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  1. Article ; Online: Test of 5- Versus 10-Day Remdesivir Treatment in Immunocompromised Patients With Coronavirus Disease 2019.

    Yan, Victoria C

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  Volume 76, Issue 6, Page(s) 1154–1155

    MeSH term(s) Humans ; COVID-19 ; COVID-19 Drug Treatment ; SARS-CoV-2 ; Antiviral Agents/therapeutic use ; Immunocompromised Host
    Chemical Substances remdesivir (3QKI37EEHE) ; Antiviral Agents
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
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  2. Article: Phosphoramidate Prodrugs Continue to Deliver: The Journey of Remdesivir (GS-5734) from the Liver to Peripheral Blood Mononuclear Cells.

    Yan, Victoria C

    ACS medicinal chemistry letters

    2022  Volume 13, Issue 4, Page(s) 520–523

    Abstract: Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of GS-441524 that is FDA-approved for the treatment of patients hospitalized for COVID-19. Despite showing strong, broad-spectrum antiviral activity in preclinical models, ... ...

    Abstract Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of GS-441524 that is FDA-approved for the treatment of patients hospitalized for COVID-19. Despite showing strong, broad-spectrum antiviral activity in preclinical models, the clinical efficacy of remdesivir is mixed. This work highlights the pharmacodynamic discordance of remdesivir between humans and non-human primates, thereby demonstrating that non-human primate disease models overestimate the therapeutic efficacy of phosphoramidate prodrugs.
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Remdesivir for COVID-19: Why Not Dose Higher?

    Yan, Victoria C / Muller, Florian L

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 4

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Antiviral Agents/therapeutic use ; Humans ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02713-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Show issues Location:
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  4. Article ; Online: Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver.

    Yan, Victoria C / Muller, Florian L

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 10, Page(s) e0133321

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Antiviral Agents ; Liver ; Sequence Analysis, RNA
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-09-17
    Publishing country United States
    Document type Letter
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01333-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola.

    Yan, Victoria C / Muller, Florian L

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 10, Page(s) e0111721

    Abstract: Remdesivir is a nucleoside monophosphoramidate prodrug that has been FDA approved for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of remdesivir for COVID-19 remains contentious, as several trials have not found statistically ... ...

    Abstract Remdesivir is a nucleoside monophosphoramidate prodrug that has been FDA approved for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of remdesivir for COVID-19 remains contentious, as several trials have not found statistically significant differences in either time to clinical improvement or mortality between remdesivir-treated and control groups. Similarly, the inability of remdesivir to provide a clinically significant benefit above other investigational agents in patients with Ebola contrasts with strong, curative preclinical data generated in rhesus macaque models. For both COVID-19 and Ebola, significant discordance between the robust preclinical data and remdesivir's lackluster clinical performance have left many puzzled. Here, we critically evaluate the assumptions of the models underlying remdesivir's promising preclinical data and show that such assumptions overpredict efficacy and minimize toxicity of remdesivir in humans. Had the limitations of
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Hemorrhagic Fever, Ebola/drug therapy ; Humans ; Macaca mulatta ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01117-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Show issues Location:
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  6. Article: Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.

    Yan, Victoria C / Muller, Florian L

    ACS medicinal chemistry letters

    2020  Volume 11, Issue 7, Page(s) 1361–1366

    Abstract: While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant ... ...

    Abstract While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.0c00316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity.

    Yan, Victoria C / Muller, Florian L

    Antimicrobial agents and chemotherapy

    2020  Volume 64, Issue 12

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; COVID-19 ; Furans ; Humans ; Lung ; Pandemics ; Pyrroles ; Renal Dialysis ; SARS-CoV-2 ; Transplant Recipients ; Triazines ; beta-Cyclodextrins
    Chemical Substances Furans ; Pyrroles ; Triazines ; beta-Cyclodextrins ; GS-441524 (1BQK176DT6) ; SBE4-beta-cyclodextrin (2PP9364507) ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01920-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
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  8. Article ; Online: Correction: Cook et al. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats.

    Cook, Sarah / Wittenburg, Luke / Yan, Victoria C / Theil, Jacob H / Castillo, Diego / Reagan, Krystle L / Williams, Sonyia / Pham, Cong-Dat / Li, Chun / Muller, Florian L / Murphy, Brian G

    Viruses

    2024  Volume 16, Issue 3

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

    Yan, Victoria C. / Muller, Florian L.

    ACS Medicinal Chemistry Letters

    2020  Volume 11, Issue 7, Page(s) 1361–1366

    Keywords covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.0c00316
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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