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  1. Book ; Thesis: Bedeutung der Prolylhydroxylase 2 in der Regeneration des Skelettmuskeltraumas

    Settelmeier, Stephan

    2020  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Stephan Settelmeier
    Language German
    Size 97 Blätter, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2020
    HBZ-ID HT020710175
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2021 E 348 order for loan Magazin

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  2. Article ; Online: New categorization of chest pain: noncardiac is in, atypical is out!

    Settelmeier, Stephan / Steven, Sebastian / Post, Felix / Ahrens, Ingo / Giannitsis, Evangelos / Breuckmann, Frank

    Herz

    2024  

    Abstract: Chest pain poses a diagnostic challenge in the emergency department and requires a thorough clinical assessment. The traditional distinction between "atypical" and "typical" chest pain carries the risk of not addressing nonischemic clinical pictures. The ...

    Title translation Neue Einordnung des Thoraxschmerzes: Nichtkardial ist in, atypisch ist out!
    Abstract Chest pain poses a diagnostic challenge in the emergency department and requires a thorough clinical assessment. The traditional distinction between "atypical" and "typical" chest pain carries the risk of not addressing nonischemic clinical pictures. The newly conceived subdivision into cardiac, possibly cardiac, and (probably) noncardiac causes of the presenting symptom complex addresses a much more interdisciplinary approach to a symptom-oriented diagnostic algorithm. The diagnostic structures of the chest pain units in Germany do not currently reflect this. An adaptation should therefore be considered.
    Language English
    Publishing date 2024-03-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8262-4
    ISSN 1615-6692 ; 0340-9937 ; 0946-1299
    ISSN (online) 1615-6692
    ISSN 0340-9937 ; 0946-1299
    DOI 10.1007/s00059-024-05240-7
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    Zs.A 1270: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 426: Show issues

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  3. Article ; Online: Imaging of Cardiac Fibrosis: How Far Have We Moved From Extracellular to Cellular?

    Telli, Tugce / Hosseini, Atefeh / Settelmeier, Stephan / Kersting, David / Kessler, Lukas / Weber, Wolfgang A / Rassaf, Tienush / Herrmann, Ken / Varasteh, Zohreh

    Seminars in nuclear medicine

    2024  

    Abstract: Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Myocardial fibrosis plays an important role in adverse outcomes such as heart failure and arrhythmias. As the pathological response and degree of scarring, and therefore ... ...

    Abstract Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Myocardial fibrosis plays an important role in adverse outcomes such as heart failure and arrhythmias. As the pathological response and degree of scarring, and therefore clinical presentation varies from patient to patient, early detection of fibrosis is crucial for identifying the appropriate treatment approach and forecasting the progression of a disease along with the likelihood of disease-related mortality. Current imaging modalities provides information about either decreased function or extracellular signs of fibrosis. Targeting activated fibroblasts represents a burgeoning approach that could offer insights prior to observable functional alterations, presenting a promising focus for potential anti-fibrotic therapeutic interventions at cellular level. In this article, we provide an overview of imaging cardiac fibrosis and discuss the role of different advanced imaging modalities with the focus on novel non-invasive imaging of activated fibroblasts.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2024.02.008
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    Zs.A 763: Show issues Location:
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  4. Article ; Online: Revealing Subtle Changes in Cardiac Function using Transthoracic Dobutamine Stress Echocardiography in Mice.

    Settelmeier, Stephan / Rassaf, Tienush / Hendgen-Cotta, Ulrike B

    Journal of visualized experiments : JoVE

    2021  , Issue 168

    Abstract: Left ventricular (LV) dysfunction paves the final pathway for a multitude of cardiac disorders. With the non-invasive high-frequency transthoracic dobutamine stress echocardiography in humans, a reductionist investigation approach to unmask subtle ... ...

    Abstract Left ventricular (LV) dysfunction paves the final pathway for a multitude of cardiac disorders. With the non-invasive high-frequency transthoracic dobutamine stress echocardiography in humans, a reductionist investigation approach to unmask subtle changes in cardiac function has become possible. Here, we provide a protocol for using this technique in mice to facilitate expanded analysis of LV architecture and function in physiology and pathology enabling the observation of alterations in models of cardiac disease hidden in unstressed hearts. This investigation can be performed in one and the same animal and allows both, basal and pharmacologically stress-induced measurements. We outline detailed criteria for appropriate anesthesia, imaging-based LV analysis, consideration of intra- and interobserver variability, and obtaining positive inotrope response that can be attained in mice after intraperitoneal injection of dobutamine under near physiological conditions. To recapitulate the characteristics of human physiology and disease in small animal models, we highlight critical pitfalls in evaluation, e.g., a pronounced Bowditch effect in mice. To further meet translational objectives, we compare stress-induced effects in humans and mice. When used in translational studies, attention must be paid to physiological differences between mice and human. Experimental rigor dictates that some parameters assessed in patients can only be used with caution due to restrictions in spatial and temporal resolution in mouse models.
    MeSH term(s) Anesthesia ; Animals ; Dobutamine/pharmacology ; Echocardiography, Stress ; Heart/diagnostic imaging ; Heart/physiopathology ; Heart Diseases ; Humans ; Image Processing, Computer-Assisted ; Male ; Mice, Inbred C57BL ; Ultrasonics ; Mice
    Chemical Substances Dobutamine (3S12J47372)
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/62019
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  5. Article ; Online: Shining Damaged Hearts: Immunotherapy-Related Cardiotoxicity in the Spotlight of Nuclear Cardiology.

    Kersting, David / Settelmeier, Stephan / Mavroeidi, Ilektra-Antonia / Herrmann, Ken / Seifert, Robert / Rischpler, Christoph

    International journal of molecular sciences

    2022  Volume 23, Issue 7

    Abstract: The emerging use of immunotherapies in cancer treatment increases the risk of immunotherapy-related cardiotoxicity. In contrast to conventional chemotherapy, these novel therapies have expanded the forms and presentations of cardiovascular damage to a ... ...

    Abstract The emerging use of immunotherapies in cancer treatment increases the risk of immunotherapy-related cardiotoxicity. In contrast to conventional chemotherapy, these novel therapies have expanded the forms and presentations of cardiovascular damage to a broad spectrum from asymptomatic changes to fulminant short- and long-term complications in terms of cardiomyopathy, arrythmia, and vascular disease. In cancer patients and, particularly, cancer patients undergoing (immune-)therapy, cardio-oncological monitoring is a complex interplay between pretherapeutic risk assessment, identification of impending cardiotoxicity, and post-therapeutic surveillance. For these purposes, the cardio-oncologist can revert to a broad spectrum of nuclear cardiological diagnostic workup. The most promising commonly used nuclear medicine imaging techniques in relation to immunotherapy will be discussed in this review article with a special focus on the continuous development of highly specific molecular markers and steadily improving methods of image generation. The review closes with an outlook on possible new developments of molecular imaging and advanced image evaluation techniques in this exciting and increasingly growing field of immunotherapy-related cardiotoxicity.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Cardiology/methods ; Cardiotoxicity/drug therapy ; Cardiotoxicity/etiology ; Humans ; Immunotherapy/adverse effects ; Medical Oncology ; Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23073802
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  6. Article ; Online: Molecular Imaging Biomarkers in Cardiooncology: A View on Established Technologies and Future Perspectives.

    Kersting, David / Mavroeidi, Ilektra-Antonia / Settelmeier, Stephan / Seifert, Robert / Schuler, Martin / Herrmann, Ken / Rassaf, Tienush / Rischpler, Christoph

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue Suppl 2, Page(s) 29S–38S

    Abstract: Novel therapeutic options have significantly improved survival and long-term outcomes in many cancer entities. Unfortunately, this improvement in outcome is often accompanied by new and increasingly relevant therapy-related cardiovascular toxicity. In ... ...

    Abstract Novel therapeutic options have significantly improved survival and long-term outcomes in many cancer entities. Unfortunately, this improvement in outcome is often accompanied by new and increasingly relevant therapy-related cardiovascular toxicity. In this context, cardiooncology has emerged as a new field of interdisciplinary individual patient care. Important tasks are pretherapeutic risk stratification and early detection and treatment of cardiotoxicity, which comprises cardiac damage in relation to cardiovascular comorbidities, the tumor disease, and cancer treatment. Clinical manifestations can cover a broad spectrum, ranging from subtle and usually asymptomatic abnormalities to serious acute or chronic complications. Typical manifestations include acute and chronic heart failure, myo- and pericarditis, arrythmias, ischemia, and endothelial damage. They can be related to almost all current cancer treatments, including cytotoxic chemotherapy, targeted therapy, immunotherapy, hormonal therapy, and radiotherapy. Molecular imaging biomarkers can aid in pretherapeutic cardiooncologic assessment for primary prevention and personalized surveillance, detection, and differential diagnosis of cardiotoxic complications. Potential advantages over conventional diagnostics are the higher detection sensitivity for subtle changes in cardiac homeostasis, higher reproducibility, and better observer independence. Hybrid imaging with highly sensitive PET/MRI may be particularly suited for early diagnosis. Important technologies that are encouraged in current multidisciplinary guidelines are equilibrium radionuclide angiography for evaluation of ventricular function and chamber morphology, as well as myocardial perfusion imaging for additional detection of ischemia. Novel modalities that may detect even earlier signs of cardiotoxicity comprise
    MeSH term(s) Humans ; Cardiotoxicity ; Gallium Radioisotopes/therapeutic use ; Reproducibility of Results ; Early Detection of Cancer ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Biomarkers ; Molecular Imaging ; Ischemia/complications
    Chemical Substances Gallium Radioisotopes ; Biomarkers
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.264868
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    Zs.A 114: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 328: Show issues

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  7. Article ; Online: Capacity changes in German certified chest pain units during COVID-19 outbreak response.

    Settelmeier, Stephan / Rassaf, Tienush / Giannitsis, Evangelos / Münzel, Thomas / Breuckmann, Frank

    Clinical research in cardiology : official journal of the German Cardiac Society

    2020  Volume 109, Issue 12, Page(s) 1469–1475

    Abstract: Background: We sought to determine structure and changes in organisation and bed capacities of certified German chest pain units (CPU) in response to the emergency plan set-up as a response to the SARS-CoV-2 pandemic.: Methods and results: The study ... ...

    Abstract Background: We sought to determine structure and changes in organisation and bed capacities of certified German chest pain units (CPU) in response to the emergency plan set-up as a response to the SARS-CoV-2 pandemic.
    Methods and results: The study was conducted in the form of a standardised telephone interview survey in certified German CPUs. Analyses comprised the overall setting of the CPU, bed capacities, possibilities for ventilation, possible changes in organisation and resources, chest pain patient admittance, overall availability of CPUs and bail-out strategies. The response rate was 91%. Nationwide, CPU bed capacities decreased by 3% in the early phase of COVID-19 pandemic response, exhibiting differences within and between the federal states. Pre-pandemic and pandemic bed capacities stayed below 1 CPU bed per 50,000 inhabitants. 97% of CPUs were affected by internal reorganisation pandemic plans at variable extent. While we observed a decrease of CPU beds within an emergency room (ER) set-up and on intermediate care units (ICU), beds in units being separated from ER and ICU were even increased in numbers.
    Conclusions: Certified German CPUs are able to maintain adequate coverage for chest pain patients in COVID-19 pandemic despite structural changes. However, at this time, it appears important to add operating procedures during pandemic outbreaks to the certification criteria of forthcoming guidelines either at the individual CPU level or more centrally steered by the German Cardiac Society or the European Society of Cardiology.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; Cardiology Service, Hospital/organization & administration ; Chest Pain/diagnosis ; Chest Pain/epidemiology ; Chest Pain/therapy ; Emergency Service, Hospital/organization & administration ; Germany/epidemiology ; Health Care Surveys ; Health Services Needs and Demand/organization & administration ; Hospital Bed Capacity ; Hospitalization ; Humans ; Intensive Care Units/organization & administration ; Needs Assessment
    Keywords covid19
    Language English
    Publishing date 2020-05-31
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-020-01676-z
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  8. Article ; Online: Nitric Oxide Generating Formulation as an Innovative Approach to Topical Skin Care

    Stephan Settelmeier / Tienush Rassaf / Ulrike B. Hendgen-Cotta / Ingo Stoffels

    Cosmetics, Vol 8, Iss 1, p

    An Open-Label Pilot Study

    2021  Volume 16

    Abstract: Nitric oxide (NO) plays multiple roles in both normal and abnormal skin processes. Its deranging disbalance is involved in the pathogenesis of multiple dermatologic diseases such as acne vulgaris, pointing towards beneficial therapeutic directions. A ... ...

    Abstract Nitric oxide (NO) plays multiple roles in both normal and abnormal skin processes. Its deranging disbalance is involved in the pathogenesis of multiple dermatologic diseases such as acne vulgaris, pointing towards beneficial therapeutic directions. A novel NO-producing gel-formulation was tested beneficial in the treatment of acne vulgaris in an open-label pilot study using clinical evaluation scores. It showed a decrease of comedones and inflammatory pustulae and reduced the Global Acne Grading System score by 50% within eight weeks. In addition, we demonstrate a potential use as cosmetic agent where NO therapy leads to an increase of skin integrity and a reduction of skin ageing processes.
    Keywords nitric oxide ; NO ; acne vulgaris ; topical therapy ; skin ageing ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Shining Damaged Hearts

    David Kersting / Stephan Settelmeier / Ilektra-Antonia Mavroeidi / Ken Herrmann / Robert Seifert / Christoph Rischpler

    International Journal of Molecular Sciences, Vol 23, Iss 3802, p

    Immunotherapy-Related Cardiotoxicity in the Spotlight of Nuclear Cardiology

    2022  Volume 3802

    Abstract: The emerging use of immunotherapies in cancer treatment increases the risk of immunotherapy-related cardiotoxicity. In contrast to conventional chemotherapy, these novel therapies have expanded the forms and presentations of cardiovascular damage to a ... ...

    Abstract The emerging use of immunotherapies in cancer treatment increases the risk of immunotherapy-related cardiotoxicity. In contrast to conventional chemotherapy, these novel therapies have expanded the forms and presentations of cardiovascular damage to a broad spectrum from asymptomatic changes to fulminant short- and long-term complications in terms of cardiomyopathy, arrythmia, and vascular disease. In cancer patients and, particularly, cancer patients undergoing (immune-)therapy, cardio-oncological monitoring is a complex interplay between pretherapeutic risk assessment, identification of impending cardiotoxicity, and post-therapeutic surveillance. For these purposes, the cardio-oncologist can revert to a broad spectrum of nuclear cardiological diagnostic workup. The most promising commonly used nuclear medicine imaging techniques in relation to immunotherapy will be discussed in this review article with a special focus on the continuous development of highly specific molecular markers and steadily improving methods of image generation. The review closes with an outlook on possible new developments of molecular imaging and advanced image evaluation techniques in this exciting and increasingly growing field of immunotherapy-related cardiotoxicity.
    Keywords molecular imaging ; PET ; SPECT ; cardiotoxicity ; immunotherapy ; nuclear medicine ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Conference proceedings: Schnittstelle Mensch – Patientensicherheit und Human Factors im SkillsLab Essen

    Fidrich, Andreas / Settelmeier, Stephan

    2017  , Page(s) V01–02

    Event/congress 12. Internationales SkillsLab Symposium 2017; Erlangen; 2017
    Keywords Medizin, Gesundheit
    Publishing date 2017-03-09
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/17isls02
    Database German Medical Science

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