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Article ; Online: Two periodization strategies in professional football and their influence on accumulated training load and its distribution: Differences between starters and non-starters.

Marín, Kévin / Castellano, Julen

2024 Volume 41, Issue 24, Page(s) 2201–2208

Abstract: This study compared weekly training-load (TL), training-monotony (TM), and training-strain (TS) in 80 professional football players (28.1 ± 3.2 yrs, 78.0 ± 5.9 kg, and 182.0 ± 4.8 cm), considering two lengths (6 and 7 days between matches), two types of ... ...

Abstract	This study compared weekly training-load (TL), training-monotony (TM), and training-strain (TS) in 80 professional football players (28.1 ± 3.2 yrs, 78.0 ± 5.9 kg, and 182.0 ± 4.8 cm), considering two lengths (6 and 7 days between matches), two types of periodization strategies (placing the compensatory session in MD+1 [P1] or MD+2 [P2] post-match-day) and two players' status, starters, and non-starters. Using Global Positioning Technology, the monitored variables were: Player Load (PL), Total Distance (TD), distances at various speeds (>21 [HSR], >24 [VHSR], and > 27 [SPR] km·h
MeSH term(s)	Humans ; Football ; Acceleration ; Mentoring
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	995528-8
ISSN	1466-447X ; 0264-0414
ISSN (online)	1466-447X
ISSN	0264-0414
DOI	10.1080/02640414.2024.2318061
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Article ; Online: Comparison of Different Coach Competition Micro-Cycle Planning Strategies in Professional Soccer

Kévin Marín / Julen Castellano

Sustainability, Vol 15, Iss 23, p

2023 Volume 16218

Abstract: Background: Coaches propose training strategies to develop their playing model, but the impact on the conditional demand of players is unknown. The objective of this study aimed to assess the conditional demands associated with five competitive micro- ... ...

Abstract	Background: Coaches propose training strategies to develop their playing model, but the impact on the conditional demand of players is unknown. The objective of this study aimed to assess the conditional demands associated with five competitive micro-cycle (Mi) planning strategies put forth by professional soccer coaches. The dependent locomotor variables were: total distance traveled (TD, in m), high-speed running distance (TD21, >21 km·h −1 , in m), sprint distance (TD27, >27 km·h −1 , in m), acceleration load (aLoaD, in AU) and number of accelerations (ACC2, >2 m·s −2 in n) and decelerations (DEC2, <−2 m·s −2 in n). The activity profile of the players was monitored during each training session using a global positioning system (GPS) during four seasons (2018–2019 to 2021–2022). Regardless of the coach, the sessions furthest from Mi (MD+1, MD-4 and MD-3) were the most conditionally demanding, where TD27 was especially stimulated on MD-3 (ES = 0.7, 0.2/1.2, mean and range; p < 0.05); furthermore, MD-2 was the least demanding session of all the trainers (ES = −2.4, −2.6/−1.5, mean and range; p < 0.01). However, there were nuances regarding the conditional demand among the coaches: Co1 and Co2 proposed a higher conditional demand in the MD-2 and MD-1 sessions ( p < 0.05). The conclusion was twofold: elite soccer coaches proposed a horizontal alternation in the weekly distribution of training stimuli; nevertheless, the differences in the style of play of each coach affected the week-planning strategy.
Keywords	soccer ; periodization ; micro-technology ; training demand ; coaching strategy ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Cannabis withdrawal induced brief psychotic disorder: a case study during the national lockdown secondary to the COVID-19 pandemic.

Marín, Julen / Pérez de Mendiola, Xabier / Fernández, Sergio / Chart, Juan Pablo

Journal of addictive diseases

2021 Volume 39, Issue 4, Page(s) 579–584

Abstract: Background: Cannabis Withdrawal Syndrome (CWS) is a key feature of Cannabis Use Disorder (CUD). The CWS causes significant distress and disability. While the relationship between CUD and psychosis has been extensively studied, the potential connection ... ...

Abstract	Background: Cannabis Withdrawal Syndrome (CWS) is a key feature of Cannabis Use Disorder (CUD). The CWS causes significant distress and disability. While the relationship between CUD and psychosis has been extensively studied, the potential connection between CWS and psychosis has not received as much attention. Case presentation: The CARE guideline's methodology is followed in the presentation of this case report. During the national lockdown decreed by the Spanish government for the containment of the CoronaVirus Disease 19 (COVID-19) pandemic, a 29-year-old man suffers a CWS and a subsequent psychotic episode. He is admitted to a psychiatric unit, obtaining a rapid and complete response to treatment. Discussion: Clinical and pathophysiological data that support the hypothesis of CWS-induced psychosis are discussed. Due to the increasing use of cannabis worldwide, we believe that more research is needed on the mental disturbances associated with CUD, including CWS and psychosis. On the other hand, the confinement and social distancing measures adopted in the face of the current COVID-19 pandemic could have restricted the availability and consumption of certain drugs, precipitating the emergence of withdrawal syndromes such as CWS.
MeSH term(s)	Adult ; COVID-19/psychology ; Humans ; Male ; Marijuana Abuse/complications ; Marijuana Abuse/psychology ; Psychoses, Substance-Induced/etiology ; Psychoses, Substance-Induced/psychology
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1077616-3
ISSN	1545-0848 ; 1055-0887
ISSN (online)	1545-0848
ISSN	1055-0887
DOI	10.1080/10550887.2021.1910473
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Article ; Online: Basic critical care echocardiography training of intensivists allows reproducible and reliable measurements of cardiac output.

Villavicencio, Christian / Leache, Julen / Marin, Judith / Oliva, Iban / Rodriguez, Alejandro / Bodí, María / Soni, Nilam J

The ultrasound journal

2019 Volume 11, Issue 1, Page(s) 5

Abstract: Background: Although pulmonary artery catheters (PACs) have been the reference standard for calculating cardiac output, echocardiographic estimation of cardiac output (CO) by cardiologists has shown high accuracy compared to PAC measurements. A few ... ...

Abstract	Background: Although pulmonary artery catheters (PACs) have been the reference standard for calculating cardiac output, echocardiographic estimation of cardiac output (CO) by cardiologists has shown high accuracy compared to PAC measurements. A few studies have assessed the accuracy of echocardiographic estimation of CO in critically ill patients by intensivists with basic training. The aim of this study was to evaluate the accuracy of CO measurements by intensivists with basic training using pulsed-wave Doppler ultrasound vs. PACs in critically ill patients. Methods: Critically ill patients who required hemodynamic monitoring with a PAC were eligible for the study. Three different intensivists with basic critical care echocardiography training obtained three measurements of CO on each patient. The maximum of three separate left-ventricular outflow tract diameter measurements and the mean of three LVOT velocity time integral measurements were used. The inter-observer reliability and correlation of CO measured by PACs vs. critical care echocardiography were assessed. Results: A total of 20 patients were included. Data were analyzed comparing the measurements of CO by PAC vs. echocardiography. The inter-observer reliability for measuring CO by echocardiography was good based on a coefficient of intraclass correlation of 0.6 (95% CI 0.48-0.86, p < 0.001). Bias and limits of agreement between the two techniques were acceptable (0.64 ± 1.18 L/min, 95% limits of agreement of - 1.73 to 3.01 L/min). In patients with CO < 6.5 L/min, the agreement between CO measured by PAC vs. echocardiography improved (0.13 ± 0.89 L/min; 95% limits of agreement of - 1.64 to 2.22 L/min). The mean percentage of error between the two methods was 17%. Conclusions: Critical care echocardiography performed at the bedside by intensivists with basic critical care echocardiography training is an accurate and reproducible technique to measure cardiac output in critically ill patients.
Language	English
Publishing date	2019-04-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2965029-X
ISSN	2524-8987 ; 2036-3176
ISSN (online)	2524-8987
ISSN	2036-3176
DOI	10.1186/s13089-019-0120-0
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Article ; Online: Basic critical care echocardiography training of intensivists allows reproducible and reliable measurements of cardiac output

Christian Villavicencio / Julen Leache / Judith Marin / Iban Oliva / Alejandro Rodriguez / María Bodí / Nilam J. Soni

The Ultrasound Journal, Vol 11, Iss 1, Pp 1-

2019 Volume 8

Abstract: Abstract Background Although pulmonary artery catheters (PACs) have been the reference standard for calculating cardiac output, echocardiographic estimation of cardiac output (CO) by cardiologists has shown high accuracy compared to PAC measurements. A ... ...

Abstract	Abstract Background Although pulmonary artery catheters (PACs) have been the reference standard for calculating cardiac output, echocardiographic estimation of cardiac output (CO) by cardiologists has shown high accuracy compared to PAC measurements. A few studies have assessed the accuracy of echocardiographic estimation of CO in critically ill patients by intensivists with basic training. The aim of this study was to evaluate the accuracy of CO measurements by intensivists with basic training using pulsed-wave Doppler ultrasound vs. PACs in critically ill patients. Methods Critically ill patients who required hemodynamic monitoring with a PAC were eligible for the study. Three different intensivists with basic critical care echocardiography training obtained three measurements of CO on each patient. The maximum of three separate left-ventricular outflow tract diameter measurements and the mean of three LVOT velocity time integral measurements were used. The inter-observer reliability and correlation of CO measured by PACs vs. critical care echocardiography were assessed. Results A total of 20 patients were included. Data were analyzed comparing the measurements of CO by PAC vs. echocardiography. The inter-observer reliability for measuring CO by echocardiography was good based on a coefficient of intraclass correlation of 0.6 (95% CI 0.48–0.86, p < 0.001). Bias and limits of agreement between the two techniques were acceptable (0.64 ± 1.18 L/min, 95% limits of agreement of − 1.73 to 3.01 L/min). In patients with CO < 6.5 L/min, the agreement between CO measured by PAC vs. echocardiography improved (0.13 ± 0.89 L/min; 95% limits of agreement of − 1.64 to 2.22 L/min). The mean percentage of error between the two methods was 17%. Conclusions Critical care echocardiography performed at the bedside by intensivists with basic critical care echocardiography training is an accurate and reproducible technique to measure cardiac output in critically ill patients.
Keywords	Pulmonary artery catheter ; Critical care echocardiography ; Cardiac output ; Pulsed-wave Doppler ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis.

Claveria-Cabello, Alex / Colyn, Leticia / Uriarte, Iker / Latasa, Maria Ujue / Arechederra, Maria / Herranz, Jose M / Alvarez, Laura / Urman, Jesus M / Martinez-Chantar, Maria L / Banales, Jesus M / Sangro, Bruno / Rombouts, Krista / Oyarzabal, Julen / Marin, Jose J G / Berasain, Carmen / Avila, Matias A / Fernandez-Barrena, Maite G

Cancers

2020 Volume 12, Issue 12

Abstract: Liver fibrosis, a common hallmark of chronic liver disease (CLD), is characterized by the accumulation of extracellular matrix secreted by activated hepatic fibroblasts and stellate cells (HSC). Fibrogenesis involves multiple cellular and molecular ... ...

Abstract	Liver fibrosis, a common hallmark of chronic liver disease (CLD), is characterized by the accumulation of extracellular matrix secreted by activated hepatic fibroblasts and stellate cells (HSC). Fibrogenesis involves multiple cellular and molecular processes and is intimately linked to chronic hepatic inflammation. Importantly, it has been shown to promote the loss of liver function and liver carcinogenesis. No effective therapies for liver fibrosis are currently available. We examined the anti-fibrogenic potential of a new drug (CM414) that simultaneously inhibits histone deacetylases (HDACs), more precisely HDAC1, 2, and 3 (Class I) and HDAC6 (Class II) and stimulates the cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) pathway activity through phosphodiesterase 5 (PDE5) inhibition, two mechanisms independently involved in liver fibrosis. To this end, we treated
Language	English
Publishing date	2020-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12123748
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Article ; Online: Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis

Alex Claveria-Cabello / Leticia Colyn / Iker Uriarte / Maria Ujue Latasa / Maria Arechederra / Jose M. Herranz / Laura Alvarez / Jesus M. Urman / Maria L. Martinez-Chantar / Jesus M. Banales / Bruno Sangro / Krista Rombouts / Julen Oyarzabal / Jose J. G. Marin / Carmen Berasain / Matias A. Avila / Maite G. Fernandez-Barrena

Cancers, Vol 12, Iss 3748, p

2020 Volume 3748

Abstract	Liver fibrosis, a common hallmark of chronic liver disease (CLD), is characterized by the accumulation of extracellular matrix secreted by activated hepatic fibroblasts and stellate cells (HSC). Fibrogenesis involves multiple cellular and molecular processes and is intimately linked to chronic hepatic inflammation. Importantly, it has been shown to promote the loss of liver function and liver carcinogenesis. No effective therapies for liver fibrosis are currently available. We examined the anti-fibrogenic potential of a new drug (CM414) that simultaneously inhibits histone deacetylases (HDACs), more precisely HDAC1, 2, and 3 (Class I) and HDAC6 (Class II) and stimulates the cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) pathway activity through phosphodiesterase 5 (PDE5) inhibition, two mechanisms independently involved in liver fibrosis. To this end, we treated Mdr2 -KO mice, a clinically relevant model of liver inflammation and fibrosis, with our dual HDAC/PDE5 inhibitor CM414. We observed a decrease in the expression of fibrogenic markers and collagen deposition, together with a marked reduction in inflammation. No signs of hepatic or systemic toxicity were recorded. Mechanistic studies in cultured human HSC and cholangiocytes (LX2 and H69 cell lines, respectively) demonstrated that CM414 inhibited pro-fibrogenic and inflammatory responses, including those triggered by transforming growth factor β (TGFβ). Our study supports the notion that simultaneous targeting of pro-inflammatory and fibrogenic mechanisms controlled by HDACs and PDE5 with a single molecule, such as CM414, can be a new disease-modifying strategy.
Keywords	liver fibrosis ; hepatobiliary carcinogenesis ; histone deacetylases ; cGMP phosphodiesterase inhibitor ; HDAC inhibitor ; precision medicine ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma.

Colyn, Leticia / Bárcena-Varela, Marina / Álvarez-Sola, Gloria / Latasa, M Ujue / Uriarte, Iker / Santamaría, Eva / Herranz, Jose M / Santos-Laso, Alvaro / Arechederra, Maria / Ruiz de Gauna, Mikel / Aspichueta, Patricia / Canale, Matteo / Casadei-Gardini, Andrea / Francesconi, Maria / Carotti, Simone / Morini, Sergio / Nelson, Leonard J / Iraburu, Maria J / Chen, Chaobo /

Sangro, Bruno / Marin, Jose J G / Martinez-Chantar, Maria L / Banales, Jesus M / Arnes-Benito, Robert / Huch, Meritxell / Patino, John M / Dar, Altaf A / Nosrati, Mehdi / Oyarzábal, Julen / Prósper, Felipe / Urman, Jesus / Cubero, Francisco Javier / Trautwein, Christian / Berasain, Carmen / Fernandez-Barrena, Maite G / Avila, Matias A

Hepatology (Baltimore, Md.)

2021 Volume 73, Issue 6, Page(s) 2380–2396

Abstract: Background and aims: Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, and therefore effective drugs are urgently needed. ... ...

Abstract	Background and aims: Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, and therefore effective drugs are urgently needed. Different epigenetic modifications occur in CCA and contribute to malignancy. Targeting epigenetic mechanisms may thus open therapeutic opportunities. However, modifications such as DNA and histone methylation often coexist and cooperate in carcinogenesis. We tested the therapeutic efficacy and mechanism of action of a class of dual G9a histone-methyltransferase and DNA-methyltransferase 1 (DNMT1) inhibitors. Approach and results: Expression of G9a, DNMT1, and their molecular adaptor, ubiquitin-like with PHD and RING finger domains-1 (UHRF1), was determined in human CCA. We evaluated the effect of individual and combined pharmacological inhibition of G9a and DNMT1 on CCA cell growth. Our lead G9a/DNMT1 inhibitor, CM272, was tested in human CCA cells, patient-derived tumoroids and xenograft, and a mouse model of cholangiocarcinogenesis with hepatocellular deletion of c-Jun-N-terminal-kinase (Jnk)-1/2 and diethyl-nitrosamine (DEN) plus CCl Conclusions: Dual targeting of G9a and DNMT1 with epigenetic small molecule inhibitors such as CM272 is a potential strategy to treat CCA and/or enhance the efficacy of other systemic therapies.
MeSH term(s)	Animals ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/metabolism ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA Methylation/drug effects ; DNA Methylation/physiology ; Enzyme Inhibitors/pharmacology ; Epigenesis, Genetic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Histocompatibility Antigens/metabolism ; Histone Code/drug effects ; Histone Code/physiology ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Mice ; Treatment Outcome ; Ubiquitin-Protein Ligases/metabolism ; Xenograft Model Antitumor Assays/methods
Chemical Substances	CCAAT-Enhancer-Binding Proteins ; Enzyme Inhibitors ; Histocompatibility Antigens ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNMT1 protein, human (EC 2.1.1.37) ; EHMT2 protein, human (EC 2.1.1.43) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; UHRF1 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2021-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.31642
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Article ; Online: Atención del maltrato infantil en el servicio de urgencias

Javier Álvaro Barriga-Marín / Mireya Robledo-Aceves

Salud Pública de México, Vol 62, Iss 4, jul-ago, Pp 453-

2020 Volume 454

Abstract: ... No ... ...

Abstract	No disponible
Keywords	Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Instituto Nacional de Salud Pública
Document type	Article ; Online
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Article ; Online: Long-term follow-up of cardiac arrest survivors: Protocol of the DESAC (Devenir des survivants d'Arrets Cardiaques) study, a French multicentric prospective cohort.

Dumas, F / Bougouin, W / Perier, M C / Marin, N / Goulenok, C / Vieillard-Baron, A / Diehl, J L / Legriel, S / Deye, N / Cronier, P / Ricôme, S / Chemouni, F / Mekontso Dessap, A / Beganton, F / Marijon, E / Jouven, X / Empana, J P / Cariou, A

Resuscitation plus

2023 Volume 16, Page(s) 100460

Abstract: ... therapeutic strategies on these two outcomes.: Methods: Between Jul 2015 and Oct 2018, adult patients over ...

Abstract	Background: While the short-term prognosis of cardiac arrest patients - nearly 250,000 new cases per year in Europe - has been extensively studied, less is known regarding the mid and long-term outcome of survivors. Objective: The aim of the DESAC study is to describe mid- and long-term survival rate and functional status of cardiac arrest survivors, and to assess the influence of pre and intra hospital therapeutic strategies on these two outcomes. Methods: Between Jul 2015 and Oct 2018, adult patients over 18 years who were discharged alive from any intensive care units (public and private hospitals) in the Ile-de-France area (Paris and suburbs, France) after a non-traumatic cardiac arrest were screened for participation in this multicentric study. Survivors were included after they signed (or the proxies) an informed consent before discharge during initial hospitalisation. We calculated that including 600 patients in total would allow an 80% power to demonstrate a 2 years survival rate difference of 10% between patients who did and those who did not receive therapeutic hypothermia after resuscitation. Pre- and in-hospital data related to the circumstances surrounding the event and to the therapeutic interventions (such as cardio-pulmonary resuscitation, defibrillation, emergent coronary revascularization, neuroprotective therapeutics) were collected. After discharge, patients were interviewed at 3 months, 6 months and every year thereafter for a minimum follow-up of 26 months and a maximum follow-up of 48 months. Information on vital status, occurrence of cardiovascular events, medications and a comprehensive assessment of the functional status (qualitive of life as assessed by the Short-Form General Health Survey (SF36) scale, activities of daily living (ADL) scale, neurological Cerebral Performance Categories (CPC) and Overall Performance Categories (OPC) scales, socio-professional activities) were collected at follow-up interviews. Discussion: The DESAC study should provide important information regarding several dimensions of the mid and long-term prognosis of cardiac arrest survivors and on the benefit (and potentially harm) of early therapeutic strategies.
Language	English
Publishing date	2023-08-31
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2023.100460
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