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Article ; Online: Enhancing reductive C-N coupling of nitrocompounds through interfacial engineering of MoO

Liu, Mengting / Dong, Xuexue / Zhong, Xiu / Wang, Zhenxiao / Gong, Juanjuan / Song, Heng / Yu, Chao / Yuan, Aihua / Yang, Fu / Ang, Edison Huixiang

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 83, Page(s) 12443–12446

Abstract: In this study, we developed an approach by coating silica nanospheres with polydopamine and metal precursor, followed by carbonization to create interfacial engineered ... ...

Abstract	In this study, we developed an approach by coating silica nanospheres with polydopamine and metal precursor, followed by carbonization to create interfacial engineered MoO
Language	English
Publishing date	2023-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc03757f
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Article ; Online: A general copper-catalysed enantioconvergent C(sp

Tian, Yu / Li, Xi-Tao / Liu, Ji-Ren / Cheng, Jian / Gao, Ang / Yang, Ning-Yuan / Li, Zhuang / Guo, Kai-Xin / Zhang, Wei / Wen, Han-Tao / Li, Zhong-Liang / Gu, Qiang-Shuai / Hong, Xin / Liu, Xin-Yuan

Nature chemistry

2023 Volume 16, Issue 3, Page(s) 466–475

Abstract: Although α-chiral C(sp ...

Abstract	Although α-chiral C(sp
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2464596-5
ISSN	1755-4349 ; 1755-4330
ISSN (online)	1755-4349
ISSN	1755-4330
DOI	10.1038/s41557-023-01385-w
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Article ; Online: Supplementation of c-type natriuretic peptide during

Ang, Li / Haixia, Cao / Hongxia, Li / Ruijiao, Li / Xingping, Guo / Huaixiu, Wang

Zygote (Cambridge, England)

2020 Volume 29, Issue 2, Page(s) 150–154

Abstract: The present study investigated the effects of c-type natriuretic peptide (CNP) on the development ...

Abstract	The present study investigated the effects of c-type natriuretic peptide (CNP) on the development of murine preantral follicles during in vitro growth (IVG). Preantral follicles isolated from ovaries of Kunming mice were cultured in vitro. In the culture system, CNP was supplemented in the experimental groups and omitted in the control groups. In Experiment 1, CNP was only supplemented at the early stage and follicle development was evaluated. In Experiments 2 and 3, CNP was supplemented during the whole period of in vitro culture. In Experiment 2, follicle development and oocyte maturity were evaluated. In Experiment 3, follicle development and embryo cleavage after in vitro fertilization (IVF) were assessed. The results showed that in the control groups in all three experiments, granulosa cells migrated from within the follicle and the follicles could not reach the antral stage. In the experimental groups in all three experiments, no migration of granulosa cells was observed and follicle development was assessed as attaining the antral stage, which was significantly superior to that of the control group (P < 0.0001). Oocyte meiotic arrest was effectively maintained, hence giving good developmental competence. In conclusion, CNP supplementation in the culture system during IVG benefited the development of murine preantral follicles.
MeSH term(s)	Animals ; Dietary Supplements ; Female ; Granulosa Cells ; Mice ; Natriuretic Peptide, C-Type ; Oocytes ; Ovarian Follicle
Chemical Substances	Natriuretic Peptide, C-Type (127869-51-6)
Language	English
Publishing date	2020-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1166294-3
ISSN	1469-8730 ; 0967-1994
ISSN (online)	1469-8730
ISSN	0967-1994
DOI	10.1017/S096719942000060X
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Article ; Online: Cu(I)-Catalyzed Chemo- and Enantioselective Desymmetrizing C-O Bond Coupling of Acyl Radicals.

Yu, Zhang-Long / Cheng, Yong-Feng / Liu, Ji-Ren / Yang, Wu / Xu, Dan-Tong / Tian, Yu / Bian, Jun-Qian / Li, Zhong-Liang / Fan, Li-Wen / Luan, Cheng / Gao, Ang / Gu, Qiang-Shuai / Liu, Xin-Yuan

Journal of the American Chemical Society

2023 Volume 145, Issue 11, Page(s) 6535–6545

Abstract: ... challenging. Herein, we describe Cu(I)-catalyzed enantioselective desymmetrizing C-O bond coupling of acyl ... particularly the industrially relevant glycerol. Mechanistic studies supported the proposed C-O bond coupling ...

Abstract	Transition-metal-catalyzed enantioselective functionalization of acyl radicals has so far not been realized, probably due to their relatively high reactivity, which renders the chemo- and stereocontrol challenging. Herein, we describe Cu(I)-catalyzed enantioselective desymmetrizing C-O bond coupling of acyl radicals. This reaction is compatible with (hetero)aryl and alkyl aldehydes and, more importantly, displays a very broad scope of challenging alcohol substrates, such as 2,2-disubstituted 1,3-diols, 2-substituted-2-chloro-1,3-diols, 2-substituted 1,2,3-triols, 2-substituted serinols, and meso primary 1,4-diols, providing enantioenriched esters characterized by challenging acyclic tetrasubstituted carbon stereocenters. Partnered by one- or two-step follow-up transformations, this reaction provides a convenient and practical strategy for the rapid preparation of chiral C3 building blocks from readily available alcohols, particularly the industrially relevant glycerol. Mechanistic studies supported the proposed C-O bond coupling of acyl radicals.
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c00671
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Article ; Online: Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous

Tao, Qiushan / Alvin Ang, Ting Fang / Akhter-Khan, Samia C / Itchapurapu, Indira Swetha / Killiany, Ronald / Zhang, Xiaoling / Budson, Andrew E / Turk, Katherine W / Goldstein, Lee / Mez, Jesse / Alosco, Michael L / Qiu, Wei Qiao

Neurology

2021 Volume 97, Issue 12, Page(s) e1243–e1252

Abstract: Background and objectives: Previous research has shown that elevated blood C-reactive protein (CRP ...

Abstract	Background and objectives: Previous research has shown that elevated blood C-reactive protein (CRP) is associated with increased Alzheimer disease (AD) risk only in Methods: Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study were analyzed, including Results: Among 566 ADNI participants, 274 (48.4%) had no, 222 (39.2%) had 1, and 70 (12.4%) had 2 Discussion: CRP released during peripheral inflammation could be a mediator in
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000012512
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Article: Cardioprotective effect of antiviral therapy among hepatitis C infected patients: A meta-analysis.

Jaiswal, Vikash / Ang, Song Peng / Hanif, Muhammad / Jha, Mayank / Kumar, Vikash / Siddiq, Abdelmonem / Vachhani, Bhavyakumar / Halder, Anupam / Koifman, Michelle / Jeanty, Herby / Soni, Siddharath / Subhan Waleed, Madeeha / Kumar, Tushar / Huang, Helen / Bandyopadhyay, Dhrubajyoti

International journal of cardiology. Heart & vasculature

2023 Volume 49, Page(s) 101270

Abstract: Background: Hepatitis C (HCV) infections have been shown to be associated a with higher risk ...

Abstract	Background: Hepatitis C (HCV) infections have been shown to be associated a with higher risk of atherosclerotic cardiovascular disease (CVD). However, the use of antiviral therapy (AVT) and the risk of CVD has not been well established with limited literature. Objective: We sought to evaluate the association between AVT use post-HCV infection and cardiovascular outcomes. Methods: We performed a systematic literature search using PubMed, Embase, and Scopus for relevant articles from inception until 10th March 2023. Primary clinical outcomes were the incidence of any CVD. Secondary endpoints were all-cause of mortality, stroke, myocardial infarction, and peripheral artery disease. Results: A total of 394,452 patients were included in the analysis (111,076 in the AVT group and 283,376 patients in the NAVT group). The mean age of patients among AVT and NAVT groups was comparable (58.7 vs 58.18). The pooled analysis of primary outcomes showed that AVT was associated with a significantly reduced risk of any CVD (HR, 0.55(95%CI: 0.41-0.75), P < 0.001) compared with the NAVT group of patients. Secondary outcomes including ACM (HR, 0.38(95%CI: 0.32-0.46), P < 0.001), MI (HR, 0.62(95%CI: 0.41-0.94), P = 0.02), and PAD (HR, 0.62(95%CI: 0.41-0.93), P = 0.02) were significantly lower among AVT groups compared with NAVT groups of patients with HCV infection. However, the risk of stroke was comparable between both groups of patients (HR, 0.79(95%CI: 0.58-1.07), P = 0.13). Conclusion: Our analysis shows HCV-infected patients post-AVT have a significantly lower risk of any CVD, MI, ACM, and PAD compared with NAVT groups of patients.
Language	English
Publishing date	2023-09-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2023.101270
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Article: Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina.

Tan, Jian / Xiao, Ang / Yang, Lin / Tao, Yu-Lin / Shao, Yi / Zhou, Qiong

World journal of diabetes

2024 Volume 15, Issue 3, Page(s) 519–529

Abstract: ... and its damage is an important indicator of DR. Receptor for activated C kinase 1 (RACK1) activates ... protein kinase C-ε (PKC-ε) to promote the generation of reactive oxygen species (ROS) in RPE cells, leading ...

Abstract	Background: Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, leading to visual impairment. Retinal pigment epithelium (RPE) injury is a key component of the outer blood retinal barrier, and its damage is an important indicator of DR. Receptor for activated C kinase 1 (RACK1) activates protein kinase C-ε (PKC-ε) to promote the generation of reactive oxygen species (ROS) in RPE cells, leading to apoptosis. Therefore, we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS, thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of DR. Aim: To investigate the role and associated underlying mechanisms of RACK1 in the development of early DR. Methods: In this study, Sprague-Dawley rats and adult RPE cell line-19 (ARPE-19) cells were used as Results: Streptozotocin-induced diabetic rats showed increased apoptosis and up-regulated expression of RACK1 and PKC-ε proteins in RPE cells following a prolonged modeling. Similarly, ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RACK1 and PKC-ε, accompanied by an increases in ROS production, apoptosis rate, and monolayer permeability. However, silencing RACK1 significantly downregulated the expression of PKC-ε and ROS, reduced cell apoptosis and permeability, and protected barrier function. Conclusion: RACK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2583471-X
ISSN	1948-9358
ISSN	1948-9358
DOI	10.4239/wjd.v15.i3.519
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Article ; Online: U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression.

Zhang, Wenrong / Song, Xinyue / Jin, Zining / Zhang, Yiqi / Li, Shan / Jin, Feng / Zheng, Ang

Breast cancer research : BCR

2024 Volume 26, Issue 1, Page(s) 60

Abstract: ... c-Myc expression. This pathway was validated using a xenograft model.: Conclusion: U2AF2-SNORA68 ... promotes TNBC stemness by retaining RPL23 in the nucleolus and increasing c-Myc expression, which provides ...

Abstract	Background: Small nucleolar RNAs (snoRNAs) play key roles in ribosome biosynthesis. However, the mechanism by which snoRNAs regulate cancer stemness remains to be fully elucidated. Methods: SNORA68 expression was evaluated in breast cancer tissues by in situ hybridization and qRT‒PCR. Proliferation, migration, apoptosis and stemness analyses were used to determine the role of SNORA68 in carcinogenesis and stemness maintenance. Mechanistically, RNA pull-down, RNA immunoprecipitation (RIP), cell fractionation and coimmunoprecipitation assays were conducted. Results: SNORA68 exhibited high expression in triple-negative breast cancer (TNBC) and was significantly correlated with tumor size (P = 0.048), ki-67 level (P = 0.037), and TNM stage (P = 0.015). The plasma SNORA68 concentration was significantly lower in patients who achieved clinical benefit. The SNORA68-high patients had significantly shorter disease-free survival (DFS) (P = 0.036). Functionally, SNORA68 was found to promote the cell stemness and carcinogenesis of TNBC in vitro and in vivo. Furthermore, elevated SNORA68 expression led to increased nucleolar RPL23 expression and retained RPL23 in the nucleolus by binding U2AF2. RPL23 in the nucleolus subsequently upregulated c-Myc expression. This pathway was validated using a xenograft model. Conclusion: U2AF2-SNORA68 promotes TNBC stemness by retaining RPL23 in the nucleolus and increasing c-Myc expression, which provides new insight into the regulatory mechanism of stemness.
MeSH term(s)	Humans ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology ; Cell Line, Tumor ; RNA ; Cell Nucleus ; Gene Expression Regulation, Neoplastic ; Carcinogenesis/genetics ; Cell Proliferation/genetics ; Splicing Factor U2AF/genetics
Chemical Substances	RNA (63231-63-0) ; U2AF2 protein, human ; Splicing Factor U2AF
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/s13058-024-01817-6
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Article ; Online: Bidirectional Enhancement of Nitrogen Removal by Indigenous Synergetic Microalgal-Bacterial Consortia in Harsh Low-C/N Wastewater.

Geng, Yanni / Xiong, Zhensheng / Yang, Liming / Lian, Chun-Ang / Pavlostathis, Spyros G / Qiu, Zhiguang / Chen, Houxing / Luo, Qingchun / Liu, Yuanqi / Liu, Zhuochao / Shao, Penghui / Zou, Jian-Ping / Jiang, Hualin / Luo, Shenglian / Yu, Ke / Luo, Xubiao

Environmental science & technology

2024 Volume 58, Issue 12, Page(s) 5394–5404

Abstract: Conventional microalgal-bacterial consortia have limited capacity to treat low-C/N wastewater due ... in treating rare earth tailing wastewaters with low-C/N. Ammonia removal reached 0.89 mg N L ...

Abstract	Conventional microalgal-bacterial consortia have limited capacity to treat low-C/N wastewater due to carbon limitation and single nitrogen (N) removal mode. In this work, indigenous synergetic microalgal-bacterial consortia with high N removal performance and bidirectional interaction were successful in treating rare earth tailing wastewaters with low-C/N. Ammonia removal reached 0.89 mg N L
MeSH term(s)	Wastewater ; Microalgae/metabolism ; Denitrification ; Nitrogen/metabolism ; Bacteria/metabolism ; Biomass
Chemical Substances	Wastewater ; Nitrogen (N762921K75)
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c10322
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Article ; Online: Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3.

Cell reports. Medicine

2024 Volume 5, Issue 2, Page(s) 101357

Abstract: ... approach to enhance antitumor immunity. Here, we identified a natural marine product, benzosceptrin C (BC ...

Abstract	Programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blockade has become a mainstay of cancer immunotherapy. Targeting the PD-1/PD-L1 axis with small molecules is an attractive approach to enhance antitumor immunity. Here, we identified a natural marine product, benzosceptrin C (BC), that enhances the cytotoxicity of T cells to cancer cells by reducing the abundance of PD-L1. Furthermore, BC exerts its antitumor effect in mice bearing MC38 tumors by activating tumor-infiltrating T cell immunity. Mechanistic studies suggest that BC can prevent palmitoylation of PD-L1 by inhibiting DHHC3 enzymatic activity. Subsequently, PD-L1 is transferred from the membrane to the cytoplasm and cannot return to the membrane via recycling endosomes, triggering lysosome-mediated degradation of PD-L1. Moreover, the combination of BC and anti-CTLA4 effectively enhances antitumor T cell immunity. Our findings reveal a previously unrecognized antitumor mechanism of BC and represent an alternative immune checkpoint blockade (ICB) therapeutic strategy to enhance the efficacy of cancer immunotherapy.
MeSH term(s)	Animals ; Mice ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Lysosomes/metabolism ; Imidazoles ; Pyrroles
Chemical Substances	benzosceptrin C ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Imidazoles ; Pyrroles
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2023.101357
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