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Article: Changes in Inflammatory Cytokines After Chronic Hepatitis C Treatment Among People Living With HIV.

Karimi-Sari, Hamidreza / Piggott, Damani A / Scully, Eileen P / Ward, Kathleen / Sutcliffe, Catherine G / Sulkowski, Mark / Falade-Nwulia, Oluwaseun

Open forum infectious diseases

2024 Volume 11, Issue 1, Page(s) ofad623

Abstract: We aimed to evaluate the effect of hepatitis C virus cure on serum inflammatory markers ...

Abstract	We aimed to evaluate the effect of hepatitis C virus cure on serum inflammatory markers among people with HIV. Among 127 people with HIV, serum alanine aminotransferase, soluble tumor necrosis factor receptor 1, and inflammatory index score were significantly lower at the 24-week time point in patients who achieved sustained virologic response as compared with those who did not.
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad623
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Article: Stability of 30 Fatty Acids in Serum Stored at -20 °C for up to 5 Years.

Powers, Carissa D / Sternberg, Maya R / Momin, Shahzad S / Pendergrast, Elizabeth C / Scully, David C / Schleicher, Rosemary L

The journal of applied laboratory medicine

2021 Volume 2, Issue 1, Page(s) 125–127

Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Journal Article
ISSN	2576-9456
ISSN	2576-9456
DOI	10.1373/jalm.2017.023531
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Article ; Online: Status epilepticus after C-4 ingestion: using liquid chromatography to quantify toxicity.

Garcia, Robert / Karimian, Amir / Donaldson, Chase / Preston, Kerry / Scully, Shawna

Clinical toxicology (Philadelphia, Pa.)

2019 Volume 57, Issue 9, Page(s) 819–821

Abstract: Context: ...

Abstract	Context:
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Electroencephalography ; Explosive Agents/blood ; Explosive Agents/toxicity ; Humans ; Male ; Status Epilepticus/chemically induced ; Status Epilepticus/diagnosis ; Triazines/blood ; Triazines/toxicity ; Young Adult
Chemical Substances	Explosive Agents ; Triazines ; cyclonite (W91SSV5831)
Language	English
Publishing date	2019-02-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2018.1562069
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Article ; Online: Identification of an orthologous clade of peroxidases that respond to feeding by greenbugs (Schizaphis graminum) in C

Scully, Erin D / Donze-Reiner, Teresa / Wang, Haichuan / Eickhoff, Thomas E / Baxendale, Frederick / Twigg, Paul / Kovacs, Frank / Heng-Moss, Tiffany / Sattler, Scott E / Sarath, Gautam

Functional plant biology : FPB

2020 Volume 43, Issue 12, Page(s) 1134–1148

Abstract: Knowledge of specific peroxidases that respond to aphid herbivory is limited in C4 grasses, but could provide targets for improving defence against these pests. A sorghum (Sorghum bicolor (L.) Moench) peroxidase (SbPrx-1; Sobic.002G416700) has been ... ...

Abstract	Knowledge of specific peroxidases that respond to aphid herbivory is limited in C4 grasses, but could provide targets for improving defence against these pests. A sorghum (Sorghum bicolor (L.) Moench) peroxidase (SbPrx-1; Sobic.002G416700) has been previously linked to biotic stress responses, and was the starting point for this study. Genomic analyses indicated that SbPrx-1 was part of a clade of five closely related peroxidase genes occurring within a ~30kb region on chromosome 2 of the sorghum genome. Comparison of this ~30-kb region to syntenic regions in switchgrass (Panicum virgatum L.) and foxtail millet (Setaria italica L.) identified similar related clusters of peroxidases. Infestation of a susceptible sorghum cultivar with greenbugs (Shizaphis graminum Rondani) induced three of the five peroxidases. Greenbug infestation of switchgrass and foxtail millet plants showed similar inductions of peroxidases. SbPrx-1 was also induced in response to aphid herbivory in a greenbug-resistant sorghum line, Cargill 607E. These data indicate that this genomic region of C4 grasses could be valuable as a marker to assess potential insect resistance in C4 grasses.
Language	English
Publishing date	2020-06-02
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2071582-1
ISSN	1445-4416 ; 1445-4408
ISSN (online)	1445-4416
ISSN	1445-4408
DOI	10.1071/FP16104
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Article ; Online: O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.

Suthakaran, Nirthieca / Wiggins, Jonathan / Giles, Andrew / Opperman, Karla J / Grill, Brock / Dawson-Scully, Ken

PloS one

2021 Volume 16, Issue 11, Page(s) e0260072

Abstract: ... of excitation and inhibition (E/I) in the central nervous system. The simplicity and tractability of C. elegans ... circuit and neuronal function. C. elegans possess conserved nervous system features ... in the C. elegans nervous system rescued enhanced electroshock defects in ogt-1; eel-1 double mutants ...

Abstract	Neurodevelopmental disorders such as epilepsy and autism have been linked to an imbalance of excitation and inhibition (E/I) in the central nervous system. The simplicity and tractability of C. elegans allows our electroconvulsive seizure (ES) assay to be used as a behavioral readout of the locomotor circuit and neuronal function. C. elegans possess conserved nervous system features such as gamma-aminobutyric acid (GABA) and GABA receptors in inhibitory neurotransmission, and acetylcholine (Ach) and acetylcholine receptors in excitatory neurotransmission. Our previously published data has shown that decreasing inhibition in the motor circuit, via GABAergic manipulation, will extend the time of locomotor recovery following electroshock. Similarly, mutations in a HECT E3 ubiquitin ligase called EEL-1 leads to impaired GABAergic transmission, E/I imbalance and altered sensitivity to electroshock. Mutations in the human ortholog of EEL-1, called HUWE1, are associated with both syndromic and non-syndromic intellectual disability. Both EEL-1 and its previously established binding protein, OGT-1, are expressed in GABAergic motor neurons, localize to GABAergic presynaptic terminals, and function in parallel to regulate GABA neuron function. In this study, we tested behavioral responses to electroshock in wildtype, ogt-1, eel-1 and ogt-1; eel-1 double mutants. Both ogt-1 and eel-1 null mutants have decreased inhibitory GABAergic neuron function and increased electroshock sensitivity. Consistent with EEL-1 and OGT-1 functioning in parallel pathways, ogt-1; eel-1 double mutants showed enhanced electroshock susceptibility. Expression of OGT-1 in the C. elegans nervous system rescued enhanced electroshock defects in ogt-1; eel-1 double mutants. Application of a GABA agonist, Baclofen, decreased electroshock susceptibility in all animals. Our C. elegans electroconvulsive seizure assay was the first to model a human X-linked Intellectual Disability (XLID) associated with epilepsy and suggests a potential novel role for the OGT-1/EEL-1 complex in seizure susceptibility.
MeSH term(s)	Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Caenorhabditis elegans Proteins/physiology ; Disease Susceptibility/metabolism ; GABAergic Neurons/metabolism ; Genes, X-Linked/genetics ; Genetic Predisposition to Disease/genetics ; Intellectual Disability/genetics ; N-Acetylglucosaminyltransferases/metabolism ; N-Acetylglucosaminyltransferases/physiology ; Nervous System/metabolism ; Nervous System Physiological Phenomena ; Presynaptic Terminals/metabolism ; Seizures/genetics ; Seizures/metabolism ; Synaptic Transmission ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/physiology ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	Caenorhabditis elegans Proteins ; Ubiquitin ; gamma-Aminobutyric Acid (56-12-2) ; EEL-1 protein, C elegans (EC 2.3.2.26) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; N-Acetylglucosaminyltransferases (EC 2.4.1.-) ; O-GlcNAc transferase (EC 2.4.1.-) ; ogt-1 protein, C elegans (EC 2.4.1.255)
Language	English
Publishing date	2021-11-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0260072
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Article ; Online: Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013.

Scully, Erik J / Basnet, Sarmi / Wrangham, Richard W / Muller, Martin N / Otali, Emily / Hyeroba, David / Grindle, Kristine A / Pappas, Tressa E / Thompson, Melissa Emery / Machanda, Zarin / Watters, Kelly E / Palmenberg, Ann C / Gern, James E / Goldberg, Tony L

Emerging infectious diseases

2018 Volume 24, Issue 2, Page(s) 267–274

Abstract: ... for which molecular and epidemiologic analyses implicate human rhinovirus C as the cause. Postmortem samples ...

Abstract	We describe a lethal respiratory outbreak among wild chimpanzees in Uganda in 2013 for which molecular and epidemiologic analyses implicate human rhinovirus C as the cause. Postmortem samples from an infant chimpanzee yielded near-complete genome sequences throughout the respiratory tract; other pathogens were absent. Epidemiologic modeling estimated the basic reproductive number (R
MeSH term(s)	Animals ; Ape Diseases/epidemiology ; Ape Diseases/virology ; Disease Outbreaks ; Enterovirus ; Genetic Predisposition to Disease ; Genotype ; Models, Biological ; Pan troglodytes/genetics ; Picornaviridae Infections/epidemiology ; Picornaviridae Infections/mortality ; Picornaviridae Infections/veterinary ; Picornaviridae Infections/virology ; Uganda
Keywords	covid19
Language	English
Publishing date	2018-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2402.170778
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Zs.A 4778: Show issues

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Article: Oral medicine: 16. Radiolucencies and radio-opacities. C. Odontogenic tumours.

Felix, David H / Luker, Jane / Scully, Crispian

Dental update

2014 Volume 41, Issue 3, Page(s) 274–278

MeSH term(s)	Ameloblastoma/diagnostic imaging ; Cementoma/diagnostic imaging ; Diagnosis, Differential ; Humans ; Jaw Cysts/diagnostic imaging ; Jaw Diseases/diagnostic imaging ; Jaw Neoplasms/diagnostic imaging ; Odontogenic Tumor, Squamous/diagnostic imaging ; Odontogenic Tumors/diagnostic imaging ; Odontoma/diagnostic imaging ; Radiography
Language	English
Publishing date	2014-04
Publishing country	England
Document type	Journal Article
ZDB-ID	423728-6
ISSN	0305-5000
ISSN	0305-5000
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Zs.B 2245: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 362: Show issues

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Article ; Online: egl-4 modulates electroconvulsive seizure duration in C. elegans.

Risley, Monica G / Kelly, Stephanie P / Minnerly, Justin / Jia, Kailiang / Dawson-Scully, Ken

Invertebrate neuroscience : IN

2018 Volume 18, Issue 2, Page(s) 8

Abstract: Increased neuronal excitability causes seizures with debilitating symptoms. Effective and noninvasive treatments are limited for easing symptoms, partially due to the complexity of the disorder and lack of knowledge of specific molecular faults. An ... ...

Abstract	Increased neuronal excitability causes seizures with debilitating symptoms. Effective and noninvasive treatments are limited for easing symptoms, partially due to the complexity of the disorder and lack of knowledge of specific molecular faults. An unexplored, novel target for seizure therapeutics is the cGMP/protein kinase G (PKG) pathway, which targets downstream K
MeSH term(s)	Animals ; Anticonvulsants/therapeutic use ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins ; Carbamates/therapeutic use ; Cyclic GMP/analogs & derivatives ; Cyclic GMP-Dependent Protein Kinases/genetics ; Cyclic GMP-Dependent Protein Kinases/metabolism ; Disease Models, Animal ; Electroshock/adverse effects ; Phenylenediamines/therapeutic use ; Recovery of Function/drug effects ; Recovery of Function/genetics ; Seizures/drug therapy ; Seizures/etiology ; Seizures/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology
Chemical Substances	Anticonvulsants ; Caenorhabditis elegans Proteins ; Carbamates ; Phenylenediamines ; ezogabine (12G01I6BBU) ; 8-bromocyclic GMP (31356-94-2) ; Cyclic GMP-Dependent Protein Kinases (EC 2.7.11.12) ; EGL-4 protein, C elegans (EC 2.7.11.12) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2018-05-30
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2003354-0
ISSN	1439-1104 ; 1354-2516
ISSN (online)	1439-1104
ISSN	1354-2516
DOI	10.1007/s10158-018-0211-9
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Article ; Online: HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells.

Körner, Christian / Simoneau, Camille R / Schommers, Philipp / Granoff, Mitchell / Ziegler, Maja / Hölzemer, Angelique / Lunemann, Sebastian / Chukwukelu, Janet / Corleis, Björn / Naranbhai, Vivek / Kwon, Douglas S / Scully, Eileen P / Jost, Stephanie / Kirchhoff, Frank / Carrington, Mary / Altfeld, Marcus

Cell host & microbe

2017 Volume 22, Issue 1, Page(s) 111–119.e4

Abstract: ... HLA-C unaltered in order to prevent NK cell activation by engaging inhibitory NK cell receptors ... but it was recently observed that most primary isolates of HIV-1 can mediate HLA-C downmodulation. Now ... we report that HIV-1-mediated downmodulation of HLA-C was associated with reduced binding to its respective ...

Abstract	It was widely accepted that HIV-1 downregulates HLA-A/B to avoid CTL recognition while leaving HLA-C unaltered in order to prevent NK cell activation by engaging inhibitory NK cell receptors, but it was recently observed that most primary isolates of HIV-1 can mediate HLA-C downmodulation. Now we report that HIV-1-mediated downmodulation of HLA-C was associated with reduced binding to its respective inhibitory receptors. Despite this, HLA-C-licensed NK cells displayed reduced antiviral activity compared to their unlicensed counterparts, potentially due to residual binding to the respective inhibitory receptors. Nevertheless, NK cells were able to sense alterations of HLA-C expression demonstrated by increased antiviral activity when exposed to viral strains with differential abilities to downmodulate HLA-C. These results suggest that the capability of HLA-C-licensed NK cells to control HIV-1 replication is determined by the strength of KIR/HLA-C interactions and is thus dependent on both host genetics and the extent of virus-mediated HLA-C downregulation.
MeSH term(s)	Antiviral Agents/metabolism ; CD4-Positive T-Lymphocytes/immunology ; Cell Line ; HEK293 Cells ; HIV Infections/metabolism ; HIV-1/genetics ; HIV-1/physiology ; HLA-A Antigens/metabolism ; HLA-B Antigens/metabolism ; HLA-C Antigens/metabolism ; Humans ; Killer Cells, Natural/immunology ; Lymphocyte Activation ; Receptors, KIR2DL1/metabolism ; Receptors, KIR2DL3/metabolism ; Virus Replication/physiology
Chemical Substances	Antiviral Agents ; HLA-A Antigens ; HLA-B Antigens ; HLA-C Antigens ; KIR2DL1 protein, human ; KIR2DL3 protein, human ; Receptors, KIR2DL1 ; Receptors, KIR2DL3
Language	English
Publishing date	2017-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2017.06.008
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Article ; Online: O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.

Nirthieca Suthakaran / Jonathan Wiggins / Andrew Giles / Karla J Opperman / Brock Grill / Ken Dawson-Scully

PLoS ONE, Vol 16, Iss 11, p e

2021 Volume 0260072

Abstract	Neurodevelopmental disorders such as epilepsy and autism have been linked to an imbalance of excitation and inhibition (E/I) in the central nervous system. The simplicity and tractability of C. elegans allows our electroconvulsive seizure (ES) assay to be used as a behavioral readout of the locomotor circuit and neuronal function. C. elegans possess conserved nervous system features such as gamma-aminobutyric acid (GABA) and GABA receptors in inhibitory neurotransmission, and acetylcholine (Ach) and acetylcholine receptors in excitatory neurotransmission. Our previously published data has shown that decreasing inhibition in the motor circuit, via GABAergic manipulation, will extend the time of locomotor recovery following electroshock. Similarly, mutations in a HECT E3 ubiquitin ligase called EEL-1 leads to impaired GABAergic transmission, E/I imbalance and altered sensitivity to electroshock. Mutations in the human ortholog of EEL-1, called HUWE1, are associated with both syndromic and non-syndromic intellectual disability. Both EEL-1 and its previously established binding protein, OGT-1, are expressed in GABAergic motor neurons, localize to GABAergic presynaptic terminals, and function in parallel to regulate GABA neuron function. In this study, we tested behavioral responses to electroshock in wildtype, ogt-1, eel-1 and ogt-1; eel-1 double mutants. Both ogt-1 and eel-1 null mutants have decreased inhibitory GABAergic neuron function and increased electroshock sensitivity. Consistent with EEL-1 and OGT-1 functioning in parallel pathways, ogt-1; eel-1 double mutants showed enhanced electroshock susceptibility. Expression of OGT-1 in the C. elegans nervous system rescued enhanced electroshock defects in ogt-1; eel-1 double mutants. Application of a GABA agonist, Baclofen, decreased electroshock susceptibility in all animals. Our C. elegans electroconvulsive seizure assay was the first to model a human X-linked Intellectual Disability (XLID) associated with epilepsy and suggests a potential novel role for the OGT-1/EEL-1 complex in seizure susceptibility.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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