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  1. Article ; Online: APMIS focus issue 2023-fungal infections: diagnostics and therapeutics.

    Ramage, Gordon / Andersen, Åse Bengård

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2023  Volume 131, Issue 11, Page(s) 559–560

    Language English
    Publishing date 2023-09-15
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13350
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  2. Article: Evaluation of Metabolomics as Diagnostic Targets in Oral Squamous Cell Carcinoma: A Systematic Review.

    Alapati, Susanth / Fortuna, Giulio / Ramage, Gordon / Delaney, Christopher

    Metabolites

    2023  Volume 13, Issue 8

    Abstract: In recent years, high-throughput technologies have facilitated the widespread use of metabolomics to identify biomarkers and targets for oral squamous cell carcinoma (OSCC). As a result, the primary goal of this systematic review is to identify and ... ...

    Abstract In recent years, high-throughput technologies have facilitated the widespread use of metabolomics to identify biomarkers and targets for oral squamous cell carcinoma (OSCC). As a result, the primary goal of this systematic review is to identify and evaluate metabolite biomarkers and their pathways for OSCC that featured consistently across studies despite methodological variations. Six electronic databases (Medline, Cochrane, Web of Science, CINAHL, ProQuest, and Embase) were reviewed for the longitudinal studies involving OSCC patients and metabolic marker analysis (in accordance with PRISMA 2020). The studies included ranged from the inception of metabolomics in OSCC (i.e., 1 January 2007) to 30 April 2023. The included studies were then assessed for their quality using the modified version of NIH quality assessment tool and QUADOMICS. Thirteen studies were included after screening 2285 studies. The majority of the studies were from South Asian regions, and metabolites were most frequently derived from saliva. Amino acids accounted for more than quarter of the detected metabolites, with glutamate and methionine being the most prominent. The top dysregulated metabolites indicated dysregulation of six significantly enriched pathways including aminoacyl-tRNA biosynthesis, glutathione metabolism and arginine biosynthesis with the false discovery rate (FDR) <0.05. Finally, this review highlights the potential of metabolomics for early diagnosis and therapeutic targeting of OSCC. However, larger studies and standardized protocols are needed to validate these findings and make them a clinical reality.
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13080890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antifungal therapy of

    Ajetunmobi, Olabayo H / Badali, Hamid / Romo, Jesus A / Ramage, Gordon / Lopez-Ribot, Jose L

    Biofilm

    2023  Volume 5, Page(s) 100126

    Abstract: Virtually ... ...

    Abstract Virtually all
    Language English
    Publishing date 2023-04-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2075
    ISSN (online) 2590-2075
    DOI 10.1016/j.bioflm.2023.100126
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  4. Article ; Online: Comparing apples and oranges: considerations for quantifying candidal biofilms with XTT [2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide] and the need for standardized testing.

    Ramage, Gordon

    Journal of medical microbiology

    2016  Volume 65, Issue 4, Page(s) 259–260

    MeSH term(s) Anilides ; Biofilms/growth & development ; Candida/physiology ; Humans ; Indicators and Reagents ; Microbiological Techniques/methods ; Microbiological Techniques/standards ; Tetrazolium Salts
    Chemical Substances 2,3-bis (2-methyloxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide ; Anilides ; Indicators and Reagents ; Tetrazolium Salts
    Language English
    Publishing date 2016-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.000237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Our current clinical understanding of Candida biofilms: where are we two decades on?

    Ramage, Gordon / Borghi, Elisa / Rodrigues, Célia Fortuna / Kean, Ryan / Williams, Craig / Lopez-Ribot, Jose

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2023  Volume 131, Issue 11, Page(s) 636–653

    Abstract: Clinically we have been aware of the concept of Candida biofilms for many decades, though perhaps without the formal designation. Just over 20 years ago the subject emerged on the back of progress made from the bacterial biofilms, and academic progress ... ...

    Abstract Clinically we have been aware of the concept of Candida biofilms for many decades, though perhaps without the formal designation. Just over 20 years ago the subject emerged on the back of progress made from the bacterial biofilms, and academic progress pace has continued to mirror the bacterial biofilm community, albeit at a decreased volume. It is apparent that Candida species have a considerable capacity to colonize surfaces and interfaces and form tenacious biofilm structures, either alone or in mixed species communities. From the oral cavity, to the respiratory and genitourinary tracts, wounds, or in and around a plethora of biomedical devices, the scope of these infections is vast. These are highly tolerant to antifungal therapies that has a measurable impact on clinical management. This review aims to provide a comprehensive overight of our current clinical understanding of where these biofilms cause infections, and we discuss existing and emerging antifungal therapies and strategies.
    MeSH term(s) Humans ; Candida ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Biofilms ; Mouth ; Bacteria ; Candida albicans
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-03-29
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13310
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  6. Article ; Online: Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of Candida auris.

    Kean, Ryan / Ramage, Gordon

    mSphere

    2019  Volume 4, Issue 4

    Abstract: The enigmatic ... ...

    Abstract The enigmatic yeast
    MeSH term(s) Antifungal Agents/pharmacology ; Biofilms/drug effects ; Candida/drug effects ; Candida/pathogenicity ; Candidiasis/microbiology ; Candidiasis/mortality ; Clinical Trials as Topic ; Drug Resistance, Multiple, Fungal ; Global Health ; Humans ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2019-07-31
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00458-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Informed development of a multi-species biofilm in chronic obstructive pulmonary disease.

    Short, Bryn / Delaney, Christopher / Johnston, William / Litherland, Gary J / Lockhart, John C / Williams, Craig / Mackay, William G / Ramage, Gordon

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2024  Volume 132, Issue 5, Page(s) 336–347

    Abstract: Recent evidence indicates that microbial biofilm aggregates inhabit the lungs of COPD patients and actively contribute towards chronic colonization and repeat infections. However, there are no contextually relevant complex biofilm models for COPD ... ...

    Abstract Recent evidence indicates that microbial biofilm aggregates inhabit the lungs of COPD patients and actively contribute towards chronic colonization and repeat infections. However, there are no contextually relevant complex biofilm models for COPD research. In this study, a meta-analysis of the lung microbiome in COPD was used to inform development of an optimized biofilm model composed of genera highly associated with COPD. Bioinformatic analysis showed that although diversity matrices of COPD microbiomes were similar to healthy controls, and internal compositions made it possible to accurately differentiate between these cohorts (AUC = 0.939). Genera that best defined these patients included Haemophilus, Moraxella and Streptococcus. Many studies fail to account for fungi; therefore, Candida albicans was included in the creation of an interkingdom biofilm model. These organisms formed a biofilm capable of tolerating high concentrations of antimicrobial therapies with no significant reductions in viability. However, combined therapies of antibiotics and an antifungal resulted in significant reductions in viable cells throughout the biofilm (p < 0.05). This biofilm model is representative of the COPD lung microbiome and results from in vitro antimicrobial challenge experiments indicate that targeting both bacteria and fungi in these interkingdom communities will be required for more positive clinical outcomes.
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive ; Lung/microbiology ; Biofilms ; Bacteria ; Anti-Infective Agents
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2024-02-21
    Publishing country Denmark
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13386
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  8. Article ; Online: An integrated transcriptomic and metabolomic approach to investigate the heterogeneous

    Delaney, Christopher / Short, Bryn / Rajendran, Ranjith / Kean, Ryan / Burgess, Karl / Williams, Craig / Munro, Carol A / Ramage, Gordon

    Biofilm

    2023  Volume 5, Page(s) 100112

    Abstract: ... Candida ... ...

    Abstract Candida albicans
    Language English
    Publishing date 2023-03-12
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2075
    ISSN (online) 2590-2075
    DOI 10.1016/j.bioflm.2023.100112
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  9. Article ; Online: Candida auris

    Kean, Ryan / Brown, Jason / Gulmez, Dolunay / Ware, Alicia / Ramage, Gordon

    Journal of fungi (Basel, Switzerland)

    2020  Volume 6, Issue 1

    Abstract: ... Candida ... ...

    Abstract Candida auris
    Language English
    Publishing date 2020-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof6010030
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  10. Article ; Online: Cell Viability Assays for Candida auris.

    Brown, Jason L / Short, Bryn / Ware, Alicia / Sherry, Leighann / Kean, Ryan / Ramage, Gordon

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2517, Page(s) 129–153

    Abstract: Cell viability assays are useful for assessing the efficacy of antifungal therapeutics and disinfection strategies in vitro. In recent years these assays have been fundamental for the testing of conventional and novel therapies against the nosocomial ... ...

    Abstract Cell viability assays are useful for assessing the efficacy of antifungal therapeutics and disinfection strategies in vitro. In recent years these assays have been fundamental for the testing of conventional and novel therapies against the nosocomial fungal pathogen Candida auris. Here we provide detailed descriptions of methods for assessing cellular viability of Candida auris in vitro, such as metabolic assays (XTT and resazurin), colony-forming unit counting, live/dead quantitative PCR, and fluorescent staining for microscopic analyses.
    MeSH term(s) Antifungal Agents/pharmacology ; Candida ; Candida auris ; Candidiasis/microbiology ; Cell Survival ; Humans ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2417-3_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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