurczyk, Michał / Bieleń, Justyna / Aleksandrovych, Veronika / Gawędzka, Anna / Stach, Paulina / Drąg, Jagoda / Gil, Krzysztof

Folia medica Cracoviensia

2021 Volume 61, Issue 1, Page(s) 121–129

Abstract: Undisturbed branched-chain amino acids (BCAA) catabolism is necessary for normal heart function. The key enzyme in BCAA catabolism is a multienzyme branched-chain α-keto acid dehydro- genase complex (BCKDH). BCKDH activity is regulated mainly by ... ...

Abstract	Undisturbed branched-chain amino acids (BCAA) catabolism is necessary for normal heart function. The key enzyme in BCAA catabolism is a multienzyme branched-chain α-keto acid dehydro- genase complex (BCKDH). BCKDH activity is regulated mainly by reversible dephosphorylation (activa- tion)/phosphorylation (inactivation) cycle catalyzed by regulatory enzymes, a specific phosphatase (PPM1K) and kinase (BDK). 5-fluorouracil (5-FU) is widely used in the treatment of different types of cancer. 5-FU has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure. We hypothesize that 5-FU modifies BCKDH activity and affects cardiac muscle metabolism. The current study was aimed at the investigation of the in vivo effect of 5-FU on BCKDH activity and mRNA levels for E1, PPM1K and BDK. Wistar male rats were administered with 4 doses of 5-FU, 150 mg/kg b.wt. each (study group) or 0.3% methylcellulose (control group). BCKDH activity was assayed spectrophotometrically. The mRNA levels were quantified by real-time PCR. 5-FU treatment caused an increase in BCKDH activity that appears to result mainly from increased dephosphorylation of the complex and is associated with an increase of PPM1K mRNA level and reduction of BDK and E1 mRNA levels. It is conceivable that 5-FU stimulation of BCKDH is an adaptive reaction with the purpose of enhancing the BCAA catabolism and protecting from toxic effect caused by excessive accumulation of these amino acids in heart.
MeSH term(s)	3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) ; Amino Acids, Branched-Chain ; Animals ; Fluorouracil/pharmacology ; Heart/drug effects ; Liver ; Male ; Myocardium/enzymology ; Rats ; Rats, Wistar
Chemical Substances	Amino Acids, Branched-Chain ; 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) (EC 1.2.4.4) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2021-08-02
Publishing country	Poland
Document type	Journal Article
ZDB-ID	412415-7
ISSN	0015-5616
ISSN	0015-5616
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Article ; Online: Characterization of Co and Fe-MCM-56 catalysts for NH

Grzybek, Justyna / Gil, Barbara / Roth, Wieslaw J / Skoczek, Monika / Kowalczyk, Andrzej / Chmielarz, Lucjan

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2018 Volume 196, Page(s) 281–288

Abstract: Two-step preparation of iron and cobalt-containing MCM-56 zeolites has been undertaken to evaluate the influence of their physicochemical properties in the selective catalytic reduction ( ... ...

Abstract	Two-step preparation of iron and cobalt-containing MCM-56 zeolites has been undertaken to evaluate the influence of their physicochemical properties in the selective catalytic reduction (NH
Language	English
Publishing date	2018-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2018.02.033
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Article ; Online: mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria.

Gurung, Sonam / Timmermand, Oskar Vilhelmsson / Perocheau, Dany / Gil-Martinez, Ana Luisa / Minnion, Magdalena / Touramanidou, Loukia / Fang, Sherry / Messina, Martina / Khalil, Youssef / Spiewak, Justyna / Barber, Abigail R / Edwards, Richard S / Pinto, Patricia Lipari / Finn, Patrick F / Cavedon, Alex / Siddiqui, Summar / Rice, Lisa / Martini, Paolo G V / Ridout, Deborah /

Heywood, Wendy / Hargreaves, Ian / Heales, Simon / Mills, Philippa B / Waddington, Simon N / Gissen, Paul / Eaton, Simon / Ryten, Mina / Feelisch, Martin / Frassetto, Andrea / Witney, Timothy H / Baruteau, Julien

Science translational medicine

2024 Volume 16, Issue 729, Page(s) eadh1334

Abstract: The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with argininosuccinic aciduria, an inherited metabolic disease with hyperammonemia and ... ...

Abstract	The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with argininosuccinic aciduria, an inherited metabolic disease with hyperammonemia and a systemic phenotype coinciding with neurocognitive impairment and chronic liver disease. Here, we describe the dysregulation of glutathione biosynthesis and upstream cysteine utilization in ASL-deficient patients and mice using targeted metabolomics and in vivo positron emission tomography (PET) imaging using (
MeSH term(s)	Adult ; Humans ; Animals ; Mice ; Argininosuccinic Aciduria/genetics ; Argininosuccinic Aciduria/therapy ; Cysteine ; Glutathione ; Metabolomics ; Liver Diseases
Chemical Substances	Cysteine (K848JZ4886) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.adh1334
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