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  1. Article ; Online: Peering Through the Haze of Smoked vs Vaporized Cannabis-To Vape or Not to Vape?

    Solowij, Nadia

    JAMA network open

    2018  Volume 1, Issue 7, Page(s) e184838

    MeSH term(s) Adult ; Cannabis ; Cross-Over Studies ; Humans ; Marijuana Smoking ; Smoke ; Vaping
    Chemical Substances Smoke
    Language English
    Publishing date 2018-11-02
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2018.4838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Cannabis and cognitive functioning

    Solowij, Nadia

    (International research monographs in the addiction)

    1998  

    Author's details Nadia Solowij
    Series title International research monographs in the addiction
    Language English
    Size XVI, 290 S.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT009056012
    ISBN 0-521-59114-7 ; 978-0-521-59114-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 6548 order for loan Magazin

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  3. Article ; Online: Parkin Mediates Cannabidiol Prevention of Amyloid-Beta-Induced Senescence in Human Astrocytes.

    Wang, Zhizhen / Zheng, Peng / Nagaratnam, Nathan / Solowij, Nadia / Huang, Xu-Feng

    Cannabis and cannabinoid research

    2023  Volume 8, Issue 2, Page(s) 309–320

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Animals ; Humans ; Cannabidiol/pharmacology ; Astrocytes/metabolism ; Astrocytes/pathology ; Reactive Oxygen Species/metabolism ; Reactive Oxygen Species/pharmacology ; Caenorhabditis elegans/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/pharmacology ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/pharmacology
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Reactive Oxygen Species ; Amyloid beta-Peptides ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2867624-5
    ISSN 2378-8763 ; 2578-5125
    ISSN (online) 2378-8763
    ISSN 2578-5125
    DOI 10.1089/can.2022.0186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Investigating the Residual Effects of Chronic Cannabis Use and Abstinence on Verbal and Visuospatial Learning.

    Lorenzetti, Valentina / Takagi, Michael / van Dalen, Yvonne / Yücel, Murat / Solowij, Nadia

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 663701

    Abstract: Rationale: ...

    Abstract Rationale:
    Language English
    Publishing date 2021-06-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.663701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Harms to body and soul--an ideological balancing act for preventing and reducing cannabis use.

    Solowij, Nadia

    Addiction (Abingdon, England)

    2010  Volume 105, Issue 8, Page(s) 1331–1332

    MeSH term(s) Humans ; Marijuana Smoking/adverse effects ; Marijuana Smoking/prevention & control ; Schizophrenia/etiology ; Nicotiana/adverse effects
    Language English
    Publishing date 2010-07-22
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/j.1360-0443.2010.02923.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 551: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The Endocannabinoid System and Cannabidiol's Promise for the Treatment of Substance Use Disorder.

    Chye, Yann / Christensen, Erynn / Solowij, Nadia / Yücel, Murat

    Frontiers in psychiatry

    2019  Volume 10, Page(s) 63

    Abstract: Substance use disorder is characterized by repeated use of a substance, leading to clinically significant distress, making it a serious public health concern. The endocannabinoid system plays an important role in common neurobiological processes ... ...

    Abstract Substance use disorder is characterized by repeated use of a substance, leading to clinically significant distress, making it a serious public health concern. The endocannabinoid system plays an important role in common neurobiological processes underlying substance use disorder, in particular by mediating the rewarding and motivational effects of substances and substance-related cues. In turn, a number of cannabinoid drugs (e.g., rimonabant, nabiximols) have been suggested for potential pharmacological treatment for substance dependence. Recently, cannabidiol (CBD), a non-psychoactive phytocannabinoid found in the cannabis plant, has also been proposed as a potentially effective treatment for the management of substance use disorder. Animal and human studies suggest that these cannabinoids have the potential to reduce craving and relapse in abstinent substance users, by impairing reconsolidation of drug-reward memory, salience of drug cues, and inhibiting the reward-facilitating effect of drugs. Such functions likely arise through the targeting of the endocannabinoid and serotonergic systems, although the exact mechanism is yet to be elucidated. This article seeks to review the role of the endocannabinoid system in substance use disorder and the proposed pharmacological action supporting cannabinoid drugs' therapeutic potential in addictions, with a focus on CBD. Subsequently, this article will evaluate the underlying evidence for CBD as a potential treatment for substance use disorder, across a range of substances including nicotine, alcohol, psychostimulants, opioids, and cannabis. While early research supports CBD's promise, further investigation and validation of CBD's efficacy, across preclinical and clinical trials will be necessary.
    Language English
    Publishing date 2019-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2019.00063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Daily Cannabidiol Administration for 10 Weeks Modulates Hippocampal and Amygdalar Resting-State Functional Connectivity in Cannabis Users: A Functional Magnetic Resonance Imaging Open-Label Clinical Trial.

    Lorenzetti, Valentina / McTavish, Eugene / Broyd, Samantha / van Hell, Hendrika / Thomson, Diny / Ganella, Eleni / Kottaram, Akhil Raja / Beale, Camilla / Martin, Jennifer / Galettis, Peter / Solowij, Nadia / Greenwood, Lisa-Marie

    Cannabis and cannabinoid research

    2023  

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2867624-5
    ISSN 2378-8763 ; 2578-5125
    ISSN (online) 2378-8763
    ISSN 2578-5125
    DOI 10.1089/can.2022.0336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity.

    Wang, Zhizhen / Zheng, Peng / Chen, Xi / Xie, Yuanyi / Weston-Green, Katrina / Solowij, Nadia / Chew, Yee Lian / Huang, Xu-Feng

    GeroScience

    2022  Volume 44, Issue 3, Page(s) 1505–1524

    Abstract: Autophagy is a catabolic process to eliminate defective cellular molecules via lysosome-mediated degradation. Dysfunctional autophagy is associated with accelerated aging, whereas stimulation of autophagy could have potent anti-aging effects. We report ... ...

    Abstract Autophagy is a catabolic process to eliminate defective cellular molecules via lysosome-mediated degradation. Dysfunctional autophagy is associated with accelerated aging, whereas stimulation of autophagy could have potent anti-aging effects. We report that cannabidiol (CBD), a natural compound from Cannabis sativa, extends lifespan and rescues age-associated physiological declines in C. elegans. CBD promoted autophagic flux in nerve-ring neurons visualized by a tandem-tagged LGG-1 reporter during aging in C. elegans. Similarly, CBD activated autophagic flux in hippocampal and SH-SY5Y neurons. Furthermore, CBD-mediated lifespan extension was dependent on autophagy genes (bec-1, vps-34, and sqst-1) confirmed by RNAi knockdown experiments. C. elegans neurons have previously been shown to accumulate aberrant morphologies, such as beading and blebbing, with increasing age. Interestingly, CBD treatment slowed the development of these features in anterior and posterior touch receptor neurons (TRN) during aging. RNAi knockdown experiments indicated that CBD-mediated age-associated morphological changes in TRNs require bec-1 and sqst-1, not vps-34. Further investigation demonstrated that CBD-induced lifespan extension and increased neuronal health require sir-2.1/SIRT1. These findings collectively indicate the anti-aging benefits of CBD treatment, in both in vitro and in vivo models, and its potential to improve neuronal health and longevity.
    MeSH term(s) Animals ; Autophagy/physiology ; Caenorhabditis elegans/genetics ; Cannabidiol/pharmacology ; Humans ; Longevity/physiology ; Neuroblastoma ; Neurons ; Sirtuin 1
    Chemical Substances Cannabidiol (19GBJ60SN5) ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-)
    Language English
    Publishing date 2022-04-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-022-00559-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Cannabis Dependence is Associated with Reduced Hippocampal Subregion Volumes Independently of Sex: Findings from an ENIGMA Addiction Working Group Multi-Country Study.

    Lorenzetti, Valentina / Gaillard, Alexandra / McTavish, Eugene / Grace, Sally / Rossetti, Maria Gloria / Batalla, Albert / Bellani, Marcella / Brambilla, Paolo / Chye, Yann / Conrod, Patricia / Cousijn, Janna / Labuschagne, Izelle / Clemente, Adam / Mackey, Scott / Rendell, Peter / Solowij, Nadia / Suo, Chao / Li, Chiang-Shan R / Terrett, Gill /
    Thompson, Paul M / Yücel, Murat / Garavan, Hugh / Roberts, Carl A

    Cannabis and cannabinoid research

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2867624-5
    ISSN 2378-8763 ; 2578-5125
    ISSN (online) 2378-8763
    ISSN 2578-5125
    DOI 10.1089/can.2023.0204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cannabis, Cannabinoids, and Brain Morphology: A Review of the Evidence.

    Chye, Yann / Kirkham, Rebecca / Lorenzetti, Valentina / McTavish, Eugene / Solowij, Nadia / Yücel, Murat

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2020  Volume 6, Issue 6, Page(s) 627–635

    Abstract: Cannabis and cannabinoid-based products are increasingly being accepted and commodified globally. Yet there is currently limited understanding of the effect of the varied cannabinoid compounds on the brain. Exogenous cannabinoids interact with the ... ...

    Abstract Cannabis and cannabinoid-based products are increasingly being accepted and commodified globally. Yet there is currently limited understanding of the effect of the varied cannabinoid compounds on the brain. Exogenous cannabinoids interact with the endogenous cannabinoid system that underpins vital functions in the brain and body, and they are thought to perturb key brain and cognitive function. However, much neuroimaging research has been confined to observational studies of cannabis users, without examining the specific role of the various cannabinoids (Δ
    MeSH term(s) Brain ; Cannabidiol ; Cannabinoids/pharmacology ; Cannabis ; Dronabinol ; Humans
    Chemical Substances Cannabinoids ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2020.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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