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  1. Article ; Online: Insights into Melanoma Fibroblast Populations and Therapeutic Strategy Perspectives: Friends or Foes?

    Avagliano, Angelica / Arcucci, Alessandro

    Current medicinal chemistry

    2022  Volume 29, Issue 40, Page(s) 6159–6168

    Abstract: Cutaneous melanoma (CM) is an aggressive and highly metastatic solid tumor associated with drug resistance. Before 2011, despite therapies based on cytokines or molecules inhibiting DNA synthesis, metastatic melanoma led to patient death within 18 months ...

    Abstract Cutaneous melanoma (CM) is an aggressive and highly metastatic solid tumor associated with drug resistance. Before 2011, despite therapies based on cytokines or molecules inhibiting DNA synthesis, metastatic melanoma led to patient death within 18 months from diagnosis. However, recent studies on bidirectional interactions between melanoma cells and tumor microenvironment (TME) have had a significant impact on the development of new therapeutic strategies represented by targeted therapy and immunotherapy. In particular, the heterogeneous stromal fibroblast populations, including fibroblasts, fibroblast aggregates, myofibroblasts, and melanoma associated fibroblasts (MAFs), represent the most abundant cell population of TME and regulate cancer growth differently. Therefore, in this perspective article, we have highlighted the different impacts of fibroblast populations on cancer development and growth. In particular, we focused on the role of MAFs in sustaining melanoma cell survival, proliferation, migration and invasion, drug resistance, and immunoregulation. The important role of constitutively activated MAFs in promoting CM growth and immunoediting makes this cell type a promising target for cancer therapy.
    MeSH term(s) Cytokines/metabolism ; DNA/metabolism ; Fibroblasts/metabolism ; Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Skin Neoplasms/drug therapy ; Skin Neoplasms/metabolism ; Tumor Microenvironment ; Melanoma, Cutaneous Malignant
    Chemical Substances Cytokines ; DNA (9007-49-2)
    Language English
    Publishing date 2022-06-11
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867329666220620124138
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Editorial: Tumor Microenvironment and Cancer Cell Interactions in Solid Tumor Growth and Therapy Resistance.

    Ruocco, Maria Rosaria / Lamberti, Annalisa / Serrano, María José / Fiume, Giuseppe / Arcucci, Alessandro

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 896194

    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.896194
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  3. Article: Enhanced pro-apoptotic activity of rituximab through IBTK silencing in non-Hodgkin lymphoma B-cells.

    Vecchio, Eleonora / Marino, Rossana / Mimmi, Selena / Canale, Camilla / Caiazza, Carmen / Arcucci, Alessandro / Ruocco, Maria Rosaria / Schiavone, Marco / Santamaria, Gianluca / Palmieri, Camillo / Iaccino, Enrico / Mallardo, Massimo / Quinto, Ileana / Fiume, Giuseppe

    Frontiers in oncology

    2024  Volume 14, Page(s) 1339584

    Abstract: Rituximab is a commonly used chemotherapeutic drug for patients with aggressive lymphomas, such as non-Hodgkin's lymphoma (NHL). Currently, the combination of Rituximab and chemotherapy (R-CHOP) stands as the most prevalent first-line therapy for NHL. ... ...

    Abstract Rituximab is a commonly used chemotherapeutic drug for patients with aggressive lymphomas, such as non-Hodgkin's lymphoma (NHL). Currently, the combination of Rituximab and chemotherapy (R-CHOP) stands as the most prevalent first-line therapy for NHL. Nevertheless, the development of new therapeutic approaches remains imperative. An increasing body of evidence highlights a novel role for IBTK in tumorigenesis and cancer growth. In this study, we aim to broaden our understanding of IBTK's function in B-lymphoma, with a particular focus on its impact on the expression of the oncogene MYC. Here, we assessed the effects of combining Rituximab with IBTK silencing on cell viability through cell cycle analysis and Annexin V assays
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1339584
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  4. Article ; Online: Editorial

    Maria Rosaria Ruocco / Annalisa Lamberti / María José Serrano / Giuseppe Fiume / Alessandro Arcucci

    Frontiers in Cell and Developmental Biology, Vol

    Tumor Microenvironment and Cancer Cell Interactions in Solid Tumor Growth and Therapy Resistance

    2022  Volume 10

    Keywords tumor microenviroment ; cutaneous melanoma ; tumour extracellular matrix ; therapy resistance ; cancer immune response ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures.

    Venuta, Alessandro / Nasso, Rosarita / Gisonna, Armando / Iuliano, Roberta / Montesarchio, Sara / Acampora, Vittoria / Sepe, Leandra / Avagliano, Angelica / Arcone, Rosaria / Arcucci, Alessandro / Ruocco, Maria Rosaria

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Cutaneous melanoma (CM) remains one of the leading causes of tumor mortality due to its high metastatic spread. CM growth is influenced by inflammation regulated by prostaglandins (PGs) whose synthesis is catalyzed by cyclooxygenases (COXs). COX ... ...

    Abstract Cutaneous melanoma (CM) remains one of the leading causes of tumor mortality due to its high metastatic spread. CM growth is influenced by inflammation regulated by prostaglandins (PGs) whose synthesis is catalyzed by cyclooxygenases (COXs). COX inhibitors, including non-steroidal anti-inflammatory drugs (NSAIDs), can inhibit tumor development and growth. In particular, in vitro experiments have shown that celecoxib, a NSAID, inhibits the growth of some tumor cell lines. However, two-dimensional (2D) cell cultures, used in traditional in vitro anticancer assays, often show poor efficacy due to a lack of an in vivo like cellular environment. Three-dimensional (3D) cell cultures, such as spheroids, are better models because they can mimic the common features displayed by human solid tumors. Hence, in this study, we evaluated the anti-neoplastic potential of celecoxib, in both 2D and 3D cell cultures of A2058 and SAN melanoma cell lines. In particular, celecoxib reduced the cell viability and migratory capability and triggered the apoptosis of melanoma cells grown as 2D cultures. When celecoxib was tested on 3D melanoma cell cultures, the drug exerted an inhibitory effect on cell outgrowth from spheroids and reduced the invasiveness of melanoma cell spheroids into the hydrogel matrix. This work suggests that celecoxib could represent a new potential therapeutic approach in melanoma therapy.
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13041067
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  6. Article ; Online: The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages.

    Caiazza, Carmen / Brusco, Teresa / D'Alessio, Federica / D'Agostino, Massimo / Avagliano, Angelica / Arcucci, Alessandro / Ambrosino, Concetta / Fiume, Giuseppe / Mallardo, Massimo

    International journal of molecular sciences

    2022  Volume 23, Issue 22

    Abstract: STING is a transmembrane ER resident protein that was initially described as a regulator of innate immune response triggered by viral DNA and later found to be involved in a broader range of immune processes. Here, we assessed its role in the antigen ... ...

    Abstract STING is a transmembrane ER resident protein that was initially described as a regulator of innate immune response triggered by viral DNA and later found to be involved in a broader range of immune processes. Here, we assessed its role in the antigen presentation by generating a STING KO macrophage cell line. In the absence of STING, we observed an impaired OVA-derived SIINFEKL peptide presentation together with a decreased level of MHC-I complex on the plasma membrane, likely due to a decreased mRNA expression of β2 m light chain as no relevant alterations of the peptide-loading complex (TAPs) were found. Moreover, JAK-STAT signaling resulted in impaired STING KO cells following OVA and LPS treatments, suggesting a dampened activation of immune response. Our data revealed a new molecular role of STING in immune mechanisms that could elucidate its role in the pathogenesis of autoimmune disorders and cancer.
    MeSH term(s) Animals ; Mice ; Antigen Presentation ; Macrophages/metabolism ; Signal Transduction ; Immunity, Innate ; Histocompatibility Antigens ; Membrane Proteins/metabolism
    Chemical Substances Histocompatibility Antigens ; Membrane Proteins
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232214232
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  7. Article ; Online: The Perceived Risk of Being Infected with COVID-19 at Work, Communication, and Employee Health

    Alessandra Falco / Damiano Girardi / Alessandro De Carlo / Elvira Arcucci / Laura Dal Corso

    Sustainability, Vol 14, Iss 1037, p

    A Longitudinal Application of the Job Demands–Resources Model

    2022  Volume 1037

    Abstract: The perceived risk of being infected at work (PRIW) with COVID-19 represents a potential risk factor for workers during the current COVID-19 pandemic. In line with the job demands–resources (JD-R) model in the context of safety at work, in this ... ...

    Abstract The perceived risk of being infected at work (PRIW) with COVID-19 represents a potential risk factor for workers during the current COVID-19 pandemic. In line with the job demands–resources (JD-R) model in the context of safety at work, in this longitudinal study we propose that PRIW can be conceptualized as a job demand (JD), whereas communication (i.e., the exchange of good-quality information across team members) can be conceived of as a job resource (JR). Accordingly, we hypothesize that PRIW at Time 1 (T1) would positively predict psychophysical strain at Time 2 (i.e., four months later), and that communication at T1 would negatively predict psychophysical strain at T2. Overall, 297 workers participated in the study. The hypothesized relationships were tested using multiple regression analysis. The results support our predictions: PRIW positively predicted psychophysical strain over time, whereas communication negatively predicted psychophysical strain over time. The results did not change after controlling for age, gender, and type of contract. Overall, this study suggests that PRIW and communication might be conceived of as a risk and a protective factor for work-related stress, respectively. Hence, to promote more sustainable working conditions, interventions should help organizations to promote an adequate balance between JDs and JRs related to COVID-19.
    Keywords COVID-19 ; perceived risk ; communication ; psychophysical strain ; longitudinal study ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 650
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Out of Sight, Out of Mind? A Longitudinal Investigation of Smart Working and Burnout in the Context of the Job Demands–Resources Model during the COVID-19 Pandemic

    Alessandro De Carlo / Damiano Girardi / Laura Dal Corso / Elvira Arcucci / Alessandra Falco

    Sustainability, Vol 14, Iss 7121, p

    2022  Volume 7121

    Abstract: The academic interest in smart working, a form of flexible work characterized by the use of technology to conduct one’s work, has dramatically increased over recent years, especially during the COVID-19 pandemic. Building on the job demands–resources (JD- ...

    Abstract The academic interest in smart working, a form of flexible work characterized by the use of technology to conduct one’s work, has dramatically increased over recent years, especially during the COVID-19 pandemic. Building on the job demands–resources (JD-R) model, in this study we investigate whether smart working affects the longitudinal association between perceived work characteristics, such as workload and social support (SS), and workers’ health and well-being, in terms of exhaustion. Overall, 185 workers completed a self-report questionnaire at two time points (four-month time-lag) during the COVID-19 outbreak. The results from moderated multiple regression analysis partially support our predictions. The longitudinal association between workload and exhaustion was positive—although marginally significant—for smart workers, but nonsignificant for in-person workers. Contrarily, the longitudinal association between SS and exhaustion was negative for in-person workers, but nonsignificant for smart workers. Overall, this study suggests that, to support employees’ health and productivity, work characteristics—both physical and psychosocial—should fit the new way of working as well as remote workers’ specific needs and expectations. Hence, to promote sustainable work, interventions should be aimed at helping smart workers to manage their workload effectively, as well as reducing professional and social isolation.
    Keywords smart working ; exhaustion ; workload ; social support ; COVID-19 ; job demands–resources ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 300
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Thyroid Cancer and Fibroblasts.

    Avagliano, Angelica / Fiume, Giuseppe / Bellevicine, Claudio / Troncone, Giancarlo / Venuta, Alessandro / Acampora, Vittoria / De Lella, Sabrina / Ruocco, Maria Rosaria / Masone, Stefania / Velotti, Nunzio / Carotenuto, Pietro / Mallardo, Massimo / Caiazza, Carmen / Montagnani, Stefania / Arcucci, Alessandro

    Cancers

    2022  Volume 14, Issue 17

    Abstract: Thyroid cancer is the most common type of endocrine cancer, and its prevalence continue to rise. Non-metastatic thyroid cancer patients are successfully treated. However, looking for new therapeutic strategies is of great importance for metastatic ... ...

    Abstract Thyroid cancer is the most common type of endocrine cancer, and its prevalence continue to rise. Non-metastatic thyroid cancer patients are successfully treated. However, looking for new therapeutic strategies is of great importance for metastatic thyroid cancers that still lead to death. With respect to this, the tumor microenvironment (TME), which plays a key role in tumor progression, should be considered as a new promising therapeutic target to hamper thyroid cancer progression. Indeed, thyroid tumors consist of cancer cells and a heterogeneous and ever-changing niche, represented by the TME, which contributes to establishing most of the features of cancer cells. The TME consists of extracellular matrix (ECM) molecules, soluble factors, metabolites, blood and lymphatic tumor vessels and several stromal cell types that, by interacting with each other and with tumor cells, affect TME remodeling, cancer growth and progression. Among the thyroid TME components, cancer-associated fibroblasts (CAFs) have gained more attention in the last years. Indeed, recent important evidence showed that thyroid CAFs strongly sustain thyroid cancer growth and progression by producing soluble factors and ECM proteins, which, in turn, deeply affect thyroid cancer cell behavior and aggressiveness. Hence, in this article, we describe the thyroid TME, focusing on the desmoplastic stromal reaction, which is a powerful indicator of thyroid cancer progression and an invasive growth pattern. In addition, we discuss the origins and features of the thyroid CAFs, their influence on thyroid cancer growth and progression, their role in remodeling the ECM and their immune-modulating functions. We finally debate therapeutic perspectives targeting CAFs.
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14174172
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  10. Article ; Online: IBtkα Activates the β-Catenin-Dependent Transcription of

    Vecchio, Eleonora / Nisticò, Nancy / Golino, Gaetanina / Iaccino, Enrico / Maisano, Domenico / Mimmi, Selena / Aloisio, Annamaria / Renna, Maurizio / Avagliano, Angelica / Arcucci, Alessandro / Fiume, Giuseppe / Quinto, Ileana

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: ... ...

    Abstract The
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Line, Tumor ; Cells, Cultured ; Cyclin D1/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; HEK293 Cells ; Humans ; Lymphoma, B-Cell/genetics ; Lymphoma, B-Cell/metabolism ; Mice ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Ubiquitination ; beta Catenin/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; CCND1 protein, human ; IBtk protein, human ; MYC protein, human ; Proto-Oncogene Proteins c-myc ; beta Catenin ; Cyclin D1 (136601-57-5) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2022-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042044
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