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Article ; Online: Construction of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides and derivatives.

Yang, Zuguang / Wei, Guangming / Chen, Zhengkai / Wu, Xiao-Feng

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 33, Page(s) 4872–4890

Abstract: Recent advances in the direct synthesis of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides (TFAICs) and derivatives, including trifluoroacetimidohydrazides (TFAIHs) and ... ...

Abstract	Recent advances in the direct synthesis of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides (TFAICs) and derivatives, including trifluoroacetimidohydrazides (TFAIHs) and CF
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc00836c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Divergent Synthesis of Trifluoromethyl-Substituted 1,2-Dihydroquinoxalines and Diimines by Cascade Reactions of CF

Wei, Guangming / Zheng, Dongling / Li, Chen / Chen, Zhengkai / Wu, Xiao-Feng

Organic letters

2023 Volume 25, Issue 38, Page(s) 7046–7050

Abstract: A base-mediated cascade reaction of ... ...

Abstract	A base-mediated cascade reaction of CF
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c02718
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Differences in Bacterial Communities of Retail Raw Pork in Different Market Types in Hangzhou, China.

Wang, Wen / Yi, Zhengkai / Cai, Wei / Ma, Jiele / Yang, Hua / Zhou, Min / Xiao, Xingning

Foods (Basel, Switzerland)

2023 Volume 12, Issue 18

Abstract: Pork is widely consumed globally, and pigs' microbiota can potentially harbor foodborne pathogens. Contaminated pork in retail markets poses significant implications for food quality and safety. However, limited studies have compared pork microbiomes in ... ...

Abstract	Pork is widely consumed globally, and pigs' microbiota can potentially harbor foodborne pathogens. Contaminated pork in retail markets poses significant implications for food quality and safety. However, limited studies have compared pork microbiomes in various marketing environments. In this study, we utilized traditional microbial culture methods and high-throughput 16S rRNA sequencing to assess pathogen contamination and bacterial diversity in raw pork samples purchased from farmers' markets and two types of supermarkets (upscale and ordinary) in Hangzhou, China. Traditional microbial plate cultures identified
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12183357
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Article ; Online: Exploring Self-Healing and Switchable Adhesives based on Multi-Level Dynamic Stable Structure.

Xu, Hualiang / Zhao, Shiwei / Yuan, Anqian / Zhao, Youlong / Wu, Xudong / Wei, Zhengkai / Lei, Jingxin / Jiang, Liang

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 26, Page(s) e2300626

Abstract: It is a challenge to develop adhesives simultaneously capable of strong adhesion and efficient switchable ability. Herein, the authors report multifunctional switchable adhesives named ... ...

Abstract	It is a challenge to develop adhesives simultaneously capable of strong adhesion and efficient switchable ability. Herein, the authors report multifunctional switchable adhesives named Cu
Language	English
Publishing date	2023-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202300626
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Article: Preoperative prognostic nutritional index associated with anastomotic leakage in colorectal cancer patients after surgery.

Wei, Haotang / Wang, Jialei / Jiang, Zhengkai / Liu, Yu / Jiang, Sheng / Hu, Bangli

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2023 Volume 33, Issue 4, Page(s) 351–359

Abstract: Background: Anastomotic leakage (AL) is a severe complication of colorectal cancer (CRC) surgery and is associated with the immune and nutritional status.: Objectives: This study aimed to investigate the role of the prognostic nutritional index (PNI) ...

Abstract	Background: Anastomotic leakage (AL) is a severe complication of colorectal cancer (CRC) surgery and is associated with the immune and nutritional status. Objectives: This study aimed to investigate the role of the prognostic nutritional index (PNI) in AL in CRC patients after surgery. Material and methods: A retrospective case-control study was designed in a single center. The clinicopathological features and preoperative laboratory data of 124 CRC patients and 120 non-cancer patients who underwent surgery were collected and examined. Among the CRC patients, 24 had AL. Results: Nutritional indicators were lower in CRC patients than in non-cancer patients (p < 0.05), but the clinical parameters analysis showed that only metastasis (M) stage, albumin, carcinoembryonic antigen (CEA), CA153, and PNI were associated with AL in CRC after surgery (p < 0.05). Prognostic nutritional index had a moderate predictive value for AL, with an area under the curve (AUC) of 0.625. Using the median value as a cutoff point, a high PNI was associated with a longer survival time in CRC patients (p = 0.033), and AL showed marginal significance (p = 0.048). The nomogram showed that PNI has a better prognostic value than tumor-node-metastasis (TNM) staging in CRC patients who underwent surgery. Conclusions: Prognostic nutritional index is a useful supplement for predicting AL in CRC patients after colorectal surgery. It also helps predict the prognosis of CRC patients.
MeSH term(s)	Humans ; Male ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/pathology ; Female ; Anastomotic Leak/etiology ; Middle Aged ; Nutrition Assessment ; Retrospective Studies ; Aged ; Prognosis ; Case-Control Studies ; Nutritional Status ; Adult ; Risk Factors
Language	English
Publishing date	2023-08-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/169495
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Zs.A 6489: Show issues

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Article ; Online: Gliotoxin elicits immunotoxicity in the early innate immune system of ducks.

Wei, Zhengkai / Jin, Qinqin / Liu, Wei / Liu, Tingting / He, Kaifeng / Jin, Zha / Chen, Meiyi / Jiang, Yuqian / Qian, Yuxiao / Hong, Hongrong / Zhang, Dezhi / Liu, Quan / Yang, Zhengtao / Li, Qianyong

Poultry science

2024 Volume 103, Issue 6, Page(s) 103717

Abstract: Gliotoxin (GT) belongs to the epipolythiodioxopiperazine (ETP) family, which is considered a crucial virulence determinant among the secondary metabolites produced by Aspergillus fumigatus. The metabolites are commonly found in food and feed, ... ...

Abstract	Gliotoxin (GT) belongs to the epipolythiodioxopiperazine (ETP) family, which is considered a crucial virulence determinant among the secondary metabolites produced by Aspergillus fumigatus. The metabolites are commonly found in food and feed, contributing to the invasion and immune escape of Aspergillus fumigatus, thereby posing a significant threat to the health of livestock, poultry, and humans. Heterophil extracellular traps (HETs), a novel form of innate immune defense, have been documented in the chicken's innate immune systems for capturing and eliminating invading microbes. However, the effects and mechanisms of GT on the production of duck HETs in vitro remain unknown. In this study, we first confirmed the presence of HETs in duck innate immune systems and further investigated the molecular mechanism underlying GT-induced HETs release. Our results demonstrate that GT can trigger typical release of HETs in duck. The structures of GT-induced HETs structures were characterized by DNA decoration, citrullinated histones 3, and elastase. Furthermore, NADPH oxidase, glycolysis, ERK
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2024.103717
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Zs.B 853: Show issues

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Article ; Online: Radical selenylative cyclization of trifluoromethyl propargyl imines for the synthesis of trifluoromethyl- and seleno-azaspiro[4,5]-tetraenones and quinolines.

Wei, Guangming / Zhang, Jiajun / Wang, Haoyuan / Chen, Zhengkai / Wu, Xiao-Feng

Organic & biomolecular chemistry

2022

Abstract: A radical selenylative cyclization of trifluoromethyl propargyl imines with diselenides for the regiodivergent construction of diversely functionalized azaspiro[4,5]-tetraenones and quinolines has been developed, which enables dual incorporation of ... ...

Abstract	A radical selenylative cyclization of trifluoromethyl propargyl imines with diselenides for the regiodivergent construction of diversely functionalized azaspiro[4,5]-tetraenones and quinolines has been developed, which enables dual incorporation of CF
Language	English
Publishing date	2022-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob02033e
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Article ; Online: Response mechanism and rapid detection of phenotypic information in rice root under heavy metal stress.

Wang, Wei / Man, Zun / Li, Xiaolong / Chen, Rongqin / You, Zhengkai / Pan, Tiantian / Dai, Xiaorong / Xiao, Hang / Liu, Fei

Journal of hazardous materials

2023 Volume 449, Page(s) 131010

Abstract: The root is an important organ affecting cadmium accumulation in grains, but there is no comprehensive research involving rice root phenotype under cadmium stress yet. To assess the effect of cadmium on root phenotypes, this paper investigated the ... ...

Abstract	The root is an important organ affecting cadmium accumulation in grains, but there is no comprehensive research involving rice root phenotype under cadmium stress yet. To assess the effect of cadmium on root phenotypes, this paper investigated the response mechanism of phenotypic information including cadmium accumulation, adversity physiology, morphological parameters, and microstructure characteristics, and explored rapid detection methods of cadmium accumulation and adversity physiology. We found that cadmium had the effect of "low-promotion and high-inhibition" on root phenotypes. In addition, the rapid detection of cadmium (Cd), soluble protein (SP), and malondialdehyde (MDA) were achieved based on spectroscopic technology and chemometrics, where the optimal prediction model was least squares support vector machine (LS-SVM) based on the full spectrum (R
MeSH term(s)	Oryza/metabolism ; Cadmium/metabolism ; Spectrum Analysis ; Phenotype ; Least-Squares Analysis
Chemical Substances	Cadmium (00BH33GNGH)
Language	English
Publishing date	2023-02-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.131010
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Article ; Online: Toxoplasma gondii triggers heterophil extracellular traps via NADPH oxidase, ERK

Chen, Meiyi / Jin, Zha / Jin, Qinqin / Liu, Wei / Gao, Xinxin / Hong, Hongrong / Qian, Yuxiao / Jiang, Yuqian / Liu, Quan / Wei, Zhengkai

Parasite immunology

2023 Volume 45, Issue 8, Page(s) e13001

Abstract: Toxoplasma gondii is a zoonotic parasite with a global distribution. Heterophil extracellular traps (HETs) are a novel innate immune mechanism of chickens against pathogens, but whether T. gondii can induce HETs release in chickens has not been reported. ...

Abstract	Toxoplasma gondii is a zoonotic parasite with a global distribution. Heterophil extracellular traps (HETs) are a novel innate immune mechanism of chickens against pathogens, but whether T. gondii can induce HETs release in chickens has not been reported. The effects of T. gondii on heterophils viability were assessed by using Cell Counting Kit-8. T. gondii-induced HETs were observed and analysed by the immunofluorescence method. T. gondii-induced reactive oxygen species (ROS) was determined by the DCFH-DA method. The mechanisms underlying T. gondii-triggered HETs were investigated by inhibitors and fluorescence microplate reader. T. gondii did not significantly affect heterophils viability at a 1:1 ratio within 1 h. It was demonstrated for the first time that T. gondii could induce HETs release in chicken, and the structure of HETs was comprised of DNA, elastase and citrullinated histone 3 (citH3). T. gondii increased ROS production in a dose-dependent manner. Inhibitors of NADPH oxidase, extracellular signal-regulated kinase 1/2 (ERK
MeSH term(s)	Animals ; Extracellular Traps ; Toxoplasma ; Chickens ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism ; Autophagy ; Glycolysis
Chemical Substances	NADPH Oxidases (EC 1.6.3.-) ; Reactive Oxygen Species
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424444-8
ISSN	1365-3024 ; 0141-9838
ISSN (online)	1365-3024
ISSN	0141-9838
DOI	10.1111/pim.13001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1509: Show issues

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Article ; Online: Molecular Characterization of Anaplasma , Ehrlichia, Babesia , and Borrelia in Ticks from Guangdong Province of Southern China

Li Zhang / Zhengkai Wei / Li Ding / Jiaming Hou / Jianhui Zhang / Bohan Zhang / Jun Ma / Mingxin Song / Quan Liu

Zoonoses, Vol 3, Iss 1, p

2023 Volume 969

Abstract: Tick-borne pathogens have become emerging global health threats in humans and animals. The objective of the present study was to investigate Anaplasma, Ehrlichia, Babesia , and Borrelia in ticks in southern China. Ticks were collected from animals and ... ...

Abstract	Tick-borne pathogens have become emerging global health threats in humans and animals. The objective of the present study was to investigate Anaplasma, Ehrlichia, Babesia , and Borrelia in ticks in southern China. Ticks were collected from animals and identified to the species level. Tick-borne Anaplasma , Ehrlichia , Babesia , and Borrelia were tested by PCR assays, and analyzed by sequencing and phylogenetics. We collected 747 ticks, including Rhipicephalus microplus (n=225) and R. sanguineus (n=522), from pet dogs in Guangdong Province of southern China. Using PCR and phylogenetic analysis we showed that these ticks carried Anaplasma platys , Ehrlichia canis , Borrelia miyamotoi , Babesia vogeli , and an unclassified Ehrlichia species in Rhipicephalus ticks. Of these pathogens, B. miyamotoi was first found in southern China. A. platys , E. canis , and B. miyamotoi were zoonotic pathogens that infected both R. microplus and R. sanguineus , whereas Ba. vogeli only infected R. sanguineus , with a prevalence of 0.3%-1.5%. The results of this study showed diversity and complexity of tick-borne pathogens in Guangdong Province of southern China, implying the importance of tick-borne pathogen surveillance and control.
Keywords	Infectious and parasitic diseases ; RC109-216 ; Veterinary medicine ; SF600-1100
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Compuscript Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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