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Article ; Online: Synergistic efficacy of alkyltrimethylammonium bromide, chlorhexidine digluconate on diverse bacterial strains causing red-heat and purple-stain deteriorations of leather.

Hussain, Syed Ammar / Sarker, Majher I / Yosief, Hailemichael O

2020 Volume 203, Issue 2, Page(s) 629–634

Abstract: This investigation assessed the synergistic effectiveness of alkyltrimethylammonium bromide (ATMB) and chlorhexidine digluconate (CDG) on selected microbes causing red-heat and purple stain degradations on salt-cured hides and leather products. This ... ...

Abstract	This investigation assessed the synergistic effectiveness of alkyltrimethylammonium bromide (ATMB) and chlorhexidine digluconate (CDG) on selected microbes causing red-heat and purple stain degradations on salt-cured hides and leather products. This biological phenomenon ultimately deteriorates the finished leather quality and grounds considerable economic losses for leather industry. In tryptic soy broth, combination of ATMB and/CDG at the concentration of 900/90 ppm for predefined time interval of 1, 3, and 6 min caused in 0.73, 2.45, and 2.95 log CFU/mL reductions of bacterial cocktail population cell survival, respectively. Whereas in saturated brine solution (SBS), the bacterial cocktail treated with 600/60 and 900/90 ppm of ATMB/CDG for 18 h resulted ~ 74% and 98% reduction, respectively, in comparison to their respective controls. Furthermore, lessening of individual bacterial cultivations by combined ATMB and CDG in SBS was also elucidated.
MeSH term(s)	Bacteria/drug effects ; Bromides/pharmacology ; Chlorhexidine/analogs & derivatives ; Chlorhexidine/pharmacology ; Industrial Microbiology ; Salts ; Sodium Chloride
Chemical Substances	Bromides ; Salts ; brine ; Sodium Chloride (451W47IQ8X) ; chlorhexidine gluconate (MOR84MUD8E) ; Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2020-10-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-020-02047-y
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Article: Physico-chemical and tribological properties of isopropyl-branched chicken fat

Yosief, Hailemichael O. / Sarker, Majher I. / Bantchev, Grigor B. / Dunn, Robert O. / Cermak, Steven C.

Fuel. 2022 May 15, v. 316

2022

Abstract: Vegetable oils have been extensively investigated as renewable resources to replace petroleum-based products such as lubricants and fuels. However, animal fats have not been extensively investigated as renewable resource to generate products like ... ...

Abstract	Vegetable oils have been extensively investigated as renewable resources to replace petroleum-based products such as lubricants and fuels. However, animal fats have not been extensively investigated as renewable resource to generate products like lubricants and biofuels. Here we explored the possibility of utilizing chicken fat as a lubricant by changing its physical and tribological properties through chemical modification. Chicken fat was chemically modified by introducing isopropyl group into the unsaturated fatty acid components of the triglyceride using the industrially produced Lewis acid, ethylaluminum sesquichloride. The modified chicken fat was characterized using a combination of different analytical techniques including GC-MS, NMR and GPC. The physical and tribological properties of the modified and regular chicken fat as well as their blends with high oleic sunflower oil (HOSuO) were investigated. Compared to regular chicken fat, the modified chicken fat displayed higher density but their solubility in HOSuO and Polyalphaolefin (POA-6) was found to be similar. The modified chicken fat also exhibited better oxidative-stability, higher kinematic viscosity but lower viscosity index compared to the regular chicken fat and HOSuO. Unlike the regular chicken fat, blending of modified chicken fat with HOSuO led to an increase in density and improvement in oxidative stability. This study demonstrated that animal fats could be chemically modified to improve their physicochemical properties like that of vegetable oils and they can be considered as alternative renewable resources for generating value-added products such as biolubricants for various applications.
Keywords	Lewis acids ; biofuels ; biolubricants ; chickens ; oxidative stability ; petroleum ; solubility ; sunflower oil ; triacylglycerols ; value added ; vegetables ; viscosity
Language	English
Dates of publication	2022-0515
Document type	Article
ISSN	0016-2361
DOI	10.1016/j.fuel.2022.123293
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Article: Chemical Modification of Beef Tallow for Lubricant Application

Yosief, Hailemichael O. / Sarker, Majher I. / Bantchev, Grigor B. / Dunn, Robert O. / Cermak, Steven C.

Industrial & engineering chemistry process design and development. 2022 June 29, v. 61, no. 27

2022

Abstract: The possible application of beef tallow as a biolubricant by improving its physicochemical properties through chemical modification has been explored. The unsaturated fatty acid chain of the regular beef tallow (RBT) was alkylated with isopropyl groups ... ...

Abstract	The possible application of beef tallow as a biolubricant by improving its physicochemical properties through chemical modification has been explored. The unsaturated fatty acid chain of the regular beef tallow (RBT) was alkylated with isopropyl groups in the presence of ethylaluminum sesquichloride. The alkyl-branched beef tallow (BBT) was characterized using a combination of various analytical techniques, including gas chromatography–mass spectroscopy (GC–MS), nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy, and gel permeation chromatography (GPC). GC–MS and NMR results indicate complete saturation (>95%) of the RBT double bonds with the attachment of isopropyl groups. GPC indicates the presence of oligomers in BBT. The physicochemical and tribological properties of the RBT and BBT as well as their blends with polyalphaolefin (PAO-6) or high-oleic sunflower oil (HOSuO) were evaluated. BBT has better oxidative stability than RBT, due to the elimination of the unsaturation. The introduction of alkyl groups into beef tallow led to improved low-temperature properties compared to RBT, both as neat materials and as blends in HOSuO or PAO-6. The BBT also displayed higher density (0.9030 vs 0.8969 g/mL) and kinematic viscosity (112.7 vs 44.2 mm²/s) than the RBT, possibly due to the presence of oligomers. The introduction of branching was also accompanied by higher solubility in HOSuO and POA-6, but a lower viscosity index (186 vs 149). Both RBT and BBT displayed good lubricity as HOSuO and were effective at improving PAO-6 lubricity at low concentrations (5 wt %). This study indicates that introducing branching into RBT produces new biobased materials, which can be blended into lubricants with improved properties.
Keywords	Fourier transform infrared spectroscopy ; biolubricants ; gel chromatography ; nuclear magnetic resonance spectroscopy ; oxidative stability ; process design ; solubility ; sunflower oil ; tallow ; unsaturated fatty acids ; viscosity
Language	English
Dates of publication	2022-0629
Size	p. 9889-9900.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.2c01207
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Article ; Online: Inactivation of foodborne and other pathogenic bacteria with pyrrolidine based fatty acid amide derivatives

Olanya, Ocen M. / Yosief, Hailemichael O. / Ashby, Richard D. / Niemira, Brendan A. / Sarker, Majher I. / Ukuku, Dike O. / Mukhopadhyay, Sudarsan / Msanne, Joseph / Fan, Xuetong

Journal of Food Safety. 2023 Dec., v. 43, no. 6 p.e13079-

2023

Abstract: Foodborne pathogens are a persistent threat to food and consumer safety. To mitigate outbreaks and contamination incited by these pathogens, the development of novel preventative safety controls and biorational inactivation measures are paramount. The ... ...

Abstract	Foodborne pathogens are a persistent threat to food and consumer safety. To mitigate outbreaks and contamination incited by these pathogens, the development of novel preventative safety controls and biorational inactivation measures are paramount. The objectives of this research were to evaluate the efficacy of pyrrolidine‐based amide derivatives of decanoic (DEPY), lauric (LAPY), myristic (MYPY) and palmitic (PAPY) fatty acids for in‐vitro inhibition and inactivation of various Gram‐positive bacterial strains including Listeria monocytogenes (typically associated with foodborne illness), Bacillus subtilis, and Streptococcus mutans and Streptococcus sobrinus (both normally present in the oral cavity and involved with dental caries). Compared to no treatment (control), significant differences (P < 0.05) in the growth of Listeria strains were seen in‐vitro with increased inhibition at higher amide concentrations (10,000–20,000 ppm). Furthermore, in‐vitro growth inhibition of B. subtilis, S. sobrinus, and S. mutans was also observed with an effectiveness of LAPY>MYPY>PAPY>DEPY. In co‐inoculation assays, LAPY treatment significantly reduced Listeria growth from 1.55 to >5.0 Log CFU/mL when a concentration range of 5 to 250 ppm was applied. Moreover, Listeria populations on pathogen‐inoculated produce were significantly (P < 0.05) reduced from 0.51 to >3.00 Log CFU/g with greater inactivation on carrots compared to alfalfa, soybean, and pistachio. These results demonstrated the potential value of these FA amides against Gram‐positive pathogenic bacteria. Biorational applications of antibacterial FA amides on fresh produce as a postharvest intervention process offers a great potential for enhancement of food safety.
Keywords	Bacillus subtilis ; Gram-positive bacteria ; Listeria monocytogenes ; Streptococcus mutans ; Streptococcus sobrinus ; alfalfa ; amides ; dental caries ; fatty acids ; food safety ; foodborne illness ; fresh produce ; growth retardation ; mouth ; pistachios ; product safety ; soybeans
Language	English
Dates of publication	2023-12
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	756159-3
ISSN	1745-4565 ; 0149-6085
ISSN (online)	1745-4565
ISSN	0149-6085
DOI	10.1111/jfs.13079
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Article: Synergistic efficacy of alkyltrimethylammonium bromide, chlorhexidine digluconate on diverse bacterial strains causing red-heat and purple-stain deteriorations of leather

Hussain, Syed Ammar / Sarker, Majher I / Yosief, Hailemichael O

Archives of microbiology. 2021 Mar., v. 203, no. 2

2021

Abstract	This investigation assessed the synergistic effectiveness of alkyltrimethylammonium bromide (ATMB) and chlorhexidine digluconate (CDG) on selected microbes causing red-heat and purple stain degradations on salt-cured hides and leather products. This biological phenomenon ultimately deteriorates the finished leather quality and grounds considerable economic losses for leather industry. In tryptic soy broth, combination of ATMB and/CDG at the concentration of 900/90 ppm for predefined time interval of 1, 3, and 6 min caused in 0.73, 2.45, and 2.95 log CFU/mL reductions of bacterial cocktail population cell survival, respectively. Whereas in saturated brine solution (SBS), the bacterial cocktail treated with 600/60 and 900/90 ppm of ATMB/CDG for 18 h resulted ~ 74% and 98% reduction, respectively, in comparison to their respective controls. Furthermore, lessening of individual bacterial cultivations by combined ATMB and CDG in SBS was also elucidated.
Keywords	brine solutions ; cell viability ; chlorhexidine ; leather ; leather industry
Language	English
Dates of publication	2021-03
Size	p. 629-634.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-020-02047-y
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Article ; Online: Evaluation of diverse biochemical stimulants to enhance growth, lipid and docosahexaenoic acid (DHA) production of Aurantiochytrium Sp. ATCC PRA-276

Hussain, Syed Ammar / Sarker, Majher I. / Yosief, Hailemichael O. / Yadav, Madhav P.

Biocatalysis and agricultural biotechnology. 2021 Sept., v. 36 p.102122-

2021

Abstract: In the current investigation, the efficacy of five different biochemical stimulants; 2-phenylacetic acid (PAA), humic acid (HA), spermidine (SPD), 1-methylcyclopropene (1-MCP), and ferric chlorides (FC), as potential stimulant in augmenting the growth/ ... ...

Abstract	In the current investigation, the efficacy of five different biochemical stimulants; 2-phenylacetic acid (PAA), humic acid (HA), spermidine (SPD), 1-methylcyclopropene (1-MCP), and ferric chlorides (FC), as potential stimulant in augmenting the growth/biomass, lipid and docosahexaenoic acid (DHA) production of Aurantiochytrium sp. ATCC PRA-276 were elucidated. After 120 h of cultivation, the individual supplementation of PAA, HA, SPD, 1-MCP, and FC, elevates the biomass, total lipid and DHA production of Aurantiochytrium sp. ATCC PRA-276 by 32%–76%, 23%–34%, and 53%–86% in comparison to the control, respectively. The highest biomass and DHA productivities was observed with the supplementation of PAA and FC achieving 76% and 67% and 86% and 66%, compared to the control, respectively. PAA supplementation may have increased biomass production by reducing the lag period and extending the log phase. While only a marginal increment on biomass and DHA contents of Aurantiochytrium sp. ATCC PRA-276 was observed with the supplementation of 1-MCP. This study suggests the potential application of biochemical stimulants for improved growth, lipid and DHA productivities of Aurantiochytrium sp. ATCC PRA-276.
Keywords	1-methylcyclopropene ; Thraustochytriaceae ; biomass production ; docosahexaenoic acid ; ferric chloride ; humic acids ; lipid metabolism ; microalgae ; phenylacetic acid ; spermidine ; Aurantiochytrium sp ; Biochemical stimulants ; Functional lipids ; Docosahexaenoic acid (DHA)
Language	English
Dates of publication	2021-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Resource is Open Access ; CHORUS License Information
ZDB-ID	2642052-1
ISSN	1878-8181
ISSN	1878-8181
DOI	10.1016/j.bcab.2021.102122
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Article ; Online: Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4

Zhou, Dawei / Hayashi, Tsuyoshi / Jean, Maxime / Kong, Weili / Fiches, Guillaume / Biswas, Ayan / Liu, Shuai / Yosief, Hailemichael O / Zhang, Xiaofeng / Bradner, Jay / Qi, Jun / Zhang, Wei / Santoso, Netty / Zhu, Jian

Science advances

2020 Volume 6, Issue 29, Page(s) eaba1941

Abstract: Although combination antiretroviral therapy is effective in controlling HIV-1 infection, latent HIV-1 proviruses cannot be eliminated. HIV-1 reactivation induced by the mere use of latency-reversing agents is insufficient to render death of reservoir ... ...

Abstract	Although combination antiretroviral therapy is effective in controlling HIV-1 infection, latent HIV-1 proviruses cannot be eliminated. HIV-1 reactivation induced by the mere use of latency-reversing agents is insufficient to render death of reservoir cells, indicating that certain intrinsic survival mechanisms exist. We report that Polo-like kinase 1 (PLK1) plays a critical role in survival of CD4
MeSH term(s)	CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/metabolism ; HIV Infections ; HIV-1/physiology ; Humans ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/metabolism ; Virus Activation ; Virus Latency ; Polo-Like Kinase 1
Chemical Substances	Cell Cycle Proteins ; Proto-Oncogene Proteins ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2020-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.aba1941
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Article ; Online: Binding of Pk-trisaccharide analogs of globotriaosylceramide to Shiga toxin variants.

Yosief, Hailemichael O / Iyer, Suri S / Weiss, Alison A

Infection and immunity

2013 Volume 81, Issue 8, Page(s) 2753–2760

Abstract: The two major forms of Shiga toxin, Stx1 and Stx2, use the glycolipid globotriaosylceramide (Gb3) as their cellular receptor. Stx1 primarily recognizes the Pk-trisaccharide portion and has three Pk binding sites per B monomer. The Stx2a subtype requires ... ...

Abstract	The two major forms of Shiga toxin, Stx1 and Stx2, use the glycolipid globotriaosylceramide (Gb3) as their cellular receptor. Stx1 primarily recognizes the Pk-trisaccharide portion and has three Pk binding sites per B monomer. The Stx2a subtype requires glycolipid residues in addition to Pk. We synthesized analogs of Pk to examine the binding preferences of Stx1 and Stx2 subtypes a to d. Furthermore, to determine how many binding sites must be engaged, the Pk analogues were conjugated to biotinylated mono- and biantennary platforms, allowing for the display of two to four Pk analogues per streptavidin molecule. Stx binding to Pk analogues immobilized on streptavidin-coated plates was assessed by enzyme-linked immunosorbent assay (ELISA). Stx1, but not the Stx2 subtypes, bound to native Pk. Stx2a and Stx2c bound to the Pk analog with a terminal GalNAc (NAc-Pk), while Stx1, Stx2b, and Stx2d did not bind to this analog. Interestingly, the purified Stx2d B subunit bound to NAc-Pk, suggesting that the A subunit of Stx2d interferes with binding. Disaccharide analogs (Galα1-4Gal, GalNAcα1-4Gal, and Galα1-4GalNAc) did not support the binding of any of the Stx forms, indicating that the trisaccharide is necessary for binding. Studies with monoantennary and biantennary analogs and mixtures suggest that Stx1, Stx2a, and Stx2c need to engage at least three Pk analogues for effective binding. To our knowledge, this is the first study examining the minimum number of Pk analogs required for effective binding and the first report documenting the role of the A subunit in influencing Stx2 binding.
MeSH term(s)	Amino Acid Sequence ; Blotting, Western ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Molecular Sequence Data ; Protein Binding ; Shiga Toxins/chemistry ; Shiga Toxins/metabolism ; Trihexosylceramides/chemistry ; Trisaccharides/chemistry ; Trisaccharides/metabolism
Chemical Substances	Shiga Toxins ; Trihexosylceramides ; Trisaccharides ; globotriaosylceramide (71965-57-6)
Language	English
Publishing date	2013-05-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00274-13
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Article ; Online: Capture of uropathogenic E. coli by using synthetic glycan ligands specific for the pap-pilus.

Yosief, Hailemichael O / Weiss, Alison A / Iyer, Suri S

Chembiochem : a European journal of chemical biology

2013 Volume 14, Issue 2, Page(s) 251–259

Abstract: Biotinylated mono- and biantennary di-/trisaccharides were synthesized to evaluate their ability to capture E. coli strains that express pilus types with different receptor specificities. The synthesized biotinylated di-/trisaccharides contain Galα(1→4) ... ...

Abstract	Biotinylated mono- and biantennary di-/trisaccharides were synthesized to evaluate their ability to capture E. coli strains that express pilus types with different receptor specificities. The synthesized biotinylated di-/trisaccharides contain Galα(1→4)Gal, Galα(1→4)GalNHAc, GalNHAcα(1→4)Gal, Galα(1→4)Galβ(1→4)Glc and GalNHAcα(1→4)Galβ(1→4)Glc as carbohydrate epitopes. These biotinylated oligosaccharides were immobilized on streptavidin-coated magnetic beads, and incubated with different strains of live E. coli. Capturing ability was assessed by using a luciferase assay that detects bacterial ATP. The trisaccharides containing Galα(1→4)Galβ(1→4)Glc and the disaccharides containing Galα(1→4)Gal as the epitopes exhibited strong capturing ability for uropathogenic E. coli strains with the pap pilus genotype, including CFT073, J96 and J96 pilE. The same ligands failed to capture E. coli strains with fim, prs, or foc genotypes. Uropathogenic CFT073 was also captured moderately by biantennary disaccharides containing a GalNHAc moiety at the reducing end; however, other saccharides containing GalNHAc at the nonreducing end did not capture the CFT073 strain. These synthetic glycoconjugates could potentially be adapted as rapid diagnostic agents to differentiate between different E. coli pathovars.
MeSH term(s)	Binding Sites ; Biotinylation ; Carbohydrate Sequence ; Disaccharides/chemistry ; Disaccharides/metabolism ; Escherichia coli/isolation & purification ; Escherichia coli/metabolism ; Escherichia coli Infections/diagnosis ; Escherichia coli Infections/microbiology ; Glycoconjugates/chemistry ; Glycoconjugates/metabolism ; Humans ; Ligands ; Molecular Sequence Data ; Trisaccharides/chemistry ; Trisaccharides/metabolism
Chemical Substances	Disaccharides ; Glycoconjugates ; Ligands ; Trisaccharides
Language	English
Publishing date	2013-01-10
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.201200582
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Article ; Online: Development of Dimethylisoxazole-Attached Imidazo[1,2-

Muthengi, Alex / Wimalasena, Virangika K / Yosief, Hailemichael O / Bikowitz, Melissa J / Sigua, Logan H / Wang, Tingjian / Li, Deyao / Gaieb, Zied / Dhawan, Gagan / Liu, Shuai / Erickson, Jon / Amaro, Rommie E / Schönbrunn, Ernst / Qi, Jun / Zhang, Wei

Journal of medicinal chemistry

2021 Volume 64, Issue 9, Page(s) 5787–5801

Abstract: The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned from targeting bromodomain extraterminal domain (BET) proteins into targeting non-BET bromodomains. The two most relevant non-BET bromodomain oncology targets are ... ...

Abstract	The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned from targeting bromodomain extraterminal domain (BET) proteins into targeting non-BET bromodomains. The two most relevant non-BET bromodomain oncology targets are cyclic AMP response element-binding protein (CBP) and E1A binding protein P300 (EP300). To explore the growing CBP/EP300 interest, we developed a highly efficient two-step synthetic route for dimethylisoxazole-attached imidazo[1,2-
MeSH term(s)	Binding Sites ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Crystallography, X-Ray ; Cyclic AMP Response Element-Binding Protein/antagonists & inhibitors ; Cyclic AMP Response Element-Binding Protein/metabolism ; E1A-Associated p300 Protein/antagonists & inhibitors ; E1A-Associated p300 Protein/metabolism ; Humans ; Isoxazoles/chemistry ; Molecular Docking Simulation ; Pyridines/chemistry ; Pyridines/metabolism ; Pyridines/pharmacology ; Structure-Activity Relationship ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism
Chemical Substances	BRD4 protein, human ; Cell Cycle Proteins ; Cyclic AMP Response Element-Binding Protein ; Isoxazoles ; Pyridines ; Transcription Factors ; E1A-Associated p300 Protein (EC 2.3.1.48) ; EP300 protein, human (EC 2.3.1.48) ; imidazo(1,2-a)pyridine (G18ZBV2HXA)
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.0c02232
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