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Article ; Online: Behçet's disease: A (silk) route to atrial fibrillation?

Suryavanshi, Santosh V / Li, Na

2019 Volume 293, Page(s) 117–118

MeSH term(s)	Atrial Fibrillation ; Behcet Syndrome ; Humans ; Silk
Chemical Substances	Silk
Language	English
Publishing date	2019-07-19
Publishing country	Netherlands
Document type	Editorial ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2019.07.059
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Zs.A 1673: Show issues

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Article ; Online: The Anti-Inflammatory Effects of

Zaiachuk, Mariia / Suryavanshi, Santosh V / Pryimak, Nazar / Kovalchuk, Igor / Kovalchuk, Olga

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 13

Abstract: Inflammation is the response of the innate immune system to any type of injury. Although acute inflammation is critical for survival, dysregulation of the innate immune response leads to chronic inflammation. Many synthetic anti-inflammatory drugs have ... ...

Abstract	Inflammation is the response of the innate immune system to any type of injury. Although acute inflammation is critical for survival, dysregulation of the innate immune response leads to chronic inflammation. Many synthetic anti-inflammatory drugs have side effects, and thus, natural anti-inflammatory compounds are still needed.
MeSH term(s)	Humans ; Anti-Inflammatory Agents/pharmacology ; Cannabidiol/analysis ; Cannabinoid Receptor Agonists ; Cannabinoids/pharmacology ; Cannabinoids/therapeutic use ; Cannabis ; Cytokines ; Hallucinogens ; Inflammation/chemically induced ; Inflammation/drug therapy ; Interleukin-6 ; Lipopolysaccharides/toxicity ; Macrophages ; Plant Extracts/pharmacology
Chemical Substances	Anti-Inflammatory Agents ; Cannabidiol (19GBJ60SN5) ; Cannabinoid Receptor Agonists ; Cannabinoids ; Cytokines ; Hallucinogens ; Interleukin-6 ; Lipopolysaccharides ; Plant Extracts
Language	English
Publishing date	2023-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28134991
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Article ; Online: Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective.

Suryavanshi, Santosh V / Kovalchuk, Igor / Kovalchuk, Olga

Frontiers in immunology

2021 Volume 11, Page(s) 613613

Abstract: Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect microbial materials, sterile inflammatory insults, and certain host-derived elements. Inflammasomes, once activated, promote caspase-1-mediated maturation and secretion of ...

Abstract	Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect microbial materials, sterile inflammatory insults, and certain host-derived elements. Inflammasomes, once activated, promote caspase-1-mediated maturation and secretion of pro-inflammatory cytokines, interleukin (IL)-1β and IL-18, leading to pyroptosis. Current advances in inflammasome research support their involvement in the development of chronic inflammatory disorders in contrast to their role in regulating innate immunity. Cannabis (marijuana) is a natural product obtained from the
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; COVID-19/immunology ; Cannabinoids/pharmacology ; Humans ; Inflammasomes/drug effects ; Inflammasomes/immunology ; SARS-CoV-2
Chemical Substances	Anti-Inflammatory Agents ; Cannabinoids ; Inflammasomes
Language	English
Publishing date	2021-01-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.613613
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Article ; Online: The Anti-Inflammatory Effects of Cannabis sativa Extracts on LPS-Induced Cytokines Release in Human Macrophages

Mariia Zaiachuk / Santosh V. Suryavanshi / Nazar Pryimak / Igor Kovalchuk / Olga Kovalchuk

Molecules, Vol 28, Iss 4991, p

2023 Volume 4991

Abstract	Inflammation is the response of the innate immune system to any type of injury. Although acute inflammation is critical for survival, dysregulation of the innate immune response leads to chronic inflammation. Many synthetic anti-inflammatory drugs have side effects, and thus, natural anti-inflammatory compounds are still needed. Cannabis sativa L. may provide a good source of anti-inflammatory molecules. Here, we tested the anti-inflammatory properties of cannabis extracts and pure cannabinoids in lipopolysaccharide (LPS)-induced inflammation in human THP-1 macrophages. We found that pre-treatment with cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), or extracts containing high levels of CBD or THC reduced the level of induction of various cytokines. The CBD was more efficient than THC, and the extracts were more efficient than pure cannabinoids. Finally, IL-6, IL-10, and MCP-1 cytokines were most sensitive to pre-treatments with CBD and THC, while IL-1β, IL-8, and TNF-α were less responsive. Thus, our work demonstrates the potential of the use of cannabinoids or/and cannabis extracts for the reduction of inflammation and establishes IL-6 and MCP-1 as the sensitive markers for the analysis of the effect of cannabinoids on inflammation in macrophages.
Keywords	cannabidiol ; cannabis ; inflammation ; lipopolysaccharide ; macrophages ; tetrahydrocannabinol ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro.

Suryavanshi, Santosh V / Zaiachuk, Mariia / Pryimak, Nazar / Kovalchuk, Igor / Kovalchuk, Olga

Cells

2022 Volume 11, Issue 9

Abstract: Cannabinoids, mainly cannabidiol (CBD) and ... ...

Abstract	Cannabinoids, mainly cannabidiol (CBD) and Δ
MeSH term(s)	COVID-19 ; Cannabidiol/pharmacology ; Cannabinoids/pharmacology ; Cytokine Release Syndrome ; Cytokines/metabolism ; Dronabinol/pharmacology ; Humans ; Inflammasomes/metabolism ; Lipopolysaccharides/pharmacology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; TYK2 Kinase/metabolism ; TYK2 Kinase/pharmacology
Chemical Substances	Cannabinoids ; Cytokines ; Inflammasomes ; Lipopolysaccharides ; NLR Family, Pyrin Domain-Containing 3 Protein ; STAT3 Transcription Factor ; STAT3 protein, human ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S) ; TYK2 Kinase (EC 2.7.10.2) ; TYK2 protein, human (EC 2.7.10.2)
Language	English
Publishing date	2022-04-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11091391
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Article ; Online: Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro

Santosh V. Suryavanshi / Mariia Zaiachuk / Nazar Pryimak / Igor Kovalchuk / Olga Kovalchuk

Cells, Vol 11, Iss 1391, p

2022 Volume 1391

Abstract: Cannabinoids, mainly cannabidiol (CBD) and Δ 9 -tetrahydrocannabinol (THC), are the most studied group of compounds obtained from Cannabis sativa because of their several pharmaceutical properties. Current evidence suggests a crucial role of cannabinoids ...

Abstract	Cannabinoids, mainly cannabidiol (CBD) and Δ 9 -tetrahydrocannabinol (THC), are the most studied group of compounds obtained from Cannabis sativa because of their several pharmaceutical properties. Current evidence suggests a crucial role of cannabinoids as potent anti-inflammatory agents for the treatment of chronic inflammatory diseases; however, the mechanisms remain largely unclear. Cytokine storm, a dysregulated severe inflammatory response by our immune system, is involved in the pathogenesis of numerous chronic inflammatory disorders, including coronavirus disease 2019 (COVID-19), which results in the accumulation of pro-inflammatory cytokines. Therefore, we hypothesized that CBD and THC reduce the levels of pro-inflammatory cytokines by inhibiting key inflammatory signaling pathways. The nucleotide-binding and oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome signaling has been implicated in a variety of chronic inflammatory diseases, which results in the release of pyroptotic cytokines, interleukin-1β (IL-1β) and IL-18. Likewise, the activation of the signal transducer and activator of transcription-3 (STAT3) causes increased expression of pro-inflammatory cytokines. We studied the effects of CBD and THC on lipopolysaccharide (LPS)-induced inflammatory response in human THP-1 macrophages and primary human bronchial epithelial cells (HBECs). Our results revealed that CBD and, for the first time, THC significantly inhibited NLRP3 inflammasome activation following LPS + ATP stimulation, leading to a reduction in the levels of IL-1β in THP-1 macrophages and HBECs. CBD attenuated the phosphorylation of nuclear factor-κB (NF-κB), and both cannabinoids inhibited the generation of oxidative stress post-LPS. Our multiplex ELISA data revealed that CBD and THC significantly diminished the levels of IL-6, IL-8, and tumor necrosis factor-α (TNF-α) after LPS treatment in THP-1 macrophages and HBECs. In addition, the phosphorylation of STAT3 was significantly ...
Keywords	delta-9-tetrahydrocannabinol ; cannabidiol ; cannabinoids ; NLRP3 inflammasome ; STAT3 ; TYK2 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System.

Suryavanshi, Santosh V / Jadhav, Shweta M / McConnell, Bradley K

Journal of cardiovascular development and disease

2018 Volume 5, Issue 1

Abstract: A-kinase anchoring proteins (AKAPs) belong to a family of scaffolding proteins that bind to protein kinase A (PKA) by definition and a variety of crucial proteins, including kinases, phosphatases, and phosphodiesterases. By scaffolding these proteins ... ...

Abstract	A-kinase anchoring proteins (AKAPs) belong to a family of scaffolding proteins that bind to protein kinase A (PKA) by definition and a variety of crucial proteins, including kinases, phosphatases, and phosphodiesterases. By scaffolding these proteins together, AKAPs build a "signalosome" at specific subcellular locations and compartmentalize PKA signaling. Thus, AKAPs are important for signal transduction after upstream activation of receptors ensuring accuracy and precision of intracellular PKA-dependent signaling pathways. Since their discovery in the 1980s, AKAPs have been studied extensively in the heart and have been proven essential in mediating cyclic adenosine monophosphate (cAMP)-PKA signaling. Although expression of AKAPs in the heart is very low, cardiac-specific knock-outs of several AKAPs have a noteworthy cardiac phenotype. Moreover, single nucleotide polymorphisms and genetic mutations in crucial cardiac proteins play a substantial role in the pathophysiology of cardiovascular diseases (CVDs). Despite the significant role of AKAPs in the cardiovascular system, a limited amount of research has focused on the role of genetic polymorphisms and/or mutations in AKAPs in increasing the risk of CVDs. This review attempts to overview the available literature on the polymorphisms/mutations in AKAPs and their effects on human health with a special focus on CVDs.
Language	English
Publishing date	2018-01-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd5010007
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Article ; Online: An efficient Sn(ii)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework.

Chavan, Santosh S / Supekar, Mrudul V / Burate, Pralhad A / Rupanwar, Bapurao D / Shelke, Anil M / Suryavanshi, Gurunath

Organic & biomolecular chemistry

2017 Volume 15, Issue 11, Page(s) 2385–2391

Abstract: A novel Sn(ii)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. This protocol provides straightforward access to ... ...

Abstract	A novel Sn(ii)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. This protocol provides straightforward access to construct the azetidine core through sequential Knoevenagel condensation, hydration and the C-N cyclization reaction.
Language	English
Publishing date	2017-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/c7ob00294g
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Article ; Online: Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling.

Suryavanshi, Santosh V / Jadhav, Shweta M / Anderson, Kody L / Katsonis, Panagiotis / Lichtarge, Olivier / McConnell, Bradley K

American journal of physiology. Heart and circulatory physiology

2018 Volume 315, Issue 1, Page(s) H109–H121

Abstract: One of the crucial cardiac signaling pathways is cAMP-mediated PKA signal transduction, which is regulated by a family of scaffolding proteins, i.e., A-kinase anchoring proteins (AKAPs). Muscle-specific AKAP (mAKAP) partly regulates cardiac cAMP/PKA ... ...

Abstract	One of the crucial cardiac signaling pathways is cAMP-mediated PKA signal transduction, which is regulated by a family of scaffolding proteins, i.e., A-kinase anchoring proteins (AKAPs). Muscle-specific AKAP (mAKAP) partly regulates cardiac cAMP/PKA signaling by binding to PKA and phosphodiesterase 4D3 (PDE4D3), among other proteins, and plays a central role in modulating cardiac remodeling. Moreover, genetics plays an incomparable role in modifying the risk of cardiovascular diseases (CVDs). Single-nucleotide polymorphisms (SNPs) in various proteins have especially been shown to predispose individuals to CVDs. Hence, we hypothesized that human mAKAP polymorphisms found in humans with CVDs alter the cAMP/PKA pathway, influencing the susceptibility of individuals to CVDs. Our computational analyses revealed two mAKAP SNPs found in cardiac disease-related patients with the highest predicted deleterious effects, Ser 1653 Arg (S1653R) and Glu 2124 Gly (E2124G). Coimmunoprecipitation data in human embryonic kidney-293T cells showed that the S1653R SNP, present in the PDE4D3-binding domain of mAKAP, changed the binding of PDE4D3 to mAKAP and that the E2124G SNP, flanking the 3'-PKA binding domain, changed the binding of PKA before and after stimulation with isoproterenol. These SNPs significantly altered intracellular cAMP levels, global PKA activity, and cytosolic PDE activity compared with the wild type before and after isoproterenol stimulation. PKA-mediated phosphorylation of pathological markers was found to be upregulated after cell stimulation in both mutants. In conclusion, human mAKAP polymorphisms may influence the propensity of developing CVDs by affecting cAMP/PKA signaling, supporting the clinical significance of PKA-mAKAP-PDE4D3 interactions. NEW & NOTEWORTHY We found that single-nucleotide polymorphisms in muscle-specific A-kinase anchoring protein found in human patients with cardiovascular diseases significantly affect the cAMP/PKA signaling pathway. Our results showed, for the first time, that human muscle-specific A-kinase anchoring protein polymorphisms might alter the susceptibility of individuals to develop cardiovascular diseases with known underlying molecular mechanisms.
MeSH term(s)	A Kinase Anchor Proteins/chemistry ; A Kinase Anchor Proteins/genetics ; A Kinase Anchor Proteins/metabolism ; Binding Sites ; Cardiovascular Diseases/genetics ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; HEK293 Cells ; Humans ; Polymorphism, Single Nucleotide ; Protein Binding ; Signal Transduction
Chemical Substances	A Kinase Anchor Proteins ; AKAP6 protein, human ; Cyclic AMP (E0399OZS9N) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Cyclic Nucleotide Phosphodiesterases, Type 4 (EC 3.1.4.17) ; PDE4D protein, human (EC 3.1.4.17)
Language	English
Publishing date	2018-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00034.2018
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Uc I Zs.89: Show issues

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Article ; Online: Force development and intracellular Ca

Li, Zhitao / Singh, Sonal / Suryavanshi, Santosh V / Ding, Wengang / Shen, Xiaoxu / Wijaya, Cori S / Gao, Wei Dong / McConnell, Bradley K

European journal of pharmacology

2017 Volume 807, Page(s) 117–126

Abstract: Gravin (AKAP12) is an A-kinase-anchoring-protein that scaffolds protein kinase A (PKA), ... ...

Abstract	Gravin (AKAP12) is an A-kinase-anchoring-protein that scaffolds protein kinase A (PKA), β
MeSH term(s)	A Kinase Anchor Proteins/genetics ; Animals ; Biomechanical Phenomena ; Calcium/metabolism ; Cell Cycle Proteins/genetics ; Cytosol/metabolism ; Excitation Contraction Coupling/genetics ; Gene Expression Regulation/genetics ; Intracellular Space/metabolism ; Mechanical Phenomena ; Mice ; Mutation ; Myocardium/cytology ; Myocardium/metabolism ; Sarcoplasmic Reticulum/metabolism
Chemical Substances	A Kinase Anchor Proteins ; Akap12 protein, mouse ; Cell Cycle Proteins ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2017-07-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2017.04.020
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