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Article ; Online: Cannabis in the Time of Coronavirus Disease 2019: The Yin and Yang of the Endocannabinoid System in Immunocompetence.

Sexton, Michelle

Journal of alternative and complementary medicine (New York, N.Y.)

2020 Volume 26, Issue 6, Page(s) 444–448

Abstract: Editor's Note: ...

Abstract	Editor's Note:
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/drug effects ; COVID-19 ; Cannabinoids/therapeutic use ; Coronavirus/drug effects ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Female ; Humans ; Immunocompetence/drug effects ; Immunocompromised Host ; Male ; Medical Marijuana/pharmacology ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; SARS-CoV-2
Chemical Substances	Cannabinoids ; Medical Marijuana
Keywords	covid19
Language	English
Publishing date	2020-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1237383-7
ISSN	1557-7708 ; 1075-5535
ISSN (online)	1557-7708
ISSN	1075-5535
DOI	10.1089/acm.2020.0144
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biphasic effects of cannabis and cannabinoid therapy on pain severity, anxiety and sleep disturbance: A scoping review.

Shustorovich, Alexander / Corroon, Jamie / Wallace, Mark S / Sexton, Michelle

Pain medicine (Malden, Mass.)

2024

Abstract: Introduction: Cannabinoids are being used by patients to help with chronic pain management and to address the two primary chronic pain comorbidities of anxiety and sleep disturbance. It is necessary to understand the biphasic effects of cannabinoids to ... ...

Abstract	Introduction: Cannabinoids are being used by patients to help with chronic pain management and to address the two primary chronic pain comorbidities of anxiety and sleep disturbance. It is necessary to understand the biphasic effects of cannabinoids to improve treatment of this symptom triad. Methods: A scoping review was conducted to identify whether biphasic effects of cannabinoids on pain severity, anxiolysis, and sleep disturbance have been reported. The search included Embase, Biosis and Medline databases of clinical literature published between 1970-2021. The inclusion criteria were: 1) adults over 18 years of age; 2) data or discussion of dose effects associated with u-shaped or linear dose responses and 3) measurements of pain and/or anxiety and/or sleep disturbance. Data were extracted by two independent reviewers (third reviewer used as a tiebreaker) and subjected to a thematic analysis. Results: After database search and study eligibility assessment, 44 publications met the final criteria for review. 18 publications that specifically provided information on dose response were included in the final synthesis: 9 related to pain outcomes, 7 measuring anxiety, and 2 reporting sleep effects. Conclusions: This scoping review reports on biphasic effects of cannabinoids related to pain, sleep, and anxiety. Dose response relationships are present, but we found gaps in the current literature for biphasic effects of cannabinoids in humans. There is a lack of prospective research in humans exploring this specific relationship.
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2015903-1
ISSN	1526-4637 ; 1526-2375
ISSN (online)	1526-4637
ISSN	1526-2375
DOI	10.1093/pm/pnae004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cannabis in the Time of Coronavirus Disease 2019: The Yin and Yang of the Endocannabinoid System in Immunocompetence

Sexton, Michelle

J Altern Complement Med

Abstract: ... Editorial Board member Michelle Sexton, ND starts by describing the multiple immune modulating effects ... for immune competency, in the context of the current COVID-19 pandemic?" A skilled edge-walker, Sexton lets the research ...

Abstract	Editor's Note: For those whose response to COVID-19 includes exploring beyond vaccines, conventional pharmaceuticals, and the watchful or healthy waiting until such tools might arrive, interest in cannabinoids has been high - and controversial. It has already stimulated one journal, the Liebert Cannabis and Cannabinoid Research, to issue a call for papers on COVID-19. The unique place of cannabis in the culture seems to always mark the herb with an exponential asterisk whenever basketed with the other natural health strategies that are both widely used, and as broadly derided. In this invited commentary, JACM Editorial Board member Michelle Sexton, ND starts by describing the multiple immune modulating effects associated with the herb. The University of California San Diego Assistant Adjunct Professor in Anesthesiology then asks: "Given these effects, can phytocannabinoids be either helpful, or harmful for immune competency, in the context of the current COVID-19 pandemic?" A skilled edge-walker, Sexton lets the research fall where it may in wending a path through this evidentiary maze. -John Weeks, Editor-in-Chief, JACM.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #209920
Database	COVID19

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Article ; Online: Posttraumatic cognitions about the self are associated with depression symptoms in veterans endorsing a history of assaultive military sexual trauma.

Fernando, Michelle / Schubert, Jessica R / Valentine, Lisa M / Koch, Ellen I / Sexton, Minden B

Psychological services

2024

Abstract: Depressive symptoms are a commonly observed yet understudied mental health sequalae of military sexual trauma (MST). Prior research supports the relationship between negative posttraumatic cognitions (NPCs) and the onset and course of trauma symptoms ... ...

Abstract	Depressive symptoms are a commonly observed yet understudied mental health sequalae of military sexual trauma (MST). Prior research supports the relationship between negative posttraumatic cognitions (NPCs) and the onset and course of trauma symptoms more broadly. We hypothesized that NPCs would be associated with depression symptoms in veterans endorsing a history of MST, specifically assaultive type MST. Our clinical sample included veterans presenting for treatment related to assaultive MST (
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2156662-8
ISSN	1939-148X ; 1541-1559
ISSN (online)	1939-148X
ISSN	1541-1559
DOI	10.1037/ser0000850
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Medical Cannabis: A New

Kogan, Mikhail / Sexton, Michelle

Journal of alternative and complementary medicine (New York, N.Y.)

2020 Volume 26, Issue 9, Page(s) 776–778

MeSH term(s)	Cannabis ; Humans ; Integrative Medicine ; Medical Marijuana/therapeutic use ; Palliative Care ; Palliative Medicine ; Phytotherapy ; Plant Extracts/therapeutic use
Chemical Substances	Medical Marijuana ; Plant Extracts
Language	English
Publishing date	2020-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1237383-7
ISSN	1557-7708 ; 1075-5535
ISSN (online)	1557-7708
ISSN	1075-5535
DOI	10.1089/acm.2019.0184
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4366: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Vaporized Cannabis versus Placebo for Acute Migraine: A Randomized Controlled Trial.

Schuster, Nathaniel M / Wallace, Mark S / Marcotte, Thomas D / Buse, Dawn C / Lee, Euyhyun / Liu, Lin / Sexton, Michelle

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Preclinical and retrospective studies suggest cannabinoids may be effective in migraine treatment. However, there have been no randomized clinical trials examining the efficacy of cannabinoids for acute migraine.: Methods: In this ... ...

Abstract	Background: Preclinical and retrospective studies suggest cannabinoids may be effective in migraine treatment. However, there have been no randomized clinical trials examining the efficacy of cannabinoids for acute migraine. Methods: In this randomized, double-blind, placebo-controlled, crossover trial, adults with migraine treated up to 4 separate migraine attacks, 1 each with vaporized 1) 6% Δ9-tetrahydrocannabinol (THC-dominant); 2) 11% cannabidiol (CBD-dominant); 3) 6% THC+11% CBD; and 4) placebo cannabis flower in a randomized order. Washout period between treated attack was ≥1 week. The primary endpoint was pain relief and secondary endpoints were pain freedom and most bothersome symptom (MBS) freedom, all assessed at 2 hours post-vaporization. Results: Ninety-two participants were enrolled and randomized, and 247 migraine attacks were treated. THC+CBD was superior to placebo at achieving pain relief (67.2% vs 46.6%, Odds Ratio [95% Confidence Interval] 2.85 [1.22, 6.65], p=0.016), pain freedom (34.5% vs. 15.5%, 3.30 [1.24, 8.80], p=0.017) and MBS freedom (60.3% vs. 34.5%, 3.32 [1.45, 7.64], p=0.005) at 2 hours, as well as sustained pain freedom at 24 hours and sustained MBS freedom at 24 and 48 hours. THC-dominant was superior to placebo for pain relief (68.9% vs. 46.6%, 3.14 [1.35, 7.30], p=0.008) but not pain freedom or MBS freedom at 2 hours. CBD-dominant was not superior to placebo for pain relief, pain freedom or MBS freedom at 2 hours. There were no serious adverse events. Conclusions: Acute migraine treatment with 6% THC+11% CBD was superior to placebo at 2 hours post-treatment with sustained benefits at 24 and 48 hours.
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.16.24302843
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differential Associations Between Posttraumatic Cognitions, Posttraumatic Stress Disorder Symptoms, and Race Among Black and White Veterans Seeking Treatment for Assaultive Military Sexual Trauma.

Fernando, Michelle / Tu, Joseph W / Grau, Peter P / Koch, Ellen I / Blevins, Emily J / Jefferson, Stephen / Sexton, Minden B

Journal of interpersonal violence

2023 Volume 39, Issue 3-4, Page(s) 631–650

Abstract: Past research supports the role of negative posttraumatic cognitions (NPCs) in the development and maintenance of posttraumatic stress disorder (PTSD). The relationship between NPCs and PTSD may be uniquely impacted by racial status and experiences of ... ...

Abstract	Past research supports the role of negative posttraumatic cognitions (NPCs) in the development and maintenance of posttraumatic stress disorder (PTSD). The relationship between NPCs and PTSD may be uniquely impacted by racial status and experiences of military sexual trauma (MST), both of which may have a unique impact on one's understanding of self, others, and the world. We explored racial differences in the association between NPCs and PTSD symptom clusters in a sample of veterans endorsing MST (
MeSH term(s)	Humans ; Cognition ; Military Sexual Trauma/diagnosis ; Military Sexual Trauma/therapy ; Stress Disorders, Post-Traumatic/therapy ; Stress Disorders, Post-Traumatic/diagnosis ; Veterans ; Racial Groups ; Black or African American ; White
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2028900-5
ISSN	1552-6518 ; 0886-2605
ISSN (online)	1552-6518
ISSN	0886-2605
DOI	10.1177/08862605231197773
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms.

Russo, Ethan B / Cuttler, Carrie / Cooper, Ziva D / Stueber, Amanda / Whiteley, Venetia L / Sexton, Michelle

Cannabis and cannabinoid research

2021 Volume 7, Issue 5, Page(s) 706–716

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Adult ; Humans ; Young Adult ; Analgesics/therapeutic use ; Cannabidiol/adverse effects ; Cannabinoids/adverse effects ; Cannabis/adverse effects ; Chronic Pain/chemically induced ; Hallucinogens/therapeutic use ; Sleep Initiation and Maintenance Disorders/chemically induced ; Substance Withdrawal Syndrome/drug therapy ; Surveys and Questionnaires
Chemical Substances	Analgesics ; Cannabidiol (19GBJ60SN5) ; cannabigerol (J1K406072N) ; Cannabinoids ; Hallucinogens
Language	English
Publishing date	2021-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2867624-5
ISSN	2378-8763 ; 2578-5125
ISSN (online)	2378-8763
ISSN	2578-5125
DOI	10.1089/can.2021.0058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Indications and administration practices amongst medical cannabis healthcare providers: a cross-sectional survey.

Corroon, Jamie / Sexton, Michelle / Bradley, Ryan

BMC family practice

2019 Volume 20, Issue 1, Page(s) 174

Abstract: Background: The medical use of cannabis has been legislatively restricted for decades in the US and abroad. In recent years, changing local and national policies have given rise to a community of healthcare providers who may be recommending the medical ... ...

Abstract	Background: The medical use of cannabis has been legislatively restricted for decades in the US and abroad. In recent years, changing local and national policies have given rise to a community of healthcare providers who may be recommending the medical use of cannabis without the benefit of formal clinical practice guidelines or sufficient training and education. In addition, a citizen science movement has emerged whereby unlicensed and untrained individuals are acting as healthcare provider proxies, offering cannabis-specific clinical care to "patients". This study sought to characterize the clinical practice characteristics of these provider groups. Methods: An anonymous, online survey was designed to describe levels of cannabis-specific education, practice characteristics, indications for medical use, dose, administration forms and adverse effects related to cannabis use. The questionnaire was disseminated via professional medical cannabis associations and by word-of-mouth. It was accessed between June 31-December 31, 2018. A self-selecting sample of respondents (n = 171) completed the survey. Results: Formal education or training in the medical use of cannabis was significantly more common among licensed respondents than unlicensed respondents (95.5% vs 76.9% respectively, OR, 6.3, 95% CI, 1.2-32.3, p = 0.03). The vast majority (n = 74, 83.15%) of licensed respondents reported having recommended cannabis as an adjunct to an existing prescription drug. Almost two-thirds (n = 64, 71.9%) reported having recommended it as a substitute. When delta-9-tetrahydrocannabinol (THC) is the principal therapeutic constituent of interest, vaporization is the most common method of administration recommended (n = 94 responses, 71.4% of respondents). In contrast, when cannabidiol (CBD) is the principal therapeutic constituent of interest, oral administration (sublingual or oromucosal absorption) is the most common method (n = 70 responses, 71.4% of respondents). Conclusions: Individuals who recommend the medical use of cannabis appear to be self-generating a community standard of practice in the absence of formal clinical guidelines on dosing, interactions and other characteristics. Reducing barriers to clinical research on cannabis products is needed, not only to better understand their risks and benefits, but also to augment the evidence-base for informing clinical practice.
MeSH term(s)	Cross-Sectional Studies ; Educational Status ; Female ; Humans ; Male ; Medical Marijuana/administration & dosage ; Medical Marijuana/adverse effects ; Medical Marijuana/therapeutic use ; Middle Aged ; Surveys and Questionnaires ; Treatment Outcome ; United States
Chemical Substances	Medical Marijuana
Language	English
Publishing date	2019-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2041495-X
ISSN	1471-2296 ; 1471-2296
ISSN (online)	1471-2296
ISSN	1471-2296
DOI	10.1186/s12875-019-1059-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Management of Cancer Symptoms and Treatment-Induced Side Effects With Cannabis or Cannabinoids.

Sexton, Michelle / Garcia, Jose M / Jatoi, Aminah / Clark, Carey S / Wallace, Mark S

Journal of the National Cancer Institute. Monographs

2021 Volume 2021, Issue 58, Page(s) 86–98

Abstract: Cannabis and cannabinoids are increasingly being accessed and used by patients with advanced cancer for various symptoms and general quality of life. Specific symptoms of pain, nausea and vomiting, loss of appetite and cachexia, anxiety, sleep ... ...

Abstract	Cannabis and cannabinoids are increasingly being accessed and used by patients with advanced cancer for various symptoms and general quality of life. Specific symptoms of pain, nausea and vomiting, loss of appetite and cachexia, anxiety, sleep disturbance, and medical trauma are among those that have prompted patients with cancer to use cannabis. This conference report from the National Cancer Institute's "Cannabis, Cannabinoid and Cancer Research Symposium" on the topic of "Cancer Symptom/Treatment Side Effect Management" is an expert perspective of cannabis intervention for cancer and cancer treatment-related symptoms. The purpose of the symposium was to identify research gaps, describe the need for high-quality randomized prospective studies of medical cannabis for palliative care in patients with cancer, and evaluate the impact of medical cannabis on cancer survivors' quality of life. Further, education of clinicians and affiliated health-care providers in guiding cancer patients in using cannabis for cancer care would benefit patients. Together, these steps will further aid in refining the use of cannabis and cannabinoids for symptom palliation and improve safety and efficacy for patients.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Congresses as Topic ; Humans ; Medical Marijuana/therapeutic use ; Neoplasms/complications ; Neoplasms/drug therapy ; Quality of Life
Chemical Substances	Antineoplastic Agents ; Medical Marijuana
Language	English
Publishing date	2021-12-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1745-6614
ISSN (online)	1745-6614
DOI	10.1093/jncimonographs/lgab011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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