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  1. Article ; Online: Genetic Contributions to Reported Childhood Maltreatment: What It Means and How It Could Mean More.

    Miller, Alex P / Agrawal, Arpana

    Biological psychiatry global open science

    2023  Volume 3, Issue 4, Page(s) 587–589

    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ISSN 2667-1743
    ISSN (online) 2667-1743
    DOI 10.1016/j.bpsgos.2023.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 3D-Printed Hydrogel for Diverse Applications: A Review.

    Agrawal, Arpana / Hussain, Chaudhery Mustansar

    Gels (Basel, Switzerland)

    2023  Volume 9, Issue 12

    Abstract: Hydrogels have emerged as a versatile and promising class of materials in the field of 3D printing, offering unique properties suitable for various applications. This review delves into the intersection of hydrogels and 3D printing, exploring current ... ...

    Abstract Hydrogels have emerged as a versatile and promising class of materials in the field of 3D printing, offering unique properties suitable for various applications. This review delves into the intersection of hydrogels and 3D printing, exploring current research, technological advancements, and future directions. It starts with an overview of hydrogel basics, including composition and properties, and details various hydrogel materials used in 3D printing. The review explores diverse 3D printing methods for hydrogels, discussing their advantages and limitations. It emphasizes the integration of 3D-printed hydrogels in biomedical engineering, showcasing its role in tissue engineering, regenerative medicine, and drug delivery. Beyond healthcare, it also examines their applications in the food, cosmetics, and electronics industries. Challenges like resolution limitations and scalability are addressed. The review predicts future trends in material development, printing techniques, and novel applications.
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9120960
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  3. Article ; Online: 3D-Printed Hydrogel for Diverse Applications

    Arpana Agrawal / Chaudhery Mustansar Hussain

    Gels, Vol 9, Iss 12, p

    A Review

    2023  Volume 960

    Abstract: Hydrogels have emerged as a versatile and promising class of materials in the field of 3D printing, offering unique properties suitable for various applications. This review delves into the intersection of hydrogels and 3D printing, exploring current ... ...

    Abstract Hydrogels have emerged as a versatile and promising class of materials in the field of 3D printing, offering unique properties suitable for various applications. This review delves into the intersection of hydrogels and 3D printing, exploring current research, technological advancements, and future directions. It starts with an overview of hydrogel basics, including composition and properties, and details various hydrogel materials used in 3D printing. The review explores diverse 3D printing methods for hydrogels, discussing their advantages and limitations. It emphasizes the integration of 3D-printed hydrogels in biomedical engineering, showcasing its role in tissue engineering, regenerative medicine, and drug delivery. Beyond healthcare, it also examines their applications in the food, cosmetics, and electronics industries. Challenges like resolution limitations and scalability are addressed. The review predicts future trends in material development, printing techniques, and novel applications.
    Keywords hydrogels ; 3D printing ; biomedical applications ; natural hydrogels ; synthetic hydrogels ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Characterisation of the genetic relationship between the domains of sleep and circadian-related behaviours with substance use phenotypes.

    Hatoum, Alexander S / Winiger, Evan A / Morrison, Claire L / Johnson, Emma C / Agrawal, Arpana

    Addiction biology

    2024  Volume 27, Issue 4, Page(s) e13184

    Abstract: Sleep problems and substance use frequently co-occur. While substance use can result in specific sleep deficits, genetic pleiotropy could explain part of the relationship between sleep and substance use and use disorders. Here we use the largest publicly ...

    Abstract Sleep problems and substance use frequently co-occur. While substance use can result in specific sleep deficits, genetic pleiotropy could explain part of the relationship between sleep and substance use and use disorders. Here we use the largest publicly available genome-wide summary statistics of substance use behaviours (N = 79,729-632,802) and sleep/activity phenotypes to date (N = 85,502-449,734) to (1) assess the genetic overlap between substance use behaviours and both sleep and circadian-related activity measures, (2) estimate clusters from genetic correlations and (3) test processes of causality versus genetic pleiotropy. We found 31 genetic correlations between substance use and sleep/activity after Bonferroni correction. These patterns of overlap were represented by two genetic clusters: (1) tobacco use severity (age of first regular tobacco use and smoking cessation) and sleep health (sleep duration, sleep efficiency and chronotype) and (2) substance consumption/problematic use (drinks per day and cigarettes per day, cannabis use disorder, opioid use disorder and problematic alcohol use) and sleep problems (insomnia, self-reported short sleep duration, increased number of sleep episodes, increased sleep duration variability and diurnal inactivity) and measures of circadian-related activity (L5, M10 and sleep midpoint). Latent causal variable analyses determined that horizontal pleiotropy (rather than genetic causality) underlies a majority of the associations between substance use and sleep/circadian related measures, except one plausible genetically causal relationship for opioid use disorder on self-reported long sleep duration. Results show that shared genetics are likely a mechanism that is at least partly responsible for the overlap between sleep and substance use traits.
    MeSH term(s) Alcohol Drinking/genetics ; Genome-Wide Association Study ; Humans ; Opioid-Related Disorders ; Phenotype ; Sleep/genetics ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/genetics
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1324314-7
    ISSN 1369-1600 ; 1355-6215
    ISSN (online) 1369-1600
    ISSN 1355-6215
    DOI 10.1111/adb.13184
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    Zs.A 4586: Show issues Location:
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  5. Article ; Online: Substance use and common contributors to morbidity: A genetics perspective.

    Sanchez-Roige, Sandra / Kember, Rachel L / Agrawal, Arpana

    EBioMedicine

    2022  Volume 83, Page(s) 104212

    Abstract: Excessive substance use and substance use disorders (SUDs) are common, serious and relapsing medical conditions. They frequently co-occur with other diseases that are leading contributors to disability worldwide. While heavy substance use may potentiate ... ...

    Abstract Excessive substance use and substance use disorders (SUDs) are common, serious and relapsing medical conditions. They frequently co-occur with other diseases that are leading contributors to disability worldwide. While heavy substance use may potentiate the course of some of these illnesses, there is accumulating evidence suggesting common genetic architectures. In this narrative review, we focus on four heritable medical conditions - cardiometabolic disease, chronic pain, depression and COVID-19, which are commonly overlapping with, but not necessarily a direct consequence of, SUDs. We find persuasive evidence of underlying genetic liability that predisposes to both SUDs and chronic pain, depression, and COVID-19. For cardiometabolic disease, there is greater support for a potential causal influence of problematic substance use. Our review encourages de-stigmatization of SUDs and the assessment of substance use in clinical settings. We assert that identifying shared pathways of risk has high translational potential, allowing tailoring of treatments for multiple medical conditions. FUNDING: SSR acknowledges T29KT0526, T32IR5226 and DP1DA054394; RLK acknowledges AA028292; AA acknowledges DA054869 & K02DA032573. The funders had no role in the conceptualization or writing of the paper.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/genetics ; Cardiovascular Diseases/complications ; Chronic Pain/etiology ; Chronic Pain/genetics ; Comorbidity ; Humans ; Morbidity ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/genetics
    Language English
    Publishing date 2022-08-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104212
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  6. Article ; Online: Substance use and common contributors to morbidity

    Sandra Sanchez-Roige / Rachel L. Kember / Arpana Agrawal

    EBioMedicine, Vol 83, Iss , Pp 104212- (2022)

    A genetics perspective

    2022  

    Abstract: Summary: Excessive substance use and substance use disorders (SUDs) are common, serious and relapsing medical conditions. They frequently co-occur with other diseases that are leading contributors to disability worldwide. While heavy substance use may ... ...

    Abstract Summary: Excessive substance use and substance use disorders (SUDs) are common, serious and relapsing medical conditions. They frequently co-occur with other diseases that are leading contributors to disability worldwide. While heavy substance use may potentiate the course of some of these illnesses, there is accumulating evidence suggesting common genetic architectures. In this narrative review, we focus on four heritable medical conditions - cardiometabolic disease, chronic pain, depression and COVID-19, which are commonly overlapping with, but not necessarily a direct consequence of, SUDs. We find persuasive evidence of underlying genetic liability that predisposes to both SUDs and chronic pain, depression, and COVID-19. For cardiometabolic disease, there is greater support for a potential causal influence of problematic substance use. Our review encourages de-stigmatization of SUDs and the assessment of substance use in clinical settings. We assert that identifying shared pathways of risk has high translational potential, allowing tailoring of treatments for multiple medical conditions. Funding: SSR acknowledges T29KT0526, T32IR5226 and DP1DA054394; RLK acknowledges AA028292; AA acknowledges DA054869 & K02DA032573. The funders had no role in the conceptualization or writing of the paper.
    Keywords Substance use ; Comorbidity ; Psychiatric ; Medical ; Genomics research ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Neuroanatomical variability associated with early substance use initiation: Results from the ABCD Study.

    Miller, Alex P / Baranger, David A A / Paul, Sarah E / Garavan, Hugh / Mackey, Scott / Tapert, Susan F / LeBlanc, Kimberly H / Agrawal, Arpana / Bogdan, Ryan

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: The extent to which neuroanatomical variability associated with substance involvement reflects pre-existing risk and/or consequences of substance exposure remains poorly understood. In the Adolescent Brain Cognitive ... ...

    Abstract The extent to which neuroanatomical variability associated with substance involvement reflects pre-existing risk and/or consequences of substance exposure remains poorly understood. In the Adolescent Brain Cognitive Development
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.06.24303876
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  8. Article ; Online: The Genetically Informed Neurobiology of Addiction (GINA) model.

    Bogdan, Ryan / Hatoum, Alexander S / Johnson, Emma C / Agrawal, Arpana

    Nature reviews. Neuroscience

    2022  Volume 24, Issue 1, Page(s) 40–57

    Abstract: Addictions are heritable and unfold dynamically across the lifespan. One prominent neurobiological theory proposes that substance-induced changes in neural circuitry promote the progression of addiction. Genome-wide association studies have begun to ... ...

    Abstract Addictions are heritable and unfold dynamically across the lifespan. One prominent neurobiological theory proposes that substance-induced changes in neural circuitry promote the progression of addiction. Genome-wide association studies have begun to characterize the polygenic architecture undergirding addiction liability and revealed that genetic loci associated with risk can be divided into those associated with a general broad-spectrum liability to addiction and those associated with drug-specific addiction risk. In this Perspective, we integrate these genomic findings with our current understanding of the neurobiology of addiction to propose a new Genetically Informed Neurobiology of Addiction (GINA) model.
    MeSH term(s) Humans ; Genome-Wide Association Study ; Behavior, Addictive/genetics ; Neurobiology ; Substance-Related Disorders/genetics
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-022-00656-8
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    Zs.A 5473: Show issues Location:
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  9. Article ; Online: Shared and unique heritability of hippocampal subregion volumes in children and adults.

    Pine, Jacob G / Agrawal, Arpana / Bogdan, Ryan / Kandala, Sridhar / Cooper, Shelly / Barch, Deanna M

    NeuroImage

    2023  Volume 285, Page(s) 120471

    Abstract: Behavioral genetic analyses have not demonstrated robust, unique, genetic correlates of hippocampal subregion volume. Genetic differentiation of hippocampal longitudinal axis subregion volume has not yet been investigated in population-based samples, ... ...

    Abstract Behavioral genetic analyses have not demonstrated robust, unique, genetic correlates of hippocampal subregion volume. Genetic differentiation of hippocampal longitudinal axis subregion volume has not yet been investigated in population-based samples, although this has been demonstrated in rodent and post-mortem human tissue work. The following study is the first population-based investigation of genetic factors that contribute to gray matter volume along the hippocampal longitudinal axis. Twin-based biometric analyses demonstrated that longitudinal axis subregions are associated with significant, unique, genetic variance, and that longitudinal axis subregions are also associated with significant shared, hippocampus-general, genetic factors. Our study's findings suggest that genetic differences in hippocampal longitudinal axis structure can be detected in individual differences in gray matter volume in population-level research designs.
    MeSH term(s) Adult ; Child ; Humans ; Magnetic Resonance Imaging ; Hippocampus/diagnostic imaging ; Cerebral Cortex ; Gray Matter/diagnostic imaging ; Twins/genetics
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2023.120471
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  10. Article ; Online: Characteristics Associated With Cannabis Use Initiation by Late Childhood and Early Adolescence in the Adolescent Brain Cognitive Development (ABCD) Study.

    Miller, Alex P / Baranger, David A A / Paul, Sarah E / Hatoum, Alexander S / Rogers, Cynthia / Bogdan, Ryan / Agrawal, Arpana

    JAMA pediatrics

    2023  Volume 177, Issue 8, Page(s) 861–863

    MeSH term(s) Humans ; Child ; Adolescent ; Cannabis ; Marijuana Smoking/adverse effects ; Brain ; Cognition ; Longitudinal Studies
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.1801
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