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  1. AU=Fernandes-Silva Hugo
  2. AU="Fahy, Damian"
  3. AU="Elham L. Zoudani"
  4. AU=Urschel J D
  5. AU="Michel Carles"
  6. AU="Haer, T."
  7. AU="Knapstein, Luke"
  8. AU="Zhao Ning"
  9. AU="Maiorka, Paulo César"
  10. AU="Dumolard, Anne"
  11. AU="Cheng-Zhong Zhang"
  12. AU="Song, Jiwu"
  13. AU="Terwilliger, Gordon"
  14. AU="Elhamzaoui, Hamza"
  15. AU="Béganton, Benoît"
  16. AU=Smith Zachary D.
  17. AU="Dotta, Federico"
  18. AU="Palmer, Andre"
  19. AU="Cai, Biao"
  20. AU="Leroux, Michel R"
  21. AU="Thomson, Jaidyn"
  22. AU="Novillo-Del Álamo, Blanca"
  23. AU="Deps, Patrícia D"

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  1. Artikel ; Online: Retinoic Acid-Mediated Control of Energy Metabolism Is Essential for Lung Branching Morphogenesis.

    Fernandes-Silva, Hugo / Alves, Marco G / Garcez, Marcia R / Correia-Pinto, Jorge / Oliveira, Pedro F / Homem, Catarina C F / Moura, Rute S

    International journal of molecular sciences

    2024  Band 25, Heft 9

    Abstract: Lung branching morphogenesis relies on intricate epithelial-mesenchymal interactions and signaling networks. Still, the interplay between signaling and energy metabolism in shaping embryonic lung development remains unexplored. Retinoic acid (RA) ... ...

    Abstract Lung branching morphogenesis relies on intricate epithelial-mesenchymal interactions and signaling networks. Still, the interplay between signaling and energy metabolism in shaping embryonic lung development remains unexplored. Retinoic acid (RA) signaling influences lung proximal-distal patterning and branching morphogenesis, but its role as a metabolic modulator is unknown. Hence, this study investigates how RA signaling affects the metabolic profile of lung branching. We performed ex vivo lung explant culture of embryonic chicken lungs treated with DMSO, 1 µM RA, or 10 µM BMS493. Extracellular metabolite consumption/production was evaluated by using
    Mesh-Begriff(e) Animals ; Tretinoin/metabolism ; Tretinoin/pharmacology ; Lung/metabolism ; Lung/drug effects ; Lung/embryology ; Energy Metabolism/drug effects ; Morphogenesis/drug effects ; Signal Transduction/drug effects ; Chick Embryo ; Cell Proliferation/drug effects ; Mitochondria/metabolism ; Mitochondria/drug effects ; Chickens
    Chemische Substanzen Tretinoin (5688UTC01R)
    Sprache Englisch
    Erscheinungsdatum 2024-05-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25095054
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  2. Artikel ; Online: Developmental Pathways Underlying Lung Development and Congenital Lung Disorders.

    Caldeira, Inês / Fernandes-Silva, Hugo / Machado-Costa, Daniela / Correia-Pinto, Jorge / Moura, Rute Silva

    Cells

    2021  Band 10, Heft 11

    Abstract: Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a ... ...

    Abstract Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a fully functional organ. Conversely, failure to correctly regulate this intricate series of events results in severe abnormalities that may compromise postnatal survival or affect/disrupt lung function through early life and adulthood. Conditions like congenital pulmonary airway malformation, bronchopulmonary sequestration, bronchogenic cysts, and congenital diaphragmatic hernia display unique forms of lung abnormalities. The etiology of these disorders is not yet completely understood; however, specific developmental pathways have already been reported as deregulated. In this sense, this review focuses on the molecular mechanisms that contribute to normal/abnormal lung growth and development and their impact on postnatal survival.
    Mesh-Begriff(e) Body Patterning ; Humans ; Lung/abnormalities ; Lung/embryology ; Lung Diseases/congenital ; Lung Diseases/embryology ; Models, Biological ; Signal Transduction
    Sprache Englisch
    Erscheinungsdatum 2021-11-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10112987
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Retinoic Acid: A Key Regulator of Lung Development.

    Fernandes-Silva, Hugo / Araújo-Silva, Henrique / Correia-Pinto, Jorge / Moura, Rute S

    Biomolecules

    2020  Band 10, Heft 1

    Abstract: Retinoic acid (RA) is a key molecular player in embryogenesis and adult tissue homeostasis. In embryo development, RA plays a crucial role in the formation of different organ systems, namely, the respiratory system. During lung development, there is a ... ...

    Abstract Retinoic acid (RA) is a key molecular player in embryogenesis and adult tissue homeostasis. In embryo development, RA plays a crucial role in the formation of different organ systems, namely, the respiratory system. During lung development, there is a spatiotemporal regulation of RA levels that assures the formation of a fully functional organ. RA signaling influences lung specification, branching morphogenesis, and alveolarization by regulating the expression of particular target genes. Moreover, cooperation with other developmental pathways is essential to shape lung organogenesis. This review focuses on the events regulated by retinoic acid during lung developmental phases and pulmonary vascular development; also, it aims to provide a snapshot of RA interplay with other well-known regulators of lung development.
    Mesh-Begriff(e) Animals ; Gene Expression Regulation, Developmental ; Humans ; Lung/blood supply ; Lung/embryology ; Lung/growth & development ; Lung/metabolism ; Lung Diseases/etiology ; Lung Diseases/metabolism ; Pulmonary Artery/embryology ; Pulmonary Artery/growth & development ; Pulmonary Artery/metabolism ; Pulmonary Veins/embryology ; Pulmonary Veins/growth & development ; Pulmonary Veins/metabolism ; Signal Transduction ; Tretinoin/analysis ; Tretinoin/metabolism
    Chemische Substanzen Tretinoin (5688UTC01R)
    Sprache Englisch
    Erscheinungsdatum 2020-01-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom10010152
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Lung branching morphogenesis is accompanied by temporal metabolic changes towards a glycolytic preference.

    Fernandes-Silva, Hugo / Alves, Marco G / Araújo-Silva, Henrique / Silva, Ana M / Correia-Pinto, Jorge / Oliveira, Pedro F / Moura, Rute S

    Cell & bioscience

    2021  Band 11, Heft 1, Seite(n) 134

    Abstract: Background: Lung branching morphogenesis is characterized by epithelial-mesenchymal interactions that ultimately define the airway conducting system. Throughout this process, energy and structural macromolecules are necessary to sustain the high ... ...

    Abstract Background: Lung branching morphogenesis is characterized by epithelial-mesenchymal interactions that ultimately define the airway conducting system. Throughout this process, energy and structural macromolecules are necessary to sustain the high proliferative rates. The extensive knowledge of the molecular mechanisms underlying pulmonary development contrasts with the lack of data regarding the embryonic lung metabolic requirements. Here, we studied the metabolic profile associated with the early stages of chicken pulmonary branching.
    Methods: In this study, we used an ex vivo lung explant culture system and analyzed the consumption/production of extracellular metabolic intermediates associated with glucose catabolism (alanine, lactate, and acetate) by
    Results: Glucose consumption decreases, whereas alanine, lactate, and acetate production progressively increase as branching morphogenesis proceeds. mRNA analysis revealed variations in the expression levels of key enzymes and transporters from the glycolytic pathway. ldha and ldhb displayed a compartment-specific expression pattern that resembles proximal-distal markers. In addition, high proliferation levels were detected at active branching sites. LDH protein expression levels suggest that LDHB may account for the progressive rise in lactate. Concurrently, there is a stable oxygen consumption rate throughout branching morphogenesis.
    Conclusions: This report describes the temporal metabolic changes that accompany the early stages of chicken lung branching morphogenesis. Overall, the embryonic chicken lung seems to shift to a glycolytic lactate-based metabolism as pulmonary branching occurs. Moreover, this metabolic rewiring might play a crucial role during lung development.
    Sprache Englisch
    Erscheinungsdatum 2021-07-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-021-00654-w
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  5. Artikel ; Online: The influence of light intensities and micropollutants on the removal of total coliforms and E. coli from wastewater in a flat-panel photobioreactor.

    Pompei, Caroline Moço Erba / Ruas, Graziele / Bolzani, Hugo Renan / Fernandes, Luiza Maria / Silva, Gustavo Henrique Ribeiro da

    Environmental pollution (Barking, Essex : 1987)

    2024  Band 349, Seite(n) 123935

    Abstract: The presence of micropollutants and pathogens in sanitary wastewater and surface water is a growing concern that impacts public health, environmental balance and the maintenance of water supply services. To improve sanitary wastewater treatment, it is ... ...

    Abstract The presence of micropollutants and pathogens in sanitary wastewater and surface water is a growing concern that impacts public health, environmental balance and the maintenance of water supply services. To improve sanitary wastewater treatment, it is necessary to develop and improve sustainable technologies. Among the available options, microalgae-based systems stand out for their efficiency and generation of value-added byproducts. To study the impact of luminosity and the presence of micropollutants (13 selected) on the removal of E. coli and total coliforms from real anaerobically treated wastewater, a pilot flat-panel photobioreactor (50 L) was operated in batch mode in a tropical climate region. This is the first study to evaluate whether micropollutants interfere with coliform groups, considering a microalgae-based system and an experiment in a tropical climate region. E. coli had better removal (from 10
    Mesh-Begriff(e) Wastewater/microbiology ; Wastewater/chemistry ; Escherichia coli ; Photobioreactors ; Waste Disposal, Fluid/methods ; Light ; Enterobacteriaceae ; Microalgae ; Water Purification/methods ; Water Purification/instrumentation
    Chemische Substanzen Wastewater
    Sprache Englisch
    Erscheinungsdatum 2024-04-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123935
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    Zs.A 2599: Hefte anzeigen Standort:
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  6. Artikel ; Online: Canonical Sonic Hedgehog Signaling in Early Lung Development.

    Fernandes-Silva, Hugo / Correia-Pinto, Jorge / Moura, Rute Silva

    Journal of developmental biology

    2017  Band 5, Heft 1

    Abstract: The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, ...

    Abstract The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, it is able to trigger tissue-specific responses that, ultimately, contribute to the formation of a fully functional organism. Of all three HH proteins, Sonic Hedgehog (SHH) plays an essential role during lung development. In fact, abnormal levels of this secreted protein lead to severe foregut defects and lung hypoplasia. Canonical SHH signal transduction relies on the presence of transmembrane receptors, such as Patched1 and Smoothened, accessory proteins, as Hedgehog-interacting protein 1, and intracellular effector proteins, like GLI transcription factors. Altogether, this complex signaling machinery contributes to conveying SHH response. Pulmonary morphogenesis is deeply dependent on SHH and on its molecular interactions with other signaling pathways. In this review, the role of SHH in early stages of lung development, specifically in lung specification, primary bud formation, and branching morphogenesis is thoroughly reviewed.
    Sprache Englisch
    Erscheinungsdatum 2017-03-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720870-9
    ISSN 2221-3759 ; 2221-3759
    ISSN (online) 2221-3759
    ISSN 2221-3759
    DOI 10.3390/jdb5010003
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  7. Artikel ; Online: Three-dimensional printed exoskeletons and orthoses for the upper limb-A systematic review.

    Fernandes da Silva, Joana Lima Grilo / Barroso Gonçalves, Sérgio Miguel / Plácido da Silva, Hugo Humberto / Tavares da Silva, Miguel Pedro

    Prosthetics and orthotics international

    2024  

    Abstract: This systematic review aims to assess and summarize the current landscape in exoskeletons and orthotic solutions developed for upper limb medical assistance, which are partly or fully produced using 3-dimensional printing technologies and contain at ... ...

    Abstract This systematic review aims to assess and summarize the current landscape in exoskeletons and orthotic solutions developed for upper limb medical assistance, which are partly or fully produced using 3-dimensional printing technologies and contain at least the elbow or the shoulder joints. The initial search was conducted on Web of Science, PubMed, and IEEEXplore, resulting in 92 papers, which were reduced to 72 after removal of duplicates. From the application of the inclusion and exclusion criteria and selection questionnaire, 33 papers were included in the review, being divided according to the analyzed joints. The analysis of the selected papers allowed for the identification of different solutions that vary in terms of their target application, actuation type, 3-dimensional printing techniques, and material selection, among others. The results show that there has been far more research on the elbow joint than on the shoulder joint, which can be explained by the relative complexity of the latter. Moreover, the findings of this study also indicate that there is still a gap between the research conducted on these devices and their practical use in real-world conditions. Based on current trends, it is anticipated that the future of 3-dimensional printed exoskeletons will revolve around the use of flexible and high-performance materials, coupled with actuated devices. These advances have the potential to replace the conventional fabrication methods of exoskeletons with technologies based on additive manufacturing.
    Sprache Englisch
    Erscheinungsdatum 2024-01-04
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 753382-2
    ISSN 1746-1553 ; 0309-3646
    ISSN (online) 1746-1553
    ISSN 0309-3646
    DOI 10.1097/PXR.0000000000000318
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1510: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Artikel ; Online: CARACTERÍSTICAS SOCIODEMOGRÁFICAS DA VIOLÊNCIA INTERPESSOAL ASSOCIADA AO CONSUMO DE ÁLCOOL

    Elric Ramos Silva / Paula Hino / Hugo Fernandes

    Cogitare Enfermagem, Vol 27, Iss

    2022  

    Abstract: Objective: to identify the sociodemographic profile of interpersonal violence associated with alcohol consumption in São Paulo-SP, Brazil. Method: a cross-sectional study carried out through notifications of suspected or confirmed cases of interpersonal ... ...

    Abstract Objective: to identify the sociodemographic profile of interpersonal violence associated with alcohol consumption in São Paulo-SP, Brazil. Method: a cross-sectional study carried out through notifications of suspected or confirmed cases of interpersonal violence from the Notifiable Diseases Information System submitted between 2016 and 2019. Collection took place between March and June 2020. Chi-square or Fisher’s exact tests were performed in the statistical analysis. Results: 27,775 notifications were obtained, whose prevalent profile was female victims (60.6%), aged between 20 and 34 years old (41.4%), brown- or black-skinned (51%), and with complete high school (18.8%). Physical violence was more frequent (81.9%), perpetrated by an intimate partner (20.3%), motivated by sexism (9.9%) and generational conflict (11.2%). In sexual violence, rape prevailed with 69.4% and there was a low supply of emergency contraception methods (14.7%). Conclusion: the study contributes to reflections and subsidies in the planning of public policies to control the problem.
    Schlagwörter consumo de bebidas alcoólicas ; violência ; enfermagem em saúde pública ; vigilância em saúde pública ; notificação de doenças ; Nursing ; RT1-120 ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Universidade Federal do Paraná
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Canonical Sonic Hedgehog Signaling in Early Lung Development

    Hugo Fernandes-Silva / Jorge Correia-Pinto / Rute Silva Moura

    Journal of Developmental Biology, Vol 5, Iss 1, p

    2017  Band 3

    Abstract: The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, ...

    Abstract The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, it is able to trigger tissue-specific responses that, ultimately, contribute to the formation of a fully functional organism. Of all three HH proteins, Sonic Hedgehog (SHH) plays an essential role during lung development. In fact, abnormal levels of this secreted protein lead to severe foregut defects and lung hypoplasia. Canonical SHH signal transduction relies on the presence of transmembrane receptors, such as Patched1 and Smoothened, accessory proteins, as Hedgehog-interacting protein 1, and intracellular effector proteins, like GLI transcription factors. Altogether, this complex signaling machinery contributes to conveying SHH response. Pulmonary morphogenesis is deeply dependent on SHH and on its molecular interactions with other signaling pathways. In this review, the role of SHH in early stages of lung development, specifically in lung specification, primary bud formation, and branching morphogenesis is thoroughly reviewed.
    Schlagwörter Sonic Hedgehog (SHH) ; lung development ; endoderm specification ; branching morphogenesis ; signaling ; transcriptional regulation ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2017-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Pharmacological, toxicological and phytochemical analysis of

    Fernandes, Felipe Hugo Alencar / Soares, Sabrina da Silva / Bekbolatova, Elmira / Boylan, Fábio / Salgado, Hérida Regina Nunes

    Natural product research

    2023  Band 38, Heft 6, Seite(n) 1049–1053

    Abstract: ... Spondias ... ...

    Abstract Spondias dulcis
    Mesh-Begriff(e) Mice ; Animals ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Parkinson Disease ; Anacardiaceae/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/analysis
    Chemische Substanzen Antioxidants ; Plant Extracts ; Phytochemicals
    Sprache Englisch
    Erscheinungsdatum 2023-05-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2210254
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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