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  1. Article: Cannulation techniques for extracorporeal life support.

    Pavlushkov, Evgeny / Berman, Marius / Valchanov, Kamen

    Annals of translational medicine

    2017  Volume 5, Issue 4, Page(s) 70

    Abstract: The article reviews cannulation strategy for different modes of extracorporeal life support. Technical aspects, pitfalls and complications are discussed for central and peripheral extracorporeal membrane oxygenation (VA, VV, VAV, VVA), biventricular ... ...

    Abstract The article reviews cannulation strategy for different modes of extracorporeal life support. Technical aspects, pitfalls and complications are discussed for central and peripheral extracorporeal membrane oxygenation (VA, VV, VAV, VVA), biventricular assist device support and extracorporeal CO
    Language English
    Publishing date 2017-02-22
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2016.11.47
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Successful lung donation at the age of 6 weeks: Challenges and lessons learned.

    Pavlushkov, Evgeny / Muthialu, Nagarajan / Spencer, Helen / Ellis, Clair / Davies, Ben / Claydon, Sarah / Berman, Marius

    Pediatric transplantation

    2019  Volume 23, Issue 4, Page(s) e13419

    Abstract: A clinical case of successful procurement and transplantation of bilateral lungs from 6-week-old infant with sepsis secondary to bacterial meningitis is reported. Forty-one-day-old male infant (height 60 cm, weight 4 kg) died of cerebral edema secondary ... ...

    Abstract A clinical case of successful procurement and transplantation of bilateral lungs from 6-week-old infant with sepsis secondary to bacterial meningitis is reported. Forty-one-day-old male infant (height 60 cm, weight 4 kg) died of cerebral edema secondary to Escherichia coli meningitis and bacteremia. Preretrieval assessment included the following: arterial gases; pO
    MeSH term(s) Bronchoscopy ; Escherichia coli ; Female ; Humans ; Infant ; Lung/surgery ; Lung Diseases/surgery ; Lung Transplantation ; Male ; Meningitis, Bacterial ; Persistent Fetal Circulation Syndrome/surgery ; Pulmonary Alveoli/abnormalities ; Pulmonary Alveoli/surgery ; Pulmonary Veins/surgery ; Sepsis ; Tissue Donors ; Tissue and Organ Procurement
    Language English
    Publishing date 2019-04-23
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.13419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4947: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Retrieval team-initiated early donor management increases the donor heart utilization rate for transplantation.

    Barbero, Cristina / Ravaglioli, Antonio / Page, Aravinda A / Betts, Graham A / Fakelman, Stephen M / Pavlushkov, Evgeny / Messer, Simon / Parizkova, Barbora / Berman, Marius / Tsui, Steven

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2018  Volume 55, Issue 3, Page(s) 468–475

    Abstract: Objectives: Heart transplantation represents the most effective therapy that is currently available for end-stage heart failure. Despite the shortage of organ donors, many donor hearts are not accepted for transplantation due to poor function. Targeted ... ...

    Abstract Objectives: Heart transplantation represents the most effective therapy that is currently available for end-stage heart failure. Despite the shortage of organ donors, many donor hearts are not accepted for transplantation due to poor function. Targeted donor management may increase the donor heart utilization rate. The aim of this study is to analyse a 2-year experience of early donor management through the 'scout programme' by a high-volume national cardiothoracic organ retrieval team.
    Methods: A prospective cohort study was carried out between 2013 and 2015 on consecutive donation from brain-dead donors. A member of the cardiothoracic retrieval team travelled to the intensive care unit of the donor hospital to assist with early management.
    Results: One hundred and seventy-eight cardiac donors were enrolled; 106 (59.5%) were 'scouted', and 72 (40.5%) were 'non-scouted'. Donor heart utilization rate in the 'scouted' group was 47.2% (50/106) compared with 30.6% (22/72) in the 'non-scouted' group (P = 0.03). On logistic regression analysis, early donor management by the scouts independently predicted donor heart utilization. The time in the operating theatre from donor arrival to skin incision was significantly reduced in the 'scouted' group. No differences were found in the 30-day graft failure rate or the 30-day, 1-year and 2-year survival rates of the recipients between the 2 groups.
    Conclusions: Early donor management delivered by the cardiothoracic retrieval team significantly increased the donor heart utilization rate from existing donors. Moreover, the time in the operating theatre from donor heart arrival to skin incision was significantly reduced.
    MeSH term(s) Adult ; Female ; Heart Failure/surgery ; Heart Transplantation/statistics & numerical data ; Humans ; Male ; Middle Aged ; Procedures and Techniques Utilization/statistics & numerical data ; Prospective Studies ; Time Factors ; Tissue Donors/supply & distribution ; Tissue and Organ Procurement/organization & administration ; Tissue and Organ Procurement/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2018-09-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezy293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A 5-year single-center early experience of heart transplantation from donation after circulatory-determined death donors.

    Messer, Simon / Cernic, Sendi / Page, Aravinda / Berman, Marius / Kaul, Pradeep / Colah, Simon / Ali, Jason / Pavlushkov, Evgeny / Baxter, Jen / Quigley, Richard / Osman, Mohamed / Nachum, Eyal / Parameshwar, Jayan / Abu-Omar, Yasir / Dunning, John / Goddard, Martin / Bhagra, Sai / Pettit, Stephen / Cheshire, Caitlin /
    Lewis, Clive / Kydd, Anna / Ali, Ayyaz / Sudarshan, Catherine / Jenkins, David / Tsui, Steven / Hall, Roger / Catarino, Pedro / Large, Stephen R

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2020  Volume 39, Issue 12, Page(s) 1463–1475

    Abstract: Background: In an effort to address the increasing demand for heart transplantation within the United Kingdom (UK), we established a clinical program of heart transplantation from donation after circulatory-determined death (DCD) donors in 2015. After 5 ...

    Abstract Background: In an effort to address the increasing demand for heart transplantation within the United Kingdom (UK), we established a clinical program of heart transplantation from donation after circulatory-determined death (DCD) donors in 2015. After 5 years, we report the clinical early outcomes and impact of the program.
    Methods: This is a single-center, retrospective, matched, observational cohort study comparing outcomes of hearts transplanted from DCD donors from March 1, 2015 to February 29, 2020 with those from matched donation after brain death (DBD) donors at Royal Papworth Hospital (RPH) (Cambridge, UK). DCD hearts were either retrieved using thoracoabdominal normothermic regional perfusion or the direct procurement and perfusion technique. All DBD hearts were procured using standard cold static storage. The primary outcomes were recipient 30-day and 1-year survival.
    Results: During the 5-year study, DCD heart donation increased overall heart transplant activity by 48% (79 for DCD and 164 for DBD). There was no difference in survival at 30 days (97% for DCD vs 99% for DBD, p = 1.00) or 1 year (91% for DCD vs 89% for DBD, p = 0.72). There was no difference in the length of stay in the intensive care unit (7 for DCD vs 6 for DBD days, p = 0.24) or in the hospital (24 for DCD vs 25 for DBD days, p = 0.84).
    Conclusions: DCD heart donation increased overall heart transplant activity at RPH by 48%, with no difference in 30-day or 1-year survival in comparison with conventional DBD heart transplantations. DCD heart donation is set to make a dramatic difference in the number of patients who can benefit from heart transplantation.
    MeSH term(s) Adult ; Female ; Follow-Up Studies ; Graft Survival ; Heart Transplantation/methods ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Time Factors ; Tissue Donors ; Tissue and Organ Procurement/methods ; United Kingdom
    Language English
    Publishing date 2020-10-03
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2020.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Outcome after heart transplantation from donation after circulatory-determined death donors.

    Messer, Simon / Page, Aravinda / Axell, Richard / Berman, Marius / Hernández-Sánchez, Jules / Colah, Simon / Parizkova, Barbora / Valchanov, Kamen / Dunning, John / Pavlushkov, Evgeny / Balasubramanian, Sendhil K / Parameshwar, Jayan / Omar, Yasir Abu / Goddard, Martin / Pettit, Stephen / Lewis, Clive / Kydd, Anna / Jenkins, David / Watson, Christopher J /
    Sudarshan, Catherine / Catarino, Pedro / Findlay, Marie / Ali, Ayyaz / Tsui, Steven / Large, Stephen R

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2017  Volume 36, Issue 12, Page(s) 1311–1318

    Abstract: Background: The requirement for heart transplantation is increasing, vastly outgrowing the supply of hearts available from donation after brain death (DBD) donors. Transplanting hearts after donation after circulatory-determined death (DCD) may be a ... ...

    Abstract Background: The requirement for heart transplantation is increasing, vastly outgrowing the supply of hearts available from donation after brain death (DBD) donors. Transplanting hearts after donation after circulatory-determined death (DCD) may be a viable additive alternative to DBD donors. This study compared outcomes from the largest single-center experience of DCD heart transplantation against matched DBD heart transplants.
    Methods: DCD hearts were retrieved using normothermic regional perfusion (NRP) or direct procurement and perfusion (DPP). During NRP, perfusion was restored to the arrested heart within the donor with the exclusion of the cerebral circulation, whereas DPP hearts were removed directly. All hearts were maintained on machine perfusion during transportation. A retrospective cohort of DBD heart transplants, matched for donor and recipient characteristics, was used as a comparison group. The primary outcome measure of this study (set by the United Kingdom regulatory body) was 90-day survival.
    Results: There were 28 DCD heart transplants performed during the 25-month study period. Survival at 90 days was not significantly different between DCD and matched DBD transplant recipients (DCD, 92%; DBD, 96%; p = 1.0). Hospital length of stay, treated rejection episodes, allograft function, and 1-year survival (DCD, 86%; DBD, 88%; p = 0.98) were comparable between groups. The method of retrieval (NRP or DPP) was not associated with a difference in outcome.
    Conclusions: These results suggest that heart transplantation from DCD heart donation provides comparable short-term outcomes to traditional DBD heart transplants and can serve to increase heart transplant activity in well-selected patients.
    MeSH term(s) Adolescent ; Adult ; Brain Death ; Female ; Graft Survival ; Heart Transplantation/mortality ; Humans ; Male ; Middle Aged ; Perfusion/methods ; Registries ; Retrospective Studies ; Survival Rate/trends ; Tissue Donors ; Tissue and Organ Procurement/methods ; Transplantation, Homologous ; United Kingdom/epidemiology ; Young Adult
    Language English
    Publishing date 2017-10-24
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2017.10.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article: Pulmonary endarterectomy - an example of treatment of right ventricular after load failure.

    Berman, Marius / Pavlushkov, Evgeny / Abraham, Essac / Dunning, John / Tsui, Steven / Hall, Roger / Klein, Andrew / Jenkins, David P

    Multimedia manual of cardiothoracic surgery : MMCTS

    2009  Volume 2009, Issue 612, Page(s) mmcts.2008.003491

    Abstract: The treatment of choice for patients with chronic thromboembolic pulmonary hypertension is pulmonary endarterectomy to reduce pulmonary vascular resistance with significant symptomatic and prognostic benefit. The fundamental aim of the surgery is to ... ...

    Abstract The treatment of choice for patients with chronic thromboembolic pulmonary hypertension is pulmonary endarterectomy to reduce pulmonary vascular resistance with significant symptomatic and prognostic benefit. The fundamental aim of the surgery is to perform a full endarterectomy (not embolectomy or thrombectomy) in both pulmonary arteries. The operation is performed via a median sternotomy with hypothermic cardiopulmonary bypass (CPB) at 20 °C. Pulmonary arteriotomies are performed within the pericardium and periods of circulatory arrest are necessary to reduce collateral blood flow from bronchial arteries and allow a clear field for dissection distally. The endarterectomy plane is raised carefully as it is essential the correct layer be identified. The dissection proceeds within the superficial media into all the affected segmental and sub-segmental vessels. A cast of the inner layer of the pulmonary arterial tree is then dissected free by eversion moving towards the periphery. After completion of the endarterectomies, and the patient is rewarmed slowly on full CPB. During weaning from CPB the right-sided filling pressures should be kept low, guided by invasive haemodynamic monitoring. Survival to hospital discharge is ≫95% in experienced centres with outcome dependent on the disease pattern and pulmonary vascular resistance pre- and post-surgery.
    Language English
    Publishing date 2009-01-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280156-X
    ISSN 1813-9175
    ISSN 1813-9175
    DOI 10.1510/mmcts.2008.003491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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