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  1. Article: Mismatch repair deficiency/microsatellite instability testing as predictive immunotherapy biomarkers-possible diagnostic missteps trusting a single method.

    Gazouli, Ioanna / Zarkavelis, George / Mauri, Davide / Pentheroudakis, George

    Annals of translational medicine

    2020  Volume 7, Issue Suppl 8, Page(s) S329

    Language English
    Publishing date 2020-01-31
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.09.144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: How I treat cancers of unknown primary.

    Zarkavelis, George / Mauri, Davide / Pentheroudakis, George

    ESMO open

    2019  Volume 4, Issue Suppl 2, Page(s) e000502

    Language English
    Publishing date 2019-05-10
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-7029
    ISSN 2059-7029
    DOI 10.1136/esmoopen-2019-000502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: TAILORing targeted therapies to the right patient at the right time: how close are we?

    Zarkavelis, George / Pentheroudakis, George

    Annals of translational medicine

    2017  Volume 6, Issue Suppl 1, Page(s) S87

    Language English
    Publishing date 2017-11-21
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.10.75
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinical Application of Next-Generation Sequencing as A Liquid Biopsy Technique in Advanced Colorectal Cancer: A Trick or A Treat?

    Kastrisiou, Myrto / Zarkavelis, George / Pentheroudakis, George / Magklara, Angeliki

    Cancers

    2019  Volume 11, Issue 10

    Abstract: Owing to its advantages over prior relevant technologies, massive parallel or next-generation sequencing (NGS) is rapidly evolving, with growing applications in a wide range of human diseases. The burst in actionable molecular alterations in many cancer ... ...

    Abstract Owing to its advantages over prior relevant technologies, massive parallel or next-generation sequencing (NGS) is rapidly evolving, with growing applications in a wide range of human diseases. The burst in actionable molecular alterations in many cancer types advocates for the practicality of using NGS in the clinical setting, as it permits the parallel characterization of multiple genes in a cost- and time-effective way, starting from low-input DNA. In advanced clinical practice, the oncological management of colorectal cancer requires prior knowledge of
    Language English
    Publishing date 2019-10-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11101573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A case report of psoriasis flare following immunotherapy: Report of an important entity and literature review.

    Politi, Anastasia / Angelos, Dimas / Mauri, Davide / Zarkavelis, George / Pentheroudakis, George

    SAGE open medical case reports

    2020  Volume 8, Page(s) 2050313X19897707

    Abstract: Immune checkpoint inhibitors, such as anti-cytotoxic T-lymphocyte-associated antigen-4 and anti-programmed death-1, are a type of cancer immunotherapy approved for late-stage malignancy treatment. However, such therapies often induce immune-related ... ...

    Abstract Immune checkpoint inhibitors, such as anti-cytotoxic T-lymphocyte-associated antigen-4 and anti-programmed death-1, are a type of cancer immunotherapy approved for late-stage malignancy treatment. However, such therapies often induce immune-related adverse events. During anti-programmed death-1 blockade therapy, the most commonly reported adverse effects are skin toxicities, such as psoriasis-a chronic immune-mediated inflammatory disorder affecting the skin. We present the clinical characteristics of flared psoriasis in one patient under anti-programmed death-1 therapy who was diagnosed with T2N2M0/IIIB squamous lung carcinoma with a history of psoriasis for the past 5 years, exacerbated after the first cycle of nivolumab. After the third cycle, the extensive skin plaques necessitated treatment cessation. Following the discontinuation of anti-programmed death-1 treatment, skin lesions were treated locally. Possibly, anti-programmed death-1 immunotherapy can trigger immune-mediated diseases, such as psoriasis. Physicians should be alert to immune-related adverse events. Continuation or permanent cessation of treatment depends on the severity and reversibility of immune-related adverse events.
    Language English
    Publishing date 2020-01-13
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X19897707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cancer of unknown primary: time to put the pieces of the puzzle together?

    Economopoulou, Panagiota / Pentheroudakis, George

    The Lancet. Oncology

    2016  Volume 17, Issue 10, Page(s) 1339–1340

    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(16)30377-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  7. Article ; Online: Metabolic consequences of immune checkpoint inhibitors: A new challenge in clinical practice.

    Parthymos, Ioannis / Liamis, George / Dounousi, Evangelia / Pentheroudakis, George / Mauri, Davide / Zarkavelis, George / Florentin, Matilda

    Critical reviews in oncology/hematology

    2020  Volume 151, Page(s) 102979

    Abstract: Treatment of oncologic patients has progressed greatly the last few years with the development of immune checkpoint inhibitors (ICPIs). These drugs are associated with the immune system and, thus, may cause side effects of immune origin, the so called ... ...

    Abstract Treatment of oncologic patients has progressed greatly the last few years with the development of immune checkpoint inhibitors (ICPIs). These drugs are associated with the immune system and, thus, may cause side effects of immune origin, the so called immune related adverse events (irAEs). Immune related AEs may actually affect all organs and systems and frequently resemble clinical entities commonly encountered in clinical practice. As ICPIs have improved both quality of life and life expectancy, clinicians of various specialties may need to deal with irAEs in their everyday practice. Therefore, they should be able to recognize them timely and treat them accordingly. Herein, we review the pathophysiology, clinical manifestations and treatment of irAEs.
    MeSH term(s) Antineoplastic Agents, Immunological/adverse effects ; Cell Cycle Checkpoints/drug effects ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Immunotherapy/adverse effects ; Metabolic Diseases/chemically induced ; Neoplasms/drug therapy ; Quality of Life
    Chemical Substances Antineoplastic Agents, Immunological
    Language English
    Publishing date 2020-05-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2020.102979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1931: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Role of chemotherapy in resectable liver metastases from colorectal cancer: food for thought from pooled evidence.

    Mauri, Davide / Filis, Panagiotis / Tsali, Lampriani / Zarkavelis, George / Pentheroudakis, George

    ESMO open

    2018  Volume 3, Issue 4, Page(s) e000367

    Language English
    Publishing date 2018-06-19
    Publishing country England
    Document type Editorial
    ISSN 2059-7029
    ISSN 2059-7029
    DOI 10.1136/esmoopen-2018-000367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: ESMO Management and treatment adapted recommendations in the COVID-19 era: Pancreatic Cancer.

    Catanese, Silvia / Pentheroudakis, George / Douillard, Jean-Yves / Lordick, Florian

    ESMO open

    2020  Volume 5, Issue Suppl 3

    Abstract: The COVID-19 pandemic is challenging the capacities of health systems in many countries. National healthcare services have to manage unexpected shortages of healthcare resources that have to be re-allocated according to the principles of fair and ethical ...

    Abstract The COVID-19 pandemic is challenging the capacities of health systems in many countries. National healthcare services have to manage unexpected shortages of healthcare resources that have to be re-allocated according to the principles of fair and ethical prioritisation, in order to maintain the highest levels of care to all patients, ensure the safety of patients and healthcare workers, and save as many lives as possible. Also, cancer care services have to pursue restructuring, following the same evidence-based dispositions. In this article, we propose a guidance to the management of pancreatic cancer during the pandemic, prioritised according to a three-tiered framework, and based on expert clinical judgement and magnitude of benefit expected from specific interventions. Since the availability of resources for diagnostic procedures, surgery and postoperative care, systemic therapy and radiotherapy may differ, the authors have separated the prioritisation analyses. The impact of postponing or abrogating cancer interventions on outcomes according to a high, medium or low priority scale is outlined and discussed. The implementation of healthcare services using telemedicine is explored; it reveals itself as functional and effective for limiting patients' need to travel to centres and thereby has the potential to reduce diffusion of SARS-CoV-2. Pancreatic cancer demands a considerable amount of medical resources. Therefore, the redefinition of its diagnostic and therapeutic algorithms with a rigorous method is crucial in order to ensure the highest quality of continuum of care in the broader context of the pandemic and the challenged healthcare systems.
    MeSH term(s) Humans ; Betacoronavirus ; Coronavirus Infections/epidemiology ; COVID-19 ; Health Resources/supply & distribution ; Medical Oncology/organization & administration ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/therapy ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Societies, Medical ; Telemedicine ; Practice Guidelines as Topic
    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1136/esmoopen-2020-000804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The significance of tumor-associated immune response in molecular taxonomy, prognosis and therapy of colorectal cancer patients.

    Nearchou, Andreas / Pentheroudakis, George

    Annals of translational medicine

    2016  Volume 4, Issue 14, Page(s) 271

    Abstract: The importance of host immune response in colorectal cancer (CRC) has been constantly revealed through the last 10 years. A number of relevant immune markers have been introduced as prognostic and are now been used alone or in combination with each other ...

    Abstract The importance of host immune response in colorectal cancer (CRC) has been constantly revealed through the last 10 years. A number of relevant immune markers have been introduced as prognostic and are now been used alone or in combination with each other in clinical practice. Efforts establishing a worldwide consensus on the implications of immune-profiles in conjunction to other factors are designed in the right direction in order to more effectively categorize patients with CRC in groups that might benefit from currently used or future applied therapies. On the other hand, a number of clinical trials have evolved the application of immunotherapies in patients with CRC both in the adjuvant and palliative setting.
    Language English
    Publishing date 2016-08-11
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2016.05.54
    Database MEDical Literature Analysis and Retrieval System OnLINE

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