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Article ; Online: Características clínicas básicas en los primeros 100 casos fatales de COVID-19 en Colombia.

Marín-Sánchez, Alejandro

Revista panamericana de salud publica = Pan American journal of public health

2020 Volume 44, Page(s) e87

Abstract: The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic. Since the INS records do not include clinical ... ...

Title translation	Basic clinical characteristics in the first 100 fatal cases of COVID-19 in Colombia.
Abstract	The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic. Since the INS records do not include clinical variables of comorbidity in the total number of cases reported as positive, but only in patients with fatal outcome, comorbidities, age and sex available in the daily INS reports were reviewed. Their frequency was identified and mortality risk behavior for the analyzed variables was established and compared with the behavior described in the international literature. Of the 100 cases, 63 were male, the mean age was 65.75 ± 18.11 years, and in 22 of them no comorbidity had been reported. The most frequently reported comorbidities were arterial hypertension (35%), diabetes mellitus (21%), cardiovascular and cerebrovascular disease (19%), chronic obstructive pulmonary disease (16%), obesity (12%), smoking (9%) and thyroid disease (8%). Patients over 60 years of age presented a higher risk of mortality (OR 10.31, IC95% 6.67-15.94, p < 0.0001). Ten percent of the deceased patients were under 60 years of age and did not present comorbidity.
Keywords	covid19
Language	Spanish
Publishing date	2020-07-31
Publishing country	United States
Document type	English Abstract ; Journal Article
ZDB-ID	1376934-0
ISSN	1680-5348 ; 1020-4989
ISSN (online)	1680-5348
ISSN	1020-4989
DOI	10.26633/RPSP.2020.87
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Article ; Online: Características clínicas básicas en los primeros 100 casos fatales de COVID-19 en Colombia

Alejandro Marín-Sánchez

Revista Panamericana de Salud Pública, Vol 44, Iss 87, Pp 1-

2020 Volume 4

Abstract: Se analizaron las características clínicas básicas de los primeros 100 casos de fallecimientos por COVID-19 en Colombia con base en los reportes del Instituto Nacional de Salud (INS) desde el inicio de la pandemia. Dado que el registro del INS no toma en ...

Abstract	Se analizaron las características clínicas básicas de los primeros 100 casos de fallecimientos por COVID-19 en Colombia con base en los reportes del Instituto Nacional de Salud (INS) desde el inicio de la pandemia. Dado que el registro del INS no toma en cuenta las variables clínicas de comorbilidad en el total de los casos reportados como positivos, sino solo en los pacientes con desenlace mortal, se revisaron la patología concomitante, la edad y el sexo disponibles en los reportes diarios del INS. Se identificó su frecuencia y se intentó establecer el comportamiento de riesgo de mortalidad para las variables analizables (OR), y se comparó con el comportamiento descrito en la literatura internacional. De los 100 casos, 63 fueron de sexo masculino, el promedio de edad fue 65,75 ± 18,11 años y en 22 de ellos no se había reportado comorbilidad. Las patologías informadas con más frecuencia fueron hipertensión arterial (35%), diabetes mellitus (21%), enfermedades cardiovasculares y cerebrovasculares (19%), enfermedad pulmonar obstructiva crónica (16%), obesidad (12%), tabaquismo (9%) y patología tiroidea (8%). Los pacientes mayores de 60 años presentaron un mayor riesgo de mortalidad (OR 10,31, IC95% 6,67-15,94, p < 0,0001). El 10% de los pacientes fallecidos eran menores de 60 años y no presentaban comorbilidad.
Keywords	coronavirus ; mortalidad ; colombia ; Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270 ; covid19
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Pan American Health Organization
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Basic clinical characteristics in the first 100 fatal cases of COVID-19 in Colombia]

Marín-Sánchez, Alejandro

Revista panamericana de salud publica = Pan American journal of public health

Abstract: The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic Since the INS records do not include clinical ... ...

Abstract	The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic Since the INS records do not include clinical variables of comorbidity in the total number of cases reported as positive, but only in patients with fatal outcome, comorbidities, age and sex available in the daily INS reports were reviewed Their frequency was identified and mortality risk behavior for the analyzed variables was established and compared with the behavior described in the international literature Of the 100 cases, 63 were male, the mean age was 65 75 ± 18 11 years, and in 22 of them no comorbidity had been reported The most frequently reported comorbidities were arterial hypertension (35%), diabetes mellitus (21%), cardiovascular and cerebrovascular disease (19%), chronic obstructive pulmonary disease (16%), obesity (12%), smoking (9%) and thyroid disease (8%) Patients over 60 years of age presented a higher risk of mortality (OR 10 31, IC95% 6 67-15 94, p < 0 0001) Ten percent of the deceased patients were under 60 years of age and did not present comorbidity
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #696197
Database	COVID19

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Article: Basic clinical characteristics in the first 100 fatal cases of COVID-19 in Colombia/ Caracteristicas clinicas basicas en los primeros 100 casos fatales de COVID-19 en Colombia

Marin-Sanchez, Alejandro

Revista panamericana de salud publica = Pan American journal of public health

Abstract: The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic Since the INS records do not include clinical ... ...

Abstract	The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic Since the INS records do not include clinical variables of comorbidity in the total number of cases reported as positive, but only in patients with fatal outcome, comorbidities, age and sex available in the daily INS reports were reviewed Their frequency was identified and mortality risk behavior for the analyzed variables was established and compared with the behavior described in the international literature Of the 100 cases, 63 were male, the mean age was 65 75 ± 18 11 years, and in 22 of them no comorbidity had been reported The most frequently reported comorbidities were arterial hypertension (35%), diabetes mellitus (21%), cardiovascular and cerebrovascular disease (19%), chronic obstructive pulmonary disease (16%), obesity (12%), smoking (9%) and thyroid disease (8%) Patients over 60 years of age presented a higher risk of mortality (OR 10 31, IC95% 6 67-15 94, p < 0 0001) Ten percent of the deceased patients were under 60 years of age and did not present comorbidity
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #706219
Database	COVID19

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Article: Application of Biostimulant in Seeds and Soil on Three Chickpea Varieties: Impacts on Germination, Vegetative Development, and Bacterial Facilitation of Nitrogen and Phosphorus.

Gómez, Elisa / Alonso, Alejandro / Sánchez, Jorge / Muñoz, Pedro / Marín, José / Mostaza-Colado, David / Mauri, Pedro V

Life (Basel, Switzerland)

2024 Volume 14, Issue 1

Abstract: Chickpeas ( ...

Abstract	Chickpeas (
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14010148
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characterization of an antarctic penguin colony ecosystem using high-resolution UAV hyperspectral imagery

Alejandro Román / Antonio Tovar-Sánchez / Beatriz Fernández-Marín / Gabriel Navarro / Luis Barbero

International Journal of Applied Earth Observations and Geoinformation, Vol 125, Iss , Pp 103565- (2023)

2023

Abstract: Penguin colonies significantly influence the distribution and diversity of vegetation communities in Maritime Antarctica, as they serve as vital sources of nutrients for both terrestrial and aquatic ecosystems. Remote sensing techniques are becoming ... ...

Abstract	Penguin colonies significantly influence the distribution and diversity of vegetation communities in Maritime Antarctica, as they serve as vital sources of nutrients for both terrestrial and aquatic ecosystems. Remote sensing techniques are becoming increasingly common for monitoring these vast Antarctic areas, especially with Unmanned Aerial Vehicles (UAVs) imagery, which provides the highest spatial resolutions to date. In fact, the use of hyperspectral (HS) sensors is crucial for accurately identifying and distinguishing between the main ground characteristics and vegetation communities in an Antarctic penguin colony, making this study one of the first UAV-based HS approaches to our knowledge. Consequently, this study provides a spectral library covering the entire spectral range from 400 to 2500 nm for the five main vegetation communities found at Hannah Point penguin colony (Livingston Island, Antarctica). Through this library, two valuable wavelength regions have been identified for distinguishing these communities based on pigments composition, specifically in the green (495–570 nm) and near-infrared (800–900 nm) ranges, that served as a reference for validating the results using 35 ground reference spectrometry data collected in 1667 wavelength bands within the 320–876 nm range. In addition, the supervised classification approach known as the “Spectral Angle Mapper” has been employed to monitor the coverage of each vegetation community based on the information provided by the aforementioned spectral library. The observed ecological gradient, which reveals an increase in vegetation complexity away from the high-nutrient content guano areas, highlights the influence of guano on the distribution of the main vegetation patterns across the entire penguin colony. The results of this study could serve as a reference point for more sophisticated research involving the use of UAV-based HS or MS sensors in Antarctica, offering unique opportunities to detect small variations in these remote ecosystems resulting ...
Keywords	Remote sensing ; Antarctic vegetation ; Multispectral ; Drones ; Biological mapping ; Spectral library ; Physical geography ; GB3-5030 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of Cytogenetics Aberrations and

Muñoz-Novas, Carolina / González-Gascón-Y-Marín, Isabel / Figueroa, Iñigo / Sánchez-Paz, Laura / Pérez-Carretero, Claudia / Quijada-Álamo, Miguel / Rodríguez-Vicente, Ana-Eugenia / Infante, María-Stefania / Foncillas, María-Ángeles / Landete, Elena / Churruca, Juan / Marín, Karen / Ramos, Victoria / Sánchez Salto, Alejandro / Hernández-Rivas, José-Ángel

Global medical genetics

2024 Volume 11, Issue 1, Page(s) 59–68

Abstract: Immunoglobulin heavy chain variable ( ...

Abstract	Immunoglobulin heavy chain variable (
Language	English
Publishing date	2024-02-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	3009997-3
ISSN	2699-9404 ; 2699-9404
ISSN (online)	2699-9404
ISSN	2699-9404
DOI	10.1055/s-0044-1779668
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Addictive disorders, psychiatric symptoms, and potentially traumatic events in individuals with disabilities.

Marín-Navarrete, Rodrigo / Sánchez-Domínguez, Ricardo / Pérez-López, Alejandro / Saracco-Alvarez, Ricardo

Frontiers in psychology

2022 Volume 13, Page(s) 936184

Abstract: Background/objectives: Individuals with disabilities (IWD) have a higher risk of potentially traumatic events (PTEs) either in childhood or adulthood, increasing the risk of suicide attempts, mental disorders, and substance use disorder. The aim of this ...

Abstract	Background/objectives: Individuals with disabilities (IWD) have a higher risk of potentially traumatic events (PTEs) either in childhood or adulthood, increasing the risk of suicide attempts, mental disorders, and substance use disorder. The aim of this study was to explore the association between substance use, psychiatric symptoms and suicidal behavior with PTEs. A Multisite cross-sectional study was conducted. Materials and methods: The sample includes 1,098 participants with any type of disability (motor, intellectual, visual, and mixed) located in Mexico City. Traumatic events, violence, discrimination, addictive disorders, and psychiatric disorders were examined. Multivariate logistic regression models were conducted. Data was collected between September-October 2014. Results: People with motor or visual disability have a higher prevalence in nicotine use disorder (NUD), generalize anxiety disorder (GAD), mayor depression disorder (MDD), want to be dead, and lifetime suicide attempts. Intellectual disability group only presents GAD and MDD. All disability groups have a high prevalence of PTEs. Verbal violence in childhood, sexual abuse, discrimination and serious accidents had a strong impact in the development of NUD, psychiatric symptoms and suicidal behavior. Conclusion: These findings show the relevance of develop specific tools for detection, referral and treatment, in order to improve the mental health of people with disabilities.
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.936184
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Targeted Metabolomics Shows That the Level of Glutamine, Kynurenine, Acyl-Carnitines and Lysophosphatidylcholines Is Significantly Increased in the Aqueous Humor of Glaucoma Patients.

Lillo, Alejandro / Marin, Silvia / Serrano-Marín, Joan / Binetti, Nicolas / Navarro, Gemma / Cascante, Marta / Sánchez-Navés, Juan / Franco, Rafael

Frontiers in medicine

2022 Volume 9, Page(s) 935084

Abstract: The composition of the aqueous humor of patients with glaucoma is relevant to understand the underlying causes of the pathology. Information on the concentration of metabolites and small molecules in the aqueous humor of healthy subjects is limited. ... ...

Abstract	The composition of the aqueous humor of patients with glaucoma is relevant to understand the underlying causes of the pathology. Information on the concentration of metabolites and small molecules in the aqueous humor of healthy subjects is limited. Among the causes of the limitations is the lack of healthy controls since, until recently, they were not surgically intervened; therefore, the aqueous humor of patients operated for cataract was used as a reference. Sixteen aqueous humor samples from healthy subjects undergoing refractive surgery and eight samples from glaucoma patients were used to assess the concentration of 188 compounds using chromatography and mass spectrometry. The concentration of 80 of the 188 was found to be reliable, allowing comparison of data from the two groups (glaucoma and control). The pattern found in the controls is similar to, but not the same as, that reported using samples from "controls" undergoing cataract surgery. Comparing data from glaucoma patients and healthy subjects, 57 of the 80 compounds were significantly (
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.935084
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Article ; Online: A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson's disease.

Serrano-Marín, Joan / Marin, Silvia / Bernal-Casas, David / Lillo, Alejandro / González-Subías, Marc / Navarro, Gemma / Cascante, Marta / Sánchez-Navés, Juan / Franco, Rafael

Fluids and barriers of the CNS

2023 Volume 20, Issue 1, Page(s) 90

Abstract: Background: The lack of accessible and informative biomarkers results in a delayed diagnosis of Parkinson's disease (PD), whose symptoms appear when a significant number of dopaminergic neurons have already disappeared. The retina, a historically ... ...

Abstract	Background: The lack of accessible and informative biomarkers results in a delayed diagnosis of Parkinson's disease (PD), whose symptoms appear when a significant number of dopaminergic neurons have already disappeared. The retina, a historically overlooked part of the central nervous system (CNS), has gained recent attention. It has been discovered that the composition of cerebrospinal fluid influences the aqueous humor composition through microfluidic circulation. In addition, alterations found in the brain of patients with PD have a correlate in the retina. This new paradigm highlights the potential of the aqueous humor as a sample for identifying differentially concentrated metabolites that could, eventually, become biomarkers if also found altered in blood or CSF of patients. In this research we aim at analyzing the composition of the aqueous humor from healthy controls and PD patients. Methods: A targeted metabolomics approach with concentration determination by mass spectrometry was used. Statistical methods including principal component analysis and linear discriminants were used to select differentially concentrated metabolites that allow distinguishing patients from controls. Results: In this first metabolomics study in the aqueous humor of PD patients, elevated levels of 16 compounds were found; molecules differentially concentrated grouped into biogenic amines, amino acids, and acylcarnitines. A biogenic amine, putrescine, alone could be a metabolite capable of differentiating between PD and control samples. The altered levels of the metabolites were correlated, suggesting that the elevations stem from a common mechanism involving arginine metabolism. Conclusions: A combination of three metabolites, putrescine, tyrosine, and carnitine was able to correctly classify healthy participants from PD patients. Altered metabolite levels suggest altered arginine metabolism. The pattern of metabolomic disturbances was not due to the levodopa-based dopamine replacement medication because one of the patients was not yet taking levodopa but a dopamine receptor agonist.
MeSH term(s)	Humans ; Parkinson Disease ; Levodopa/metabolism ; Aqueous Humor/metabolism ; Putrescine/metabolism ; Biomarkers/cerebrospinal fluid ; Arginine/metabolism
Chemical Substances	Levodopa (46627O600J) ; Putrescine (V10TVZ52E4) ; Biomarkers ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2595406-4
ISSN	2045-8118 ; 2045-8118
ISSN (online)	2045-8118
ISSN	2045-8118
DOI	10.1186/s12987-023-00494-5
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